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Novel subharmonic-aided pressure estimation for identifying high-risk esophagogastric varices
Novel subharmonic-aided pressure estimation for identifying high-risk esophagogastric varices
Subharmonic-aided pressure estimation (SHAPE) is a technique for determining changes in ambient pressure. We aimed to anal...
FGFR2 fusions assessed by NGS, FISH, and immunohistochemistry in intrahepatic cholangiocarcinoma
FGFR2 fusions assessed by NGS, FISH, and immunohistochemistry in intrahepatic cholangiocarcinoma
FGFR2 fusion has become a promising therapeutic target in iCCAs; however, the procedure for screening FGFR2 fusion has not...
Impact of ursodeoxycholic acid treatment on Fontan-associated liver disease
Impact of ursodeoxycholic acid treatment on Fontan-associated liver disease
Fontan-associated liver disease (FALD) is a type of progressive liver fibrosis that occurs following Fontan surgery and ca...
Determination of optimal cutoff value of ulcerative colitis intestinal ultrasound index to estimate endoscopic improvement in ulcerative colitis
Determination of optimal cutoff value of ulcerative colitis intestinal ultrasound index to estimate endoscopic improvement in ulcerative colitis
The ulcerative colitis intestinal ultrasound (UC-IUS) index (UII) has been reported as a sonographic scoring system correl...
Comprehensive pathological evaluation of risk factors for metastasis after endoscopic resection of superficial esophageal squamous cell carcinoma
Comprehensive pathological evaluation of risk factors for metastasis after endoscopic resection of superficial esophageal squamous cell carcinoma
Esophageal cancer is a major cause of cancer mortality worldwide. Endoscopic resection (ER) is a curative treatment for es...
Functions and clinical significance of KCNB1 in esophageal squamous cell carcinoma
Functions and clinical significance of KCNB1 in esophageal squamous cell carcinoma
Voltage-gated potassium channel subfamily B member 1 (KCNB1) encodes the α-subunit of the Kv2.1 channel and mediates ...
Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization
Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization
Field cancerization defined by multiple development of squamous cell carcinomas (SCCs) in upper aerodigestive tract was ex...
A clinicopathological study of IgG4-related autoimmune hepatitis and IgG4-hepatopathy
A clinicopathological study of IgG4-related autoimmune hepatitis and IgG4-hepatopathy
Although IgG4-related autoimmune hepatitis (IgG4-AIH) and IgG4-hepatopathy have been proposed as hepatic phenotypes of IgG...
Age distribution and risk factors for Barrett's esophagus by sex at health check-up settings in Japan
Age distribution and risk factors for Barrett's esophagus by sex at health check-up settings in Japan
Given the high prevalence of esophageal adenocarcinoma and Barrett's esophagus (BE), a precancerous lesion, among male...
Diagnostic accuracy and cut-off values of serum leucine-rich alpha-2 glycoprotein for Crohn’s disease activity in the small bowel
Diagnostic accuracy and cut-off values of serum leucine-rich alpha-2 glycoprotein for Crohn’s disease activity in the small bowel
Small bowel (SB) lesions in Crohn’s disease (CD) are often asymptomatic despite being highly active. Fecal calprotec...
Clinical impact of epithelial types on postoperative outcomes for intraductal papillary mucinous neoplasms: a multicenter retrospective study
Clinical impact of epithelial types on postoperative outcomes for intraductal papillary mucinous neoplasms: a multicenter retrospective study
Intraductal papillary mucinous neoplasms (IPMNs) are classified into three epithelial types with distinct biological behav...
Gut microbiota and metabolites of cirrhotic portal hypertension: a novel target on the therapeutic regulation
Gut microbiota and metabolites of cirrhotic portal hypertension: a novel target on the therapeutic regulation
The regulatory role of gut microbiota and gut-derived metabolites through the gut-liver axis in the development of cirrhot...
Single-molecule sequencing of the whole HCV genome revealed envelope deletions in decompensated cirrhosis associated with NS2 and NS5A mutations
Single-molecule sequencing of the whole HCV genome revealed envelope deletions in decompensated cirrhosis associated with NS2 and NS5A mutations
Defective hepatitis C virus (HCV) genomes with deletion of the envelope region have been occasionally reported by short-re...
