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The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research
The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research
Alcohol pharmacotherapies pose unknown teratogenic risks in pregnancy and are therefore recommended to be avoided. This li...
The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review
The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review
GABA (γ-aminobutyric acid) receptors are constituents of many inhibitory synapses within the central nervous system. ...
An Open-Label Extension Study Assessing the Long-Term Safety and Efficacy of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder
An Open-Label Extension Study Assessing the Long-Term Safety and Efficacy of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder
Viloxazine ER (extended-release capsules; Qelbree®) is a nonstimulant medication that has been approved by the United...
Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial
Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial
Although there are several treatments for narcolepsy type 2 and idiopathic hypersomnia, studies that assess amphetamines, ...
Ozanimod: A Review in Relapsing Forms of Multiple Sclerosis
Ozanimod: A Review in Relapsing Forms of Multiple Sclerosis
Ozanimod (Zeposia®), an orally administered sphingosine 1-phosphate (S1P) receptor modulator (S1PRM) that is selectiv...
Glutamatergic Modulators for Major Depression from Theory to Clinical Use
Glutamatergic Modulators for Major Depression from Theory to Clinical Use
Major depressive disorder (MDD) is a chronic, burdensome, highly prevalent disease that is characterized by depressed mood...
Current Landscape of NTRK Inhibition for Pediatric CNS Tumors
Current Landscape of NTRK Inhibition for Pediatric CNS Tumors
Over the last decade, as molecular platforms have permitted the characterization of the genomic landscape of pediatric cen...
Effectiveness of Disease-Modifying Treatment on Spinal Cord Lesion Formation in Relapse-Onset Multiple Sclerosis: An MSBase Registry Study
Effectiveness of Disease-Modifying Treatment on Spinal Cord Lesion Formation in Relapse-Onset Multiple Sclerosis: An MSBase Registry Study
Spinal cord lesions in multiple sclerosis (MS) have considerable impact on disability. High-efficacy disease-modifying tre...
TICA-CLOP STUDY: Ticagrelor Versus Clopidogrel in Acute Moderate and Moderate-to-Severe Ischemic Stroke, a Randomized Controlled Multi-Center Trial
TICA-CLOP STUDY: Ticagrelor Versus Clopidogrel in Acute Moderate and Moderate-to-Severe Ischemic Stroke, a Randomized Controlled Multi-Center Trial
Many studies evaluated the efficacy and safety of ticagrelor versus clopidogrel in patients with ischemic stroke; none of ...
Comparative Safety of Antipsychotic Medications and Mood Stabilizers During Pregnancy: A Systematic Review and Network Meta-analysis of Congenital Malformations and Prenatal Outcomes
Comparative Safety of Antipsychotic Medications and Mood Stabilizers During Pregnancy: A Systematic Review and Network Meta-analysis of Congenital Malformations and Prenatal Outcomes
A network meta-analysis was performed to evaluate the risk of congenital malformations and other prenatal outcomes in fetu...
Efficacy of Cariprazine in the Psychosis Spectrum: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials in Schizophrenia and Bipolar Disorder
Efficacy of Cariprazine in the Psychosis Spectrum: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials in Schizophrenia and Bipolar Disorder
Psychosis represents one of the most challenging clinical presentations in psychiatry. Schizophrenia and bipolar disorder ...
Research Progress on NMDA Receptor Enhancement Drugs for the Treatment of Depressive Disorder
Research Progress on NMDA Receptor Enhancement Drugs for the Treatment of Depressive Disorder
Major depressive disorder (MDD) is a severe mental illness with a complex etiology. Currently, many medications employed i...
Recent Advances in Pharmacologic Treatments of Drug-Resistant Epilepsy: Breakthrough in Sight
Recent Advances in Pharmacologic Treatments of Drug-Resistant Epilepsy: Breakthrough in Sight
Epilepsy affects approximately 1% of the world population. Patients have recurrent seizures, increased physical and psychi...
A Multicenter, Open-Label Study to Evaluate the Long-term Safety and Efficacy of Adjunctive Brexpiprazole 2 mg Daily in Japanese Patients with Major Depressive Disorder
A Multicenter, Open-Label Study to Evaluate the Long-term Safety and Efficacy of Adjunctive Brexpiprazole 2 mg Daily in Japanese Patients with Major Depressive Disorder
Inadequate response to antidepressant monotherapy is common among patients with major depressive disorder (MDD). The effic...
Long-Term (12-Month) Safety and Tolerability of STS101 (Dihydroergotamine Nasal Powder) in the Acute Treatment of Migraine: Data from the Phase 3 Open-Label ASCEND Study
Long-Term (12-Month) Safety and Tolerability of STS101 (Dihydroergotamine Nasal Powder) in the Acute Treatment of Migraine: Data from the Phase 3 Open-Label ASCEND Study
STS101 is an investigational drug–device combination comprising 5.2 mg dihydroergotamine (DHE) powder (6.0 mg DHE me...
