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Involvement of the ipsilateral-to-the-pain anterior–superior hypothalamic subunit in chronic cluster headache
Involvement of the ipsilateral-to-the-pain anterior–superior hypothalamic subunit in chronic cluster headache
Despite hypothalamus has long being considered to be involved in the pathophysiology of cluster headache, the inconsistenc...
Different vulnerability of fast and slow cortical oscillations to suppressive effect of spreading depolarization: state-dependent features potentially relevant to pathogenesis of migraine aura
Different vulnerability of fast and slow cortical oscillations to suppressive effect of spreading depolarization: state-dependent features potentially relevant to pathogenesis of migraine aura
Spreading depolarization (SD), underlying mechanism of migraine aura and potential activator of pain pathways, is known to...
Mechanosensitive receptors in migraine: a systematic review
Mechanosensitive receptors in migraine: a systematic review
Migraine is a debilitating neurological disorder with pain profile, suggesting exaggerated mechanosensation. Mechanosensit...
Calcitonin gene-related peptide antagonists in pregnancy: a disproportionality analysis in VigiBase®
Calcitonin gene-related peptide antagonists in pregnancy: a disproportionality analysis in VigiBase®
Current evidence on the safety of calcitonin gene–related peptide antagonists (CGRP-A) in pregnancy for the treatmen...
Anti-CGRP antibody galcanezumab modifies the function of the trigeminovascular nocisensor complex in the rat
Anti-CGRP antibody galcanezumab modifies the function of the trigeminovascular nocisensor complex in the rat
Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) are effective in the preven...
Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus
Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus
Migraine is a disabling neurological disorder, characterized by recurrent headaches. During migraine attacks, individuals ...
Headaches during pregnancy and the risk of subsequent stroke
Headaches during pregnancy and the risk of subsequent stroke
Primary headache disorder is a known risk factor for stroke in women and usually improves during the first trimester of pr...
What to do with non-responders to CGRP(r) monoclonal antibodies: switch to another or move to gepants?
What to do with non-responders to CGRP(r) monoclonal antibodies: switch to another or move to gepants?
In this editorial we aim to provide potential therapeutic options in patients who do not benefit from treatment with CGRP(...
Competing treatments for migraine: a headache for decision-makers
Competing treatments for migraine: a headache for decision-makers
Migraine is the world’s second most common disabling disorder, affecting 15% of UK adults and costing the UK over &#...
Clinical effectiveness of pharmacological interventions for managing chronic migraine in adults: a systematic review and network meta-analysis
Clinical effectiveness of pharmacological interventions for managing chronic migraine in adults: a systematic review and network meta-analysis
Chronic migraine can be a profoundly disabling disorder that may be treated with preventive medications. However, uncertai...
Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study
Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study
The brain functional network topology in new daily persistent headache (NDPH) is not well understood. In this study, we ai...
Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China
Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China
Migraine is a primary headache, which has been producing heavy disease burden globally. There is no data on the incidence ...
Long-term effectiveness of eptinezumab in patients with migraine and prior preventive treatment failures: extension of a randomized controlled trial
Long-term effectiveness of eptinezumab in patients with migraine and prior preventive treatment failures: extension of a randomized controlled trial
Eptinezumab demonstrated efficacy in adults with migraine and prior preventive treatment failures in the placebo-controlle...
Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
Galcanezumab has shown efficacy and effectiveness in the treatment of episodic and chronic migraine (CM), however, the pop...
Correction: Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15–39 years from 1990 to 2019: findings from the global burden of disease study 2019
Correction: Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15–39 years from 1990 to 2019: findings from the global burden of disease study 2019
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
Women are disproportionately affected by migraine, representing up to 75% of all migraine cases. This discrepancy has been...
One-year prospective real-world assessment of effectiveness and safety of erenumab in migraine prevention: results of the French FHU INOVPAIN registry study
One-year prospective real-world assessment of effectiveness and safety of erenumab in migraine prevention: results of the French FHU INOVPAIN registry study
Randomized clinical trials have demonstrated efficacy and safety of erenumab. The aim of this study is to evaluate the eff...
Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study
Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study
Individuals with migraine frequently experience pre- and post-headache symptoms. This analysis aimed to characterize the r...
Medication overuse headache is associated with elevated lipopolysaccharide binding protein and pro-inflammatory molecules in the bloodstream
Medication overuse headache is associated with elevated lipopolysaccharide binding protein and pro-inflammatory molecules in the bloodstream
Medication overuse headache (MOH) is a secondary headache that accompanies chronic migraine. Nonsteroidal anti-inflammator...
Treatment patterns for patients initiating novel acute migraine specific medications (nAMSMs) in the context of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway
Treatment patterns for patients initiating novel acute migraine specific medications (nAMSMs) in the context of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway
New acute and preventive migraine medications are available, but data on current treatment patterns are limited. This stud...
Rethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030
Rethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030
The 2030 Agenda for Sustainable Development sets out, through 17 Sustainable Development Goals (SDGs), a path for the pros...
BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination
BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination
BMP7 has been shown to have neuroprotective effects and to alleviate demyelination. However, its role in trigeminal neural...
Correction: Preventive treatment patterns and treatment satisfaction in migraine: results of the OVERCOME (EU) study
Correction: Preventive treatment patterns and treatment satisfaction in migraine: results of the OVERCOME (EU) study
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Characteristic oscillatory brain networks for predicting patients with chronic migraine
Characteristic oscillatory brain networks for predicting patients with chronic migraine
To determine specific resting-state network patterns underlying alterations in chronic migraine, we employed oscillatory c...
Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study
Amygdala, an essential element of the limbic system, has served as an important structure in pain modulation. There is sti...
The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain model
The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain model
Chronic primary pain (CPP) is an intractable pain of unknown cause with significant emotional d...
Increased MRI-based Brain Age in chronic migraine patients
Increased MRI-based Brain Age in chronic migraine patients
Neuroimaging has revealed that migraine is linked to alterations in both the structure and function of the brain. However,...
Preventive therapy with galcanezumab for two consecutive cluster bouts in patients with episodic cluster headache: an observational multicenter study
Preventive therapy with galcanezumab for two consecutive cluster bouts in patients with episodic cluster headache: an observational multicenter study
Cluster headache is a severe and disabling primary headache disorder. Galcanezumab is a monoclonal antibody against calcit...
Triptan non-response in specialized headache care: cross-sectional data from the DMKG Headache Registry
Triptan non-response in specialized headache care: cross-sectional data from the DMKG Headache Registry
Triptans are effective for many migraine patients, but some do not experience adequate efficacy and tolerability. The Euro...
European Headache Federation (EHF) critical reappraisal and meta-analysis of oral drugs in migraine prevention – part 3: topiramate
European Headache Federation (EHF) critical reappraisal and meta-analysis of oral drugs in migraine prevention – part 3: topiramate
Topiramate is a repurposed first-line treatment for migraine prophylaxis. The aim of this systematic review and meta-analy...
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