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In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with Down syndrome
In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with Down syndrome
Down syndrome (DS, Trisomy 21) is the most common chromosomal disorder in humans, affecting 1 in 700 newborns in the Unite...
TGF-β2-induced alterations of m6A methylation in hTERT RPE-1 cells
TGF-β2-induced alterations of m6A methylation in hTERT RPE-1 cells
N6-methyladenosine (m6A) is a methylation modification of the nitrogen atom at position 6 of adenine, which is widely foun...
Allele-specific antisense oligonucleotides for the treatment of BEST1-related dominantly inherited retinal diseases: An in vitro model
Allele-specific antisense oligonucleotides for the treatment of BEST1-related dominantly inherited retinal diseases: An in vitro model
The utility of gene therapy has increased greatly in recent years and is critical to the implementation of personalized tr...
Detection of retinal dysfunction induced by HCN channel inhibitors using multistep light stimulus and long-duration light stimulus ERG in rats
Detection of retinal dysfunction induced by HCN channel inhibitors using multistep light stimulus and long-duration light stimulus ERG in rats
Ivabradine, a hyperpolarization-activated cyclic nucleotide–gated (HCN) channel inhibitor used as a therapeutic agent for ...
Therapeutic effect and mechanism of action of pterostilbene nano drugs in dry eye models
Therapeutic effect and mechanism of action of pterostilbene nano drugs in dry eye models
Dry eye disease is a multifactorial dysfunction of the tear film and ocular surface, with etiology involving inflammation ...
Isolation and characterization of rabbit limbal niche cells
Isolation and characterization of rabbit limbal niche cells
Limbal niche cells (LNCs) are one of the most important supporting cells for corneal epithelial stem cells (CES), however,...
Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia
Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia
Myopia has become a public health issue globally and is a leading cause of blindness in East Asia district, where the prev...
CircSTRBP contributes to H2O2-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1
CircSTRBP contributes to H2O2-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1
Age-related cataract (ARC) is one of the leading causes of blindness and distance vision impairment (Liu et al., 2017; Asb...
Causal associations of refractive error and early age-related macular degeneration: A Mendelian randomization study
Causal associations of refractive error and early age-related macular degeneration: A Mendelian randomization study
Age-related macular degeneration (AMD) constitutes a degenerative condition impacting the macula, resulting in the gradual...
Oleic acid induces lipogenesis and NLRP3 inflammasome activation in organotypic mouse meibomian gland and human meibomian gland epithelial cells
Oleic acid induces lipogenesis and NLRP3 inflammasome activation in organotypic mouse meibomian gland and human meibomian gland epithelial cells
The meibomian gland (MG) is a modified functional sebaceous gland (SG) anatomically arranged within the tarsal plates of t...
Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation
Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation
Mucosal chemokines have antimicrobial properties and play an important role in mucosal immunity. However, little is known ...
Stop codon variant in EFEMP1 is associated with primary open-angle glaucoma due to impaired regulation of aqueous humor outflow
Stop codon variant in EFEMP1 is associated with primary open-angle glaucoma due to impaired regulation of aqueous humor outflow
Primary open angle glaucoma (POAG), the most prevalent subtype of glaucoma, is considered as a lifelong disease involving ...
Modeling autosomal dominant retinitis pigmentosa by using patient-specific retinal organoids with a class-3 RHO mutation
Modeling autosomal dominant retinitis pigmentosa by using patient-specific retinal organoids with a class-3 RHO mutation
Retinitis pigmentosa (RP) is a group of hereditary retinal degenerative diseases in which patients typically lose night vi...
Optical development in the murine eye lens of accelerated senescence-prone SAMP8 and senescence-resistant SAMR1 strains
Optical development in the murine eye lens of accelerated senescence-prone SAMP8 and senescence-resistant SAMR1 strains
The eye lens is a transparent optical structure the major function of which is to focus light onto the retina. The lens co...
Targeting mechanics-induced trabecular meshwork dysfunction through YAP-TGFβ Ameliorates high myopia-induced ocular hypertension
Targeting mechanics-induced trabecular meshwork dysfunction through YAP-TGFβ Ameliorates high myopia-induced ocular hypertension
Glaucoma is a chronic, irreversible, and degenerative form of optic neuropathy (Gao et al., 2018). According to epidemiolo...
A minimally invasive method for diagnosing diseases of the eye
A minimally invasive method for diagnosing diseases of the eye
Vera B. Morhenn: Writing – original draft, Project administration, Methodology, Conceptualization. Jonathan N. Mansbridge:...
