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Evolution and function of chromatin domains across the tree of life
Evolution and function of chromatin domains across the tree of life
The genome of all organisms is spatially organized to function efficiently. The advent of genome-wide chromatin conformati...
Diverse anti-NMDAR autoantibodies from individuals with encephalitis
Diverse anti-NMDAR autoantibodies from individuals with encephalitis
Autoantibodies targeting glutamatergic N-methyl-d-aspartic acid receptors (NMDARs) are found in people with anti-NMDAR enc...
A lesson in symmetry
A lesson in symmetry
Duarte, J. M., Dutta, S., Goodsell, D. S. & Burley, S. K. Emerg. Top. Life Sci. 6, 231–243 (2022).Article  CAS  ...
Looking back at the timely launch of Nature Structural Biology in 1994
Structural biology has continued to advance over the past decades, owing to the development of improved and new technologi...
Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism
Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism
The CorA/Mrs2 family of pentameric proteins are cardinal for the influx of Mg2+ across cellular membranes, importing the c...
Structure and function of the human mitochondrial MRS2 channel
Structure and function of the human mitochondrial MRS2 channel
The human mitochondrial RNA splicing 2 protein (MRS2) has been implicated in Mg2+ transport across mitochondrial inner mem...
Supporting structural biologists in Africa requires resources and capacity building
E.N. is funded by the Wellcome Trust (grant number 222999/Z/21/Z) and is a recipient of the Google award for “Support for ...
The ribosome termination complex remodels release factor RF3 and ejects GDP
The ribosome termination complex remodels release factor RF3 and ejects GDP
Translation termination involves release factors RF1, RF2 and the GTPase RF3 that recycles RF1 and RF2 from the ribosome. ...
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) have a major role in the physiology of eukaryotic cell...
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells
Cell size is tightly controlled in healthy tissues and single-celled organisms, but it remains unclear how cell size influ...
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Tumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either pro...
Poised PABP–RNA hubs implement signal-dependent mRNA decay in development
Poised PABP–RNA hubs implement signal-dependent mRNA decay in development
Signaling pathways drive cell fate transitions largely by changing gene expression. However, the mechanisms for rapid and ...
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies
This work has been funded by the Vagelos Scholars Program in the Molecular Life Sciences grant at the University of Pennsy...
The cyanobacterial protein VIPP1 forms ESCRT-III-like structures on lipid bilayers
The cyanobacterial protein VIPP1 forms ESCRT-III-like structures on lipid bilayers
The biogenesis and maintenance of thylakoid membranes require vesicle-inducing protein in plastids 1 (VIPP1). VIPP1 is a m...
Identifying nature’s smallest fractals
Identifying nature’s smallest fractals
Snowflakes, seashells and Romanesco broccoli are striking examples of fractal geometries in nature. A recent study publish...
A personal perspective of the voltage-gated potassium channel studies
The identification of sodium and potassium currents as underlying action potential propagation, more than 70 years ago, op...
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
Cryo-electron microscopy of brain tissue from two individuals with Down syndrome showed amyloid-β (Aβ) and tau f...
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS a...
Shifting our perspective on orphan G protein-coupled receptors
G protein-coupled receptors (GPCRs) with no known endogenous ligand are termed orphans. Deorphanization of a GPCR involves...
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-k...
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-a...
SCAF1 drives the compositional diversity of mammalian respirasomes
SCAF1 drives the compositional diversity of mammalian respirasomes
Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their ro...
Author Correction: Structural basis for partial agonism in 5-HT3A receptors
Author notesThese authors contributed equally: Madeleine Stauffer, Leslie Salas-Estrada.Authors and AffiliationsDepartment...
Structural insights into the iron nitrogenase complex
Structural insights into the iron nitrogenase complex
Nitrogenases are best known for catalyzing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently...
Structural organization of the retriever–CCC endosomal recycling complex
Structural organization of the retriever–CCC endosomal recycling complex
The recycling of membrane proteins from endosomes to the cell surface is vital for cell signaling and survival. Retriever,...
Rational optimization of a transcription factor activation domain inhibitor
Rational optimization of a transcription factor activation domain inhibitor
Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable̵...
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineag...
Transient protein folding in condensates reveals ways to target disordered oncoproteins
Transient protein folding in condensates reveals ways to target disordered oncoproteins
The androgen receptor forms nuclear condensates associated with gene transcription. Investigating the molecular basis of c...
Structural basis of branching during RNA splicing
Structural basis of branching during RNA splicing
Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome stru...
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose ...
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