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Sex Differences in Adverse Effects of Antiseizure Medications in Adults with Epilepsy: A Systematic Review
Sex Differences in Adverse Effects of Antiseizure Medications in Adults with Epilepsy: A Systematic Review
Sex differences in epilepsy have been described in prevalence, seizure propensity and response to treatment. Therefore, ta...
Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data
Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data
Adequate antipsychotic treatment intensity is required before diagnosing resistant schizophrenia and initiating clozapine ...
Semi-physiological Pharmacokinetic Model of Clozapine and Norclozapine in Healthy, Non-smoking Volunteers: The Impact of Race and Genetics
Semi-physiological Pharmacokinetic Model of Clozapine and Norclozapine in Healthy, Non-smoking Volunteers: The Impact of Race and Genetics
Clozapine is the medication of choice for treatment-resistant schizophrenia. However, it has a complex metabolism and unex...
Observation on the Analgesic Effect of Different Doses of a Combination of Esketamine and Dexmedetomidine Administered for Percutaneous Endoscopic Transforaminal Discectomy: A Randomized, Double-Blind Controlled Trial
Observation on the Analgesic Effect of Different Doses of a Combination of Esketamine and Dexmedetomidine Administered for Percutaneous Endoscopic Transforaminal Discectomy: A Randomized, Double-Blind Controlled Trial
Percutaneous endoscopic transforaminal discectomy (PETD) is an effective method for treating lumbar disc herniation, and i...
When, Why and How to Re-challenge Clozapine in Schizophrenia Following Myocarditis
When, Why and How to Re-challenge Clozapine in Schizophrenia Following Myocarditis
Clozapine-induced myocarditis (CIM) is among the most important adverse events limiting the use of clozapine as the most e...
Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
In recent years, pregabalin has received growing attention due to its abuse liability. The aim of this study was to furthe...
Psychotropic Drugs Reemerging as Headache Medicines
Psychotropic Drugs Reemerging as Headache Medicines
Scientific and public attention on the therapeutic effects of psychedelics and other psychoactive compounds in headache di...
The Use of Ketamine for the Treatment of Anhedonia in Depression
The Use of Ketamine for the Treatment of Anhedonia in Depression
Anhedonia, a complex symptom rooted in deficits across reward processes, is primarily linked to depression and schizophren...
A Long-Term Safety and Tolerability Study of TV-46000 for Subcutaneous Use in Patients with Schizophrenia: A Phase 3, Randomized, Double-Blinded Clinical Trial
A Long-Term Safety and Tolerability Study of TV-46000 for Subcutaneous Use in Patients with Schizophrenia: A Phase 3, Randomized, Double-Blinded Clinical Trial
TV-46000 is a long-acting subcutaneous antipsychotic (LASCA) formulation of risperidone that is approved by the United Sta...
Effectiveness of Anti-Calcitonin Gene-Related Peptide Medication in Vestibular Migraine: A Retrospective Cohort Study in an Asian Population
Effectiveness of Anti-Calcitonin Gene-Related Peptide Medication in Vestibular Migraine: A Retrospective Cohort Study in an Asian Population
Migraine and dizziness often coexist, with vestibular migraine (VM) presenting with vestibular symptoms and headaches. Cal...
Sex Differences in the Dual Antiplatelet Therapy Versus Alteplase for Patients with Minor Nondisabling Acute Ischemic Stroke: A Secondary Analysis of the ARAMIS Study
Sex Differences in the Dual Antiplatelet Therapy Versus Alteplase for Patients with Minor Nondisabling Acute Ischemic Stroke: A Secondary Analysis of the ARAMIS Study
Sex is associated with clinical outcome in stroke. The present study aimed to determine the effect of sex on efficacy of d...
Targeting Pannexin-1 Channels: Addressing the ‘Gap’ in Chronic Pain
Targeting Pannexin-1 Channels: Addressing the ‘Gap’ in Chronic Pain
Chronic pain complicates many diseases and is notoriously difficult to treat. In search of new therapeutic targets, pannex...
Trends in Pregabalin Use and Prescribing Patterns in the Adult Population: A 10-Year Pharmacoepidemiologic Study
Trends in Pregabalin Use and Prescribing Patterns in the Adult Population: A 10-Year Pharmacoepidemiologic Study
Pregabalin is steadily gaining popularity worldwide, with epidemiological studies indicating an increase in labeled, off-l...
Evaluating Monitoring Guidelines of Clozapine-Induced Adverse Effects: a Systematic Review
Evaluating Monitoring Guidelines of Clozapine-Induced Adverse Effects: a Systematic Review
Despite the evidence that no other antipsychotic is effective as clozapine for the treatment of resistant schizophrenia, i...
The Efficacy and Safety of Different Targeted Drugs for the Treatment of Generalized Myasthenia Gravis: A Systematic Review and Bayesian Network Meta-analysis
The Efficacy and Safety of Different Targeted Drugs for the Treatment of Generalized Myasthenia Gravis: A Systematic Review and Bayesian Network Meta-analysis
The treatment of generalized myasthenia gravis (gMG) has been transformed by the development and approval of new targeted ...
Effect of Cenobamate on Cognition in Patients with Drug-Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
Effect of Cenobamate on Cognition in Patients with Drug-Resistant Epilepsy with Focal Onset Seizures: An Exploratory Study
Most second and third generation antiseizure medications (ASMs) are associated with cognitive adverse events, which are a ...
