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Carbon dots in oncology: multifunctional nanoplatforms for diagnosis, targeted therapy, and drug discovery

Alfonso Fernández-González is an associate professor at the University of Oviedo, specializing in analytical chemistry and...

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People analytics and organizational psychology: building a high-performance, innovative culture in the pharmaceutical industry

Pharmaceutical innovation is a sequentially vulnerable enterprise: discovery, development, and launch depend on a tightly ...

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Clinical Status and CNS Adverse Drug Report of Sphingosine-1-Phosphate Receptor Modulators in Multiple Sclerosis

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that synchronizes an extensive range of cellular responses throu...

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New Approach Methodologies in Drug Development

For decades, preclinical drug development has relied on animal testing as the regulatory gold standard. Yet nearly 90% of ...

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Nutrient-transporter-driven cytotoxic potential: an emerging nanotherapeutic approach

A multifaceted pathophysiological cascade associated with numerous genes, pathways and factors makes cancer a grave and so...

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Harnessing zebrafish as a model for photopharmacology: Insights into light-controlled biological effects of photoswitchable drugs

Available online 15 September 2025, 104477Author links open overlay panel, , , , , Highlights•Zebrafish embryos enable mic...

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Indole therapeutics: Latest FDA updates, ongoing trials, and future directions

Indole is a privileged structural motif in medicinal chemistry, known for its unique bicyclic fusion of benzene and pyrrol...

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Evolutionary hallmark-inspired identification of prognostic biomarkers and drug targets for cancers

Cancers are well-known as complex diseases with high incidence and mortality rates.1 Recently, evolutionary biomedicine ha...

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The Role of Data Monitoring Committees in drug research

Markus Hinder is professor at Fresenius University of Applied Sciences, mandated lecturer at the Faculty of Medicine at Un...

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What future for drug safety?

As the COVID-19 pandemic unfolded, the role of drug safety received new attention. As new vaccines entered the market and ...

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Determinants and implications of mobile health application acceptability in high-income countries: an assessment

mHealth technologies have become an integral part of healthcare delivery, supporting remote monitoring, disease management...

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Beyond purinergic signaling: Dual ligand approaches to multitarget drug discovery

For several years the ‘one-molecule, one-target’ paradigm dominated scientific research, and drug development was concentr...

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Shining light on liquid–liquid phase separation in chronic liver disease

Hui Tao holds the position of Associate Director of the Research Laboratory Center at the Second Affiliated Hospital of An...

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Global landscape and translational trajectories of flavonoid-based wound-healing research

Yafei Yang is a postdoctoral fellow at the Third Affiliated Hospital of Shenzhen University, focusing on tumor genomics an...

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Advances in the computational development of hepatitis B virus capsid assembly modulators

HBV is a hepatotropic, non-cytopathic DNA virus that generates a covalently closed circular DNA (cccDNA) intermediate in t...

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Quantum intelligence in drug discovery: Advancing insights with quantum machine learning

Drug discovery pipelines are often time-consuming, expensive, and challenging at each level of the workflow for validation...

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Recent advances in computational strategies for allosteric site prediction: Machine learning, molecular dynamics, and network-based approaches

Allosteric regulation, a fundamental mechanism controlling biomolecular activity, occurs when an effector binds to a site ...

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Advanced therapy medicinal products are coming of age: A pipeline analysis of the clinical trial landscape

Michiel Vanhaeren: Writing – original draft, Visualization, Validation, Investigation, Formal analysis. Rik Gijsbers: Writ...

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Commercialization of cell and gene therapy in Canada: Current landscape, challenges and opportunities

Cell and gene therapies (CGTs) offer transformative treatments for certain genetic diseases and cancers, with a growing nu...

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Addressing global regulatory challenges in rare disease drug development

Despite progress in rare disease treatment, many conditions still lack therapeutic options. In addition to specific legisl...

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Corrigendum to “A review of in vitro and in vivo methods and their correlations to assess mouthfeel of solid oral dosage forms” [Drug Discov. Today 26(3) (2021) 740–753]