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Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclast is critical in skeletal development and fracture healing, yet the impact and underlying mechanisms of their met...
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Osteoarthritis (OA) is the most common form of arthritic disease, and phenotypic modification of chondrocytes is an import...
Bone targeted nano-drug and nano-delivery
Bone targeted nano-drug and nano-delivery
There are currently no targeted delivery systems to satisfactorily treat bone-related disorders. Many clinical drugs consi...
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone forma...
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Intervertebral disc degeneration (IDD) is a major cause of discogenic pain, and is attributed to the dysfunction of nucleu...
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Heterotopic ossification (HO) is a pathological process that commonly arises following severe polytrauma, characterized by...
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall surviv...
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonuni...
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
To review recent research using various stem cell-related therapies, including bone marrow, adipose tissue, hematopoietic ...
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
There is an urgent unmet clinical need for effective therapies for obstetric complications such as fetal growth restrictio...
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of t...
Heterochromatin as a balancing act between transcription and gene silencing
Heterochromatin as a balancing act between transcription and gene silencing
An elegant study revealed the distinct roles of different H3K9 methylation states in heterochromatin formation and function.
Long-lived proteomes in healthy ovaries
Long-lived proteomes in healthy ovaries
Many proteins in the mouse ovary are extremely stable; they enhance proteostasis and limit protein aggregation, thereby su...
Virus–host warfare by PROTACs
Virus–host warfare by PROTACs
The studies that paved the way for the development of PROTACs (proteolysis-targeting chimeras) as therapeutic strategies, ...
The discovery of cyclin-dependent kinases
The discovery of cyclin-dependent kinases
Paul Nurse discusses how a 1971 paper by Culotti and Hartwell inspired him to investigate the cell cycle in fission yeast,...
Cellular and pathological functions of tau
Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of m...
Regulation of and challenges in targeting NAD+ metabolism
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a reduction–oxidation (redox)...
What does it take to build a nucleus?
What does it take to build a nucleus?
Abigail Buchwalter recounts what happened to the nuclei of cells lacking all lamin genes.
MYB-related proteins make chloroplasts
MYB-related proteins make chloroplasts
MYB-related transcription factors are found to function in chloroplast biogenesis alongside GLK in the distantly related s...
Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections
Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections
Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and imp...
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border...
Author Correction: FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Author Correction: FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold an opinion that gut microbiota is environmentally a...
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Extracellular matrix (ECM) stiffening is a typical characteristic of cartilage aging, which is a quintessential feature of...
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types, including osteoblast (OB) ...
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling
Degenerated endplate appears with cheese-like morphology and sensory innervation, contributing to low back pain and subseq...
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
DNAX-associated protein 12 kD size (DAP12) is a dominant immunoreceptor tyrosine-based activation motif (ITAM)-signa...
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Spina bifida (SB) is a severe birth defect that affects 1400 newborns annually in the USA. SB is often diagnosed before ir...
TRASCET—Transamniotic Stem Cell Therapy
TRASCET—Transamniotic Stem Cell Therapy
This is an overview of the current state of development of transamniotic stem cell therapy (TRASCET) as an emerging therap...
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a cor...
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