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Integrative analysis of multiple cell death model for precise prognosis and drug response prediction in gastric cancer
Integrative analysis of multiple cell death model for precise prognosis and drug response prediction in gastric cancer
Gastric cancer (GC) is a common upper gastrointestinal tumor. However, the evaluation of prognosis and treatment response ...
CircTSN promotes the proliferation and metastasis of gastric cancer through the miR-1825/SLC38A2 signaling axis
CircTSN promotes the proliferation and metastasis of gastric cancer through the miR-1825/SLC38A2 signaling axis
Comprehensive treatment of gastric cancer (GC) is progressing, but the rapid proliferation and metastasis of GC remains a ...
T cell exhaustion methylation signature drives differential immune responses in glioblastoma
T cell exhaustion methylation signature drives differential immune responses in glioblastoma
Methylation-related signatures play crucial roles in tumorigenesis and progression. However, their roles in the immune res...
A basement membrane-related signature for prognosis and immunotherapy benefit in bladder cancer based on machine learning
A basement membrane-related signature for prognosis and immunotherapy benefit in bladder cancer based on machine learning
Bladder cancer has a poor clinical outcome because of its high aggressiveness. Basement membrane plays vital functions in ...
Global research and current trends on nanotherapy in lung cancer research: a bibliometric analysis of 20 years
Global research and current trends on nanotherapy in lung cancer research: a bibliometric analysis of 20 years
Lung cancer ranks as one of the most rapidly growing malignancies. Which is characterized by its poor prognosis and a low ...
Exploring the significance and potential mechanisms of hippo pathway-associated genes in prognosis of glioma patients
Exploring the significance and potential mechanisms of hippo pathway-associated genes in prognosis of glioma patients
Despite the efforts of countless researchers to develop glioma treatment strategies, the current therapeutic effect of gli...
Exploring the role of ADAMTSL2 across multiple cancer types: A pan-cancer analysis and validated in colorectal cancer
Exploring the role of ADAMTSL2 across multiple cancer types: A pan-cancer analysis and validated in colorectal cancer
Recent studies have established a correlation between ADAMTSL2 (ADAMTS-like 2) and the development of various cancers. Thi...
The unique CARWL score stratifies locally advanced nasopharyngeal cancer patients receiving concurrent chemoradiotherapy into risk groups for radiation-induced trismus
The unique CARWL score stratifies locally advanced nasopharyngeal cancer patients receiving concurrent chemoradiotherapy into risk groups for radiation-induced trismus
To determine the utility of the novel CARWL score, which integrates C-reactive protein-to-albumin ratio (CAR) and signific...
Selection determines therapeutic effects: a retrospective analysis of the application of different frailty tools in elderly patients with multiple myeloma
Selection determines therapeutic effects: a retrospective analysis of the application of different frailty tools in elderly patients with multiple myeloma
The aim was to explore the effectiveness of the International Myeloma Working Group Frailty Index (IMWG-FI), Mayo Score, U...
Application of artificial intelligence model in pathological staging and prognosis of clear cell renal cell carcinoma
Application of artificial intelligence model in pathological staging and prognosis of clear cell renal cell carcinoma
This study aims to develop a deep learning (DL) model based on whole-slide images (WSIs) to predict the pathological stage...
Identification of novel diagnostic biomarkers associated with liver metastasis in colon adenocarcinoma by machine learning
Identification of novel diagnostic biomarkers associated with liver metastasis in colon adenocarcinoma by machine learning
Liver metastasis is one of the primary causes of poor prognosis in colon adenocarcinoma (COAD) patients, but there are few...
Long noncoding RNA DDX11-AS1 represses sorafenib-induced ferroptosis in hepatocellular carcinoma cells via Nrf2-Keap1 pathway
Long noncoding RNA DDX11-AS1 represses sorafenib-induced ferroptosis in hepatocellular carcinoma cells via Nrf2-Keap1 pathway
Sorafenib, a first-line therapeutic option for advanced hepatocellular carcinoma (HCC), faces a formidable challenge in th...
Prognostic risk model of LIHC T-cells based on scRNA-seq and RNA-seq and the regulation of the tumor immune microenvironment
Prognostic risk model of LIHC T-cells based on scRNA-seq and RNA-seq and the regulation of the tumor immune microenvironment
T-cell-related genes play a crucial role in LIHC development. However, a reliable prognostic profile based on risk models ...
STARD7 could be an immunological and prognostic biomarker: from pan-cancer analysis to hepatocellular carcinoma validation
STARD7 could be an immunological and prognostic biomarker: from pan-cancer analysis to hepatocellular carcinoma validation
As the emergence of technologies such as sequencing and gene mapping, significant advancements have been made in understan...
Deciphering the IGF2BP3-mediated control of ferroptosis: mechanistic insights and therapeutic prospects
Deciphering the IGF2BP3-mediated control of ferroptosis: mechanistic insights and therapeutic prospects
The rapid expansion of the oncology field has revealed new insights into cell death processes, with a particular emphasis ...
