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Olive oil and castor oil-based self-nanoemulsifying drug delivery system of flurbiprofen can relieve peripheral pain and inflammation through reduction of oxidative stress and inflammatory biomarkers: a comprehensive formulation and pharmacological insights
Olive oil and castor oil-based self-nanoemulsifying drug delivery system of flurbiprofen can relieve peripheral pain and inflammation through reduction of oxidative stress and inflammatory biomarkers: a comprehensive formulation and pharmacological insights
Flurbiprofen (FBP) is poorly water-soluble BCS class II drug with anti-inflammatory and analgesic effects, used to treat a...
Methotrexate for osteoarthritis: a systematic review meta-analysis of randomized controlled trials
Methotrexate for osteoarthritis: a systematic review meta-analysis of randomized controlled trials
Osteoarthritis (OA) is a common joint disorder causing pain and stiffness, with limited effective treatment options. Metho...
A randomized clinical study to evaluate the possible antifibrotic effect of zinc sulfate in chronic HCV patient receiving direct-acting anti-viral therapy
A randomized clinical study to evaluate the possible antifibrotic effect of zinc sulfate in chronic HCV patient receiving direct-acting anti-viral therapy
This study aimed to assess the potential antifibrotic impact of zinc sulfate in chronic Hepatitis C Virus (HCV) patients r...
Exploration of molecular interactions responsible for anti-inflammatory attributes of GI friendly micro-sized formulation of flurbiprofen and clove oil
Exploration of molecular interactions responsible for anti-inflammatory attributes of GI friendly micro-sized formulation of flurbiprofen and clove oil
Clove oil obtained from Syzygium aromaticum (L.) is traditionally employed to treat inflammation associated with ...
Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review
Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review
Nuclear factor kappa B (NF-kB) is a kind of transcription factor which resides in cytoplasm of each cell and on activation...
Therapeutic applications of eucalyptus essential oils
Therapeutic applications of eucalyptus essential oils
Eucalyptus essential oils (EEOs) have gained significant attention recently anticipated to their broad range of prospectiv...
Unraveling the hormonal approaches for the treatment of rheumatoid arthritis and its complementary interventions
Unraveling the hormonal approaches for the treatment of rheumatoid arthritis and its complementary interventions
Rheumatoid Arthritis (RA) is an autoimmune, chronic, systemic inflammatory disease that causes redness, swelling, stiffnes...
Advancements in nose-to-brain drug targeting for Alzheimer’s disease: a review of nanocarriers and clinical insights
Advancements in nose-to-brain drug targeting for Alzheimer’s disease: a review of nanocarriers and clinical insights
Alzheimer’s disease (AD) is a type of neurodegenerative disease that describes cognitive decline and memory loss res...
Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis
Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis
Impacts of milk proteins (MPs) on inflammation are uncertain. The current systematic review and dose–response meta-a...
Effect of intramuscular vs intra-articular betamethasone injection on pain and inflammatory factors among patients with severe traumatic knee osteoarthritis
Effect of intramuscular vs intra-articular betamethasone injection on pain and inflammatory factors among patients with severe traumatic knee osteoarthritis
The aim of this study was to comprehensively investigate the clinical efficacy of intraoperative local joint injection and...
Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis
Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis
Osteoarthritis, the most common arthritic condition, is an age-related progressive disease characterized by the l...
Connecting dots: Preclinical foundations to clinical realities of PDE4 inhibitors in Alzheimer's disease
Connecting dots: Preclinical foundations to clinical realities of PDE4 inhibitors in Alzheimer's disease
Alzheimer's Disease (AD), a progressive and age-associated neurodegenerative disorder, is primarily characterized by a...
Casticin reduces rosacea-related inflammation by inhibiting mast cell activation via Mas-related G protein-coupled receptor X2
Casticin reduces rosacea-related inflammation by inhibiting mast cell activation via Mas-related G protein-coupled receptor X2
Rosacea is a chronic inflammatory disease characterized by persistent erythema, papules, and pustules, mainly on the skin ...
The neuroprotective role of volatile oils: insights into chemical profiles, characteristics, neurochemical mechanisms, and preclinical studies in Alzheimer's disease
The neuroprotective role of volatile oils: insights into chemical profiles, characteristics, neurochemical mechanisms, and preclinical studies in Alzheimer's disease
Volatile oils (VOs), synonymously termed essential oils (EOs), are highly hydrophobic liquids obtained from aromatic plant...
Neuroprotective effects of phytochemicals through autophagy modulation in ischemic stroke
Neuroprotective effects of phytochemicals through autophagy modulation in ischemic stroke
Stroke is a serious life-threatening medical condition. Understanding the underlying molecular mechanisms of this conditio...
Uncovering the intricacies of IGF-1 in Alzheimer’s disease: new insights from regulation to therapeutic targeting
Uncovering the intricacies of IGF-1 in Alzheimer’s disease: new insights from regulation to therapeutic targeting
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-&#...
Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights
Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights
Atopic dermatitis (AD) is a paradigmatic prevalent, long-lasting, and inflammatory skin condition with a diverse range of ...
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications
This review explores the pivotal role of the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP...
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Opiorphin: an endogenous human peptide with intriguing application in diverse range of pathologies
Mammalian zinc ectopeptidases have significant functions in deactivating neurological and hormonal peptide signals on the ...
Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench
Verbascoside: comprehensive review of a phenylethanoid macromolecule and its journey from nature to bench
Polyphenolic compounds are among the most widely researched compounds for various therapeutic applications. However, natur...
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotriene signaling in neurodegeneration: implications for treatment strategies
Leukotrienes (LTs) are a group of substances that cause inflammation. They are produced by the enzyme 5-lipoxygenase (5-LO...
Talabostat, fibroblast activation protein inhibitor, attenuates inflammation and fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive fibrosis, where activated fibroblasts ...
Neuroinflammation and the role of epigenetic-based therapies for Huntington’s disease management: the new paradigm
Neuroinflammation and the role of epigenetic-based therapies for Huntington’s disease management: the new paradigm
Huntington’s disease (HD) is an inherited, autosomal, neurodegenerative ailment that affects the striatum of the bra...
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
Gastric ulcer (GU) is one of the most common diseases of the upper gastrointestinal tract that affects millions of people ...
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorb...
The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study
The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study
The development of nanoparticles (NPs) with active components with upgraded stability, and prolonged release helps in enha...
IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
Acute myocardial infarction is an important cardiovascular disease worldwide. Although the mortality rate of myocardial in...
Synthesized pyrrole ester ameliorates adjuvant‑induced arthritis in Wistar rats by alleviating inflammation and downregulating the pro‑inflammatory cytokines
Synthesized pyrrole ester ameliorates adjuvant‑induced arthritis in Wistar rats by alleviating inflammation and downregulating the pro‑inflammatory cytokines
Piperine is an amide alkaloid responsible for producing the pungent smell that comes from black pepper. Piperine has been ...
Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review
Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review
This study comprehensively explores the complexities of rheumatoid arthritis during pregnancy and its impact on offspring....
Anti-inflammatory activity of the phenol rich fraction of Garcinia pedunculata Roxb (ex. Buch Ham): an in vitro and in vivo study
Anti-inflammatory activity of the phenol rich fraction of Garcinia pedunculata Roxb (ex. Buch Ham): an in vitro and in vivo study
Garcinia pedunculata, a tropical plant found abundantly in the north-east region of India, has been used by many tradition...
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