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Ethanol consumption prior to cocaine self-administration reduced vulnerability to cocaine reinforcement in socially subordinate female and male monkeys
Ethanol consumption prior to cocaine self-administration reduced vulnerability to cocaine reinforcement in socially subordinate female and male monkeys
Although ethanol consumption is ubiquitous among individuals who use cocaine, most preclinical work investigating factors ...
Early oral administration of THC:CBD formulations prevent pain-related behaviors without exacerbating paclitaxel-induced changes in weight, locomotion, and anxiety in a rat model of chemotherapy-induced neuropathy
Early oral administration of THC:CBD formulations prevent pain-related behaviors without exacerbating paclitaxel-induced changes in weight, locomotion, and anxiety in a rat model of chemotherapy-induced neuropathy
Paclitaxel-induced neuropathy stands out as the primary, dose-limiting side effect of this extensively used chemotherapy a...
Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial
Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial
Negative affect plays a prominent role in the maintenance of alcohol use disorder (AUD) and has been identified as a risk ...
Decoding the genetic links between substance use disorder and cancer vulnerability
Decoding the genetic links between substance use disorder and cancer vulnerability
Cancer remains a leading cause of mortality and morbidity worldwide, imposing a significant public health burden. While ca...
Agonism at mGluR2 receptors reduces dysfunctional checking on a rodent analogue of compulsive-like checking in obsessive compulsive disorder
Agonism at mGluR2 receptors reduces dysfunctional checking on a rodent analogue of compulsive-like checking in obsessive compulsive disorder
Obsessive-compulsive disorder (OCD) affects 1–3% of the population. Current therapies, including selective serotonin...
Comment on the study “the efficacy and safety of zuranolone for treatment of depression: a systematic review and meta-analysis”
Comment on the study “the efficacy and safety of zuranolone for treatment of depression: a systematic review and meta-analysis”
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR (2009) Introduction to Meta-Analysis, 1st edn. WileyClayton AH, Lasser ...
Sex specific effects of ketamine, but not other glutamate receptor modulators, on ethanol self-administration and reinstatement of ethanol seeking in rats
Sex specific effects of ketamine, but not other glutamate receptor modulators, on ethanol self-administration and reinstatement of ethanol seeking in rats
Alcohol use and major depressive disorder are frequently comorbid, with individuals diagnosed with a substance use disorde...
Quercetin ameliorates chronic restraint stress- and LPS-induced anxiety-like behaviors by modulating neuroinflammation in the lateral hypothalamus
Quercetin ameliorates chronic restraint stress- and LPS-induced anxiety-like behaviors by modulating neuroinflammation in the lateral hypothalamus
Quercetin is a natural flavonoid which has been shown to exhibit anti-inflammatory and anxiolytic properties. Neuroinflamm...
The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity
The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity
N, N-Dimethyltryptamine (DMT), a potent serotonergic psychedelic, bridges ancient wisdom and modern science. The mechanism...
Behavioural effects of oral cannabidiol (CBD) treatment in the () mouse model of amyotrophic lateral sclerosis
Behavioural effects of oral cannabidiol (CBD) treatment in the () mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting voluntary muscle movement as well...
Modulation of strategic status signaling: oxytocin changes men’s fluctuations of status products preferences in their female partners’ menstrual cycle
Modulation of strategic status signaling: oxytocin changes men’s fluctuations of status products preferences in their female partners’ menstrual cycle
Women exhibit subtle fluctuations in mating-related behaviors throughout their menstrual cycle, and men are capable of det...
Disruptive effects of d-amphetamine on conditioned sexual inhibition in the male rat
Disruptive effects of d-amphetamine on conditioned sexual inhibition in the male rat
Male rats trained to associate a neutral odor (almond) with nonreceptive females during their initial sexual experiences d...
Distinct subcircuits within the mesolimbic dopamine system encode the salience and valence of social stimuli
Distinct subcircuits within the mesolimbic dopamine system encode the salience and valence of social stimuli
The mesolimbic dopamine (DA) system (MDS) is the canonical “reward” pathway that has been studied extensively ...