Influence of the calcium voltage-gated channel auxiliary subunit (CACNA2D1) absence on intraocular pressure in mice
Influence of the calcium voltage-gated channel auxiliary subunit (CACNA2D1) absence on intraocular pressure in mice
The etiology of elevated intraocular pressure (IOP), a major risk factor for glaucoma (optic nerve atrophy), is poorly und...
Intraocular pressure across the lifespan of Tg-MYOCY437H mice
Intraocular pressure across the lifespan of Tg-MYOCY437H mice
Transgenic C57BL/6 mice expressing human myocilinY437 (Tg-MYOCY437H) are a well-established model for primary open-angle g...
Extracellular vesicle biomarkers in ocular fluids associated with ophthalmic diseases
Extracellular vesicle biomarkers in ocular fluids associated with ophthalmic diseases
Extracellular vesicles (EVs) are released as highly stable lipid bilayer particles carrying proteins, lipids, glycans and ...
Drp1-dependent mitochondrial fragmentation mediates photoreceptor abnormalities in type 1 diabetic retina
Drp1-dependent mitochondrial fragmentation mediates photoreceptor abnormalities in type 1 diabetic retina
In 2019, 463 million adults globally grappled with diabetes, as reported by the International Diabetes Federation (Saeedi ...
An enhanced model for environmental dry eye: Exploring pathological features and underlying factors
An enhanced model for environmental dry eye: Exploring pathological features and underlying factors
Dry eye is a prevalent ocular surface disease that significantly affects visual acuity and quality of life, with hundreds ...
The role of the JAK/STAT3 signaling pathway in acquired corneal diseases
The role of the JAK/STAT3 signaling pathway in acquired corneal diseases
The health of the cornea has always been of great concern in the field of ophthalmology. The cornea is a transparent fibro...
Verteporfin regulates corneal neovascularization through inhibition of YAP protein activation
Verteporfin regulates corneal neovascularization through inhibition of YAP protein activation
As a transparent and avascular tissue, cornea is one of the most important refractive structures of the eye. At present, a...
Impact of a 50bp insertion/deletion polymorphism of the superoxide dismutase-1 on oxidative stress status and risk of keratoconus
Impact of a 50bp insertion/deletion polymorphism of the superoxide dismutase-1 on oxidative stress status and risk of keratoconus
Keratoconus (KC), as the most common corneal ectasia, is a significant clinical issue, affecting individuals worldwide. It...
Visualization of choroidal vasculature in pigmented mouse eyes from experimental models of AMD
Visualization of choroidal vasculature in pigmented mouse eyes from experimental models of AMD
There is increasing evidence that alterations in the choroidal vasculature play a key role in the early pathogenesis of ag...
Trolox aids coenzyme Q10 in neuroprotection against NMDA induced damage via upregulation of VEGF in rat model of glutamate excitotoxicity
Trolox aids coenzyme Q10 in neuroprotection against NMDA induced damage via upregulation of VEGF in rat model of glutamate excitotoxicity
Due to excess in glutamate levels, overstimulation of the glutamate receptors occurs and causes toxicity to retinal neuron...
Short peptides derived from pigment epithelium-derived factor attenuate retinal ischemia reperfusion injury through inhibition of apoptosis and inflammatory response in rats
Short peptides derived from pigment epithelium-derived factor attenuate retinal ischemia reperfusion injury through inhibition of apoptosis and inflammatory response in rats
Ischemia reperfusion (IR) injury is usually induced by high intraocular pressure (IOP) and is a pathological hallmark asso...
Reduction of lens size in PAX6-related aniridia
Reduction of lens size in PAX6-related aniridia
Heterozygous mutation of PAX6 in humans leads to congenital aniridia (OMIM 106210) which is typified by congenital iris an...
Inhibition of Rho kinase (ROCK) impairs cytoskeletal contractility in human Müller glial cells without effects on cell viability, migration, and extracellular matrix production
Inhibition of Rho kinase (ROCK) impairs cytoskeletal contractility in human Müller glial cells without effects on cell viability, migration, and extracellular matrix production
The epiretinal membrane is a common pathological condition characterized by the formation of fibrocontractile tissue at th...
Mouse model of radiation retinopathy reveals vascular and neuronal injury
Mouse model of radiation retinopathy reveals vascular and neuronal injury
Brachytherapy using episcleral 125I seed-filled plaques is the standard treatment for uveal melanoma, the most common prim...
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