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Prevalence and Temporal Trends of Attention Deficit Hyperactivity Disorder Medication Fills During Pregnancy and Breastfeeding in Denmark
Prevalence and Temporal Trends of Attention Deficit Hyperactivity Disorder Medication Fills During Pregnancy and Breastfeeding in Denmark
Females of reproductive age are increasingly using attention deficit hyperactivity disorder (ADHD) medication, but its use...
Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature
Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature
Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Since IL-1 has been shown to play a key role in the etiology of...
Adverse Events of Factor Xa Inhibitors in Pediatric Patients: A Meta-analysis and Pharmacovigilance Study
Adverse Events of Factor Xa Inhibitors in Pediatric Patients: A Meta-analysis and Pharmacovigilance Study
This study aimed to provide a comprehensive review of adverse events (AEs) associated with factor Xa (FXa) inhibitors in p...
Efficacy and Safety of Proactive Therapy with 2% Crisaborole Ointment in Children with Mild-to-Moderate Atopic Dermatitis: A Randomized Controlled Study
Efficacy and Safety of Proactive Therapy with 2% Crisaborole Ointment in Children with Mild-to-Moderate Atopic Dermatitis: A Randomized Controlled Study
The effectiveness of crisaborole for proactive treatment of atopic dermatitis (AD) is not well established. This study aim...
Neuroimaging as a Tool for Advancing Pediatric Psychopharmacology
Neuroimaging as a Tool for Advancing Pediatric Psychopharmacology
Neuroimaging, specifically magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and positron emission ...
Drug Development in Pediatric Chronic Kidney Disease: A Review of Promising Treatments, Old Challenges, and New Strategies
Drug Development in Pediatric Chronic Kidney Disease: A Review of Promising Treatments, Old Challenges, and New Strategies
Youth under the age of 18 years represent a distinct subset of the population living with chronic kidney disease (CKD). Th...
Meningococcal Vaccination in the United States: Past, Present, And Future
Meningococcal Vaccination in the United States: Past, Present, And Future
Meningococcal disease is rare but serious, often striking previously healthy adolescents or young adults, with substantial...
Cardioprotective Effect of in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study
Cardioprotective Effect of in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study
Nigella sativa is a widely used medicinal plant with several potential therapeutic uses. This study aimed to investigate t...
Diagnosis and Oral Sirolimus Treatment of Fibro-Adipose Vascular Anomaly in Pediatric Patients: A Case Series and Comprehensive Review
Diagnosis and Oral Sirolimus Treatment of Fibro-Adipose Vascular Anomaly in Pediatric Patients: A Case Series and Comprehensive Review
Fibro-adipose vascular anomaly (FAVA) is a rare and complex vascular malformation that, to date, has hardly been studied, ...
Macitentan: Pediatric First Approval
Macitentan: Pediatric First Approval
Macitentan (Opsumit®), an endothelin receptor antagonist (ERA) developed by Johnson & Johnson, is well establ...
Emerging Treatments in Neonatal Fungal Infections: Progress and Prospects
Emerging Treatments in Neonatal Fungal Infections: Progress and Prospects
Fungal infections in neonates are potentially life threatening. The differential diagnosis for neonatal rashes is extensiv...
Tapinarof Cream 1%: Pediatric First Approval
Tapinarof Cream 1%: Pediatric First Approval
The aryl hydrocarbon receptor (AhR) has an integral role in maintaining skin homeostasis. Tapinarof cream 1% (VTAMA®)...
Risk Factors for Nephrotoxicity Among Neonates Receiving Vancomycin: A Systematic Review and Meta-analysis
Risk Factors for Nephrotoxicity Among Neonates Receiving Vancomycin: A Systematic Review and Meta-analysis
Nephrotoxicity may increase the risk of neonatal mortality. Early identification of risk factors for nephrotoxicity is ess...
Prescription Trends for Primary Headache in Children and Adolescents in China During 2019–2023: A Retrospective Study
Prescription Trends for Primary Headache in Children and Adolescents in China During 2019–2023: A Retrospective Study
Globally, primary headache disorders, including migraine, tension type headache and cluster headache, are a leading cause ...
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Adverse Drug Reactions in Children with Congenital Heart Disease: A Scoping Review
Congenital heart disease (CHD) is one of the leading causes of death. Safe and timely medical interventions, especially in...
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Impact of Prolonged Continuous Ketamine Infusions in Critically Ill Children: A Prospective Cohort Study
Ketamine has been considered as an adjunct for children who do not reach their predefined target sedation depth. However, ...
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Effectiveness and Safety of Ustekinumab in Pediatric Ulcerative Colitis: A Multi-center Retrospective Study from the Pediatric IBD Porto Group of ESPGHAN
Current data on ustekinumab therapy in children with ulcerative colitis (UC) or unclassified inflammatory bowel disease (I...
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Distal renal tubular acidosis (dRTA) is characterized by a primary defect in proton secretion by α-intercalated cells...
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
Antiseizure medications (ASMs) can potentially trigger psychobehavioral adverse events associated with the onset or exacer...
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy: A Systematic Review
Vamorolone has recently been approved for the management of Duchenne muscular dystrophy to replace glucocorticosteroids, w...
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain
This narrative review examines the evolving role of opioids in managing procedural and surgical pain in pediatric oncology...
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Acetaminophen, ibuprofen, and indomethacin are widely used as first-line drugs for patent ductus arteriosus (PDA) closure ...
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Developing CAR T-Cell Therapies for Pediatric Solid Tumors
Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of hematological malignancies, inducing notable ...
Paediatric Drug Development in China: Current Status and Future Prospects
Paediatric Drug Development in China: Current Status and Future Prospects
For more than two decades, regulatory agencies throughout the world released guidelines, rules and laws to stimulate and a...
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
Bacterial infection is one of the major causes of neonatal morbidity and mortality worldwide. Finding rapid and reliable m...
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disorder that primarily affects the joints in children. Notabl...
Inotuzumab Ozogamicin: First Pediatric Approval
Inotuzumab Ozogamicin: First Pediatric Approval
Inotuzumab ozogamicin (BESPONSA™) is a CD22-targeted monoclonal antibody drug conjugate (ADC) developed by Pfizer fo...
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
CROCuS, a Phase II Study Evaluating the Antiviral Activity, Clinical Outcomes, and Safety of Rilematovir in Children Aged ≥ 28 Days and ≤ 3 Years with Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus
Respiratory syncytial virus (RSV) causes significant morbidity and mortality in children aged ≤ 5 years and...
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Diagnosis and Management of Pediatric Neuropsychiatric Systemic Lupus Erythematosus: An Update
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a potentially serious and life-threatening complication of SLE. T...
Alirocumab: Pediatric First Approval
Alirocumab: Pediatric First Approval
Alirocumab (Praluent®), a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor that has been co-developed ...
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