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Antinociceptive, anti-inflammatory, and antiophidic potential of leaves extract and fraction: an in vitro and in vivo evaluation
Antinociceptive, anti-inflammatory, and antiophidic potential of leaves extract and fraction: an in vitro and in vivo evaluation
Punica granatum (Punicaceae) is a shrub with a worldwide distribution that has been used in folk medicine for the treatmen...
Anti-inflammatory effects of Calebin A on metabolic syndrome via NF-κB signaling pathway modulation
Anti-inflammatory effects of Calebin A on metabolic syndrome via NF-κB signaling pathway modulation
Metabolic syndrome is a complex disorder characterized by a combination of events such as insulin resistance, obesity, dys...
The hydroalcoholic extract of the leaves of red mombin ( L.) is more effective in accelerating ulcer healing than preventing them in rodents
The hydroalcoholic extract of the leaves of red mombin ( L.) is more effective in accelerating ulcer healing than preventing them in rodents
This study evaluated the anti-ulcer effects of the hydroalcoholic extract from the leaves of Spondias purpurea L. (SPHE). ...
Potentiation of analgesic activity following the complexation of Sobral, Faria & Proença () leaf essential oil with β-cyclodextrin
Potentiation of analgesic activity following the complexation of Sobral, Faria & Proença () leaf essential oil with β-cyclodextrin
Pain is a fundamental biological process; however, its acute manifestation may result in dysregulation and tissue injury. ...
Dexketoprofen enhances NLRP3 activation via ATPase activity after canonical stimuli
Dexketoprofen enhances NLRP3 activation via ATPase activity after canonical stimuli
Inflammasomes are crucial elements of the innate immune system, responsible for triggering inflammation through the activa...
Targeting mGluR7 in Parkinson’s disease: a novel approach to neuroprotection and synaptic therapies
Targeting mGluR7 in Parkinson’s disease: a novel approach to neuroprotection and synaptic therapies
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in t...
Beyond the blood–brain barrier: unraveling T cell subsets in CNS immunity and disease
Beyond the blood–brain barrier: unraveling T cell subsets in CNS immunity and disease
The complicated interplay between the central nervous system (CNS) and immune system is critical for both neuroprotection ...
Gastroprotective effect of nifuroxazide against indomethacin-induced gastric ulcers in rats via modulation of Nrf2/HO-1, HMGB1/TLR4/NF-κB p65, and apoptotic caspase-3 signaling pathways
Gastroprotective effect of nifuroxazide against indomethacin-induced gastric ulcers in rats via modulation of Nrf2/HO-1, HMGB1/TLR4/NF-κB p65, and apoptotic caspase-3 signaling pathways
Gastric ulcer (GU) is a common gastrointestinal disease linked to the consumption of non-steroidal anti-inflammatory drugs...
Aspirin’s effect on macrophages beyond its chemopreventive role in inflammation and cancer
Aspirin’s effect on macrophages beyond its chemopreventive role in inflammation and cancer
Aspirin's antineoplastic activities are primarily executed by irreversibly prohibiting COX-1 in platelets, hindering p...
Ozone therapy and the role of the glutathione pathway
Ozone therapy and the role of the glutathione pathway
Oxygen-ozone therapy (OOT) represents a multi-target intervention that engages redox modulation, endothelial repair, nitri...
Targeting the cytokine–redox axis: dose-dependent immunomodulation by methotrexate in a biomarker-guided ovine endotoxaemia model
Targeting the cytokine–redox axis: dose-dependent immunomodulation by methotrexate in a biomarker-guided ovine endotoxaemia model
Oxidative stress and excessive inflammation are central to the pathophysiology of sepsis and its large-animal analogue, en...
Unveiling the secret of cellular metamorphosis: the crucial role of EndMT mechanisms in COVID-19-induced pulmonary fibrosis
Unveiling the secret of cellular metamorphosis: the crucial role of EndMT mechanisms in COVID-19-induced pulmonary fibrosis
The COVID-19 pandemic has resulted in several long-term complications, with COVID-19-induced pulmonary fibrosis being a si...
L. essential oil attenuates inflammation and pain via TRPV1
L. essential oil attenuates inflammation and pain via TRPV1
Pain and inflammation are complex physiological responses. The drugs that are available in the market have multiple side e...
Olive oil and castor oil-based self-nanoemulsifying drug delivery system of flurbiprofen can relieve peripheral pain and inflammation through reduction of oxidative stress and inflammatory biomarkers: a comprehensive formulation and pharmacological insights
Olive oil and castor oil-based self-nanoemulsifying drug delivery system of flurbiprofen can relieve peripheral pain and inflammation through reduction of oxidative stress and inflammatory biomarkers: a comprehensive formulation and pharmacological insights
Flurbiprofen (FBP) is poorly water-soluble BCS class II drug with anti-inflammatory and analgesic effects, used to treat a...
