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HIV-1 gp120 Interactions with Nicotine Modulate Mitochondrial Network Properties and Amyloid Release in Microglia
HIV-1 gp120 Interactions with Nicotine Modulate Mitochondrial Network Properties and Amyloid Release in Microglia
Human immunodeficiency virus (HIV) infections remain a significant public health burden globally with infected individuals...
Fluoride Exposure Increases the Activity of the Cystine/Glutamate Exchanger in Glia Cells
Fluoride Exposure Increases the Activity of the Cystine/Glutamate Exchanger in Glia Cells
Fluoride exposure in drinking water has been widely related to impairment of cognitive...
Sortilin and L-type Calcium Channels May be Involved in the Unusual Mechanism of proBDNF Signaling in Regenerating Mouse Neuromuscular Junctions
Sortilin and L-type Calcium Channels May be Involved in the Unusual Mechanism of proBDNF Signaling in Regenerating Mouse Neuromuscular Junctions
proBDNF and its main proteolytic product BDNF play crucial roles in maturation of neuromuscular junctions during developme...
Corydaline Alleviates 1-Methyl-4-Phenylpyridium (MPP)-Induced Human Neuroblastoma Cell Injury by BAP1-NRF2/HO-1/GPX4 Pathway
Corydaline Alleviates 1-Methyl-4-Phenylpyridium (MPP)-Induced Human Neuroblastoma Cell Injury by BAP1-NRF2/HO-1/GPX4 Pathway
Corydaline (Cory) is a naturally extracted acetylcholinesterase inhibitor. In this study, we aimed to explore the possible...
Pyrrolidine Dithiocarbamate Ameliorates Sepsis-Associated Encephalopathy by Inhibiting Autophagy and Inflammation in the Brain
Pyrrolidine Dithiocarbamate Ameliorates Sepsis-Associated Encephalopathy by Inhibiting Autophagy and Inflammation in the Brain
Sepsis-associated encephalopathy (SAE) is common and has poor clinical outcome. Sepsis increases autophagy in the brain. T...
Infant Maltreatment Induces Early Alterations in Adrenal Glands and Stress Response in Juvenile Rat Offspring
Infant Maltreatment Induces Early Alterations in Adrenal Glands and Stress Response in Juvenile Rat Offspring
Chronic stressors, such as infant maltreatment during early development, can have long-lasting effects on an individual...
Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia
Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia
Acute and chronic exposure to high altitude causes multiple negative neurological consequences. Further research has shown...
Regulation of Synaptic NMDA Receptor Activity by Post-Translational Modifications
Regulation of Synaptic NMDA Receptor Activity by Post-Translational Modifications
NMDA receptors for the neurotransmitter glutamate are widely distributed in the central nervous system, playing important ...
Dopamine Toxicity Induces ROS-Dependent Death of Murine Neuroblastoma Cells: Impact on the Interactions of Cofilin With UCHL1 and MMP9
Dopamine Toxicity Induces ROS-Dependent Death of Murine Neuroblastoma Cells: Impact on the Interactions of Cofilin With UCHL1 and MMP9
The death of dopaminergic neurons, a hallmark event during Parkinson’s disease (PD), leads to increased dopamine con...
Systemic Rejuvenating Interventions: Perspectives on Neuroinflammation and Blood–Brain Barrier Integrity
Systemic Rejuvenating Interventions: Perspectives on Neuroinflammation and Blood–Brain Barrier Integrity
The aging process results in structural, functional, and immunological changes in the brain, which contribute to cognitive...
Systemic Neuroprotection by Chlorogenic Acid: Antioxidant and Anti-inflammatory Evaluation in Early Neurodegeneration Induced by 3-Nitropropionic Acid in Mice
Systemic Neuroprotection by Chlorogenic Acid: Antioxidant and Anti-inflammatory Evaluation in Early Neurodegeneration Induced by 3-Nitropropionic Acid in Mice
Neurodegeneration is characterized by the progressive loss of neurons commonly attributed to neurological causes. Studies ...
Extract Protects against Beta-amyloid-induced Memory Impairment Through Modulation of Monoaminoxidase Enzymes in the Rat’s Hippocampus
Extract Protects against Beta-amyloid-induced Memory Impairment Through Modulation of Monoaminoxidase Enzymes in the Rat’s Hippocampus
Ferulago angulata, a medicinal plant of the Apiaceae family, is known for its antioxidative, anti-inflammatory, anti-apopt...
Costunolide Ameliorates the Methylmalonic Acidemia Via the PINK1/Parkin Pathway
Costunolide Ameliorates the Methylmalonic Acidemia Via the PINK1/Parkin Pathway
Methylmalonic acidemia (MMA) is a congenital organic acidemia characterized by mitochondrial dysfunction due to the abnorm...
Alkaloids from (Amaryllidaceae) as Regulators of AChE, BuChE, NMDA and GSK3 Activity: An In Vitro and In Silico Approach for Mimicking Alzheimer´s Disease
Alkaloids from (Amaryllidaceae) as Regulators of AChE, BuChE, NMDA and GSK3 Activity: An In Vitro and In Silico Approach for Mimicking Alzheimer´s Disease
Patients with Alzheimer’s disease (AD) have two types of abnormal protein buildups: amyloid plaques and neurofibrill...
