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Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute the only medication class that consistently prevents or atte...
Role of inflammatory signaling pathways involving the CD40–CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies
Role of inflammatory signaling pathways involving the CD40–CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies
CD40L–CD40–TRAF signaling plays a role in atherosclerosis progression and affects the pathogenesis of coronary...
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Understanding the mechanisms underlying vascular regeneration in the heart is crucial for developing novel therapeutic str...
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
The mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolis...
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Despite recent progress, ischemic heart disease poses a persistent global challenge, driving significant morbidity and mor...
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Placental growth factor (PlGF)-2 induces angio- and arteriogenesis in rodents but its therapeutic potential in a clinicall...
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
Hyperglycaemia is common during acute coronary syndromes (ACS) irrespective of diabetic status and portends excess infarct...
Cardioprotection in cardiovascular surgery
Cardioprotection in cardiovascular surgery
Since the invention of cardiopulmonary bypass, cardioprotective strategies have been investigated to mitigate ischemic inj...
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium (Ca2+) signals play a central role in cardiac homeostasis and disease. In the healthy heart, mitocho...
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that S1P transport by Mfsd2b is inv...
Proprioceptors of the human pericardium
Proprioceptors of the human pericardium
In the human organism, all functions are regulated and, therefore, require a feedback mechanism. This control involves a p...
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor (β3AR) agonists have been shown to protect against ischemia–reperfusion injury (IRI...
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3
Exercise is an effective way to alleviate breast cancer-induced cardiac injury to a certain extent. However, whether volun...
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients
Immunotherapy represents an emergent and heterogeneous group of anticancer treatments harnessing the human immune-surveill...
Cardioprotection strategies for anthracycline cardiotoxicity
Cardioprotection strategies for anthracycline cardiotoxicity
Thanks to the fantastic progress in cancer therapy options, there is a growing population of cancer survivors. This succes...
Pathophysiology and clinical relevance of atrial myopathy
Pathophysiology and clinical relevance of atrial myopathy
Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria...
Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes
Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes
Recognizing that cells “feel” and respond to their mechanical environment, recent studies demonstrate that man...
The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics
The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics
The rupture of an atherosclerotic plaque cap overlying a lipid pool and/or necrotic core can lead to thrombotic cardiovasc...
Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord
Lysophosphatidic acid (LPA) is a bioactive phospholipid that plays a crucial role in cardiovascular diseases. Here, we que...
Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor
Crosstalk of human coronary perivascular adipose-derived stem cells with vascular cells: role of tissue factor
The coronary perivascular adipose tissue (cPVAT) has been associated to the burden of cardiovascular risk factors and to t...
Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2
Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2
Exercise improves cardiac function and metabolism. Although long-term exercise leads to circulating and micro-environmenta...
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival
Hypertrophic cardiomyopathy (HCM) constitutes the most common genetic cardiac disorder. However, current pharmacotherapeut...
“Expression of concern”: publication bias for positive preclinical cardioprotection studies
“Expression of concern”: publication bias for positive preclinical cardioprotection studies
The present analysis reports on the robustness of preclinical cardioprotection studies with infarct size as endpoint which...
Targeting cardiomyocyte cell cycle regulation in heart failure
Targeting cardiomyocyte cell cycle regulation in heart failure
Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limite...
Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections
Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections
Ascending thoracic aortic aneurysm (ATAA) remains a significant medical concern, with its asymptomatic nature posing diagn...
The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity
The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity
Cardiovascular disease is the main factor contributing to the global burden of diseases, and the cardiotoxicity caused by ...
Connexin 43 modulates reverse electron transfer in cardiac mitochondria from inducible knock-out Cx43Cre−ER(T)/fl mice by altering the coenzyme Q pool
Connexin 43 modulates reverse electron transfer in cardiac mitochondria from inducible knock-out Cx43Cre−ER(T)/fl mice by altering the coenzyme Q pool
Succinate accumulates during myocardial ischemia and is rapidly oxidized during reperfusion, leading to reactive oxygen sp...
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat
The right ventricle (RV) differs developmentally, anatomically and functionally from the left ventricle (LV). Therefore, c...
Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
Regulation of RNA stability and translation by RNA-binding proteins (RBPs) is a crucial process altering gene expression. ...
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Barth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the mitochondrial transacylase TAFAZZIN (Taz), r...
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