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Transporter expressions as part of required scaling factor to support in vitro in vivo extrapolation for blood-brain barrier drug permeability
Access of drugs to the central nervous system is limited by the blood–brain barrier, and this in turn affects drug efficac...
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor
The possibility to control the effects of drugs in time and space represents an ideal condition for developing safer and m...
Cancer-type OATP1B3-V1 is a functional plasma membrane transporter mediating increased uptake of chemotherapeutics in vitro and in vivo
Cancer-type Organic anion transporting polypeptide 1B3, ct-OATP1B3-V1 is a tumor-specific isoform of liver-type OATP1B3 (L...
Transport of statins by multidrug resistance-associated proteins 1 and 5
Statins are widely used in the treatment of hypercholesterolemia but also associated with muscle-related adverse effects. ...
Safety, tolerability, and pharmacokinetics of intranasal 2-deoxy-D-glucose in normal healthy volunteers: A randomized, double-blind, placebo-controlled, single and multiple ascending dose phase 1 study
Background2-deoxy-D-glucose is a synthetic glucose analog and a potent inhibitor of glycolysis. Preclinical models demonst...
Evaluating polymer influence on resuspendability of indomethacin suspensions produced by microfluidization
Long-acting injectables improve treatment outcomes for chronic diseases by reducing dosing frequency. Long-acting injectab...
Evaluation of folic acid-targeted gadolinium-loaded perfluorohexane nanodroplets on the megavoltage X-ray treatment efficiency of liver cancer
The efficacy of radiation therapy can decrease due to the inherent radioresistance of different tumor cells. Gadolinium sh...
Comparative uptake of statins by hepatic organic anion transporting polypeptides
Uptake into hepatocytes by the organic anion transporting polypeptides (OATP) 1B1, 1B3, and 2B1 can form a rate-determinin...
A physiologically based biopharmaceutics modeling (PBBM) framework for characterizing formulation-dependent food effects: Paving the road towards fed state virtual BE studies for itraconazole amorphous solid dispersions
This study leverages physiologically based biopharmaceutics modeling (PBBM) to predict the clinical performance of two itr...
Real-time component-based particle size measurement and dissolution prediction during continuous powder feeding using machine vision and artificial intelligence-based object detection
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In vitro identification of decreased function genetic variants of ABCB1
The efflux transporter ABCB1 (P-glycoprotein, P-gp) has an important role in drug disposition, and thus, genetic variants ...
Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition
The purpose of this study was to evaluate EpiColon, a novel human organotypic 3D colon microtissue prototype, developed to...
Development and preclinical evaluation of a gallium-68 labeled novel diagnostic tracer for visualizing ALK expression in tumor
Anaplastic lymphoma kinase (ALK) is prominently expressed in numerous malignant tumors, which lead to aberrant tumor proli...
Synthesis and physicochemical characterization of new potential haptens and their precursors with morphine skeleton
Opiate analgetics are widely used therapeutic agents, but their side-effects can cause serious harm to users, and they are...
Investigating accumulation of budesonide and tacrolimus in an ex vivo porcine oesophageal model: Translational potential for local application of drugs to treat eosinophilic oesophagitis
Eosinophilic oesophagitis (EoE) is a chronic inflammatory disease afflicting the oesophagus and causing lifelong morbidity...
Co-milling of glass forming ability class III drugs: Comparing the impact of low and high glass transition temperatures
With an increasing focus on sustainable technologies in the pharmaceutical industry, milling provides a solvent-free appro...
Overcoming barriers in formulating practically insoluble loteprednol etabonate in ophthalmic nanoemulsion
Loteprednol etabonate (LE) is a soft corticosteroid recently approved for the short-term treatment of signs and symptoms o...
Enhancing drug release from PEG-PLGA implants: The role of Hydrophilic Dexamethasone Phosphate in modulating release kinetics and degradation behavior
Poly(lactic-co-glycolic acid) (PLGA) is a prominent biodegradable polymer used in biomedical applications, including drug ...
Direct comparison of single peak and gradient chromatographic methods for routine analysis of surfactants in biopharmaceuticals
The non-ionic surfactants polysorbate 20, polysorbate 80 and poloxamer 188 are prone to degradation, which necessitates th...
“Assessing impact of hinge flexibility on predicted second osmotic virial coefficients”
Monoclonal antibodies (MAbs) are a key modality for treating a range of diseases because of their unique biophysical prope...
Optimization and evaluation of a chitosan-coated PLGA nanocarrier for mucosal delivery of Porphyromonas gingivalis antigens
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State-of-the-art and future perspectives in ingestible remotely controlled smart capsules for drug delivery: A GENEGUT review
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Comparative inhibition by oral bilastine, parenteral dexchlorpheniramine, and a new bilastine parenteral (i.v. and i.m.) formulation of histamine-induced wheal and flare response: A randomised phase I trial
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The metabolic profiles of endogenous and exogenous substances in a poor metabolizer of humanized CYP2D6 model
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Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport
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In vitro assessment of inhibitory effects of kinase inhibitors on CYP2C9, 3A and 1A2: Prediction of drug-drug interaction risk with warfarin and direct oral anticoagulants
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Analyzing the distribution of progression-free survival for combination therapies: A study of model-based translational predictive methods in oncology
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Comparison of ionizable lipids for lipid nanoparticle mediated DNA delivery
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Evaluation and application of population pharmacokinetic models for optimising linezolid treatment in non-adherence multidrug-resistant tuberculosis patients
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A novel sodium caseinate lipid-based auto-emulsifying delivery system to increase resveratrol intestinal permeation: Characterization and in vitro assessment
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