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Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts
Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts
Endometriosis is a multifactorial gynecological disease, with angiogenesis as a key hallmark. The role of exosomal microRN...
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
MEDNIK syndrome is a rare autosomal recessive disease characterized by mental retardation, enteropathy, deafness, peripher...
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets
Major depressive disorder (MDD) is a prevalent mental health condition characterized by persistent feelings of sadness and...
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy
Circular RNAs (circRNAs) are an interesting class of conserved single-stranded RNA molecules derived from exon or intron s...
Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene
Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene
COVID-19 pandemic is caused by the SARS-CoV-2 virus, whose internalization and infection are mediated by the angiotensin-c...
Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation
Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation
The deubiquitinating enzyme CYLD negatively regulates NF-κB signaling by removing activating ubiquitin chains from se...
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer
Eukaryotic initiation factor 4A-3 (EIF4A3) is a key component of the exon junction complex (EJC) and is extensively involv...
Extragustatory bitter taste receptors in head and neck health and disease
Extragustatory bitter taste receptors in head and neck health and disease
Taste receptors, first described for their gustatory functions within the oral cavity and oropharynx, are now known to be ...
Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies
Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies
Psoriasis is a chronic condition caused by an inflammation mediated mainly by cytokines and T cells. In COVID-19, the same...
TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
Metabolic rewiring promotes cancer cell adaptation to a hostile microenvironment, representing a hallmark of cancer. This ...
WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33
WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33
Fibrosis is an important pathological change in inflammatory bowel disease (IBD), but the mechanism has yet to be elucidat...
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease
One of the hallmarks of chronic kidney disease (CKD) is the development of vascular calcification. Inorganic pyrophosphate...
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis
Osteoarthritis (OA) is a chronic joint disease with an unclear cause characterized by secondary osteophytes and degenerati...
β-Adrenergic blockade attenuates adverse adipose tissue responses after burn
β-Adrenergic blockade attenuates adverse adipose tissue responses after burn
Severe burn injuries are defined by a prolonged hypermetabolic response characterized by increases in resting energy expen...
Endoplasmic reticulum stress induces hepatic steatosis through interaction between PPARα and FoxO6 in vivo and in vitro
Endoplasmic reticulum stress induces hepatic steatosis through interaction between PPARα and FoxO6 in vivo and in vitro
Endoplasmic reticulum (ER) stress is a major cause of hepatic steatosis through increasing de novo lipogenesis. Forkhead b...
New CRISPR/Cas9-based Fgfr2C361Y/+ mouse model of Crouzon syndrome exhibits skull and behavioral abnormalities
New CRISPR/Cas9-based Fgfr2C361Y/+ mouse model of Crouzon syndrome exhibits skull and behavioral abnormalities
Crouzon syndrome (CS), a syndromic craniosynostosis, is a craniofacial developmental deformity caused by mutations in fibr...
Emerging technologies in regenerative medicine: The future of wound care and therapy
Emerging technologies in regenerative medicine: The future of wound care and therapy
Wound healing, an intricate biological process, comprises orderly phases of simple biological processed including hemostas...
Umbelliferone alleviates impaired wound healing and skin barrier dysfunction in high glucose-exposed dermal fibroblasts and diabetic skins
Umbelliferone alleviates impaired wound healing and skin barrier dysfunction in high glucose-exposed dermal fibroblasts and diabetic skins
Skin wound healing is a complex process involving various cellular and molecular events. However, chronic wounds, particul...
PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma
PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma
Immune checkpoint inhibitors (ICIs) have achieved impressive success in lung adenocarcinoma (LUAD). However, the response ...
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder
DEAD-box helicase 53 (DDX53) is a member of the DEAD-box protein family of RNA helicases. Unlike other family members that...
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review
Liver cirrhosis due to nonalcoholic steatohepatitis (NASH) is a life-threatening condition with increasing incidence world...
Mitochondria targeted esculetin administration improves insulin resistance and hyperglycemia-induced atherosclerosis in db/db mice
Mitochondria targeted esculetin administration improves insulin resistance and hyperglycemia-induced atherosclerosis in db/db mice
The development and progression of hyperglycemia (HG) and HG-associated atherosclerosis are exacerbated by mitochondrial d...
Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions
Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions
Pancreas ductal adenocarcinoma belongs to the most common cancers, but also to the tumors with the poorest prognosis. Here...
Research progress and application of liver organoids for disease modeling and regenerative therapy
Research progress and application of liver organoids for disease modeling and regenerative therapy
The liver is a major metabolic organ of the human body and has a high incidence of diseases. In recent years, the annual i...
Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology
Tumor-derived extracellular vesicle proteins as new biomarkers and targets in precision oncology
Extracellular vesicles (EVs) are important carriers of signaling molecules, such as nucleic acids, proteins, and lipids, a...
Abnormal protein SUMOylation in liver disease: novel target for therapy
Abnormal protein SUMOylation in liver disease: novel target for therapy
SUMOylation is an important protein post-translational modification (PTM) process, in which the small ubiquitin-like modif...
The role of annexins in central nervous system development and disease
The role of annexins in central nervous system development and disease
Annexins, a group of Ca2+-dependent phospholipid-binding proteins, exert diverse roles in neuronal development, normal cen...
Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins
Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins
Autosomal dominant polycystic kidney disease is a genetic kidney disease caused by mutations in the genes PKD1 or PKD2. It...
Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective
Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective
Ischemic stroke is the major contributor to morbidity and mortality in people with diabetes mellitus. In ischemic stroke p...
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
The accumulation of senescent cells within tissues is a hallmark of the aging process. Senescent cells are also commonly p...
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