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Formulation development of pharmaceutical nanoemulgel for transdermal delivery of feboxostat: Physical characterization and in vivo evaluation
Formulation development of pharmaceutical nanoemulgel for transdermal delivery of feboxostat: Physical characterization and in vivo evaluation
Volume 195, 1 April 2024, 106665Author links open overlay panel, , , , , AbstractThis study aimed to fabricate and charact...
Specific transport of temozolomide does not override DNA repair-mediated chemoresistance
Specific transport of temozolomide does not override DNA repair-mediated chemoresistance
KeywordsTemozolomide (TMZ)L-type amino acid transporter 1 (LAT1)ProdrugChemoresistanceDNA repairAbbreviationAIC4-amino-5-i...
Modifying peptide/lipid-associated nucleic acids (PLANAs) for CRISPR/Cas9 ribonucleoprotein delivery
Modifying peptide/lipid-associated nucleic acids (PLANAs) for CRISPR/Cas9 ribonucleoprotein delivery
Volume 195, 1 April 2024, 106708Author links open overlay panel, , , , , , AbstractWith the first reports on the possibili...
Application of nanofiber-based drug delivery systems in improving anxiolytic effect of new 1,2,3-triazolo-1,4-benzodiazepine derivatives
Application of nanofiber-based drug delivery systems in improving anxiolytic effect of new 1,2,3-triazolo-1,4-benzodiazepine derivatives
Anxiety disorders are highly prevalent worldwide and can affect people of all ages, genders and backgrounds. Much efforts ...
Small molecules modified mesoporous silica nanoparticles orally deliver indomethacin with synergistic effect
Small molecules modified mesoporous silica nanoparticles orally deliver indomethacin with synergistic effect
Molecularly functional drug delivery systems possessed huge potentials to realize novel drug administration. To explore sm...
Methotrexate-loaded hyaluronan-modified liposomes integrated into dissolving microneedles for the treatment of psoriasis
Methotrexate-loaded hyaluronan-modified liposomes integrated into dissolving microneedles for the treatment of psoriasis
Volume 195, 1 April 2024, 106711Author links open overlay panel, , , , , , , , AbstractMethotrexate (MTX) is a first-line ...
Predicting the intrinsic membrane permeability of Caco-2/MDCK cells by the solubility-diffusion model
Predicting the intrinsic membrane permeability of Caco-2/MDCK cells by the solubility-diffusion model
Membrane permeability is one of the main determinants for the absorption, distribution, metabolism and excretion of compou...
Evaluation of omadacycline dosing regimens in Chinese using population pharmacokinetic-pharmacodynamic analysis
Evaluation of omadacycline dosing regimens in Chinese using population pharmacokinetic-pharmacodynamic analysis
PurposeOmadacycline (PTK-0796) is a first-in-class aminomethylcycline for adult patients with community-acquired bacterial...
The role of partial area under the curve and maximum concentrations in assessing the bioequivalence of long-acting injectable formulation of exenatide_A sensitivity analysis
The role of partial area under the curve and maximum concentrations in assessing the bioequivalence of long-acting injectable formulation of exenatide_A sensitivity analysis
To ensure therapeutic equivalence between the long-acting injectable (LAI) products, additional PK metrics other than Cmax...
A remodeled ivermectin polycaprolactone-based nanoparticles for inhalation as a promising treatment of pulmonary inflammatory diseases
A remodeled ivermectin polycaprolactone-based nanoparticles for inhalation as a promising treatment of pulmonary inflammatory diseases
In recent years, ivermectin (IVM), an antiparasitic drug of low water solubility and poor oral bioavailability, has shown ...
Effects of H2S-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts
Effects of H2S-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts
Hydrogen sulfide (H2S), a gasotransmitter, plays a crucial role in vasorelaxation, anti-inflammatory processes and mitigat...
Investigating distributions of inhaled aerosols in the lungs of post-COVID-19 clusters through a unified imaging and modeling approach
Investigating distributions of inhaled aerosols in the lungs of post-COVID-19 clusters through a unified imaging and modeling approach
BackgroundRecent studies, based on clinical data, have identified sex and age as significant factors associated with an in...
Safety, tolerability, pharmacokinetics and neutrophil elastase inhibitory effects of Sivelestat: A randomized, double-blind, placebo-controlled single- and multiple-dose escalation study in Chinese healthy subjects
Safety, tolerability, pharmacokinetics and neutrophil elastase inhibitory effects of Sivelestat: A randomized, double-blind, placebo-controlled single- and multiple-dose escalation study in Chinese healthy subjects
Volume 195, 1 April 2024, 106723Author links open overlay panel, , , , , , , , , , , , , , , Highlights•Sivelestat was saf...
Implementing physics-based digital patient twins to tailor the switch of oral morphine to transdermal fentanyl patches based on patient physiology
Implementing physics-based digital patient twins to tailor the switch of oral morphine to transdermal fentanyl patches based on patient physiology
Volume 195, 1 April 2024, 106727Author links open overlay panel, , , , , AbstractFentanyl transdermal patches are widely i...
Solubility of digitoxin in supercritical CO2: Experimental study and modeling
Solubility of digitoxin in supercritical CO2: Experimental study and modeling
In this communication, the solubility of digitoxin drug in supercritical CO2 was studied at different operating conditions...