RBMS1 interference inhibits malignant progression of glioblastoma cells and promotes ferroptosis
RBMS1 interference inhibits malignant progression of glioblastoma cells and promotes ferroptosis
Glioblastoma (GBM) is a brain tumor characterized by the highest malignancy and the poorest prognoses. RNA binding motif s...
EBNA1BP2 identified as potential prognostic biomarker for multiple tumor types in pan-cancer analysis
EBNA1BP2 identified as potential prognostic biomarker for multiple tumor types in pan-cancer analysis
Epstein-Barr virus (EBV) infection has been closely linked to the development of various types of cancer. EB nuclear antig...
Repurposing FDA-approved compounds to target JAK2 for colon cancer treatment
Repurposing FDA-approved compounds to target JAK2 for colon cancer treatment
Colorectal cancer is one of the common cancers worldwide and the second leading cause of cancer-related death. The current...
Cuproptosis-related DNA methylation signature predict prognosis and immune microenvironment in cutaneous melanoma
Cuproptosis-related DNA methylation signature predict prognosis and immune microenvironment in cutaneous melanoma
The prognosis for Cutaneous Melanoma (CM), a skin malignant tumor that is extremely aggressive, is not good. A recently id...
Exploring prognostic values of DNA ploidy, stroma-tumor fraction and nucleotyping in stage II colon cancer patients
Exploring prognostic values of DNA ploidy, stroma-tumor fraction and nucleotyping in stage II colon cancer patients
To assess the prognostic value of three novel biomarkers, DNA ploidy, stroma-tumor fraction, and nucleotyping, seeking for...
PG I and PG II show unique value in diagnosing postoperative biochemical recurrence in patients with gastric cancer after total gastrectomy
PG I and PG II show unique value in diagnosing postoperative biochemical recurrence in patients with gastric cancer after total gastrectomy
To investigate the potential of group I pepsinogen (PG I) and group II pepsinogen (PG II) as diagnostic markers for recurr...
Effect of exercise on postoperative recovery of patients with non-small cell lung cancer: a systematic review and meta-analysis
Effect of exercise on postoperative recovery of patients with non-small cell lung cancer: a systematic review and meta-analysis
Patients with non-small cell lung cancer (NSCLC) in the postoperative recovery period often experience reduced exercise ca...
Targeting IL-11R/EZH2 signaling axis as a therapeutic strategy for osteosarcoma lung metastases
Targeting IL-11R/EZH2 signaling axis as a therapeutic strategy for osteosarcoma lung metastases
Lung metastases are the primary cause of death for osteosarcoma (OS) patients. We recently validated interleukin-11 recept...
DcR3-associated risk score: correlating better prognosis and enhanced predictive power in colorectal cancer
DcR3-associated risk score: correlating better prognosis and enhanced predictive power in colorectal cancer
Decoy receptor 3 (DcR3), a novel soluble protein belonging to the tumor necrosis factor receptor (TNFR) family, has been p...
Asperuloside inhibits the activation of pancreatic cancer-associated fibroblasts via activating transcription factor 6
Asperuloside inhibits the activation of pancreatic cancer-associated fibroblasts via activating transcription factor 6
Pancreatic cancer-associated fibroblasts (CAFs) play a crucial role in tumor progression and immune evasion. Asperuloside ...
Establishment and validation of a novel CD8+ T cell-associated prognostic signature for predicting clinical outcomes and immunotherapy response in hepatocellular carcinoma via integrating single-cell RNA-seq and bulk RNA-seq
Establishment and validation of a novel CD8+ T cell-associated prognostic signature for predicting clinical outcomes and immunotherapy response in hepatocellular carcinoma via integrating single-cell RNA-seq and bulk RNA-seq
CD8+ T lymphocytes are critical in the immune response against neoplasms, yet the prognostic relevance of CD8+ ...
BOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer
BOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer
The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) and exemestane (EXE) in the ...
Establishment and validation of a novel disulfidptosis-related immune checkpoint gene signature in clear cell renal cell carcinoma
Establishment and validation of a novel disulfidptosis-related immune checkpoint gene signature in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal tumors and is associated with a unfavorable...
PARP1 bound to XRCC2 promotes tumor progression in colorectal cancer
PARP1 bound to XRCC2 promotes tumor progression in colorectal cancer
By complexing poly (ADP-ribose) (PAR) in reaction to broke strand, PAR polymerase1 (PARP1) acts as the key enzyme particip...
A novel mitochondrial-related lncRNA signature mediated prediction of overall survival, immune landscape, and the chemotherapeutic outcomes for bladder cancer patients
A novel mitochondrial-related lncRNA signature mediated prediction of overall survival, immune landscape, and the chemotherapeutic outcomes for bladder cancer patients
To develop a prognostic risk model for Bladder Cancer (BLCA) based on mitochondrial-related long non-coding RNAs (lncRNAs)...
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