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Real-World Data on the Use of Sirolimus in Asian Children with Vascular Malformations
Real-World Data on the Use of Sirolimus in Asian Children with Vascular Malformations
The management of vascular malformations is complex and challenging. This study aimed to explore efficacy, plasma trough c...
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
Concerns exist regarding the rising use of methylphenidate. A double-blind, placebo-controlled methylphenidate titration (...
Existing and Emerging Targeted Therapies in Juvenile Psoriatic Arthritis: Challenges and Unmet Needs
Existing and Emerging Targeted Therapies in Juvenile Psoriatic Arthritis: Challenges and Unmet Needs
Juvenile psoriatic arthritis (JPsA) is a heterogeneous type of non-systemic chronic inflammatory arthritis affecting child...
Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review
Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review
Prescribing is a high-risk task within the pediatric medication-use process and requires defenses to prevent errors. Such ...
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations
Oral Ibuprofen for the Treatment of PDA in Preterm Neonates: Urgent Need for a Safer Alternative to Hyperosmolar Formulations
Funding No funding was received for the preparation of this...
Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms
Safety and Effectiveness of Prucalopride in Children with Functional Constipation with and without Upper Symptoms
Pediatric prucalopride studies for treatment of gastrointestinal (GI) disorders have reported mixed results. We aimed to a...
Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Practical Approach to Diagnosis and Management of IL-1-Mediated Autoinflammatory Diseases (CAPS, TRAPS, MKD, and DIRA)
Systemic autoinflammatory diseases (SAIDs) are a group of rare genetic and nongenetic immune dysregulatory disorders assoc...
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System
Toxicity Spectrum of Anti-GD2 Immunotherapy: A Real-World Study Leveraging the US Food and Drug Administration Adverse Event Reporting System
Anti-disialoganglioside (anti-GD2) monoclonal antibodies are effective immunotherapeutic drugs for treating neuroblastoma,...
Managing Lupus Nephritis in Children and Adolescents
Managing Lupus Nephritis in Children and Adolescents
Lupus nephritis is an important manifestation of systemic lupus erythematosus, which leads to chronic kidney disease, kidn...
Infections in Children Aged 6 Months to 5 Years Treated with Dupilumab in a Placebo-Controlled Clinical Trial of Moderate-to-Severe Atopic Dermatitis
Infections in Children Aged 6 Months to 5 Years Treated with Dupilumab in a Placebo-Controlled Clinical Trial of Moderate-to-Severe Atopic Dermatitis
Patients with atopic dermatitis (AD), particularly infants and young children, are at greater risk of developing skin infe...
Bosutinib: Pediatric First Approval
Bosutinib: Pediatric First Approval
Bosutinib (BOSULIF®), an orally administered BCR–ABL tyrosine kinase inhibitor (TKI) developed by Pfizer Inc., ...
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection (LRTI) in children, and is...
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin (YCANTH™) is a proprietary drug-device combination product containing a formulation of cantharidin 0.7% ...
Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach
Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach
Patent ductus arteriosus (PDA) in preterm infants is associated with increased morbidities and mortality. Prophylactic tre...
Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs
Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs
Epilepsy is a common pediatric neurological condition, affecting approximately 470,000 children in the USA and having a pr...
Emerging Treatments for Childhood Interstitial Lung Disease
Emerging Treatments for Childhood Interstitial Lung Disease
Childhood interstitial lung disease (chILD) is a large and heterogeneous group of disorders characterized by diffuse lung ...
Correction to: Viloxazine: Pediatric First Approval
Correction to: Viloxazine: Pediatric First Approval
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International ...
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Psoriasis is a chronic immune-mediated disorder that commonly affects adults and children. In recent years, pediatric psor...
Pediatric Drugs, Accelerated Approval, and Prospects for Reform
Pediatric Drugs, Accelerated Approval, and Prospects for Reform
U.S. Food and Drug Administration. Accelerated approval. 2023. https://www.fda.gov/patients/fast-track-breakthrough-therap...
Respiratory Syncytial Virus Prefusion F Subunit Vaccine: First Approval of a Maternal Vaccine to Protect Infants
Respiratory Syncytial Virus Prefusion F Subunit Vaccine: First Approval of a Maternal Vaccine to Protect Infants
Pfizer is developing a bivalent respiratory syncytial virus (RSV) prefusion F subunit vaccine (RSVpreF; ABRYSVO™) fo...
Diagnosis and Management of the Systemic Juvenile Idiopathic Arthritis Patient with Emerging Lung Disease
Diagnosis and Management of the Systemic Juvenile Idiopathic Arthritis Patient with Emerging Lung Disease
Chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD) is an emerging and potentially life...
Scope of JAK Inhibitors in Children: Recent Evidence and Way Forward
Scope of JAK Inhibitors in Children: Recent Evidence and Way Forward
Over the last decade, there has been an increase in the use of targeted therapy using small molecules such as Janus kinase...
Hidradenitis Suppurativa in Children and Adolescents: An Update on Pharmacologic Treatment Options
Hidradenitis Suppurativa in Children and Adolescents: An Update on Pharmacologic Treatment Options
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin condition that manifests as painful, deep-seated,...
Diagnosis and Management of Non-Infectious Uveitis in Pediatric Patients
Diagnosis and Management of Non-Infectious Uveitis in Pediatric Patients
Uveitis in children accounts for 5–10% of all cases. The causes vary considerably. Classically, uveitis is distingui...
Low-Dose Remifentanil in Preterm Cesarean Section with General Anesthesia: A Randomized Controlled Trial
Low-Dose Remifentanil in Preterm Cesarean Section with General Anesthesia: A Randomized Controlled Trial
The conventional technique of general anesthesia induction during a Cesarean section involves the use of opioids only afte...
Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)
Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)
Advanced myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematological malignancies in...
Developments in the Management of Severe Asthma in Children and Adolescents: Focus on Dupilumab and Tezepelumab
Developments in the Management of Severe Asthma in Children and Adolescents: Focus on Dupilumab and Tezepelumab
Severe asthma in children and adolescents exerts a substantial health, financial, and societal burden. Severe asthma is a ...
Pharmacotherapy for Cancer Treatment-Related Cardiac Dysfunction and Heart Failure in Childhood Cancer Survivors
Pharmacotherapy for Cancer Treatment-Related Cardiac Dysfunction and Heart Failure in Childhood Cancer Survivors
The number of childhood cancer survivors is increasing rapidly. According to American Association for Cancer Research, the...
The Future of Advanced Therapies for Pediatric Crohn’s Disease
The Future of Advanced Therapies for Pediatric Crohn’s Disease
Pediatric Crohn’s disease commonly presents with moderate-to-severe intestinal inflammation with a greater risk of c...
Impact of Dexmedetomidine Infusion on Opioid and Benzodiazepine Doses in Ventilated Pediatric Patients in the Cardiac Intensive Care Unit
Impact of Dexmedetomidine Infusion on Opioid and Benzodiazepine Doses in Ventilated Pediatric Patients in the Cardiac Intensive Care Unit
Dexmedetomidine (DEX) is frequently used as an adjunct agent for prolonged sedation in the intensive care unit (ICU), thou...
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