Intrinsic immunogenicity of liposomes for tuberculosis vaccines: Effect of cationic lipid and cholesterol
Intrinsic immunogenicity of liposomes for tuberculosis vaccines: Effect of cationic lipid and cholesterol
AERAg85B-ESAT6-Rv2034 antigenAPCantigen-presenting cellBCGMycobacterium bovis Bacillus Calmette–GuérinCCLchemokine (C-C mo...
Water-mediated phase transformations of posaconazole: An intricate jungle of crystal forms
Water-mediated phase transformations of posaconazole: An intricate jungle of crystal forms
Posaconazole is a broad-spectrum antifungal agent exhibiting rich polymorphism. Up to now, a total of fourteen different c...
Advancements in preclinical human-relevant modeling of pulmonary vasculature on-chip
Advancements in preclinical human-relevant modeling of pulmonary vasculature on-chip
Preclinical human-relevant modeling of organ-specific vasculature offers a unique opportunity to recreate pathophysiologic...
A study on the quantity, type, economic value and reasons for pharmaceutical waste returned to pharmacies in Finland
A study on the quantity, type, economic value and reasons for pharmaceutical waste returned to pharmacies in Finland
Volume 195, 1 April 2024, 106729Author links open overlay panel, , , , , , AbstractIntroductionSome medicines purchased ar...
Equivalence assessment of creams with quali-quantitative differences in light of the EMA and FDA regulatory framework
Equivalence assessment of creams with quali-quantitative differences in light of the EMA and FDA regulatory framework
Volume 195, 1 April 2024, 106726Author links open overlay panel, , , , , , AbstractEMA and FDA are upgrading guidelines on...
A first-in-human study of Brozopentyl Sodium, following single and multiple ascending intravenous infusion in Chinese healthy volunteers
A first-in-human study of Brozopentyl Sodium, following single and multiple ascending intravenous infusion in Chinese healthy volunteers
Ischemic stroke has emerged as the leading cause of death and adult disability in China. Brozopentyl Sodium (BZP), an inno...
Folic acid-functionalized chitosan nanoparticles with bioenzyme activity for the treatment of spinal cord injury
Folic acid-functionalized chitosan nanoparticles with bioenzyme activity for the treatment of spinal cord injury
Volume 192, 1 January 2024, 106667Author links open overlay panel, , , , , , , , , , , AbstractSpinal cord injury (SCI) is...
In vitro trypanocidal potency and in vivo treatment efficacy of oligomeric ethylene glycol-tethered nitrofurantoin derivatives
In vitro trypanocidal potency and in vivo treatment efficacy of oligomeric ethylene glycol-tethered nitrofurantoin derivatives
Volume 192, 1 January 2024, 106668Author links open overlay panel, , Highlights•T. congolense trypomastigotes were most su...
Gellan gum-based bi-polymeric hydrogel scaffolds loaded with Rosuvastatin calcium: A useful tool for tendon tissue regeneration
Gellan gum-based bi-polymeric hydrogel scaffolds loaded with Rosuvastatin calcium: A useful tool for tendon tissue regeneration
Volume 192, 1 January 2024, 106659Author links open overlay panel, , , AbstractStatins have been long used in tissue engin...
Design, synthesis and bioevaluation of novel prenylated chalcones derivatives as potential antitumor agents
Design, synthesis and bioevaluation of novel prenylated chalcones derivatives as potential antitumor agents
A series of novel prenylated chalcone derivatives with broad spectrum anticancer potential were designed and synthesized. ...
In vitro and in vivo pharmacokinetics, disposition, and drug-drug interaction potential of tinengotinib (TT-00420), a promising investigational drug for treatment of cholangiocarcinoma and other solid tumors
In vitro and in vivo pharmacokinetics, disposition, and drug-drug interaction potential of tinengotinib (TT-00420), a promising investigational drug for treatment of cholangiocarcinoma and other solid tumors
Early-stage clinical evaluation of tinengotinib (TT-00420) demonstrated encouraging preliminary efficacies in multiple typ...
In-house CHO HCPs platform: A promising approach for HCPs ELISA monitoring
In-house CHO HCPs platform: A promising approach for HCPs ELISA monitoring
A key aspect that must be supervised during the development of recombinant therapeutic products is the potential presence ...
Evaluation of the impact of tragacanth/xanthan gum interpolymer complexation with chitosan on pharmaceutical performance of gels with secnidazole as potential periodontal treatment
Evaluation of the impact of tragacanth/xanthan gum interpolymer complexation with chitosan on pharmaceutical performance of gels with secnidazole as potential periodontal treatment
Volume 192, 1 January 2024, 106657Author links open overlay panel, , , , Highlights•Polyelectrolyte complexes-based hydrog...
Development and characterization of a spray-dried inhalable ternary combination for the treatment of Pseudomonas aeruginosa biofilm infection in cystic fibrosis
Development and characterization of a spray-dried inhalable ternary combination for the treatment of Pseudomonas aeruginosa biofilm infection in cystic fibrosis
Cystic fibrosis (CF) is an inherited lung disease characterised by the accumulation of thick layers of dried mucus in the ...
In vitro biodistribution studies on clinically approved FGFR inhibitors ponatinib, nintedanib, erlotinib and the investigational inhibitor KP2692
In vitro biodistribution studies on clinically approved FGFR inhibitors ponatinib, nintedanib, erlotinib and the investigational inhibitor KP2692
Volume 192, 1 January 2024, 106651Author links open overlay panel, , Highlights•Lipophilicity, proton dissociation constan...
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