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CAR T cell therapy for children with rheumatic disease: the time is now
CAR T cell therapy for children with rheumatic disease: the time is now
Initial success with B cell-targeted chimeric antigen receptor (CAR) T cells for the treatment of systemic lupus erythemat...
Synovial fluid as a complex molecular pool contributing to knee osteoarthritis
Synovial fluid as a complex molecular pool contributing to knee osteoarthritis
The main homeostatic function of the synovial fluid is joint lubrication. However, during knee osteoarthritis (KOA), synov...
Platelets as drivers of immunothrombosis in rheumatic diseases
Platelets as drivers of immunothrombosis in rheumatic diseases
Platelets are central players in inflammatory and thrombotic responses that drive the onset and progression of rheumatic d...
Synovial fibroblast-mediated neovascularization in RA
A study provides insights into the factors that regulate synovial fibroblast interactions with endothelial cells in RA and...
Tissue-resident memory CD8+ T cells on the skin–joint route
Skin- and joint-resident CD8+ T cells that share clonality also share phenotypic similarities in psoriatic arthritis.
Nerandomilast slows progression of pulmonary fibrosis
The anti-fibrotic and anti-inflammatory agent nerandomilast has shown promise for the treatment of both idiopathic and pro...
Guided management of familial Mediterranean fever
Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with high prevalence in Mediterranean populati...
Insights into chondrocyte populations in cartilaginous tissues at the single-cell level
Insights into chondrocyte populations in cartilaginous tissues at the single-cell level
Chondrocyte biology is being revolutionized by single-cell multi-omics technologies, revealing cellular heterogeneity with...
Dupuytren contracture treatments compared
In an open-label clinical trial, collagenase injection was not noninferior to limited fasciectomy for the treatment of Dup...
The management of adult and paediatric uveitis for rheumatologists
The management of adult and paediatric uveitis for rheumatologists
Uveitis encompasses multiple different conditions that are all characterized by intra-ocular inflammation. Uveitis occurs ...
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus
The essential roles of memory B cells in the pathogenesis of systemic lupus erythematosus
Emerging evidence indicates that memory B cells are dysfunctional in systemic lupus erythematosus (SLE). They are hyporesp...
Publisher Correction: Recent advances in the diagnosis and management of neuropsychiatric lupus
Authors and AffiliationsDivision of Rheumatology, Department of Medicine, Dalhousie University and Queen Elizabeth II Heal...
The emergence of SLE-causing UNC93B1 variants in 2024
During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chap...
The quest for targetable pain mechanisms in 2024
Studies published in 2024 suggest that although the repurposing of established rheumatology drugs seems to deliver increme...
EULAR and PReS bridge the age gap in Still’s disease
EULAR and PReS bridge the age gap in Still’s disease
EULAR and the Paediatric Rheumatology European Society (PReS) now view systemic juvenile idiopathic arthritis and adult-on...
An update on autoantibodies in the idiopathic inflammatory myopathies
An update on autoantibodies in the idiopathic inflammatory myopathies
Myositis-specific autoantibodies (MSAs) have become pivotal biomarkers for idiopathic inflammatory myopathies and have rev...
Nanoparticle-based pazopanib shows promise in OA
A nanoparticle-based formulation of the anticancer drug pazopanib, which inhibits VEGFR1 and VEGFR2, shows promise as a di...
Reply to: Current classification criteria underestimate the incidence of idiopathic inflammatory myopathies by ignoring subgroups
We thank Giannini et al.1 for their response (Giannini, M. et al. Current classification criteria und...
Current classification criteria underestimate the incidence of idiopathic inflammatory myopathies by ignoring subgroups
We read with great interest the Review article by Khoo et al. (Epidemiology of the idiopathic inflamm...
Low-frequency and rare genetic variants associated with rheumatoid arthritis risk
Low-frequency and rare genetic variants associated with rheumatoid arthritis risk
Rheumatoid arthritis (RA) has an estimated heritability of nearly 50%, which is particularly high in seropositive RA. HLA ...
Author Correction: International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative
National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, ...
Author Correction: Proposals for the rheumatological use of JAK inhibitors
Authors and AffiliationsUniversity della Campania, Department of Precision Medicine, Naples, ItalyFrancesco CicciaUniversi...
Time for a new approach to drug development for rare systemic autoinflammatory diseases
Despite the transformative potential of treatments for systemic autoinflammatory diseases, these conditions remain underfu...
Author Correction: Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells
Author notesThese authors contributed equally: Christian Jorgensen, Danièle Noël.Authors and AffiliationsIRMB, University ...
Biological and clinical roles of IL-18 in inflammatory diseases
Biological and clinical roles of IL-18 in inflammatory diseases
Several new discoveries have revived interest in the pathogenic potential and possible clinical roles of IL-18. IL-18 is a...
Nanohybrid therapy hits multiple arthritis targets
A novel combination of ceria nanoparticles and mesenchymal stem cell nanovesicles modified both inflammation and autoimmun...
Shifting the SLE management paradigm: challenges and implications
Shifting the SLE management paradigm: challenges and implications
Newly published European guidelines for the management of systemic lupus erythematosus (SLE) and lupus nephritis, specific...
Primary care rheumatology: towards sustainable development in health
Globally, rheumatic musculoskeletal diseases constitute the most common causes of disability, related morbidity and econom...
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of derm...
Profiling joint tissues at single-cell resolution: advances and insights
Profiling joint tissues at single-cell resolution: advances and insights
Advances in the profiling of human joint tissues at single-cell resolution have provided unique insights into the organiza...
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