Epidermal Neural Crest Stem Cell Conditioned Medium Enhances Spinal Cord Injury Recovery via PI3K/AKT-Mediated Neuronal Apoptosis Suppression
Epidermal Neural Crest Stem Cell Conditioned Medium Enhances Spinal Cord Injury Recovery via PI3K/AKT-Mediated Neuronal Apoptosis Suppression
This study aimed to assess the impact of conditioned medium from epidermal neural crest stem cells (EPI-NCSCs-CM) on funct...
LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression
LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression
The non-coding RNA LINC00894 modulates tumor proliferation and drug resistance. However, its role in brain is still unclea...
Propofol Protects the Blood-Brain Barrier After Traumatic Brain Injury by Stabilizing the Extracellular Matrix via Prrx1: From Neuroglioma to Neurotrauma
Propofol Protects the Blood-Brain Barrier After Traumatic Brain Injury by Stabilizing the Extracellular Matrix via Prrx1: From Neuroglioma to Neurotrauma
The purpose of this study is to explore the shared molecular pathogenesis of traumatic brain injury (TBI) and high-grade g...
Therapeutic Potential of Fingolimod on Psychological Symptoms and Cognitive Function in Neuropsychiatric and Neurological Disorders
Therapeutic Potential of Fingolimod on Psychological Symptoms and Cognitive Function in Neuropsychiatric and Neurological Disorders
Neuropsychiatric and neurological disorders pose a significant global health burden, highlighting the need for innovative ...
Ribosomal Protein Dynamics and Its Association with Actin Filaments and Local Translation in Axonal Growth Cones of Dorsal Root Ganglia Neurons
Ribosomal Protein Dynamics and Its Association with Actin Filaments and Local Translation in Axonal Growth Cones of Dorsal Root Ganglia Neurons
Local translation in growth cones plays a critical role in responses to extracellular stimuli, such as axon guidance cues....
Neuroprotection of Human Umbilical Cord-Derived Mesenchymal Stem Cells (hUC-MSCs) in Alleviating Ischemic Stroke-Induced Brain Injury by Regulating Inflammation and Oxidative Stress
Neuroprotection of Human Umbilical Cord-Derived Mesenchymal Stem Cells (hUC-MSCs) in Alleviating Ischemic Stroke-Induced Brain Injury by Regulating Inflammation and Oxidative Stress
Brain injury caused by stroke has a high rate of mortality and remains a major medical challenge worldwide. In recent year...
Neuroprotective Effects Exerted by a Combination of Selected Lactic Acid Bacteria in a Mouse Parkinsonism Model under Levodopa-Benserazide Treatment
Neuroprotective Effects Exerted by a Combination of Selected Lactic Acid Bacteria in a Mouse Parkinsonism Model under Levodopa-Benserazide Treatment
Alterations of the microbiota-gut-brain axis has been associated with intestinal and neuronal inflammation in Parkinson...
Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus
Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus
A ketogenic diet (KD) is a high-fat, low-carbohydrate, and low-protein diet that exerts antiepileptic effects by attenuati...
NMN Synbiotics: A Multifaceted Therapeutic Approach for Alzheimer’s Disease
NMN Synbiotics: A Multifaceted Therapeutic Approach for Alzheimer’s Disease
With the aging global population, Alzheimer’s disease (AD) has become a significant social and economic burden, nece...
Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection
Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection
Luteolin is an essential natural polyphenol found in a variety of plants. Numerous studies have supported its protective r...
Omega-3 Attenuates Disrupted Neurotransmission and Partially Protects Metabolic Dysfunction Caused by Obesity in Wistar Rats
Omega-3 Attenuates Disrupted Neurotransmission and Partially Protects Metabolic Dysfunction Caused by Obesity in Wistar Rats
Omega-3 (n3) is a polyunsaturated fatty acid well known for its anti-inflammatory and neuroprotective properties. Obesity ...
The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment
The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease with a challenging treatment landscape, due to its...
Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice
Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice
Dexmedetomidine (DEX) is a highly selective α2-adrenoceptor agonist with sedative effects on sleep homeostasis. Oxyto...
Single-cell RNA Sequencing Identifies a Novel Subtype of Microglia with High Cd74 Expression that Facilitates White Matter Inflammation During Chronic Cerebral Hypoperfusion
Single-cell RNA Sequencing Identifies a Novel Subtype of Microglia with High Cd74 Expression that Facilitates White Matter Inflammation During Chronic Cerebral Hypoperfusion
Vascular dementia (VaD) causes progressive cognitive decline in the elderly population, but there is short of available th...
The Identification of Potential Anti-Depression/Anxiety Drug Targets by Stress-Induced Rat Brain Regional Proteome and Network Analyses
The Identification of Potential Anti-Depression/Anxiety Drug Targets by Stress-Induced Rat Brain Regional Proteome and Network Analyses
Depression and anxiety disorders are prevalent stress-related neuropsychiatric disorders and involve multiple molecular ch...
Scavenger Receptor Class B Type I Modulates Epileptic Seizures and Receptor α2δ-1 Expression
Scavenger Receptor Class B Type I Modulates Epileptic Seizures and Receptor α2δ-1 Expression
Scavenger receptor class B type I (SR-BI) is abundant in adult mouse and human brains, but its function in the central ner...
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