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The Immunology of Psoriasis—Current Concepts in Pathogenesis
The Immunology of Psoriasis—Current Concepts in Pathogenesis
Psoriasis is one of the most common inflammatory skin diseases with a chronic, relapsing-remitting course. The last decade...
Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy
Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy
Tropomyosin has been identified as the major cross-reactive shellfish allergen, but recent studies showed the presence of ...
Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis
Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis
This systematic review aims to identify the association between prenatal exposure to air pollutants and allergic diseases ...
Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway...
Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections
Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, modulate immune cell functions, particularly m...
Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases
Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases
The role of abnormal epigenetic modifications, particularly DNA methylation, in the pathogenesis of autoimmune rheumatic d...
Down Syndrome and Autoimmune Disease
Down Syndrome and Autoimmune Disease
Down syndrome is the most common genetic cause of intellectual disability and has previously been associated with a variet...
Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases
Single-Cell Sequencing: High-Resolution Analysis of Cellular Heterogeneity in Autoimmune Diseases
Autoimmune diseases (AIDs) are complex in etiology and diverse in classification but clinically show similar symptoms such...
Fibroblast: A Novel Target for Autoimmune and Inflammatory Skin Diseases Therapeutics
Fibroblast: A Novel Target for Autoimmune and Inflammatory Skin Diseases Therapeutics
Fibroblasts are crucial components of the skin structure. They were traditionally believed to maintain the skin’s st...
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Atopic dermatitis and psoriasis are common chronic inflammatory diseases of high incidence that share some clinical featur...
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory...
Fungal Head and Neck Dermatitis: Current Understanding and Management
Fungal Head and Neck Dermatitis: Current Understanding and Management
Head and neck dermatitis (HND) is a form of atopic dermatitis (AD) that affects the seborrheic areas of the body and cause...
Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy
Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy
Allergen-based diagnostics are essential in the management algorithm of allergic diseases. Unlike systemic allergy, where ...
Neutrophils in Atopic Dermatitis
Neutrophils in Atopic Dermatitis
Neutrophils have a critical role in inflammation. Recent studies have identified their distinctive presence in certain typ...
Efficacy of Capsaicin for Non-allergic Rhinitis: An Updated Systematic Review and Meta-analysis
Efficacy of Capsaicin for Non-allergic Rhinitis: An Updated Systematic Review and Meta-analysis
Non-allergic rhinitis (NAR) is a prevalent condition with limited effective treatments. Capsaicin, an agonist of the trans...
Non-allergic Hypersensitivity Reactions to Immunoglobulin Preparations in Antibody Deficiencies: What Role for Anti-IgA IgG and Complement Activation?
Non-allergic Hypersensitivity Reactions to Immunoglobulin Preparations in Antibody Deficiencies: What Role for Anti-IgA IgG and Complement Activation?
The presence of IgG anti-IgA in the serum of primary immunodeficiency (PID) patients has long been considered responsible ...
MDA5 Is a Major Determinant of Developing Symptoms in Critically Ill COVID-19 Patients
MDA5 Is a Major Determinant of Developing Symptoms in Critically Ill COVID-19 Patients
Apart from the skin and mucosal immune barrier, the first line of defense of the human immune system includes MDA5 (ifih1 ...
A Novel Subset of Regulatory T Cells Induced by B Cells Alleviate the Severity of Immunological Diseases
A Novel Subset of Regulatory T Cells Induced by B Cells Alleviate the Severity of Immunological Diseases
Regulatory T (Treg) cells are crucial for maintaining immune tolerance by suppressing response to self-antigens and harmle...
Hereditary Angioedema Attacks in Patients Receiving Long-Term Prophylaxis: A Systematic Review
Hereditary Angioedema Attacks in Patients Receiving Long-Term Prophylaxis: A Systematic Review
Long-term prophylaxis (LTP) has been shown to reduce the frequency of hereditary angioedema (HAE) attacks; however, attack...
Tumor Necrosis Factor Alpha Inhibitors and Cardiovascular Risk in Rheumatoid Arthritis
Tumor Necrosis Factor Alpha Inhibitors and Cardiovascular Risk in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by an increased risk of cardiovascular events, d...
A Comprehensive Review of Sulfonamide Hypersensitivity: Implications for Clinical Practice
A Comprehensive Review of Sulfonamide Hypersensitivity: Implications for Clinical Practice
Sulfonamides, which are drugs commonly prescribed in hospital and outpatient settings, have historically been associated w...
Autoinflammatory Keratinization Diseases—The Concept, Pathophysiology, and Clinical Implications
Autoinflammatory Keratinization Diseases—The Concept, Pathophysiology, and Clinical Implications
Recent advances in medical genetics elucidated the background of diseases characterized by superficial dermal and epiderma...
Diverse Endotypes of Chronic Rhinosinusitis and Clinical Implications
Diverse Endotypes of Chronic Rhinosinusitis and Clinical Implications
Chronic rhinosinusitis (CRS) is a highly heterogeneous disease characterized by inflammation in the nasal and sinus mucosa...
B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases
B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases
In the field of contemporary medicine, autoimmune diseases (AIDs) are a prevalent and debilitating group of illnesses. How...
Is Food-Triggered Atopic Dermatitis a Form of Systemic Contact Dermatitis?
Is Food-Triggered Atopic Dermatitis a Form of Systemic Contact Dermatitis?
Food allergy in atopic dermatitis is mediated by complex immune interactions between genetics, diet, environment, and the ...
Tissue-Resident Memory T Cells in Allergy
Tissue-Resident Memory T Cells in Allergy
Tissue-resident memory T (TRM) cells constitute a distinct subset within the memory T cell population, serving as the vang...
A Global View of Pemphigus: Geographical Variations
A Global View of Pemphigus: Geographical Variations
Pemphigus, an autoimmune intraepidermal bullous disease group with roughly eight distinct forms, includes pemphigus vulgar...
Clinical Presentation and Diagnosis of Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) in Children: A Scoping Review
Clinical Presentation and Diagnosis of Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) in Children: A Scoping Review
Effective treatment of drug reactions with eosinophilia and systemic symptoms (DReSS) requires early diagnosis and close m...
Advancing Understanding of Childhood Asthma: Lessons Learned from Birth Cohort Studies
Advancing Understanding of Childhood Asthma: Lessons Learned from Birth Cohort Studies
Asthma and allergies are some of the most common chronic disorders affecting children, the prevalence of which has been in...
Cellular and Molecular Mechanisms of Mast Cells in Atherosclerotic Plaque Progression and Destabilization
Cellular and Molecular Mechanisms of Mast Cells in Atherosclerotic Plaque Progression and Destabilization
Mast cells (MCs) are commonly recognized for their crucial involvement in the pathogenesis of allergic diseases, but over ...
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