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The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
Ketamine produces dissociative, psychomimetic, anxiolytic, antidepressant, and anesthetic effects in a dose dependent mann...
Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study
Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study
Major Depressive Disorder (MDD) is a pervasive psychiatric condition effecting approximately 21 million adults in the U.S....
Noribogaine acute administration in rats promotes wakefulness and suppresses REM sleep
Noribogaine acute administration in rats promotes wakefulness and suppresses REM sleep
Ibogaine is a potent atypical psychedelic that has gained considerable attention due to its antiaddictive and antidepressa...
Allosteric inhibition of phosphodiesterase 4D induces biphasic memory-enhancing effects associated with learning-activated signaling pathways
Allosteric inhibition of phosphodiesterase 4D induces biphasic memory-enhancing effects associated with learning-activated signaling pathways
Phosphodiesterase 4D negative allosteric modulators (PDE4D NAMs) enhance memory and cognitive function in animal models wi...
Supraphysiological testosterone levels from anabolic steroid use and reduced sensitivity to negative facial expressions in men
Supraphysiological testosterone levels from anabolic steroid use and reduced sensitivity to negative facial expressions in men
Anabolic-androgenic steroids (AAS) are used to improve physical performance and appearance, but have been associated with ...
Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
Emerging evidence indicates that persistent alcohol consumption escalates psychosocial trauma achieved by social defeat st...
Synergistic antidepressant-like effect of citicoline and CB 1 agonist in male mice
Synergistic antidepressant-like effect of citicoline and CB 1 agonist in male mice
The endocannabinoid system plays a key role in the control of many emotional-correlated reactions such as stress, depresse...
Behavioral and transcriptional effects of repeated electroconvulsive seizures in the neonatal MK-801-treated rat model of schizophrenia
Behavioral and transcriptional effects of repeated electroconvulsive seizures in the neonatal MK-801-treated rat model of schizophrenia
Electroconvulsive therapy (ECT) is an effective treatment modality for schizophrenia. However, its antipsychotic-like mech...
Gut microbiota connects the brain and the heart: potential mechanisms and clinical implications
Gut microbiota connects the brain and the heart: potential mechanisms and clinical implications
Nowadays, high morbidity and mortality of cardiovascular diseases (CVDs) and high comorbidity rate of neuropsychiatric dis...
Levels of neuronal pentraxin 2 in plasma is associated with cognitive function in patients with schizophrenia
Levels of neuronal pentraxin 2 in plasma is associated with cognitive function in patients with schizophrenia
The precise diagnosis and treatment of cognitive impairment remains a major challenge in the field of schizophrenia (SCZ) ...
Changes in distinct brain systems identified with fMRI during smoking cessation treatment with varenicline: a review
Changes in distinct brain systems identified with fMRI during smoking cessation treatment with varenicline: a review
Varenicline is considered one of the most effective treatment options for smoking cessation. Nonetheless, it is only modes...
Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
Insufficient autophagy enables the nuclear factor erythroid 2-related factor 2 (NRF2) to promote ferroptosis in morphine-treated SH-SY5Y cells
While morphine has important therapeutic value it is also one of the most widely abused drugs in the world. As a newly dis...
Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation
Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation
Behavioral effects of testosterone depend on dose, acute versus sustained formulation, duration of administration, persona...
Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients
Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients
In bipolar disorder (BD), immunological factors play a role in the pathogenesis and treatment of the illness. Studies show...
A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized clinical trial
A practice quit model to test early efficacy of medications for alcohol use disorder in a randomized clinical trial
Screening novel medications for alcohol use disorder (AUD) requires models that are both efficient and ecologically-valid....
Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner
Se-(Methyl)-selenocysteine ameliorates blood-brain barrier disruption of focal cerebral ischemia mice via ferroptosis inhibition and tight junction upregulation in an Akt/GSK3β-dependent manner
Ischemic stroke still ranks as the most fatal disease worldwide. Blood-brain barrier (BBB) is a promising therapeutic targ...
Acute effects of outdoor and indoor walking on cigarette cravings, withdrawal symptoms and affective response during temporary smoking abstinence
Acute effects of outdoor and indoor walking on cigarette cravings, withdrawal symptoms and affective response during temporary smoking abstinence
Cigarette smoking is one of the leading preventable causes of premature death worldwide. There is evidence in the literatu...
The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice
The neutral CB1 antagonist AM6527 reduces ethanol seeking, binge-like consumption, reinforcing, and withdrawal effects in male and female mice
Alcohol use disorder (AUD) is a debilitating physiological and psychiatric disorder which affects individuals globally. Th...
Noradrenergic regulation of cue-guided decision making and impulsivity is doubly dissociable across frontal brain regions
Noradrenergic regulation of cue-guided decision making and impulsivity is doubly dissociable across frontal brain regions
Win-paired stimuli can promote risk taking in experimental gambling paradigms in both rats and humans. We previously demon...
The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference
The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference
Relapse into substance use is often triggered by exposure to drug-related environmental cues. The magnitude of drug seekin...
Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct
Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct
Substance use disorders (SUDs) rank among the most severely debilitating psychiatric conditions. Among others, decreased r...
Effect of dietary supplementation with Lactobacillus helveticus R0052 on seizure thresholds and antiseizure potency of sodium valproate in mice
Effect of dietary supplementation with Lactobacillus helveticus R0052 on seizure thresholds and antiseizure potency of sodium valproate in mice
Both animal and human studies, though limited, showed that multi-strain probiotic supplementation may reduce the number of...
Correction to: Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
Correction to: Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats
Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats
Cabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppresses the r...
Liraglutide ameliorates delirium-like behaviors of aged mice undergoing cardiac surgery by mitigating microglia activation via promoting mitophagy
Liraglutide ameliorates delirium-like behaviors of aged mice undergoing cardiac surgery by mitigating microglia activation via promoting mitophagy
Postoperative delirium (POD) is a prevalent complication in cardiac surgery patients, particularly the elderly, with neuro...
Contingent administration of typical and biased kappa opioid agonists reduces cocaine and oxycodone choice in a drug vs. food choice procedure in male rhesus monkeys
Contingent administration of typical and biased kappa opioid agonists reduces cocaine and oxycodone choice in a drug vs. food choice procedure in male rhesus monkeys
Combinations of mu and kappa-opioid receptor (KOR) agonists have been proposed as analgesic formulations with reduced abus...
Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance test
Effects of psilocybin, the 5-HT2A receptor agonist TCB-2, and the 5-HT2A receptor antagonist M100907 on visual attention in male mice in the continuous performance test
Neuropsychiatric disorders such as depression are characterized in part by attention deficits. Attention is modulated by t...
Venlafaxine’s therapeutic reference range in the treatment of depression revised: a systematic review and meta-analysis
Venlafaxine’s therapeutic reference range in the treatment of depression revised: a systematic review and meta-analysis
The selective serotonin and norepinephrine reuptake inhibitor venlafaxine is among the most prescribed antidepressant drug...
Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study
Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study
A subanesthetic dose of ketamine, a non-competitive N-methyl-D-aspartate glutamate receptor (NMDAR) antagonist, elicits di...
Psychedelic use and psychiatric risks
Psychedelic use and psychiatric risks
Research on psychedelics has recently shown promising results in the treatment of various psychiatric disorders, but relat...
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