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FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
Deletion of CDKN2A occurs in 50% of glioblastomas (GBM), and IFNA locus deletion in 25%. These genes reside closely on chr...
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
Patients with histiocytic sarcoma occurring in the central nervous system (CNS) are rare and have a very poor prognosis. T...
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology (TIC) and frozen section (FS) procedures are essential for intraoperative pathological diagnosis (I...
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Central neurocytoma (CN) is classically defined by its intraventricular location, neuronal/neurocytic differentiation, and...
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
To explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometr...
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (pHGG) is a rare and aggressive brain tumor charac...
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Malignant peripheral nerve sheath tumors (MPNSTs) arising from the trigeminal nerves are extremely rare (only 45 cases, in...
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
EPN-ZFTA is a rare brain tumor where prognostic factors remain unclear and no effective immunotherapy or chemotherapy is c...
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
Approximately 60% of hemangioblastomas (HBs) have peritumoral cysts adjacent to the tumor, which can cause neurological de...
IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis
IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis
The WHO 2021 classification defines IDH wild type (IDHw) histologically lower-grade glioma (hLGG) as molecular glioblastom...
Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors
Lynch syndrome-associated chordoma with high tumor mutational burden and significant response to immune checkpoint inhibitors
Chordoma is a rare malignant bone tumor arising from notochordal tissue. Conventional treatments, such as radical resectio...
Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs
Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs
Pituitary neuroendocrine tumors (PitNETs) lacking lineage affiliation are termed “null cell” PitNETs (NCTs). N...
Spatial metabolic heterogeneity of oligodendrogliomas at single-cell resolution
Spatial metabolic heterogeneity of oligodendrogliomas at single-cell resolution
Oligodendrogliomas are a type of rare and incurable gliomas whose metabolic profiles have yet to be fully examined. The pr...
An enduring debate on gliomatosis cerebri
An enduring debate on gliomatosis cerebri
Gliomatosis cerebri (GC) is a unique glial tumor that extensively invades the cerebral white matter and has been recognize...
Preface for Brain Tumor Pathology vol.40 issue 2
Preface for Brain Tumor Pathology vol.40 issue 2
I am delighted to be given the opportunity to introduce the special issue of Brain Tumor Path...
Utility of genome-wide DNA methylation profiling for pediatric-type diffuse gliomas
Utility of genome-wide DNA methylation profiling for pediatric-type diffuse gliomas
Despite the current progress of treatment, pediatric-type diffuse glioma is one of the most lethal primary malignant tumor...
Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas
Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas
Adult-type diffuse gliomas are divided into Astrocytoma, IDH-mutant, Oligodendroglioma, IDH-mutant and 1p/19q-codeleted an...
Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology
Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology
Tumor markers in CNS germ cell tumors (GCTs) include human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP), which...
Clinical characteristics and radiological features of glioblastoma, IDH-wildtype, grade 4 with histologically lower-grade gliomas
Clinical characteristics and radiological features of glioblastoma, IDH-wildtype, grade 4 with histologically lower-grade gliomas
The 2021 World Health Organization (WHO) classification of central nervous system tumors applied molecular criteria and fu...
Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence
Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence
Pilocytic astrocytomas (PAs) are benign tumors. However, clinically aggressive PAs despite benign histology have been repo...
High-grade neuroepithelial tumor with EP300::BCOR fusion and negative BCOR immunohistochemical expression: a case report
High-grade neuroepithelial tumor with EP300::BCOR fusion and negative BCOR immunohistochemical expression: a case report
In the World Health Organization tumor classification (fifth edition), central nervous system (CNS) tumors with BCOR inter...
Liquid biomarkers in glioma
Liquid biomarkers in glioma
An ideal biomarker must meet several parameters to enable its successful adoption; however, the nature of glioma makes it ...
Utility of real-time polymerase chain reaction for the assessment of CDKN2A homozygous deletion in adult-type IDH-mutant astrocytoma
Utility of real-time polymerase chain reaction for the assessment of CDKN2A homozygous deletion in adult-type IDH-mutant astrocytoma
The World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5) introduced a n...
Correction: Morphologically, genetically and spatially mixed astrocytoma and oligodendroglioma; chronological acquisition of 1p/19q codeletion and CDKN2A deletion: a case report
Correction: Morphologically, genetically and spatially mixed astrocytoma and oligodendroglioma; chronological acquisition of 1p/19q codeletion and CDKN2A deletion: a case report
Departments of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, JapanHirokazu Taka...
Morphologically, genetically and spatially mixed astrocytoma and oligodendroglioma; chronological acquisition of 1p/19q codeletion and CDKN2A deletion: a case report
Morphologically, genetically and spatially mixed astrocytoma and oligodendroglioma; chronological acquisition of 1p/19q codeletion and CDKN2A deletion: a case report
“Oligoastrocytoma” disappeared as of the revised fourth edition of the World Health Organization Classificatio...
Correlation of MTAP immunohistochemical deficiency with CDKN2A homozygous deletion and clinicopathological features in pleomorphic xanthoastrocytoma
Correlation of MTAP immunohistochemical deficiency with CDKN2A homozygous deletion and clinicopathological features in pleomorphic xanthoastrocytoma
Pleomorphic xanthoastrocytoma (PXA) is a rare tumor ranging from World Health Organization (WHO) grades 2–3 and can ...
Update of the 2021 WHO classification of tumors of the central nervous system: adult diffuse gliomas
Update of the 2021 WHO classification of tumors of the central nervous system: adult diffuse gliomas
The fifth edition of the WHO classification of tumors of the central nervous system (CNS) [17], published in 2021, has bec...
Three-dimensional visualization of human brain tumors using the CUBIC technique
Three-dimensional visualization of human brain tumors using the CUBIC technique
Application of tissue clearing techniques on human brain tumors is still limited. This study was to investigate the applic...
PBRM1 and BAP1: novel genetic mutations in malignant transformation of craniopharyngioma—a case report
PBRM1 and BAP1: novel genetic mutations in malignant transformation of craniopharyngioma—a case report
Malignant craniopharyngioma is especially rare, so the causes and genetic mutations associated with the malignant transfor...
An extracranial CNS presentation of the emerging “intracranial” mesenchymal tumor, FET: CREB-fusion positive
An extracranial CNS presentation of the emerging “intracranial” mesenchymal tumor, FET: CREB-fusion positive
A novel histomolecular tumor, the “intracranial mesenchymal tumor (IMT), FET::CREB fusion-positive”, has recen...
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