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A personal perspective of the voltage-gated potassium channel studies
The identification of sodium and potassium currents as underlying action potential propagation, more than 70 years ago, op...
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome
Cryo-electron microscopy of brain tissue from two individuals with Down syndrome showed amyloid-β (Aβ) and tau f...
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome
Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS a...
Shifting our perspective on orphan G protein-coupled receptors
G protein-coupled receptors (GPCRs) with no known endogenous ligand are termed orphans. Deorphanization of a GPCR involves...
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-k...
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-a...
SCAF1 drives the compositional diversity of mammalian respirasomes
SCAF1 drives the compositional diversity of mammalian respirasomes
Supercomplexes of the respiratory chain are established constituents of the oxidative phosphorylation system, but their ro...
Author Correction: Structural basis for partial agonism in 5-HT3A receptors
Author notesThese authors contributed equally: Madeleine Stauffer, Leslie Salas-Estrada.Authors and AffiliationsDepartment...
Structural insights into the iron nitrogenase complex
Structural insights into the iron nitrogenase complex
Nitrogenases are best known for catalyzing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently...
Structural organization of the retriever–CCC endosomal recycling complex
Structural organization of the retriever–CCC endosomal recycling complex
The recycling of membrane proteins from endosomes to the cell surface is vital for cell signaling and survival. Retriever,...
Rational optimization of a transcription factor activation domain inhibitor
Rational optimization of a transcription factor activation domain inhibitor
Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable̵...
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
3D Enhancer–promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineag...
Transient protein folding in condensates reveals ways to target disordered oncoproteins
Transient protein folding in condensates reveals ways to target disordered oncoproteins
The androgen receptor forms nuclear condensates associated with gene transcription. Investigating the molecular basis of c...
Structural basis of branching during RNA splicing
Structural basis of branching during RNA splicing
Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome stru...
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose ...
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping
Atg8, a ubiquitin-like protein, is conjugated with phosphatidylethanolamine (PE) via Atg7 (E1), Atg3 (E2) and Atg12–...
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a...
Author Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search
Author notesThese authors contributed equally: Judith Miné-Hattab, Marie Villemeur.Authors and AffiliationsInstitut Curie,...
AGO2 localizes to the nucleus in quiescence and represses transposon expression
AGO2 localizes to the nucleus in quiescence and represses transposon expression
An Ago2HA/HA mouse model combined with super-resolution microscopy, molecular and biochemical assays allowed us to stringe...
POLQ to the rescue for double-strand break repair during mitosis
POLQ to the rescue for double-strand break repair during mitosis
DNA polymerase θ (POLQ) repairs mitotic DNA breaks; this requires RHINO and PLK1, averts genomic instability and may ...
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism
Global changes in transcriptional regulation and RNA metabolism are crucial features of cancer development. However, littl...
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior
We describe how transcription start site (TSS) choice of thousands of genes results in transcript isoforms with potential ...
Multidomain interactions and ring opening of the p97 ATPase by the UBXD1 adapter
Multidomain interactions and ring opening of the p97 ATPase by the UBXD1 adapter
The human ATPase p97 (also known as VCP) unfolds protein substrates by translocating them through its central channel. Thi...
AGO2 silences mobile transposons in the nucleus of quiescent cells
AGO2 silences mobile transposons in the nucleus of quiescent cells
Argonaute 2 (AGO2) is a cytoplasmic component of the miRNA pathway, with essential roles in development and disease. Yet l...
MOF acetylates COX17 to preserve functional mitochondria: a KAT with two lives
MOF acetylates COX17 to preserve functional mitochondria: a KAT with two lives
Writing in Nature Metabolism, Guhathakurta et al. provide pertinent functional and mechanistic insight about this elusive ...
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ p...
The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions
The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions
p97, also known as valosin-containing protein, is an essential cytosolic AAA+ (ATPases associated with diverse cellular ac...
FSP1 inhibition: pick your pocket
FSP1 inhibition: pick your pocket
Ferroptosis suppressor protein 1 (FSP1, or AIFM2), an NADPH quinone reductase noted to protect cancer cells from ferroptos...
OAT1 structures reveal insights into drug transport in the kidney
OAT1 structures reveal insights into drug transport in the kidney
OAT1 has a fundamental role in the kidney by facilitating the urinary excretion of various drugs and endogenous metabolite...
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation
A translating ribosome is typically thought to follow the reading frame defined by the selected start codon. Using super-r...
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