Early Disease-Modifying Treatments for Presymptomatic Multiple Sclerosis
Early Disease-Modifying Treatments for Presymptomatic Multiple Sclerosis
Radiologically isolated syndrome (RIS) is the earliest stage in the disease continuum of multiple sclerosis (MS). RIS is d...
Sex Differences in Adverse Effects of Antiseizure Medications in Adults with Epilepsy: A Systematic Review
Sex Differences in Adverse Effects of Antiseizure Medications in Adults with Epilepsy: A Systematic Review
Sex differences in epilepsy have been described in prevalence, seizure propensity and response to treatment. Therefore, ta...
Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data
Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data
Adequate antipsychotic treatment intensity is required before diagnosing resistant schizophrenia and initiating clozapine ...
Semi-physiological Pharmacokinetic Model of Clozapine and Norclozapine in Healthy, Non-smoking Volunteers: The Impact of Race and Genetics
Semi-physiological Pharmacokinetic Model of Clozapine and Norclozapine in Healthy, Non-smoking Volunteers: The Impact of Race and Genetics
Clozapine is the medication of choice for treatment-resistant schizophrenia. However, it has a complex metabolism and unex...
Observation on the Analgesic Effect of Different Doses of a Combination of Esketamine and Dexmedetomidine Administered for Percutaneous Endoscopic Transforaminal Discectomy: A Randomized, Double-Blind Controlled Trial
Observation on the Analgesic Effect of Different Doses of a Combination of Esketamine and Dexmedetomidine Administered for Percutaneous Endoscopic Transforaminal Discectomy: A Randomized, Double-Blind Controlled Trial
Percutaneous endoscopic transforaminal discectomy (PETD) is an effective method for treating lumbar disc herniation, and i...
When, Why and How to Re-challenge Clozapine in Schizophrenia Following Myocarditis
When, Why and How to Re-challenge Clozapine in Schizophrenia Following Myocarditis
Clozapine-induced myocarditis (CIM) is among the most important adverse events limiting the use of clozapine as the most e...
Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
In recent years, pregabalin has received growing attention due to its abuse liability. The aim of this study was to furthe...
Psychotropic Drugs Reemerging as Headache Medicines
Psychotropic Drugs Reemerging as Headache Medicines
Scientific and public attention on the therapeutic effects of psychedelics and other psychoactive compounds in headache di...
The Use of Ketamine for the Treatment of Anhedonia in Depression
The Use of Ketamine for the Treatment of Anhedonia in Depression
Anhedonia, a complex symptom rooted in deficits across reward processes, is primarily linked to depression and schizophren...
A Long-Term Safety and Tolerability Study of TV-46000 for Subcutaneous Use in Patients with Schizophrenia: A Phase 3, Randomized, Double-Blinded Clinical Trial
A Long-Term Safety and Tolerability Study of TV-46000 for Subcutaneous Use in Patients with Schizophrenia: A Phase 3, Randomized, Double-Blinded Clinical Trial
TV-46000 is a long-acting subcutaneous antipsychotic (LASCA) formulation of risperidone that is approved by the United Sta...
Effectiveness of Anti-Calcitonin Gene-Related Peptide Medication in Vestibular Migraine: A Retrospective Cohort Study in an Asian Population
Effectiveness of Anti-Calcitonin Gene-Related Peptide Medication in Vestibular Migraine: A Retrospective Cohort Study in an Asian Population
Migraine and dizziness often coexist, with vestibular migraine (VM) presenting with vestibular symptoms and headaches. Cal...
Sex Differences in the Dual Antiplatelet Therapy Versus Alteplase for Patients with Minor Nondisabling Acute Ischemic Stroke: A Secondary Analysis of the ARAMIS Study
Sex Differences in the Dual Antiplatelet Therapy Versus Alteplase for Patients with Minor Nondisabling Acute Ischemic Stroke: A Secondary Analysis of the ARAMIS Study
Sex is associated with clinical outcome in stroke. The present study aimed to determine the effect of sex on efficacy of d...
Targeting Pannexin-1 Channels: Addressing the ‘Gap’ in Chronic Pain
Targeting Pannexin-1 Channels: Addressing the ‘Gap’ in Chronic Pain
Chronic pain complicates many diseases and is notoriously difficult to treat. In search of new therapeutic targets, pannex...
Trends in Pregabalin Use and Prescribing Patterns in the Adult Population: A 10-Year Pharmacoepidemiologic Study
Trends in Pregabalin Use and Prescribing Patterns in the Adult Population: A 10-Year Pharmacoepidemiologic Study
Pregabalin is steadily gaining popularity worldwide, with epidemiological studies indicating an increase in labeled, off-l...
Evaluating Monitoring Guidelines of Clozapine-Induced Adverse Effects: a Systematic Review
Evaluating Monitoring Guidelines of Clozapine-Induced Adverse Effects: a Systematic Review
Despite the evidence that no other antipsychotic is effective as clozapine for the treatment of resistant schizophrenia, i...
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