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Efficacy and continuability of 675 mg fremanezumab administration over 2 years
Efficacy and continuability of 675 mg fremanezumab administration over 2 years
Real-world data on the long-term adherence to- and efficacy of fremanezumab 675 mg quarterly dosing remain scarce...
Headache types and characteristics in patients with Amyotrophic Lateral Sclerosis
Headache types and characteristics in patients with Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive loss of motor neuron...
Temporomandibular disorders and mental health: shared etiologies and treatment approaches
Temporomandibular disorders and mental health: shared etiologies and treatment approaches
The biopsychosocial model suggests that temporomandibular disorders (TMDs) often coexist with mental health disorders, par...
Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study
Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study
Chronic migraine (CM) patients with medication overuse headache (MOH) exhibit distinct neurobiological alterations compare...
Activation of central and peripheral transient receptor potential melastatin 8 increases susceptibility to spreading depolarization and facilitates trigeminal neuroinflammation
Activation of central and peripheral transient receptor potential melastatin 8 increases susceptibility to spreading depolarization and facilitates trigeminal neuroinflammation
Transient receptor potential melastatin 8 (TRPM8), a gene encoding a nonselective cation channel responsive to cold stimul...
1H-MRS reveals abnormal energy metabolism and excitatory-inhibitory imbalance in a chronic migraine-like state induced by nitroglycerin in mice
1H-MRS reveals abnormal energy metabolism and excitatory-inhibitory imbalance in a chronic migraine-like state induced by nitroglycerin in mice
Chronic migraine is closely related to the dysregulation of neurochemical substances in the brain, with metabolic imbalanc...
Household income is associated with attack frequency, but not with the prevalence of headache: an analysis of self-reported headache in the general population in Germany
Household income is associated with attack frequency, but not with the prevalence of headache: an analysis of self-reported headache in the general population in Germany
Headache disorders are among the most prevalent neurological disorders worldwide. However, whether groups differing in soc...
Effects of passive smoking on cortical spreading depolarization in male and female mice
Effects of passive smoking on cortical spreading depolarization in male and female mice
Patients with migraine are typically advised to avoid passive smoking because it may aggravate headaches and other health ...
Phasic perfusion dynamics among migraine subtypes: a multimodel arterial spin labeling investigation
Phasic perfusion dynamics among migraine subtypes: a multimodel arterial spin labeling investigation
Migraine-related perfusion changes are documented but inconsistent across studies due to limited sample size and insuffici...
Endogenous pain modulation after sleep restriction in migraine: a blinded crossover study
Endogenous pain modulation after sleep restriction in migraine: a blinded crossover study
Patients with migraine are vulnerable to insufficient sleep, but the impact of sleep restriction is largely unknown. In ad...
Therapeutic patterns and migraine disease burden in switchers of CGRP-targeted monoclonal antibodies – insights from the German NeuroTransData registry
Therapeutic patterns and migraine disease burden in switchers of CGRP-targeted monoclonal antibodies – insights from the German NeuroTransData registry
Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have shown good efficacy in migr...
Plasma calcitonin gene-related peptide levels in idiopathic intracranial hypertension: an exploratory study
Plasma calcitonin gene-related peptide levels in idiopathic intracranial hypertension: an exploratory study
Idiopathic intracranial hypertension (IIH) is a debilitating condition characterized by increased intracranial pressure of...
A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine
A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine
Migraine is a common neurological disorder with a strong genetic component. Despite the identification of over 100 loci as...
Genetic evidence for the causal relationships between migraine, dementia, and longitudinal brain atrophy
Genetic evidence for the causal relationships between migraine, dementia, and longitudinal brain atrophy
Migraine is a neurological disease with a significant genetic component and is characterized by recurrent and prolonged ep...
Involvement of the ipsilateral-to-the-pain anterior–superior hypothalamic subunit in chronic cluster headache
Involvement of the ipsilateral-to-the-pain anterior–superior hypothalamic subunit in chronic cluster headache
Despite hypothalamus has long being considered to be involved in the pathophysiology of cluster headache, the inconsistenc...
Different vulnerability of fast and slow cortical oscillations to suppressive effect of spreading depolarization: state-dependent features potentially relevant to pathogenesis of migraine aura
Different vulnerability of fast and slow cortical oscillations to suppressive effect of spreading depolarization: state-dependent features potentially relevant to pathogenesis of migraine aura
Spreading depolarization (SD), underlying mechanism of migraine aura and potential activator of pain pathways, is known to...
Mechanosensitive receptors in migraine: a systematic review
Mechanosensitive receptors in migraine: a systematic review
Migraine is a debilitating neurological disorder with pain profile, suggesting exaggerated mechanosensation. Mechanosensit...
Calcitonin gene-related peptide antagonists in pregnancy: a disproportionality analysis in VigiBase®
Calcitonin gene-related peptide antagonists in pregnancy: a disproportionality analysis in VigiBase®
Current evidence on the safety of calcitonin gene–related peptide antagonists (CGRP-A) in pregnancy for the treatmen...
Anti-CGRP antibody galcanezumab modifies the function of the trigeminovascular nocisensor complex in the rat
Anti-CGRP antibody galcanezumab modifies the function of the trigeminovascular nocisensor complex in the rat
Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) are effective in the preven...
Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus
Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus
Migraine is a disabling neurological disorder, characterized by recurrent headaches. During migraine attacks, individuals ...
Headaches during pregnancy and the risk of subsequent stroke
Headaches during pregnancy and the risk of subsequent stroke
Primary headache disorder is a known risk factor for stroke in women and usually improves during the first trimester of pr...
What to do with non-responders to CGRP(r) monoclonal antibodies: switch to another or move to gepants?
What to do with non-responders to CGRP(r) monoclonal antibodies: switch to another or move to gepants?
In this editorial we aim to provide potential therapeutic options in patients who do not benefit from treatment with CGRP(...
Competing treatments for migraine: a headache for decision-makers
Competing treatments for migraine: a headache for decision-makers
Migraine is the world’s second most common disabling disorder, affecting 15% of UK adults and costing the UK over &#...
Clinical effectiveness of pharmacological interventions for managing chronic migraine in adults: a systematic review and network meta-analysis
Clinical effectiveness of pharmacological interventions for managing chronic migraine in adults: a systematic review and network meta-analysis
Chronic migraine can be a profoundly disabling disorder that may be treated with preventive medications. However, uncertai...
Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study
Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study
The brain functional network topology in new daily persistent headache (NDPH) is not well understood. In this study, we ai...
Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China
Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China
Migraine is a primary headache, which has been producing heavy disease burden globally. There is no data on the incidence ...
Long-term effectiveness of eptinezumab in patients with migraine and prior preventive treatment failures: extension of a randomized controlled trial
Long-term effectiveness of eptinezumab in patients with migraine and prior preventive treatment failures: extension of a randomized controlled trial
Eptinezumab demonstrated efficacy in adults with migraine and prior preventive treatment failures in the placebo-controlle...
Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
Galcanezumab has shown efficacy and effectiveness in the treatment of episodic and chronic migraine (CM), however, the pop...
Correction: Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15–39 years from 1990 to 2019: findings from the global burden of disease study 2019
Correction: Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15–39 years from 1990 to 2019: findings from the global burden of disease study 2019
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
Women are disproportionately affected by migraine, representing up to 75% of all migraine cases. This discrepancy has been...
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