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Localized translation in the embryo
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the im...
A code within the genetic code
A code within the genetic code
The story of a paper that established the concept of codon optimality and its connection with translation efficiency and m...
Protein N-terminal acetylation is entering the degradation end game
Despite being one of the most common protein modifications in eukaryotes, the cellular effect of N-terminal acetylation re...
Single-cell live volume measurements using the fluorescence exclusion method
In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion met...
Cellular and molecular mechanisms of skin wound healing
Cellular and molecular mechanisms of skin wound healing
Wound healing is a complex process that involves the coordinated actions of many different tissues and cell lineages. It r...
How ancient RNA survives and what we can learn from it
Although normally transient, RNA can persist postmortem when preserved by cold, desiccation or chemical treatment. In this...
Opportunities and challenges in design and optimization of protein function
Opportunities and challenges in design and optimization of protein function
The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely...
Seeing transcription in real time
Seeing transcription in real time
Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenou...
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral nerve end...
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent tr...
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as ...
A new perspective on intervertebral disc calcification—from bench to bedside
A new perspective on intervertebral disc calcification—from bench to bedside
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to unders...
The role and applications of extracellular vesicles in osteoporosis
The role and applications of extracellular vesicles in osteoporosis
Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture...
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized ...
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but ...
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues, including cartilage, bone, sy...
Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It
Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It
This article gives a broad overview of quantitative modelling approaches in biology and provides guidance on how to employ...
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
Describe the rationale for preconditioning MSCs prior to use as therapy and the state-of-the-art of using preconditioning ...
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amou...
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives
Despite no general conclusions regarding the therapeutic effect of MSCs on virus-induced acute lung injury in pre-clinical...
The molecular basis of translation initiation and its regulation in eukaryotes
The molecular basis of translation initiation and its regulation in eukaryotes
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional regulation of gene expressi...
Does species-specific alternative splicing make us human?
Florian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdow...
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Bone formation is a highly energy-demanding process that can be impacted by metabolic disorders. Glucose has been consider...
Structure and function of the membrane microdomains in osteoclasts
Structure and function of the membrane microdomains in osteoclasts
The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed ...
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling
To explore the advances and future research directions in image analysis and computational modelling of human stem cells (...
Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways
Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways
Hand osteoarthritis is a common heterogeneous joint disorder with unclear molecular mechanisms and no disease-modifying dr...
Spatial transcriptomic interrogation of the murine bone marrow signaling landscape
Spatial transcriptomic interrogation of the murine bone marrow signaling landscape
Self-renewal and differentiation of skeletal stem and progenitor cells (SSPCs) are tightly regulated processes, with SSPC ...
Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic calcification and pathological calcif...
Local and systemic mechanisms that control the hair follicle stem cell niche
Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregul...
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