Real-World Retrospective Analysis of Alemtuzumab Outcomes in Relapsing-Remitting Multiple Sclerosis: The LEMCAM Study
Real-World Retrospective Analysis of Alemtuzumab Outcomes in Relapsing-Remitting Multiple Sclerosis: The LEMCAM Study
Alemtuzumab is a high-efficacy treatment approved for relapsing-remitting multiple sclerosis (RRMS). Although clinical tri...
Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis
Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis
Multiple sclerosis is a chronic inflammatory disease that affects the central nervous system and can cause various types o...
The Effect of Levetiracetam Compared with Enzyme-Inducing Antiseizure Medications on Apixaban and Rivaroxaban Peak Plasma Concentrations
The Effect of Levetiracetam Compared with Enzyme-Inducing Antiseizure Medications on Apixaban and Rivaroxaban Peak Plasma Concentrations
Post-stroke epilepsy represents an important clinical challenge as it often requires both treatment with direct oral antic...
The Dose-Response Relationship between Opioid Agonist Therapy and Alterations in Pain Pathways in Patients with Opioid Use Disorders: A Cross-Sectional Study
The Dose-Response Relationship between Opioid Agonist Therapy and Alterations in Pain Pathways in Patients with Opioid Use Disorders: A Cross-Sectional Study
The administration of opioids can be followed by enduring neuroplastic changes in the peripheral and central nervous syste...
Attention-Deficit Hyperactivity Disorder (ADHD) Medication Use Trajectories Among Women in the Perinatal Period
Attention-Deficit Hyperactivity Disorder (ADHD) Medication Use Trajectories Among Women in the Perinatal Period
An increasing number of women of reproductive age are treated with attention-deficit hyperactivity disorder (ADHD) medicat...
Magnetic Resonance Imaging Evidence Supporting the Efficacy of Cladribine Tablets in the Treatment of Relapsing-Remitting Multiple Sclerosis
Magnetic Resonance Imaging Evidence Supporting the Efficacy of Cladribine Tablets in the Treatment of Relapsing-Remitting Multiple Sclerosis
Numerous therapies are currently available to modify the disease course of multiple sclerosis (MS). Magnetic resonance ima...
SAFE-ROCK: A Phase I Trial of an Oral Application of the ROCK Inhibitor Fasudil to Assess Bioavailability, Safety, and Tolerability in Healthy Participants
SAFE-ROCK: A Phase I Trial of an Oral Application of the ROCK Inhibitor Fasudil to Assess Bioavailability, Safety, and Tolerability in Healthy Participants
The intravenous (IV) formulation of Rho-kinase (ROCK) inhibitor fasudil has been approved for the treatment of subarachnoi...
An Evidence-Based Update on Anticholinergic Use for Drug-Induced Movement Disorders
An Evidence-Based Update on Anticholinergic Use for Drug-Induced Movement Disorders
Drug-induced movement disorders (DIMDs) are associated with use of dopamine receptor blocking agents (DRBAs), including an...
Effect of BI 1358894 on Cholecystokinin-Tetrapeptide (CCK-4)-Induced Anxiety, Panic Symptoms, and Stress Biomarkers: A Phase I Randomized Trial in Healthy Males
Effect of BI 1358894 on Cholecystokinin-Tetrapeptide (CCK-4)-Induced Anxiety, Panic Symptoms, and Stress Biomarkers: A Phase I Randomized Trial in Healthy Males
Depression, anxiety, and/or panic disorder are often comorbid and have a complex etiology mediated through the same neuron...
Thrombolysis with Recombinant Human Prourokinase 4.5–6 h After Acute Ischemic Stroke: A Phase IIa, Randomized, and Open-Label Multicenter Clinical Trial
Thrombolysis with Recombinant Human Prourokinase 4.5–6 h After Acute Ischemic Stroke: A Phase IIa, Randomized, and Open-Label Multicenter Clinical Trial
Ischemic stroke is a major cause of disability and death worldwide. A narrow therapeutic window profoundly constrained the...
Effects of Single and Multiple Ascending Doses of BI 1358894 in Healthy Male Volunteers on Safety, Tolerability and Pharmacokinetics: Two Phase I Partially Randomised Studies
Effects of Single and Multiple Ascending Doses of BI 1358894 in Healthy Male Volunteers on Safety, Tolerability and Pharmacokinetics: Two Phase I Partially Randomised Studies
The transient receptor potential canonical (TRPC) ion channels have been implicated in the pathophysiology of major depres...
Levetiracetam Interaction with Direct Oral Anticoagulants: A Pharmacovigilance Study
Levetiracetam Interaction with Direct Oral Anticoagulants: A Pharmacovigilance Study
Levetiracetam is widely used in post-stroke epilepsy. However, it is suspected to possess P-glycoprotein (P-gp) induction ...
Long-Term Treatment Over 52 Weeks with Monthly Fremanezumab in Drug-Resistant Migraine: A Prospective Multicenter Cohort Study
Long-Term Treatment Over 52 Weeks with Monthly Fremanezumab in Drug-Resistant Migraine: A Prospective Multicenter Cohort Study
Real-world studies on fremanezumab, an anti-calcitonin gene-related peptide monoclonal antibody for migraine prevention, a...
Context is a Critical for Psychoactive Drug Effects
Context is a Critical for Psychoactive Drug Effects
Pouyan N, Younesi Sisi F, Kargar A, Scheidegger M, McIntyre R, Morrow J. The effects of lysergic acid diethylamide (LSD) o...
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