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Resection margins, lymph node harvest and 3 year survival in open and laparoscopic colorectal cancer surgery; a prospective cohort study
Resection margins, lymph node harvest and 3 year survival in open and laparoscopic colorectal cancer surgery; a prospective cohort study
Laparoscopic colorectal cancer surgery has been gaining popularity in the last decade. However, there are concerns about a...
The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology
The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology
Breast cancer is the most common cancer worldwide, with an estimated 2.3 million new cases diagnosed every year. Effective...
β-Arrestin2 promotes docetaxel resistance of castration-resistant prostate cancer via promoting hnRNP A1-mediated PKM2 alternative splicing
β-Arrestin2 promotes docetaxel resistance of castration-resistant prostate cancer via promoting hnRNP A1-mediated PKM2 alternative splicing
To investigate the influence of β-arrestin2 on the docetaxel resistance in castration-resistant prostate cancer (CRPC...
ALOX5AP is a new prognostic indicator in acute myeloid leukemia
ALOX5AP is a new prognostic indicator in acute myeloid leukemia
The overexpression of ALOX5AP has been observed in many types of cancer and has been identified as an oncogene. However, i...
Mapping the immunological battlefield in gastric cancer: prognostic implications of an immune gene expression signature
Mapping the immunological battlefield in gastric cancer: prognostic implications of an immune gene expression signature
Gastric cancer (GC) is a heterogeneous malignancy with variable clinical outcomes. The immune system has been implicated i...
ARAP1 negatively regulates stress fibers formation and metastasis in lung adenocarcinoma via controlling Rho signaling
ARAP1 negatively regulates stress fibers formation and metastasis in lung adenocarcinoma via controlling Rho signaling
Small GTPases regulate multiple important cellular behaviors and their activities are strictly controlled by a mass of reg...
A comprehensive analysis of SLC25A1 expression and its oncogenic role in pan-cancer
A comprehensive analysis of SLC25A1 expression and its oncogenic role in pan-cancer
The solute carrier family 25 member 1 (SLC25A1) is currently the only known human transporter for citrat...
Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma
Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma
To improve early diagnosis and chemotherapy efficacy monitoring in primary central nervous system lymphoma (PCNSL), cerebr...
A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation
A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation
Lipid metabolism is a key factor in tumorigenesis and drug resistance, and models related to lipid metabolism have shown p...
Integrated analysis of single-cell and bulk RNA-sequencing reveals the poor prognostic value of ABCA1 in gastric adenocarcinoma
Integrated analysis of single-cell and bulk RNA-sequencing reveals the poor prognostic value of ABCA1 in gastric adenocarcinoma
ATP-binding cassette A1 (ABCA1) is a potential prognostic marker for various tumor types. However, the biological effects ...
Machine learning-based predictive model for the differential diagnosis of ≤ 5 cm gastric stromal tumor and gastric schwannoma based on CT images
Machine learning-based predictive model for the differential diagnosis of ≤ 5 cm gastric stromal tumor and gastric schwannoma based on CT images
The clinical symptoms of ≤ 5 cm gastric stromal tumor (GST) and gastric schwannoma (GS) are sim...
PIK3CD correlates with prognosis, epithelial–mesenchymal transition and tumor immune infiltration in breast carcinoma
PIK3CD correlates with prognosis, epithelial–mesenchymal transition and tumor immune infiltration in breast carcinoma
Breast carcinoma (BRCA) is one of the most common, fatal, and aggressive cancers, with increasing morbidity that has a maj...
Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer
Myeloid-derived suppressor cells (MDSCs), major components maintaining the immune suppressive microenvironment in lung can...
Prediction model of no-response before the first transarterial chemoembolization for hepatocellular carcinoma: TACF score
Prediction model of no-response before the first transarterial chemoembolization for hepatocellular carcinoma: TACF score
Previous clinic models for patients with hepatocellular carcinoma (HCC) receiving transarterial chemoembolization (TACE) m...
Clinical advances in oncolytic virus therapy for malignant glioma: a systematic review
Clinical advances in oncolytic virus therapy for malignant glioma: a systematic review
In the past decade, there has been little progress in the treatment of malignant glioma. Recently, oncolytic virus has mad...