A scoping review of the effects of serotonergic psychedelics on attitudes towards death
A scoping review of the effects of serotonergic psychedelics on attitudes towards death
Emerging evidence suggests that psychedelic experiences have the potential to change attitudes towards death and reduce de...
The effect of nicotine on threat avoidance behaviour in healthy non-smokers
The effect of nicotine on threat avoidance behaviour in healthy non-smokers
Developing adaptive strategies for survival relies on distinguishing danger from safety through aversive learning mechanis...
Cognitive flexibility of male rats is increased by augmented punishment in a reversal learning task but ketamine has no detectable long-term effects
Cognitive flexibility of male rats is increased by augmented punishment in a reversal learning task but ketamine has no detectable long-term effects
The probabilistic reversal learning task (PRL) is sometimes used in the context of major depressive disorder (MDD) to asse...
Incremental efficacy systematic review and meta-analysis of psilocybin-for-depression RCTs
Incremental efficacy systematic review and meta-analysis of psilocybin-for-depression RCTs
Psilocybin is a potentially paradigm-shifting depression intervention. We conducted a systematic review and meta-analysis ...
Embracing change: impermanence acceptance mediates differences in death processing between long-term ayahuasca users and non-users
Embracing change: impermanence acceptance mediates differences in death processing between long-term ayahuasca users and non-users
The human psyche's interaction with death fundamentally shapes cognition, emotions, and behavior in both individuals a...
Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats
Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats
Motivational dysfunctions related to effort exertion are common in psychiatric disorders. Dopamine systems regulate exerti...
Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer’ s Disease Mouse Model
Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer’ s Disease Mouse Model
Alzheimer’s disease (AD), an age-dependent devastating neuropsychiatric disorder, is a leading cause of learning, me...
Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement
Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement
Nicotine dependence is highly comorbid with opioid use disorders (OUDs). The use of nicotine-containing products increases...
Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal
Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal
The persistent use of opioids leads to profound changes in neuroplasticity of the brain, contributing to the emergence and...
Hypocretin-1 receptor antagonism improves inhibitory control during the Go/No-Go task in highly motivated, impulsive male mice
Hypocretin-1 receptor antagonism improves inhibitory control during the Go/No-Go task in highly motivated, impulsive male mice
Motivation and inhibitory control are dominantly regulated by the dopaminergic (DA) and noradrenergic (NA) systems, respec...
Choice of alcohol over a natural reward: an experimental study in light and heavy social drinkers
Choice of alcohol over a natural reward: an experimental study in light and heavy social drinkers
A core symptom of alcohol use disorder (AUD) is a progressively increased choice of alcohol over alternative rewards despi...
Oxytocin differentially modulates reward system responses to social and non-social incentives
Oxytocin differentially modulates reward system responses to social and non-social incentives
Oxytocin has been shown to modulate behavior related to processing of monetary incentives and to regulate social and repro...
Perceived changes in mental health and social engagement attributed to a single psychedelic experience in autistic adults: results from an online survey
Perceived changes in mental health and social engagement attributed to a single psychedelic experience in autistic adults: results from an online survey
Anecdotal reports suggest that psychedelic drugs can improve psychological wellbeing and social engagement in autistic peo...
Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear
Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear
Despite the existing anatomical and physiological evidence pointing to the involvement of orexinergic projections from the...
Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice
Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice
The newly emerging synthetic cannabinoids (SCs) 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 have been observed to produce e...
Dose-dependent effect of acute THC on extinction memory recall and fear renewal: a randomized, double-blind, placebo-controlled study
Dose-dependent effect of acute THC on extinction memory recall and fear renewal: a randomized, double-blind, placebo-controlled study
Prior work from our lab and others demonstrates that the endocannabinoid system is a promising avenue for improving fear m...
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Morphine withdrawal leads to serious cognitive deficits in which dynorphins are directly involved. Recently, exercise has ...
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