Development of a novel oncolytic adenovirus controlled by CDX2 promoter for esophageal adenocarcinoma therapy
Development of a novel oncolytic adenovirus controlled by CDX2 promoter for esophageal adenocarcinoma therapy
Prognosis of esophageal adenocarcinoma (EAC) is still poor. Therefore, the development of novel therapeutic modalities is ...
Multisample lipidomic profiles of irritable bowel syndrome and irritable bowel syndrome-like symptoms in patients with inflammatory bowel disease: new insight into the recognition of the same symptoms in different diseases
Multisample lipidomic profiles of irritable bowel syndrome and irritable bowel syndrome-like symptoms in patients with inflammatory bowel disease: new insight into the recognition of the same symptoms in different diseases
Overlapping clinical manifestations of irritable bowel syndrome (IBS) and IBS-like symptoms in patients with inflammatory ...
Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study
Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study
Focal pancreatic parenchymal atrophy (FPPA) and upstream pancreatic atrophy (UPA) may indicate the presence of early pancr...
CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study
CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study
Although atezolizumab plus bevacizumab (Atezo/Bev) therapy has been used as the preferred first-line treatment for advance...
Advances in omics data for eosinophilic esophagitis: moving towards multi-omics analyses
Advances in omics data for eosinophilic esophagitis: moving towards multi-omics analyses
Eosinophilic esophagitis (EoE) is a chronic, allergic inflammatory disease of the esophagus characterized by eosinophil ac...
Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8
Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8
Intestinal fibrosis is one of the most frequent and severe complications of Crohn’s disease. Accumulating studies ha...
Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis
Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis
Rapid skeletal muscle loss adversely affects the clinical outcomes of liver cirrhosis. However, the relationships between ...
Profile of plasma microRNAs as a potential biomarker of Wilson’s disease
Profile of plasma microRNAs as a potential biomarker of Wilson’s disease
Wilson’s disease (WD) is a rare condition resulting from autosomal recessive mutations in ATP7B, a copper transporte...
The potential of an artificial intelligence for diagnosing MRI images in rectal cancer: multicenter collaborative trial
The potential of an artificial intelligence for diagnosing MRI images in rectal cancer: multicenter collaborative trial
An artificial intelligence-based algorithm we developed, mrAI, satisfactorily segmented the rectal tumor, rectum, and meso...
Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis
Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis
The intake of high-fructose corn syrup (HFCS) may increase the risk of colorectal cancer (CRC). This study aimed to explor...
Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study
Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study
The cancer risk for each length of Barrett’s esophagus (BE) in Japanese is unknown. This nationwide, multi-instituti...
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia
Hypoxic microenvironment is a common feature of most solid tumors including hepatocellular carcinoma (HCC). Vasculogenic m...
Patient-derived organoids of pancreatic ductal adenocarcinoma for subtype determination and clinical outcome prediction
Patient-derived organoids of pancreatic ductal adenocarcinoma for subtype determination and clinical outcome prediction
Recently, two molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) have been proposed: the “Classical”...
Pancreatic injury in patients treated with immune checkpoint inhibitors: a retrospective multicenterstudy
Pancreatic injury in patients treated with immune checkpoint inhibitors: a retrospective multicenterstudy
Immune checkpoint inhibitor-related pancreatic injury (ICI-PI) is a rare occurrence, which has not been reported in detail...
The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia
The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia
Achalasia is an esophageal motility disorder with an unknown etiology. We aimed to determine the pathogenesis of achalasia...
Characterization of tumor microbiome and associations with prognosis in intrahepatic cholangiocarcinoma
Characterization of tumor microbiome and associations with prognosis in intrahepatic cholangiocarcinoma
The tumor microbiome has been characterized in several malignancies; however, no previous studies have investigated its ro...
Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan
Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan
The clinicopathological features and prognosis of primary small bowel adenocarcinoma (PSBA), excluding duodenal cancer, re...
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