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Pathophysiology and clinical relevance of atrial myopathy
Pathophysiology and clinical relevance of atrial myopathy
Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria...
Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes
Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes
Recognizing that cells “feel” and respond to their mechanical environment, recent studies demonstrate that man...
The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics
The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics
The rupture of an atherosclerotic plaque cap overlying a lipid pool and/or necrotic core can lead to thrombotic cardiovasc...
Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Lysophosphatidic acid (LPA) is a bioactive phospholipid that plays a crucial role in cardiovascular diseases. Here, we que...
Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor
Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor
The coronary perivascular adipose tissue (cPVAT) has been associated to the burden of cardiovascular risk factors and to t...
Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2
Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2
Exercise improves cardiac function and metabolism. Although long-term exercise leads to circulating and micro-environmenta...
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival
Hypertrophic cardiomyopathy (HCM) constitutes the most common genetic cardiac disorder. However, current pharmacotherapeut...
“Expression of concern”: publication bias for positive preclinical cardioprotection studies
“Expression of concern”: publication bias for positive preclinical cardioprotection studies
The present analysis reports on the robustness of preclinical cardioprotection studies with infarct size as endpoint which...
Targeting cardiomyocyte cell cycle regulation in heart failure
Targeting cardiomyocyte cell cycle regulation in heart failure
Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limite...
Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections
Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections
Ascending thoracic aortic aneurysm (ATAA) remains a significant medical concern, with its asymptomatic nature posing diagn...
The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity
The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity
Cardiovascular disease is the main factor contributing to the global burden of diseases, and the cardiotoxicity caused by ...
Connexin 43 modulates reverse electron transfer in cardiac mitochondria from inducible knock-out Cx43Cre−ER(T)/fl mice by altering the coenzyme Q pool
Connexin 43 modulates reverse electron transfer in cardiac mitochondria from inducible knock-out Cx43Cre−ER(T)/fl mice by altering the coenzyme Q pool
Succinate accumulates during myocardial ischemia and is rapidly oxidized during reperfusion, leading to reactive oxygen sp...
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat
The right ventricle (RV) differs developmentally, anatomically and functionally from the left ventricle (LV). Therefore, c...
Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
Regulation of RNA stability and translation by RNA-binding proteins (RBPs) is a crucial process altering gene expression. ...
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Barth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the mitochondrial transacylase TAFAZZIN (Taz), r...
The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-communicable disease deaths. Gly...
Targeting mitochondrial shape: at the heart of cardioprotection
Targeting mitochondrial shape: at the heart of cardioprotection
There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detr...
Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion
Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion
The spleen contributes importantly to myocardial ischemia/reperfusion (MI/R) injury. Nucleotide-binding oligomerization do...
Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts
Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts
A hallmark of heart failure is a metabolic switch away from fatty acids β-oxidation (FAO) to glycolysis. Here, we sho...
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
Numerous physiological and pathological roles have been attributed to the formation of mitochondrial reactive oxygen speci...
Outcomes of hypothalamic oxytocin neuron-driven cardioprotection after acute myocardial infarction
Outcomes of hypothalamic oxytocin neuron-driven cardioprotection after acute myocardial infarction
Altered autonomic balance is a hallmark of numerous cardiovascular diseases, including myocardial infarction (MI). Althoug...
Mitophagy for cardioprotection
Mitophagy for cardioprotection
Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively termed mitochondrial quality...
Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Activation of gasdermin D (GSDMD) and its concomitant cardiomyocyte pyroptosis are critically involved in multiple cardiac...
Giant mitochondria in cardiomyocytes: cellular architecture in health and disease
Giant mitochondria in cardiomyocytes: cellular architecture in health and disease
Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac mus...
The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
Ischemic heart disease remains a leading cause of human mortality worldwide. One form of ischemic heart disease is ischemi...
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressu...
Cardiac fibroblast GSK-3α aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis
Cardiac fibroblast GSK-3α aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis
Myocardial infarction (MI) is the leading cause of death worldwide. Glycogen synthase kinase-3 (GSK-3) has been considered...
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy
Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacothera...
Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease
Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease
While low concentrations of high-density lipoprotein-cholesterol (HDL-C) are widely accepted as an independent cardiovascu...
Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
In the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex ...
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