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Post-antibiotics microbiome restoration driven by diet
Gut microbiome dysbiosis is associated with a wide range of diseases, but factors influencing restoration of the microbiom...
The IDEAL framework for machine perfusion in liver transplantation
The IDEAL framework for machine perfusion in liver transplantation
Liver transplantation is challenged by organ scarcity and ageing donors. Machine perfusion is a promising technique to enh...
The oesophagus as an immune organ
The oesophagus as an immune organ
The oesophagus has traditionally been viewed as a simple conduit for food transport. In performing this delivery function,...
Promise and pitfalls of liver xenotransplantation
Promise and pitfalls of liver xenotransplantation
Liver xenotransplantation and genetically engineered pig livers have potential to save human lives. Liver xenotransplants ...
Reply to ‘Pregnancy and liver health: delivering new collaborations to advance the MASLD and MASH field’
Competing interests A.M.A. has received grants from the National Institutes of H...
Lessons from incretin-based therapy in MASH and obesity
Lessons from incretin-based therapy in MASH and obesity
Glucagon-like peptide 1 receptor agonists are effective pharmacotherapies for the treatment of obesity and related disorde...
Pregnancy and liver health: delivering new collaborations to advance the MASLD and MASH field
We read with great interest the article by Allen et al. (Envisioning how to advance the MASH field. Nat. Rev. Gastroentero...
Intestinal pH: a major driver of human gut microbiota composition and metabolism
Intestinal pH: a major driver of human gut microbiota composition and metabolism
In the human gastrointestinal tract, pH is a key factor in shaping gut microbial composition and activity, while also bein...
A new treatment and updated clinical practice guidelines for MASLD
A new treatment and updated clinical practice guidelines for MASLD
The year 2024 was momentous for metabolic dysfunction-associated steatotic liver disease (MASLD): the approval of the firs...
High-density lipoprotein lipidome: a neglected source of hepatic lipids
To define the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD) and identify therapeutic...
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Advances in 2024 have transformed our understanding of CD8+ T cell dysfunction in chronic hepatitis B virus infection, rev...
Transforming the landscape of liver cancer detection and care
Transforming the landscape of liver cancer detection and care
In 2024, important studies highlighted the ongoing global battle against liver cancer, a deadly yet common cancer. Despite...
Non-canonical metastatic colorectal cancer
A new study published in Nature explores the dynamic changes that colorectal cancer (CRC) cells undergo during their trans...
The ins and outs of tumour resistance
New research published in Science Translational Medicine identifies an interplay between tumour-intrinsic and tumour-extri...
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract
Visceral pain is a major clinical problem and one of the most common reasons patients with gastrointestinal disorders seek...
Moving towards more personalized approaches in locally advanced and metastatic colorectal cancer
Colorectal cancer remains a challenging heterogeneous disease with substantial morbidity and mortality. However, progressi...
Disability inclusion in research and health care
Globally, one in six people have a disability, and individuals with disabilities often experience a narrow margin of healt...
A roadmap for clinical trials in MASH-related compensated cirrhosis
A roadmap for clinical trials in MASH-related compensated cirrhosis
Although metabolic dysfunction-associated steatohepatitis (MASH) is rapidly becoming a leading cause of cirrhosis worldwid...
Shifting targets for eosinophilic oesophagitis
Shifting targets for eosinophilic oesophagitis
Two phase III trials of new drugs for eosinophilic oesophagitis (EoE) have been reported in The New England Journal of Med...
Hepatitis E virus: from innate sensing to adaptive immune responses
Hepatitis E virus: from innate sensing to adaptive immune responses
Hepatitis E virus (HEV) infections are a major cause of acute viral hepatitis in humans worldwide. In immunocompetent indi...
Western lifestyle, metaflammation and the cell of origin of colon cancer
Western lifestyle, metaflammation and the cell of origin of colon cancer
Western lifestyles cause a low-grade but chronic and metabolic inflammation (or metaflammation), which might prime committ...
Mother-to-child transmission of hepatitis B: current status and the road forward
Mother-to-child transmission of hepatitis B virus remains a mode of transmission in high-burden regions where there are ga...
Viral hepatitis elimination — time to act
The countdown to the 2030 viral hepatitis elimination goal continues, but time is running out and progress is not keeping ...
Food inequity and insecurity and MASLD: burden, challenges, and interventions
Food inequity and insecurity and MASLD: burden, challenges, and interventions
Liver disease prevalence, severity, outcomes and hepatic risk factors (for example, unhealthy diet) are heavily affected b...
HCC genomic landscape in Chinese individuals
Researchers from the Chinese Liver Cancer Atlas project performed deep whole-genome sequencing of hepatocellular carcinoma...
Seladelpar in primary biliary cholangitis
In a phase III, double-blind, placebo-controlled trial, 193 patients with primary biliary cholangitis and an inadequate re...
Bacteriophages and host inflammation in IBD
Researchers analysed metagenomic data from 1,618 patients with inflammatory bowel disease (IBD) and 791 healthy individual...
Tackling sorbitol intolerance
Tackling sorbitol intolerance
Sorbitol, a poorly absorbable sweetener, is catabolized by gut microbiota, mainly Clostridia. Lee et al. now elucidate the...
New understanding of hepatobiliary MRI
New understanding of hepatobiliary MRI
Magnetic resonance imaging following injection of hepatobiliary contrast agents improves the detection of hepatocellular c...
Improving culturally safe engagement with sexual and gender minority populations
Cultural safety seeks to remediate health inequities through empowering marginalized and minoritized patient populations, ...
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