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Association Between Diverse Cell Death Patterns Related Gene Signature and Prognosis, Drug Sensitivity, and Immune Microenvironment in Glioblastoma
Association Between Diverse Cell Death Patterns Related Gene Signature and Prognosis, Drug Sensitivity, and Immune Microenvironment in Glioblastoma
Glioblastoma (GBM) is the most invasive type of glioma and is difficult to treat. Diverse programmed cell death (PCD) patt...
Uncovering the Therapeutic Potential of Phosphocreatine in Diabetic Retinopathy: Mitigating Mitochondrial Dysfunction and Apoptosis via JAK2/STAT3 Signaling Pathway
Uncovering the Therapeutic Potential of Phosphocreatine in Diabetic Retinopathy: Mitigating Mitochondrial Dysfunction and Apoptosis via JAK2/STAT3 Signaling Pathway
Diabetic retinopathy (DR) stands as a prevalent complication of diabetes mellitus, causing damage to the delicate retinal ...
Identification of Immune Infiltration and Iron Metabolism–Related Subgroups in Autism Spectrum Disorder
Identification of Immune Infiltration and Iron Metabolism–Related Subgroups in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with a broad spectrum of symptoms and prognoses....
Multi-faceted Anti-obesity Effects of N-Methyl-D-Aspartate (NMDA) Receptor Modulators: Central-Peripheral Crosstalk
Multi-faceted Anti-obesity Effects of N-Methyl-D-Aspartate (NMDA) Receptor Modulators: Central-Peripheral Crosstalk
Hypothalamus is central to food intake and satiety. Recent data unveiled the expression of N-methyl-D-aspartate receptors ...
Transcriptional Inhibition of the Mecp2 Promoter by MeCP2E1 and MeCP2E2 Isoforms Suggests Negative Auto-Regulatory Feedback that can be Moderated by Metformin
Transcriptional Inhibition of the Mecp2 Promoter by MeCP2E1 and MeCP2E2 Isoforms Suggests Negative Auto-Regulatory Feedback that can be Moderated by Metformin
The epigenetic factor Methyl-CpG-Binding Protein 2 (MeCP2) is a nuclear protein that binds methylated DNA molecules (both ...
Longitudinal Genotype-Phenotype (Vineland Questionnaire) Characterization of 15 ADNP Syndrome Cases Highlights Mutated Protein Length and Structural Characteristics Correlation with Communicative Abilities Accentuated in Males
Longitudinal Genotype-Phenotype (Vineland Questionnaire) Characterization of 15 ADNP Syndrome Cases Highlights Mutated Protein Length and Structural Characteristics Correlation with Communicative Abilities Accentuated in Males
Activity-dependent neuroprotective protein (ADNP) is essential for neurodevelopment and de novo mutations in ADNP cause th...
Whole Blood Transcriptome Analysis in Patients with Trigeminal Neuralgia: a Prospective Clinical Study
Whole Blood Transcriptome Analysis in Patients with Trigeminal Neuralgia: a Prospective Clinical Study
Trigeminal neuralgia (TN) brings a huge burden to patients, without long-term effective treatment. This study aimed to exp...
The Role of Serum Matrix Metalloproteinase-9 as a Predictor of Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage
The Role of Serum Matrix Metalloproteinase-9 as a Predictor of Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage
Delayed cerebral ischemia (DCI) is one of the major causes of a poor neurological outcome following aneurysmal subarachnoi...
Molecular Determinants of Neurocognitive Deficits in Glioma: Based on 2021 WHO Classification
Molecular Determinants of Neurocognitive Deficits in Glioma: Based on 2021 WHO Classification
Cognitive impairment is a common feature among patients with diffuse glioma. The objective of the study is to investigate ...
Generation of Functional and Mature Sympathetic Neurons from Human Pluripotent Stem Cells via a Neuroepithelial Route
Generation of Functional and Mature Sympathetic Neurons from Human Pluripotent Stem Cells via a Neuroepithelial Route
The sympathetic nervous system (SNS) is a crucial branch of the autonomic nervous system (ANS) that is responsible for reg...
Identification of Potentially Repurposable Drugs for Lewy Body Dementia Using a Network-Based Approach
Identification of Potentially Repurposable Drugs for Lewy Body Dementia Using a Network-Based Approach
The conventional method of one drug being used for one target has not yielded therapeutic solutions for Lewy body dementia...
MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke
MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke
Neuronal apoptosis is crucial in the pathophysiology of ischemic stroke (IS), albeit its underly24ing mechanism remaining ...
Effect of Intracerebroventricular Administration of Galanin-Like Peptide on Hepatokines in C57BL/6 J Mice
Effect of Intracerebroventricular Administration of Galanin-Like Peptide on Hepatokines in C57BL/6 J Mice
Galanin-like peptide (GALP) is a neuropeptide that was first isolated and identified from the porcine hypothalamus. Studie...
Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage
Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage
Previous research has found that an adaptive response to ferroptosis involving glutathione peroxidase 4 (GPX4) is triggere...
Potential Impact of Hypoxic Astrocytes on the Aggravation of Depressive Symptoms in Parkinson’s Disease
Potential Impact of Hypoxic Astrocytes on the Aggravation of Depressive Symptoms in Parkinson’s Disease
Mounting evidence suggests a significant correlation between depressive disorders and neurodegenerative conditions, encomp...
Role of Senataxin in Amyotrophic Lateral Sclerosis
Role of Senataxin in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive, uncurable neurodegenerative disorder characterized by the degradatio...
Correction: Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
Correction: Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
University of Cincinnati Neuroscience Graduate Program, Cincinnati, OH, 45229, USAEmma V. Parkins, Sarah Yaser & Chris...
A Novel Truncating Mutation in PAX1 Gene Causes Otofaciocervical Syndrome Without Immunodeficiency
A Novel Truncating Mutation in PAX1 Gene Causes Otofaciocervical Syndrome Without Immunodeficiency
Otofaciocervical syndrome (OTFCS) is a rare genetic disorder of both autosomal recessive and autosomal dominant patterns o...
A Comprehensive Investigation of Risk Association Between the -786 T > C, + 884 G > A, VNTR, rs743506, rs3918226 of eNOS and Susceptibility of Migraine: A Updated Meta-Analysis Utilizing Trial Sequential Analysis
A Comprehensive Investigation of Risk Association Between the -786 T > C, + 884 G > A, VNTR, rs743506, rs3918226 of eNOS and Susceptibility of Migraine: A Updated Meta-Analysis Utilizing Trial Sequential Analysis
With a feature of complex pathogenic mechanisms, migraine is a well-known common neurovascular disorder. Multiple genes ar...
Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells
Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells
Alzheimer’s disease (AD) is a multifactorial disease affecting aging population worldwide. Neuroinflammation became ...
Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities
Hederagenin Upregulates PTPN1 Expression in Aβ-Stimulated Neuronal Cells, Exerting Anti-Oxidative Stress and Anti-Apoptotic Activities
Alzheimer’s disease (AD) is a prevalently neurodegenerative disease characterized by neuronal damage which is associ...
IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM
IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM
Advanced age is an important risk factor for the worse clinical presentation of gliomas, especially glioblastoma (GBM). Th...
The Role of Cystathionine-β-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies
The Role of Cystathionine-β-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies
We aimed to investigate the mechanism underlying the roles of miRNA-377, Cystathionine-β-synthase (CBS), and hydrogen...
A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression
A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression
Many homeostatic genes are thought to play a role in the susceptibility to migraine, making it a highly complex neurovascu...
Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Glioblastoma multiforme (GBM) is a prevalent and aggressive primary brain tumor, presenting substantial treatment challeng...
Assessment of tRNAThr and tRNAGln Variants and Mitochondrial Functionality in Parkinson’s Disease (PD) Patients of Tamil Nadu Population
Assessment of tRNAThr and tRNAGln Variants and Mitochondrial Functionality in Parkinson’s Disease (PD) Patients of Tamil Nadu Population
Parkinson’s disease (PD) is speculated with genetic and environmental factors. At molecular level, the mitochondrial...
Investigation of LncRNA PVT1 and MiR-21-5p Expression as Promising Novel Biomarkers for Autism Spectrum Disorder
Investigation of LncRNA PVT1 and MiR-21-5p Expression as Promising Novel Biomarkers for Autism Spectrum Disorder
The characteristics of ncRNA in children with autism spectrum disorder (ASD) were observed to disclose a theoretical basis...
Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
Age-Dependent Regulation of Dendritic Spine Density and Protein Expression in Mir324 KO Mice
Dendritic spines are small, dynamic protrusions along the dendrite that comprise more than 90% of excitatory connections i...
Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats
Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats
Stress is a state that is known to impact an organism’s physiological and psychological balance as well as the morph...
A Novel Mutation in the MAP7D3 Gene in Two Siblings with Severe Intellectual Disability and Autistic Traits: Concurrent Assessment of BDNF Functional Polymorphism, X-Inactivation and Oxidative Stress to Explain Disease Severity
A Novel Mutation in the MAP7D3 Gene in Two Siblings with Severe Intellectual Disability and Autistic Traits: Concurrent Assessment of BDNF Functional Polymorphism, X-Inactivation and Oxidative Stress to Explain Disease Severity
Intellectual disabilities (ID) and autism spectrum disorders (ASD) are characterized by extreme genetic and phenotypic het...
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