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The function of chaperones in the radioresistance of glioblastoma: a new insight into the current knowledge
The function of chaperones in the radioresistance of glioblastoma: a new insight into the current knowledge
Radiotherapy remains a cornerstone of brain tumor treatment; however, its effectiveness is frequently undermined by the de...
Rapidly progressive scalp and lung metastases with fatal pneumothorax in glioblastoma, IDH-wildtype, with and amplifications: a case report of clinical course and postmortem autopsy, including genetic analysis
Rapidly progressive scalp and lung metastases with fatal pneumothorax in glioblastoma, IDH-wildtype, with and amplifications: a case report of clinical course and postmortem autopsy, including genetic analysis
We report a rare case of extracranial metastases of a glioblastoma, IDH-wildtype, in a 77-year-old man who initially prese...
Targeting TGF-β signaling in glioblastoma: therapeutic implications and novel drug development strategies
Targeting TGF-β signaling in glioblastoma: therapeutic implications and novel drug development strategies
Glioma, a prevalent primary brain tumor, arises from the supporting cells of the central nervous system (CNS) and is categ...
Primary pigmented papillary epithelial tumor of the sella: case report and literature review
Primary pigmented papillary epithelial tumor of the sella: case report and literature review
Primary pigmented papillary epithelial tumor of the sella (PPPET) is a recently identified tumor entity that commonly orig...
Comprehensive molecular characterization of craniopharyngiomas using whole transcriptome and spatial transcriptomics approaches
Comprehensive molecular characterization of craniopharyngiomas using whole transcriptome and spatial transcriptomics approaches
Craniopharyngiomas (CPs) are rare benign brain tumors that are classified as WHO grade I, with two subtypes: adamantinomat...
Integrated analysis of MYC expression, 8q24.21 copy number, and recurrence patterns in astrocytoma, IDH-mutant
Integrated analysis of MYC expression, 8q24.21 copy number, and recurrence patterns in astrocytoma, IDH-mutant
Compared to oligodendrogliomas, astrocytomas may have a relatively higher frequency of intracranial remote recurrence, des...
Activated astrocytes drive the accumulation of apolipoprotein E at the brain tumor edge
Activated astrocytes drive the accumulation of apolipoprotein E at the brain tumor edge
While tumor-associated macrophages (TAMs) have been extensively studied, the role of tumor-associated astrocytes (TAAs) in...
How is rosette formation in brain tumours linked with cerebrospinal fluid spread?
How is rosette formation in brain tumours linked with cerebrospinal fluid spread?
Rosette formation, a characteristic histopathological feature of various paediatric brain tumours, appears to be linked wi...
A case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression
A case of primary papillary epithelial tumor of the sella with reverse polarity and paired box 8 expression
Primary papillary epithelial tumor of the sella (PPETS) is a rare sellar neoplasm characterized by distinctive papillary a...
Emergence of NEC features in corticotroph PitNETs: primary tumor, radiation-induced transformation, or metastasis?
Emergence of NEC features in corticotroph PitNETs: primary tumor, radiation-induced transformation, or metastasis?
Pituitary neuroendocrine tumors (PitNETs) are generally benign, but a small subset may demonstrate aggressive behavior or ...
Meningioma with trabecular architecture: a harbinger of BAP1 deficiency
Meningioma with trabecular architecture: a harbinger of BAP1 deficiency
BRCA (BReast CAncer gene)-associated protein 1 (BAP1) is a tumor suppressor protein encoded by the BAP1 gene. BAP1 mutatio...
Diffuse midline glioma, H3K27-altered: a rare presentation with gliomatosis cerebri growth pattern and progression toward midline
Diffuse midline glioma, H3K27-altered: a rare presentation with gliomatosis cerebri growth pattern and progression toward midline
A limited number of cases involving non-midline lesions have been documented in diffuse midline glioma (DMG), H3K27-altere...
Ataxin-2 as a candidate blood biomarker for estimating disease status in cases of suspected glioblastoma recurrence
Ataxin-2 as a candidate blood biomarker for estimating disease status in cases of suspected glioblastoma recurrence
Differentiating pseudoprogression (PsP) from recurrence in cases of glioblastoma (GBM) after chemoradiotherapy is challeng...
