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The ribosome termination complex remodels release factor RF3 and ejects GDP
The ribosome termination complex remodels release factor RF3 and ejects GDP
Translation termination involves release factors RF1, RF2 and the GTPase RF3 that recycles RF1 and RF2 from the ribosome. ...
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) have a major role in the physiology of eukaryotic cell...
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells
Cell size is tightly controlled in healthy tissues and single-celled organisms, but it remains unclear how cell size influ...
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
Tumor-suppressor let-7 pre-microRNAs (miRNAs) are regulated by terminal uridylyltransferases TUT7 and TUT4 that either pro...
Poised PABP–RNA hubs implement signal-dependent mRNA decay in development
Poised PABP–RNA hubs implement signal-dependent mRNA decay in development
Signaling pathways drive cell fate transitions largely by changing gene expression. However, the mechanisms for rapid and ...
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies
This work has been funded by the Vagelos Scholars Program in the Molecular Life Sciences grant at the University of Pennsy...
The cyanobacterial protein VIPP1 forms ESCRT-III-like structures on lipid bilayers
The cyanobacterial protein VIPP1 forms ESCRT-III-like structures on lipid bilayers
The biogenesis and maintenance of thylakoid membranes require vesicle-inducing protein in plastids 1 (VIPP1). VIPP1 is a m...
Identifying nature’s smallest fractals
Identifying nature’s smallest fractals
Snowflakes, seashells and Romanesco broccoli are striking examples of fractal geometries in nature. A recent study publish...
A personal perspective of the voltage-gated potassium channel studies
The identification of sodium and potassium currents as underlying action potential propagation, more than 70 years ago, op...
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
Cryo-electron microscopy of brain tissue from two individuals with Down syndrome showed amyloid-β (Aβ) and tau f...
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS a...
Shifting our perspective on orphan G protein-coupled receptors
G protein-coupled receptors (GPCRs) with no known endogenous ligand are termed orphans. Deorphanization of a GPCR involves...
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-k...
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-a...
SCAF1 drives the compositional diversity of mammalian respirasomes
SCAF1 drives the compositional diversity of mammalian respirasomes
Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their ro...
Author Correction: Structural basis for partial agonism in 5-HT3A receptors
Author notesThese authors contributed equally: Madeleine Stauffer, Leslie Salas-Estrada.Authors and AffiliationsDepartment...
Structural insights into the iron nitrogenase complex
Structural insights into the iron nitrogenase complex
Nitrogenases are best known for catalyzing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently...
Structural organization of the retriever–CCC endosomal recycling complex
Structural organization of the retriever–CCC endosomal recycling complex
The recycling of membrane proteins from endosomes to the cell surface is vital for cell signaling and survival. Retriever,...
Rational optimization of a transcription factor activation domain inhibitor
Rational optimization of a transcription factor activation domain inhibitor
Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable̵...
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineag...
Transient protein folding in condensates reveals ways to target disordered oncoproteins
Transient protein folding in condensates reveals ways to target disordered oncoproteins
The androgen receptor forms nuclear condensates associated with gene transcription. Investigating the molecular basis of c...
Structural basis of branching during RNA splicing
Structural basis of branching during RNA splicing
Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome stru...
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose ...
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
Atg8, a ubiquitin-like protein, is conjugated with phosphatidylethanolamine (PE) via Atg7 (E1), Atg3 (E2) and Atg12–...
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a...
Author Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search
Author notesThese authors contributed equally: Judith Miné-Hattab, Marie Villemeur.Authors and AffiliationsInstitut Curie,...
AGO2 localizes to the nucleus in quiescence and represses transposon expression
AGO2 localizes to the nucleus in quiescence and represses transposon expression
An Ago2HA/HA mouse model combined with super-resolution microscopy, molecular and biochemical assays allowed us to stringe...
POLQ to the rescue for double-strand break repair during mitosis
POLQ to the rescue for double-strand break repair during mitosis
DNA polymerase θ (POLQ) repairs mitotic DNA breaks; this requires RHINO and PLK1, averts genomic instability and may ...
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism
Global changes in transcriptional regulation and RNA metabolism are crucial features of cancer development. However, littl...
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior
We describe how transcription start site (TSS) choice of thousands of genes results in transcript isoforms with potential ...
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