Methotrexate for osteoarthritis: a systematic review meta-analysis of randomized controlled trials
Methotrexate for osteoarthritis: a systematic review meta-analysis of randomized controlled trials
Osteoarthritis (OA) is a common joint disorder causing pain and stiffness, with limited effective treatment options. Metho...
A randomized clinical study to evaluate the possible antifibrotic effect of zinc sulfate in chronic HCV patient receiving direct-acting anti-viral therapy
A randomized clinical study to evaluate the possible antifibrotic effect of zinc sulfate in chronic HCV patient receiving direct-acting anti-viral therapy
This study aimed to assess the potential antifibrotic impact of zinc sulfate in chronic Hepatitis C Virus (HCV) patients r...
Exploration of molecular interactions responsible for anti-inflammatory attributes of GI friendly micro-sized formulation of flurbiprofen and clove oil
Exploration of molecular interactions responsible for anti-inflammatory attributes of GI friendly micro-sized formulation of flurbiprofen and clove oil
Clove oil obtained from Syzygium aromaticum (L.) is traditionally employed to treat inflammation associated with ...
Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review
Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review
Nuclear factor kappa B (NF-kB) is a kind of transcription factor which resides in cytoplasm of each cell and on activation...
Therapeutic applications of eucalyptus essential oils
Therapeutic applications of eucalyptus essential oils
Eucalyptus essential oils (EEOs) have gained significant attention recently anticipated to their broad range of prospectiv...
Unraveling the hormonal approaches for the treatment of rheumatoid arthritis and its complementary interventions
Unraveling the hormonal approaches for the treatment of rheumatoid arthritis and its complementary interventions
Rheumatoid Arthritis (RA) is an autoimmune, chronic, systemic inflammatory disease that causes redness, swelling, stiffnes...
Advancements in nose-to-brain drug targeting for Alzheimer’s disease: a review of nanocarriers and clinical insights
Advancements in nose-to-brain drug targeting for Alzheimer’s disease: a review of nanocarriers and clinical insights
Alzheimer’s disease (AD) is a type of neurodegenerative disease that describes cognitive decline and memory loss res...
Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis
Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis
Impacts of milk proteins (MPs) on inflammation are uncertain. The current systematic review and dose–response meta-a...
Effect of intramuscular vs intra-articular betamethasone injection on pain and inflammatory factors among patients with severe traumatic knee osteoarthritis
Effect of intramuscular vs intra-articular betamethasone injection on pain and inflammatory factors among patients with severe traumatic knee osteoarthritis
The aim of this study was to comprehensively investigate the clinical efficacy of intraoperative local joint injection and...
Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis
Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis
Osteoarthritis, the most common arthritic condition, is an age-related progressive disease characterized by the l...
Connecting dots: Preclinical foundations to clinical realities of PDE4 inhibitors in Alzheimer's disease
Connecting dots: Preclinical foundations to clinical realities of PDE4 inhibitors in Alzheimer's disease
Alzheimer's Disease (AD), a progressive and age-associated neurodegenerative disorder, is primarily characterized by a...
Casticin reduces rosacea-related inflammation by inhibiting mast cell activation via Mas-related G protein-coupled receptor X2
Casticin reduces rosacea-related inflammation by inhibiting mast cell activation via Mas-related G protein-coupled receptor X2
Rosacea is a chronic inflammatory disease characterized by persistent erythema, papules, and pustules, mainly on the skin ...
The neuroprotective role of volatile oils: insights into chemical profiles, characteristics, neurochemical mechanisms, and preclinical studies in Alzheimer's disease
The neuroprotective role of volatile oils: insights into chemical profiles, characteristics, neurochemical mechanisms, and preclinical studies in Alzheimer's disease
Volatile oils (VOs), synonymously termed essential oils (EOs), are highly hydrophobic liquids obtained from aromatic plant...
Neuroprotective effects of phytochemicals through autophagy modulation in ischemic stroke
Neuroprotective effects of phytochemicals through autophagy modulation in ischemic stroke
Stroke is a serious life-threatening medical condition. Understanding the underlying molecular mechanisms of this conditio...
Uncovering the intricacies of IGF-1 in Alzheimer’s disease: new insights from regulation to therapeutic targeting
Uncovering the intricacies of IGF-1 in Alzheimer’s disease: new insights from regulation to therapeutic targeting
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-&#...
Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights
Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights
Atopic dermatitis (AD) is a paradigmatic prevalent, long-lasting, and inflammatory skin condition with a diverse range of ...
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