Reappraisal of novel molecular parameters for meningioma grading by cIMPACT-NOW update 8 proposals
Reappraisal of novel molecular parameters for meningioma grading by cIMPACT-NOW update 8 proposals
Banan R, Abbetmeier-Basse M, Hong B, Dumitru CA, Sahm F, Nakamura M, Krauss JK, Hartmann C (2021) The prognostic significa...
Gyriform infiltration indicates tumor invasion burden of isocitrate dehydrogenase 1/2-wildtype gliomas
Gyriform infiltration indicates tumor invasion burden of isocitrate dehydrogenase 1/2-wildtype gliomas
Few robust radiological markers have been identified for predicting the molecular status of gliomas. Recently, gyriform in...
Primary sellar glomus tumor with mutation: an aggressive tumor of uncertain malignant potential
Primary sellar glomus tumor with mutation: an aggressive tumor of uncertain malignant potential
Glomus tumor (GT) is a mesenchymal neoplasm composed of modified perivascular cells exhibiting smooth muscle-like features...
Primary papillary epithelial tumor of the sella: a case report of an emerging tumor type
Primary papillary epithelial tumor of the sella: a case report of an emerging tumor type
Primary papillary epithelial tumor of the sella (PPETS) is a newly described tumor entity with prototypical location in th...
Pediatric diffuse glioma with EP300::BCOR fusion manifesting as low-grade epilepsy-associated neuroepithelial tumor: a case presentation
Pediatric diffuse glioma with EP300::BCOR fusion manifesting as low-grade epilepsy-associated neuroepithelial tumor: a case presentation
Wu Z, Rajan S, Chung HJ et al (2022) Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions. ...
Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma
Intratumoral heterogeneity of CDKN2A deletions in IDH-mutant astrocytoma
Broggi G, Barresi V (2023) Assessment of CDKN2A/B homozygous deletion in gliomas: to FISH or not to FISH? J Neuropathol Ex...
Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis
Clinical and radiological features of intracranial ancient schwannomas: a single-institution, retrospective analysis
Ancient schwannoma (AS) is a subtype of schwannoma characterized by slow progression despite degenerative changes in patho...
Status of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
Status of alternative angiogenic pathways in glioblastoma resected under and after bevacizumab treatment
Glioblastoma multiforme (GBM) acquires resistance to bevacizumab (Bev) treatment. Bev affects angiogenic factors other tha...
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma
Deletion of CDKN2A occurs in 50% of glioblastomas (GBM), and IFNA locus deletion in 25%. These genes reside closely on chr...
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
A rare case of primary central nervous system histiocytic sarcoma harboring a novel ARHGAP45::BRAF fusion: a case report and literature review
Patients with histiocytic sarcoma occurring in the central nervous system (CNS) are rare and have a very poor prognosis. T...
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology is useful for the intraoperative pathological diagnosis of PitNETs’ surgical margins
Touch imprint cytology (TIC) and frozen section (FS) procedures are essential for intraoperative pathological diagnosis (I...
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Intraventricular central neurocytoma molecularly defined as extraventricular neurocytoma: a case representing the discrepancy between clinicopathological and molecular classifications
Central neurocytoma (CN) is classically defined by its intraventricular location, neuronal/neurocytic differentiation, and...
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
To explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometr...
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype: case series of a new entity
Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (pHGG) is a rare and aggressive brain tumor charac...
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Spontaneous malignant transformation of trigeminal schwannoma: consideration of responsible gene alterations for tumorigenesis—a case report
Malignant peripheral nerve sheath tumors (MPNSTs) arising from the trigeminal nerves are extremely rare (only 45 cases, in...
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
A clinicopathological analysis of supratentorial ependymoma, ZFTA fusion-positive: utility of immunohistochemical detection of CDKN2A alterations and characteristics of the immune microenvironment
EPN-ZFTA is a rare brain tumor where prognostic factors remain unclear and no effective immunotherapy or chemotherapy is c...
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
α-SMA positive vascular mural cells suppress cyst formation in hemangioblastoma
Approximately 60% of hemangioblastomas (HBs) have peritumoral cysts adjacent to the tumor, which can cause neurological de...
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