Exploring oncogenes for renal clear cell carcinoma based on G protein-coupled receptor-associated genes
Exploring oncogenes for renal clear cell carcinoma based on G protein-coupled receptor-associated genes
G protein-coupled receptors (GPCRs) are a class of receptors on cell membranes that regulate various biological processes ...
Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score
Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score
Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the ...
Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment
Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment
Various new treatments are emerging constantly in anti-tumor therapies, including chemotherapy, immunotherapy, and targete...
Comparative analysis of single-cell transcriptome reveals heterogeneity in the tumor microenvironment of lung adenocarcinoma and brain metastases
Comparative analysis of single-cell transcriptome reveals heterogeneity in the tumor microenvironment of lung adenocarcinoma and brain metastases
Solid tumors such as lung adenocarcinoma include not only the tumor cells but also the microenvironment in which the tumor...
Integrating TCGA and single-cell sequencing data for colorectal cancer: a 10-gene prognostic risk assessment model
Integrating TCGA and single-cell sequencing data for colorectal cancer: a 10-gene prognostic risk assessment model
Colorectal cancer represents a significant health threat, yet a standardized method for early clinical assessment and prog...
Correction: MUC13 promotes the development of esophageal cancer by upregulating the expression of o-glycan process-related molecules
Correction: MUC13 promotes the development of esophageal cancer by upregulating the expression of o-glycan process-related molecules
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Chemotherapy following immune checkpoint inhibitors in recurrent or metastatic head and neck squamous cell carcinoma: clinical effectiveness and influence of inflammatory and nutritional factors
Chemotherapy following immune checkpoint inhibitors in recurrent or metastatic head and neck squamous cell carcinoma: clinical effectiveness and influence of inflammatory and nutritional factors
This study aimed to evaluate the clinical effectiveness of chemotherapy following immune checkpoint inhibitors (ICI). The ...
Caveolin-1 promotes glioma progression and maintains its mitochondrial inhibition resistance
Caveolin-1 promotes glioma progression and maintains its mitochondrial inhibition resistance
Glioma is a lethal brain cancer and lacking effective therapies. Challenges include no effective therapeutic target, intra...
OSR1 downregulation indicates an unfavorable prognosis and activates the NF-κB pathway in ovarian cancer
OSR1 downregulation indicates an unfavorable prognosis and activates the NF-κB pathway in ovarian cancer
Odd-skipped related 1 (OSR1) has been reported as a tumor suppressor gene in various malignant tumors. The mechanism throu...
Results of a pilot risk-based lung cancer screening study: outcomes and comparisons to a Medicare eligible cohort
Results of a pilot risk-based lung cancer screening study: outcomes and comparisons to a Medicare eligible cohort
Risk-based lung cancer screening holds potential to detect more cancers and avert more cancer deaths than screening based ...
Effects of metalloprotease ADAMTS12 on cervical cancer cell phenotype and its potential mechanism
Effects of metalloprotease ADAMTS12 on cervical cancer cell phenotype and its potential mechanism
ADAMTS12 is a gene widely expressed in human tissues. We studied the expression level of ADAMTS12 in cervical cancer tissu...
Immune changes induced by periampullary adenocarcinoma are reversed after tumor resection and modulate the postoperative survival
Immune changes induced by periampullary adenocarcinoma are reversed after tumor resection and modulate the postoperative survival
Tumor growth encompasses multiple immunologic processes leading to impaired immunity. Regarding cancer surgery, the periop...
A MRI-based radiomics model for predicting the response to anlotinb combined with temozolomide in recurrent malignant glioma patients
A MRI-based radiomics model for predicting the response to anlotinb combined with temozolomide in recurrent malignant glioma patients
Anlotinib is a multitarget anti-angiogenic drug that combined with temozolomide (TMZ) can effectively prolongs the overall...
Classification and function of γδT cells and its research progress in anti-glioblastoma
Classification and function of γδT cells and its research progress in anti-glioblastoma
Human peripheral blood T lymphocytes are classified into alpha–beta T (αβΤ) cells and gamma–del...
Identification of hepatocellular carcinoma-related subtypes and development of a prognostic model: a study based on ferritinophagy-related genes
Identification of hepatocellular carcinoma-related subtypes and development of a prognostic model: a study based on ferritinophagy-related genes
Hepatocellular carcinoma still has a high incidence and mortality rate worldwide, and further research is needed to invest...
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