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Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora
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Toxicological Research
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Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure
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Pulmonary toxicity assessment of polypropylene, polystyrene, and polyethylene microplastic fragments in mice
Polypropylene (PP), polystyrene (PS), and polyethylene (PE) plastics are commonly used in household items such as electron...
Toxicological Research
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Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration
ATB1651 gel is an antifungal drug candidate that enhances antifungal activity through substitution of several aryl rings, ...
Toxicological Research
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Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption
Several patients with cutaneous adverse drug reactions exhibit extracutaneous organ damages, and it becomes severe in a fe...
Toxicological Research
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Distribution of molybdenum in soft tissues and blood of rats after intratracheal instillation of molybdenum(IV) sulfide nano- and microparticles
There is still little literature data on the toxicity and safety of the commonly used molybdenum (Mo) disulfide which is p...
Toxicological Research
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Molecular mechanism of empagliflozin cardioprotection in 5-fluorouracil (5-FU)-induced cardiotoxicity via modulation of SGLT2 and TNFα/TLR/NF-κB signaling pathway in rats
One of the commoly used chemotherapeutic agents is 5-Fluorouracil (5-FU). Unfortunately, the clinical administration of 5-...
Toxicological Research
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Assessment of reproductive toxicity of gold nanoparticles and its reversibility in male albino rats
Nanotechnology has become a trending area in science all over the world. Although gold nanoparticles (AuNPs) have been uti...
Toxicological Research
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Potential role of inducible nitric oxide synthase (iNOS) activity in testicular dysfunction following co-administration of alcohol and combination antiretroviral therapy (cART) in diabetic rats: an immunohistochemistry study
Diabetes, alcohol abuse, and combination antiretroviral therapy (cART) use have been reported to cause multi-organ complic...
Toxicological Research
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Re-evaluation of a microbiological acceptable daily intake for tylosin based on its impact on human intestinal microflora
As veterinary drugs available for fish is very restricted, there is growing trials for repurposing livestock drugs as aqua...
Toxicological Research
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Acute toxicity assessment of nine organic UV filters using a set of biotests
UV filters in environmental compartments are a source of concern related to their ecotoxicological effects. However, littl...
Toxicological Research
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Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss
Chronic exposure to Poly aromatic hydrocarbons (PAHs) may be associated with adverse pregnancy outcomes. Disruption of hor...
Toxicological Research
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Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model
The Organization for Economic Co-operation and Development approved a reconstructed human epidermis (RHE) model for in vit...
Toxicological Research
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A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies
Deep learning has recently become one of the most popular methods of image analysis. In non-clinical studies, several tiss...
Toxicological Research
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Effects of stabilizer magnesium nirate on CMIT/MIT-induced respiratory toxicity
Despite a humidifier disinfectant (HD) product containing chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MI...
Toxicological Research
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In vitro toxicological assessment of PhSeZnCl in human liver cells
Phenylselenenylzinc chloride (PhSeZnCl) is an air-stable selenolate, easily synthesizable through oxidative insertion of e...
Toxicological Research
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The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin
Data on the cumulative effects of chemical substances are necessary for the proper risk assessment, but their availability...
Toxicological Research
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Theracurmin (Highly Bioavailable Curcumin) Prevents High Fat Diet-Induced Hepatic Steatosis Development in Mice
Curcumin, a hydrophobic polyphenol isolated from the Curcuma longa L. plant, has many pharmacological properties, includin...
Toxicological Research
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Extrapolation of Hepatic Concentrations of Industrial Chemicals Using Pharmacokinetic Models to Predict Hepatotoxicity
In this review, we describe the absorption rates (Caco-2 cell permeability) and hepatic/plasma pharmacokinetics of 53 dive...
Toxicological Research
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Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin
The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-in...
Toxicological Research
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Study on Consumer Exposure to Sun Spray and Sun Cream in South Korea
When conducting risk assessments of cosmetic ingredients, it is important that reliable exposure information is obtained f...
Toxicological Research
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Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue
Subcutaneous adipose tissue (SAT) accumulation is a constitutional disorder resulting from metabolic syndrome. Although su...
Toxicological Research
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Molecular Markers in Sex Differences in Cancer
Cancer is one of the common causes of death with a high degree of mortality, worldwide. In many types of cancers, if not a...
Toxicological Research
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Implications for the Predictivity of Cell-Based Developmental Toxicity Assays Developed Two Decades Apart
Many in vitro developmental toxicity assays have been proposed over several decades. Since the late 1980s, we have made in...
Toxicological Research
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1,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis
1,2-Dichloropropane (1,2-DCP) has been used as an industrial solvent and a chemical intermediate, as well as in soil fumig...
Toxicological Research
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A general toxicity and biodistribution study of human natural killer cells by single or repeated intravenous dose in severe combined immune deficient mice
Natural killer (NK) cells are a part of the innate immune system and represent the first line of defense against infection...
Toxicological Research
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Semi-automated approach for generation of biological networks on drug-induced cholestasis, steatosis, hepatitis, and cirrhosis
Drug-induced liver injury (DILI) is one of the leading reasons for discontinuation of a new drug development project. Dive...
Toxicological Research
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RETRACTED ARTICLE: Genotoxicity and alteration of the Gene Regulatory Network expression during Paracentrotus lividus development in the presence of carbon nanoparticles
The Editor-in-Chief has retracted this article. After publication, two of the panels in Figure 1C were found to overlap wi...
Toxicological Research
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Toxicological and safety evaluations of Weissella cibaria strain CMU in animal toxicity and genotoxicity
Weissella cibaria belongs to the Lactobacillaceae family and has been isolated from traditional fermented foods and saliva...
Toxicological Research
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Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells
Nanoparticles (NPs) have been recognized as both useful tools and potentially toxic materials in various industrial and me...
Toxicological Research
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