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The role of microbiome in gastrointestinal cancer
Two ideas often center stage in the medical discourse of today: “microbiome” and “cancer”. The human body is host to a vas...
Effect of diet and lifestyle on microbiome composition
Human body is a host to a large number of microorganisms. These microorganisms form a very integrated and complex communit...
Role of microbiome in cancer progression
The human microbiome is one of the most diverse and well-characterized microbiomes, consisting of many bacteria, protozoa,...
CTCs and liquid biopsies in patients with colorectal cancer
Liquid biopsy, which includes both circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) has become a valuable ...
The key role of immunomodulatory cytokines for the development of novel NK cell-based cancer therapies
Natural killer (NK) cells are lymphocytes that belong to the innate immune system known to eliminate transformed cells (ma...
Biomarkers for cancer therapy-related cardiovascular toxicity
Cancer and cardiovascular disease are among the leading causes of death worldwide, posing significant threats to human hea...
Introduction to microbiomes in health and diseases
The term microbiome was coined by Dr. Joshua Lederberg and refers to an ecological system of commensal, symbiotic and path...
Autoimmune diseases and microbiome targeted therapies
Previously regarded solely as a digestive entity, the human gut has been revealed to harbor a rich diversity of microbial ...
Microbiome-mediated immune modulation in tumor microenvironment
The tumor microenvironment (TME) is composed of three categories of cells: tumor cells, extracellular matrix, and immune c...
Cytokine-driven cancer immune evasion mechanisms
Since the discovery of the first two cytokines, Interleukin (IL)−1α and IL-1β in 1974 by Charles A. Dinarello, (Dinarello,...
Circulation tumor cell isolation and enrichment technologies
During cancer metastasis, tumor cells migrate from the primary tumor site and spread to distant tissue or organs through t...
Epigenetic insights of microRNAs: Pioneering cancer detection via advanced biosensors
The term “Epigenetics” was first coined in 1942 by embryologist Conrad Waddington, who described it as the “complex develo...
Extracellular vesicles as dynamic biomarkers: Monitoring therapeutic responses and drug resistance in cancer
Cancer is still a serious health problem that requires continuous monitoring. New approaches for tracking therapy response...
The antiviral potential of Vγ9Vδ2 T cells: Therapeutic implications for immunocompromised adult and pediatric hosts
A growing number of pediatric and adult subjects worldwide suffer from impaired immune response to pathogens, due to both ...
Unraveling the role of γδ T cells in inflammatory bowel disease: Development and prevention strategies
Inflammatory bowel diseases (IBD) are autoimmune disorders characterized by considerable heterogeneity in their clinical m...
γδ T cells: Beyond being simple actors in allergic disease
Allergic diseases are conditions triggered by localized or systemic dysfunctions of the immune system (IS). These patholog...
γδ T cells and head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor that originates from the squamous epithelial cells in t...
Cytokine-based immunotherapy in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent type of pancreatic neoplasm, accounting for more than 90 % o...
Immunocytokines based on IL-12 for cancer therapy: Enhancing efficacy and reducing toxicity
Immunocytokines (ICKs) are based on the fusion of a cytokine with an antibody in a single molecule. This type of approach ...
Interleukin-33: A new frontier in cancer immunotherapy
Cancer development is a complex process driven by cell-intrinsic genetic changes that confer survival advantages and incre...
Chapter Seven - Unravelling the molecular basis of PARP inhibitor resistance in prostate cancer with homologous recombination repair deficiency
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Liver as a nexus of daily metabolic cross talk
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Circuits involving the hypothalamic suprachiasmatic nucleus for controlling diverse physiologies verified by the aid of optogenetics and chemogenetics
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Circadian rhythms and cardiac physiology: An essential interplay
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Advances in metastatic prostate cancer circulating tumor cell enrichment technologies and clinical studies
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Circulating biomarkers for diagnosis and response to therapies in cancer patients
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Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity
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Identification of circulating tumor DNA as a biomarker for diagnosis and response to therapies in cancer patients
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DOGMA-seq and multimodal, single-cell analysis in acute myeloid leukemia
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Nectin-4: A promising prognostic marker and therapeutic target in cancer
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