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Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer
Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer
PD-1/PD-L1 blockade therapies have displayed extraordinary clinical efficacy for melanoma, renal, bladder and lung cancer;...
Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies
Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies
Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clin...
Single-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma
Single-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS) and related tumors are the most common type of soft tissue sarcoma. However, th...
Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope
Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope
Normal life requires cell division to produce new cells, but cell death is necessary to maintain balance. Dysregulation of...
Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer
Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer
Fibroblast growth factors (FGFs) and their receptors regulate numerous cellular processes, such as metabolism and signal t...
Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer
Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer
Breast cancer (BC) is the most common cancer in women, with triple negative BC (TNBC) accounting for 20% of cases. While e...
ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway
ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway
Emerging evidence indicates the pivotal involvement of circular RNAs (circRNAs) in cancer initiation and progression. Unde...
Unveiling the PDK4-centered rituximab-resistant mechanism in DLBCL: the potential of the “Smart” exosome nanoparticle therapy
Unveiling the PDK4-centered rituximab-resistant mechanism in DLBCL: the potential of the “Smart” exosome nanoparticle therapy
Diffuse large B-cell lymphoma (DLBCL) represents a prevalent malignant tumor, with approximately 40% of patients encounter...
PD1/PD-L1 blockade in clear cell renal cell carcinoma: mechanistic insights, clinical efficacy, and future perspectives
PD1/PD-L1 blockade in clear cell renal cell carcinoma: mechanistic insights, clinical efficacy, and future perspectives
The advent of PD1/PD-L1 inhibitors has significantly transformed the therapeutic landscape for clear cell renal cell carci...
Clinical application of liquid biopsy in colorectal cancer: detection, prediction, and treatment monitoring
Clinical application of liquid biopsy in colorectal cancer: detection, prediction, and treatment monitoring
Colorectal cancer (CRC) is one of the most prevalent malignancies affecting the gastrointestinal tract and is ranked third...
CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib
CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib
Tyrosine kinase inhibitors (TKIs) are crucial in the targeted treatment of advanced colorectal cancer (CRC). Anlotinib, a ...
CTLs heterogeneity and plasticity: implications for cancer immunotherapy
CTLs heterogeneity and plasticity: implications for cancer immunotherapy
Cytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets including CD4+, NK, and γ&...
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling
Cancer stem-like cell is a key barrier for therapeutic resistance and metastasis in various cancers, including breast canc...
A review of the clinical efficacy of FDA-approved antibody‒drug conjugates in human cancers
A review of the clinical efficacy of FDA-approved antibody‒drug conjugates in human cancers
While strategies such as chemotherapy and immunotherapy have become the first-line standard therapies for patients with ad...
An international phase II trial and immune profiling of SBRT and atezolizumab in advanced pretreated colorectal cancer
An international phase II trial and immune profiling of SBRT and atezolizumab in advanced pretreated colorectal cancer
Immuno-radiotherapy may improve outcomes for patients with advanced solid tumors, although optimized combination modalitie...
Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to ...
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgk...
Effects of RNA methylation on Tumor angiogenesis and cancer progression
Effects of RNA methylation on Tumor angiogenesis and cancer progression
Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common mod...
A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
Colorectal cancer (CRC) is one of the most threatening tumors in the world, and chemotherapy remains dominant in the treat...
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provid...
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT...
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma
Circular RNAs (circRNAs) play important roles in the occurrence and development of cancer and chemoresistance. DNA damage ...
Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Hepatocellular carcinoma (HCC), one of the most prevalent forms of cancer worldwide, presents a significant global healthc...
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely re...
Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
Immune checkpoint inhibitors (ICIs) are a therapeutic strategy for various cancers although only a subset of patients resp...
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major o...
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lac...
The University of Kansas Cancer Center (KUCC), an NCI designated comprehensive cancer center
The University of Kansas Cancer Center (KUCC), an NCI designated comprehensive cancer center
With world-class, transdisciplinary, expertise and technical capabilities in drug discovery and cellular immunotherapeutic...
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for...
CDK5: an oncogene or an anti-oncogene: location location location
CDK5: an oncogene or an anti-oncogene: location location location
Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 an...
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