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Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease
Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease
The mechanisms underlying neurodegeneration in Parkinson’s disease (PD) are still not fully understood. Glycosylatio...
Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis
Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis
Endothelial cell (EC) dysfunction is associated with atherosclerosis. Circular RNAs (circRNAs) are covalently closed loops...
Traumatic brain injury-induced disruption of the circadian clock
Traumatic brain injury-induced disruption of the circadian clock
Disturbances in the circadian rhythm have been reported in patients following traumatic brain injury (TBI). However, the r...
Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis
Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an age-dependent neurodegenerative disease affecting motor neurons in the spinal co...
Ubiquitination and deubiquitination in the regulation of N6-methyladenosine functional molecules
Ubiquitination and deubiquitination in the regulation of N6-methyladenosine functional molecules
N6 methyladenosine (m6A) is the most prevalent RNA epigenetic modification, regulated by methyltransferases and demethyltr...
A simple tool for evaluation of inflammation in psoriasis: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as markers in psoriasis patients and related murine models of psoriasis-like skin disease
A simple tool for evaluation of inflammation in psoriasis: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as markers in psoriasis patients and related murine models of psoriasis-like skin disease
Objective parameters to quantify psoriatic inflammation are needed for interdisciplinary patient care, as well as preclini...
Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated macrophage activation by ERK pathway to accelerate liver injury
Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated macrophage activation by ERK pathway to accelerate liver injury
Liver injury is closely associated with macrophage activation following HBV infection. Our previous study showed that only...
Correction to: Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR
Correction to: Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR
Department of Thoracic Surgery, The Affiliated Hospital of Medical School of Ningbo University, 247 Renmin Road, Ningbo, 3...
The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding
The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding
EN1 encodes a homeodomain-containing transcription factor and is a determinant of bone density and fracture. Previous powe...
Liquid–liquid phase separation in Alzheimer’s disease
Liquid–liquid phase separation in Alzheimer’s disease
The pathological aggregation and misfolding of tau and amyloid-β play a key role in Alzheimer’s disease (AD). H...
Etiopathogenesis of medication-related osteonecrosis of the jaws: a review
Etiopathogenesis of medication-related osteonecrosis of the jaws: a review
This study compiles the main hypotheses involved in the etiopathogenesis of medication-related osteonecrosis of the jaw (M...
High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response
High expression of BCAT1 sensitizes AML cells to PARP inhibitor by suppressing DNA damage response
Previous evidence has confirmed that branched-chain aminotransferase-1 (BCAT1), a key enzyme governing branched-chain amin...
FDA-approved disulfiram as a novel treatment for aggressive leukemia
FDA-approved disulfiram as a novel treatment for aggressive leukemia
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are assoc...
Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
Osteocalcin (OC) is the most abundant non-collagenous and osteoblast-secreted protein in bone. It consists of two forms su...
Correction to: Efficient generation of gene-modified human natural killer cells via alpharetroviral vectors
Correction to: Efficient generation of gene-modified human natural killer cells via alpharetroviral vectors
Correction to: J Mol Med (2016) 94:83–93 https://doi.org/10.1007/s00109-015-1327-6An ...
DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis
DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis
Cancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific fi...
TAT-W61 peptide attenuates neuronal injury through blocking the binding of S100b to the V-domain of Rage during ischemic stroke
TAT-W61 peptide attenuates neuronal injury through blocking the binding of S100b to the V-domain of Rage during ischemic stroke
Ischemic stroke is a devastative nervous system disease associated with high mortality and morbidity rates. Unfortunately,...
CTHRC1 promotes colorectal cancer progression by recruiting tumor-associated macrophages via up-regulation of CCL15
CTHRC1 promotes colorectal cancer progression by recruiting tumor-associated macrophages via up-regulation of CCL15
Tumor-associated macrophages (TAMs) represent a key factor in the tumor immune microenvironment (TME), exerting significan...
A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology
A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology
Diabetic cardiomyopathy describes heart disease in patients with diabetes who have no other cardiac conditions but have a ...
The role of CD146 in renal disease: from experimental nephropathy to clinics
The role of CD146 in renal disease: from experimental nephropathy to clinics
Vascular endothelial dysfunction is a major risk factor in the development of renal diseases. Recent studies pointed out a...
IL-23 contributes to Particulate Matter induced allergic asthma in the early life of mice and promotes asthma susceptibility
IL-23 contributes to Particulate Matter induced allergic asthma in the early life of mice and promotes asthma susceptibility
Air pollutant exposure leads to and exacerbates respiratory diseases. Particulate Matter (PM) is a major deleterious facto...
Sphingolipids: drivers of cardiac fibrosis and atrial fibrillation
Sphingolipids: drivers of cardiac fibrosis and atrial fibrillation
Sphingolipids (SLs) are vital constituents of the plasma membrane of animal cells and concurrently regulate numerous cellu...
Effects of different amosite preparations on macrophages, lung damages, and autoimmunity
Effects of different amosite preparations on macrophages, lung damages, and autoimmunity
The underlying mechanisms of asbestos-related autoimmunity are poorly understood. As the size, surface reactivity, and fre...
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway
Hepatic fibrosis (HF) could be developed into liver cirrhosis or even hepatocellular carcinoma. Stress has an important ro...
Comparing plasma and skin imprint metabolic profiles in COVID-19 diagnosis and severity assessment
Comparing plasma and skin imprint metabolic profiles in COVID-19 diagnosis and severity assessment
As SARS-CoV-2 continues to produce new variants, the demand for diagnostics and a better understanding of COVID-19 remain ...
Progress in diagnosis and treatment of Leber’s hereditary optic neuropathy
Progress in diagnosis and treatment of Leber’s hereditary optic neuropathy
Leber’s hereditary optic neuropathy (LHON) is a mitochondrial genetic disease with central vision loss as the main s...
Correction to: Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14
Correction to: Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14
The authors were notified of error that occurred in Fig. 5E of the above paper. The abscissa axis of Fig. 5E should be the...
Identifying survival of pan-cancer patients under immunotherapy using genomic mutation signature with large sample cohorts
Identifying survival of pan-cancer patients under immunotherapy using genomic mutation signature with large sample cohorts
Although immune checkpoint inhibitors have led to durable clinical response in multiple cancers, only a small proportion o...
Correction to: Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform
Correction to: Microdevices for cancer stem cell culture as a predictive chemotherapeutic response platform
Facultad de Ciencias Médicas, Instituto de Oncología “Ángel H. Roffo”, Área de Investigación, Universidad de Buenos Aires,...
Two-trace two-dimensional correlation spectra (2T2D-COS) analysis using FTIR spectra to monitor the immune response by COVID-19
Two-trace two-dimensional correlation spectra (2T2D-COS) analysis using FTIR spectra to monitor the immune response by COVID-19
There is a growing trend in using saliva for SARS-CoV-2 detection with reasonable accuracy. We have studied the responses ...
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