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A new treatment and updated clinical practice guidelines for MASLD
A new treatment and updated clinical practice guidelines for MASLD
The year 2024 was momentous for metabolic dysfunction-associated steatotic liver disease (MASLD): the approval of the firs...
High-density lipoprotein lipidome: a neglected source of hepatic lipids
To define the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD) and identify therapeutic...
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Advances in 2024 have transformed our understanding of CD8+ T cell dysfunction in chronic hepatitis B virus infection, rev...
Transforming the landscape of liver cancer detection and care
Transforming the landscape of liver cancer detection and care
In 2024, important studies highlighted the ongoing global battle against liver cancer, a deadly yet common cancer. Despite...
Non-canonical metastatic colorectal cancer
A new study published in Nature explores the dynamic changes that colorectal cancer (CRC) cells undergo during their trans...
The ins and outs of tumour resistance
New research published in Science Translational Medicine identifies an interplay between tumour-intrinsic and tumour-extri...
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract
Visceral pain is a major clinical problem and one of the most common reasons patients with gastrointestinal disorders seek...
Moving towards more personalized approaches in locally advanced and metastatic colorectal cancer
Colorectal cancer remains a challenging heterogeneous disease with substantial morbidity and mortality. However, progressi...
Disability inclusion in research and health care
Globally, one in six people have a disability, and individuals with disabilities often experience a narrow margin of healt...
A roadmap for clinical trials in MASH-related compensated cirrhosis
A roadmap for clinical trials in MASH-related compensated cirrhosis
Although metabolic dysfunction-associated steatohepatitis (MASH) is rapidly becoming a leading cause of cirrhosis worldwid...
Shifting targets for eosinophilic oesophagitis
Shifting targets for eosinophilic oesophagitis
Two phase III trials of new drugs for eosinophilic oesophagitis (EoE) have been reported in The New England Journal of Med...
Hepatitis E virus: from innate sensing to adaptive immune responses
Hepatitis E virus: from innate sensing to adaptive immune responses
Hepatitis E virus (HEV) infections are a major cause of acute viral hepatitis in humans worldwide. In immunocompetent indi...
Western lifestyle, metaflammation and the cell of origin of colon cancer
Western lifestyle, metaflammation and the cell of origin of colon cancer
Western lifestyles cause a low-grade but chronic and metabolic inflammation (or metaflammation), which might prime committ...
Mother-to-child transmission of hepatitis B: current status and the road forward
Mother-to-child transmission of hepatitis B virus remains a mode of transmission in high-burden regions where there are ga...
Viral hepatitis elimination — time to act
The countdown to the 2030 viral hepatitis elimination goal continues, but time is running out and progress is not keeping ...
Food inequity and insecurity and MASLD: burden, challenges, and interventions
Food inequity and insecurity and MASLD: burden, challenges, and interventions
Liver disease prevalence, severity, outcomes and hepatic risk factors (for example, unhealthy diet) are heavily affected b...
HCC genomic landscape in Chinese individuals
Researchers from the Chinese Liver Cancer Atlas project performed deep whole-genome sequencing of hepatocellular carcinoma...
Seladelpar in primary biliary cholangitis
In a phase III, double-blind, placebo-controlled trial, 193 patients with primary biliary cholangitis and an inadequate re...
Bacteriophages and host inflammation in IBD
Researchers analysed metagenomic data from 1,618 patients with inflammatory bowel disease (IBD) and 791 healthy individual...
Tackling sorbitol intolerance
Tackling sorbitol intolerance
Sorbitol, a poorly absorbable sweetener, is catabolized by gut microbiota, mainly Clostridia. Lee et al. now elucidate the...
New understanding of hepatobiliary MRI
New understanding of hepatobiliary MRI
Magnetic resonance imaging following injection of hepatobiliary contrast agents improves the detection of hepatocellular c...
Improving culturally safe engagement with sexual and gender minority populations
Cultural safety seeks to remediate health inequities through empowering marginalized and minoritized patient populations, ...
Publisher Correction: Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Authors and AffiliationsAPC Microbiome Ireland, University College Cork, Cork, IrelandMaría R. Aburto & John F. CryanD...
The changing metabolic landscape of bile acids – keys to metabolism and immune regulation
The changing metabolic landscape of bile acids – keys to metabolism and immune regulation
Bile acids regulate nutrient absorption and mitochondrial function, they establish and maintain gut microbial community co...
RET signalling controls gut motility
RET signalling controls gut motility
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
New options for late-line treatment of metastatic colorectal cancer
New options for late-line treatment of metastatic colorectal cancer
Metastatic colorectal cancer is a heterogeneous disease associated with poor patient outcomes. Although the past ...
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Overweight and obesity are characterized by excessive fat mass accumulation produced when energy intake exceeds energy exp...
Microbiota-based biomarkers and therapeutics for cancer management
Microbiota-based biomarkers and therapeutics for cancer management
New light is being shed on the interactions between the gut microbiome, cancer cell signalling and the host immune respons...
Tumour-associated macrophages and pancreatic cancer: an inflammatory loop
Tumour-associated macrophages and pancreatic cancer: an inflammatory loop
In a new study published in Nature, researchers have investigated the role of tumour-associated macrophages (TAMs) in panc...
Upgrading therapeutic ambitions and treatment outcomes
Upgrading therapeutic ambitions and treatment outcomes
Important studies published in 2023 outlined new agents and strategies for the management of inflammatory bowel disease. T...
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