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Macrophage co-culture promotes cell reprogramming and prevents ferroptosis in aging fibroblasts for neurodegeneration therapy
Macrophage co-culture promotes cell reprogramming and prevents ferroptosis in aging fibroblasts for neurodegeneration therapy
Ferroptosis, a form of programmed cell death associated with lipid peroxidation and iron dependency, plays a critical role...
Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogramming
Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogramming
Uterine fibroids (UFs) are the most common non-cutaneous tumors in women worldwide. UFs arise from genetic alterations in ...
Glucose enrichment reduces lifespan and promotes tau phosphorylation in human tau-expressing , unaffected by O-β-GlcNAcylation induction
Glucose enrichment reduces lifespan and promotes tau phosphorylation in human tau-expressing , unaffected by O-β-GlcNAcylation induction
Alzheimer’s disease (AD) is associated with the formation of tau-hyperphosphorylated neurofibrillary tangles (NFTs)....
Role of CYLD in brain physiology and pathology
Role of CYLD in brain physiology and pathology
A common hallmark of several neuropsychiatric conditions is an altered protein homeostasis. In this context, ubiquitinatio...
Role of endosomal RANKL–LGR4 signaling during osteoclast differentiation
Role of endosomal RANKL–LGR4 signaling during osteoclast differentiation
Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also known as GPR48) is a membrane receptor that negati...
Evaluation of circulating glypican 4 as a novel biomarker in disease – A comprehensive review
Evaluation of circulating glypican 4 as a novel biomarker in disease – A comprehensive review
Glypican 4 (GPC4), a member of the cell surface heparan sulfate proteoglycan family, plays a crucial role in regulating va...
Lipidomic insights on abdominal aortic aneurysm and peripheral arterial disease
Lipidomic insights on abdominal aortic aneurysm and peripheral arterial disease
Abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD) are two cardiovascular diseases associated with cons...
FATP1-mediated fatty acid uptake in renal tubular cells as a countermeasure for hypothermia
FATP1-mediated fatty acid uptake in renal tubular cells as a countermeasure for hypothermia
Hypothermia is a condition in which body temperature falls below 35 °C, resulting from exposure to low envir...
Correction to: Metanephric mesenchyme-derived Foxd1 mesangial precursor cells alleviate mesangial proliferative glomerulonephritis
Correction to: Metanephric mesenchyme-derived Foxd1 mesangial precursor cells alleviate mesangial proliferative glomerulonephritis
Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidne...
Longitudinal study on immunologic, lipoproteomic, and inflammatory responses indicates the safety of sequential COVID-19 vaccination
Longitudinal study on immunologic, lipoproteomic, and inflammatory responses indicates the safety of sequential COVID-19 vaccination
COVID-19 vaccines are crucial in reducing SARS-CoV-2 transmission and severe health outcomes. Despite widespread administr...
Targeting ferroptosis for the treatment of female reproductive system disorders
Targeting ferroptosis for the treatment of female reproductive system disorders
Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has emerged as a critical factor ...
DNA-RNA hybrids in inflammation: sources, immune response, and therapeutic implications
DNA-RNA hybrids in inflammation: sources, immune response, and therapeutic implications
Cytoplasmic DNA-RNA hybrids are emerging as important immunogenic nucleic acids, that were previously underappreciated. DN...
Mechanism and application of HDAC inhibitors in the treatment of hepatocellular carcinoma
Mechanism and application of HDAC inhibitors in the treatment of hepatocellular carcinoma
Hepatoma is the sixth most malignant tumor in the world and the second leading cause of cancer death. Among the types of h...
Regulation of innate lymphoid cell by microbial metabolites
Regulation of innate lymphoid cell by microbial metabolites
Innate lymphoid cells (ILCs) are a unique category of immune cell that lack antigen-specific receptors yet possess the cap...
Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections
Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections
Tuberculous mycobacterial infections pose a substantial global health burden because of their prevalence and multi-drug re...
Rare and low-frequency variants in families with otitis media
Rare and low-frequency variants in families with otitis media
Otitis media is a highly frequent diagnosis in children that causes significant morbidity but remains understudied as a ge...
Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts
Exosomal miR-21-5p derived from endometrial stromal cells promotes angiogenesis by targeting TIMP3 in ovarian endometrial cysts
Endometriosis is a multifactorial gynecological disease, with angiogenesis as a key hallmark. The role of exosomal microRN...
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
MEDNIK syndrome is a rare autosomal recessive disease characterized by mental retardation, enteropathy, deafness, peripher...
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets
Prefrontal cortex astrocytes in major depressive disorder: exploring pathogenic mechanisms and potential therapeutic targets
Major depressive disorder (MDD) is a prevalent mental health condition characterized by persistent feelings of sadness and...
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy
The role of circular RNA targeting IGF2BPs in cancer—a potential target for cancer therapy
Circular RNAs (circRNAs) are an interesting class of conserved single-stranded RNA molecules derived from exon or intron s...
Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene
Molecular mechanisms of thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target gene
COVID-19 pandemic is caused by the SARS-CoV-2 virus, whose internalization and infection are mediated by the angiotensin-c...
Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation
Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation
The deubiquitinating enzyme CYLD negatively regulates NF-κB signaling by removing activating ubiquitin chains from se...
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer
Eukaryotic initiation factor 4A-3 (EIF4A3) is a key component of the exon junction complex (EJC) and is extensively involv...
Extragustatory bitter taste receptors in head and neck health and disease
Extragustatory bitter taste receptors in head and neck health and disease
Taste receptors, first described for their gustatory functions within the oral cavity and oropharynx, are now known to be ...
Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies
Current treatment of Psoriasis triggered by Cytokine Storm and future immunomodulation strategies
Psoriasis is a chronic condition caused by an inflammation mediated mainly by cytokines and T cells. In COVID-19, the same...
TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
Metabolic rewiring promotes cancer cell adaptation to a hostile microenvironment, representing a hallmark of cancer. This ...
WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33
WNT2B high‑expressed fibroblasts induce the fibrosis of IBD by promoting NK cells secreting IL-33
Fibrosis is an important pathological change in inflammatory bowel disease (IBD), but the mechanism has yet to be elucidat...
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease
Oral pyrophosphate protects Abcc6-/- mice against vascular calcification induced by chronic kidney disease
One of the hallmarks of chronic kidney disease (CKD) is the development of vascular calcification. Inorganic pyrophosphate...
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis
New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis
Osteoarthritis (OA) is a chronic joint disease with an unclear cause characterized by secondary osteophytes and degenerati...
β-Adrenergic blockade attenuates adverse adipose tissue responses after burn
β-Adrenergic blockade attenuates adverse adipose tissue responses after burn
Severe burn injuries are defined by a prolonged hypermetabolic response characterized by increases in resting energy expen...
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