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Advanced rehabilitation in ischaemic stroke research
Advanced rehabilitation in ischaemic stroke research
For most of the last century, doctors advised less activities and movements after stroke attack. In the 1950s, Twitchell b...
White matter disease derived from vascular and demyelinating origins
White matter disease derived from vascular and demyelinating origins
IntroductionThe white matter of the central nervous system (CNS) is primarily constituted of myelinated axons (tracts) and...
Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical
Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical
IntroductionTo date, stroke remains the second-leading cause of death and the leading cause of disability in much of the w...
Tenecteplase versus alteplase for acute ischaemic stroke: a meta-analysis of phase III randomised trials
Tenecteplase versus alteplase for acute ischaemic stroke: a meta-analysis of phase III randomised trials
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionStroke is the secon...
One-year direct and indirect costs of ischaemic stroke in China
One-year direct and indirect costs of ischaemic stroke in China
IntroductionStroke is one of the leading causes of mortality and disability worldwide,1 and the burden of stroke in China ...
Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke
Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke
IntroductionIschaemic stroke injury disrupts neuronal mitochondrial homeostasis, leading to oxidative stress and subsequen...
Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThe association strengths of current PRSs with risks of stroke and ...
Haemorrhage after thrombectomy with adjuvant thrombolysis in unknown onset stroke depends on high early lesion water uptake
Haemorrhage after thrombectomy with adjuvant thrombolysis in unknown onset stroke depends on high early lesion water uptake
MethodsPatientsThe local high-volume university hospital stroke registry was screened consecutively to select all patients...
Longitudinal associations of cardiovascular health and vascular events with incident dementia
Longitudinal associations of cardiovascular health and vascular events with incident dementia
WHAT IS ALREADY KNOWN ON THIS TOPICCardiovascular health is considered as one of the critical factors in the pathogenesis ...
Residual inflammatory risk predicts long-term outcomes following stenting for symptomatic intracranial atherosclerotic stenosis
Residual inflammatory risk predicts long-term outcomes following stenting for symptomatic intracranial atherosclerotic stenosis
IntroductionIn patients with cerebrovascular diseases, elevated high-sensitivity C-reactive protein (hs-CRP) and low-densi...
Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations
Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations
WHAT IS ALREADY KNOWN ON THIS TOPICSpinal cord cavernous malformations (SCCMs) are rare low-flow vascular malformations wh...
Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage
Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage
IntroductionCortical superficial siderosis (cSS) and cerebral microbleed (CMB) are both haemorrhagic imaging biomarkers of...
Mass effect, aneurysms and flow diverters: Is the pipeline embolization device the Lone Virtuoso? Commentary on 'Pipeline embolization device for intracranial aneurysms presenting with mass effect: a large Chinese cohort by Zhao et al
Mass effect, aneurysms and flow diverters: Is the pipeline embolization device the Lone Virtuoso? Commentary on 'Pipeline embolization device for intracranial aneurysms presenting with mass effect: a large Chinese cohort by Zhao et al
In the treatment of symptomatic intracranial aneurysms, the study by Zhao et al stands as a notable addition to the growin...
Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage
Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage
IntroductionThe pathophysiology of spontaneous intracerebral haemorrhage (ICH) reflects injury to small cerebral blood ves...
Implications of MMP-12 in the pathophysiology of ischaemic stroke
Implications of MMP-12 in the pathophysiology of ischaemic stroke
IntroductionStroke ranks as the fifth top cause of death in the USA and as a second-leading cause of mortality worldwide.1...
Atherosclerosis-related biomarker PABPC1 predicts pan-cancer events
Atherosclerosis-related biomarker PABPC1 predicts pan-cancer events
IntroductionCardiovascular diseases, including atherosclerosis (AS) and severe hypertension,1 are among the leading causes...
Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy
Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy
IntroductionThrombus migration (TM) was commonly seen in intravenous thrombolysis (IVT) patients with large vessel occlusi...
Penumbra-targeted CircOGDH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia
Penumbra-targeted CircOGDH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia
What is already known on this topicNanoparticles (NPs) are reported to be effective vehicles to transport therapeutic agen...
Enhanced diagnostic workup increases pathological findings in patients with acute ischaemic stroke: results of the prospective HEBRAS study
Enhanced diagnostic workup increases pathological findings in patients with acute ischaemic stroke: results of the prospective HEBRAS study
WHAT IS ALREADY KNOWN ON THIS TOPICRoutine diagnostic care in-hospital does not allow a definite conclusion on stoke aetio...
Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study
Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study
IntroductionTwenty to thirty percent of ischaemic strokes are of cardioembolic aetiology while up to 25% of them do not ha...
STING mediates microglial pyroptosis via interaction with NLRP3 in cerebral ischaemic stroke
STING mediates microglial pyroptosis via interaction with NLRP3 in cerebral ischaemic stroke
IntroductionIschaemic stroke represents a major cerebrovascular disease, which results from embolism or thrombosis of a br...
Randomised study of bailout intracranial angioplasty following thrombectomy for acute large vessel occlusion (ANGEL-REBOOT): protocol of a multicentre randomised controlled trial
Randomised study of bailout intracranial angioplasty following thrombectomy for acute large vessel occlusion (ANGEL-REBOOT): protocol of a multicentre randomised controlled trial
Introduction and rationaleStroke ranks as the second most prevalent cause of death globally, accounting for approximately ...
Dural sinus septum: an underlying cause of cerebral venous sinus stenting failure and complications
Dural sinus septum: an underlying cause of cerebral venous sinus stenting failure and complications
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionCerebral venous sin...
Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update
Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update
HighlightsThe clinical management of ischaemic cerebrovascular diseases comprises a total of 287 recommendations, includin...
Comparing a novel Catfish flow restoration device and the Solitaire stent retriever for thrombectomy revascularisation in emergent largevessel occlusion stroke: a prospective randomised controlled study
Comparing a novel Catfish flow restoration device and the Solitaire stent retriever for thrombectomy revascularisation in emergent largevessel occlusion stroke: a prospective randomised controlled study
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYThere are many distinct kinds o...
Photochemically induced thalamus infarction impairs cognition in a mouse model
Photochemically induced thalamus infarction impairs cognition in a mouse model
IntroductionSmall subcortical infarct, commonly known as lacunar infarct, mostly results from ischaemia in the territory o...
Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas
Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas
IntroductionExtra-axial cavernous hemangiomas (ECHs) are rare intracranial lesions,1 mostly in the cavernous sinus (repres...
Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects
Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects
IntroductionTo date, stroke remained the second-leading cause of death and one of the leading causes of disability in much...
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages
IntroductionIntracerebral haemorrhage (ICH) accounts for 12%–20% of all types of stroke with over 2 million individuals wo...
Development of machine learning-based models to predict 10-year risk of cardiovascular disease: a prospective cohort study
Development of machine learning-based models to predict 10-year risk of cardiovascular disease: a prospective cohort study
WHAT IS ALREADY KNOWN ON THIS TOPICSeveral cardiovascular diseases (CVD) prediction models have been developed to deliver ...
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