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Boosting effect of high-dose influenza vaccination on innate immunity among elderly
Clinical Research and Public HealthImmunologyVaccines Open Access | 10.1172/jci.insight.184128 ...
A toxic gain-of-function variant in MAPK8IP3 provides insights into JIP3 cellular roles
MT-JIP3 induces JNK signaling–dependent apoptosis in HeLa cells, reducing cell growth, and JIP4 interacts with JIP3. Sinc...
Investigation of a mouse model of Prader-Willi Syndrome with combined disruption of Necdin and Magel2
Research ArticleGeneticsNeuroscience Open Access | 10.1172/jci.insight.185159 Pierre-Yves Bar...
Tape strip expression profiling of juvenile dermatomyositis skin reveals mitochondrial dysfunction contributing to disease endotype
JDM cohort clinical characteristics at enrollment visit. There were 28 JDM and 20 healthy control (CTL) patients in this ...
Development and characterization of an Sf-1-Flp mouse model
Research ArticleMetabolismNeuroscience Open Access | 10.1172/jci.insight.190105 Marco Galvan,...
Testosterone affects female CD4+ T cells in healthy individuals and autoimmune liver diseases
Research ArticleHepatologyImmunology Open Access | 10.1172/jci.insight.184544 Lara Henze,1 ...
In vitro fertilization induces reproductive changes in male mouse offspring and has multigenerational effects
Effects of IVF on testis weight and histology. To ascertain whether IVF could influence male reproductive function, we fi...
Apremilast reduces co-occurring alcohol drinking and mechanical allodynia and regulates central amygdala GABAergic transmission
Research ArticleNeurosciencePublic Health Open Access | 10.1172/jci.insight.189732 Valentina ...
Anoctamin-5 deficiency enhances ATG9A-dependent autophagy, inducing osteogenesis and gnathodiaphyseal dysplasia–like bone formation
Autophagic flux is promoted by the absence of Ano5 in mCOBs. To investigate whether autophagic activity is implicated in ...
MSC transplantation ameliorates depression in lupus by suppressing Th1 cell–shaped synaptic stripping
Research ArticleInflammationNeuroscience Open Access | 10.1172/jci.insight.181885 Xiaojuan Ha...
Metabolic and transcriptional effects of bazedoxifene/conjugated estrogens in a model of obesity-associated breast cancer risk
Research ArticleMetabolismOncology Open Access | 10.1172/jci.insight.182694 Erin D. Giles,1,2...
Rapamycin immunomodulation utilizes time-dependent alterations of lymph node architecture, leukocyte trafficking, and gut microbiome
Rapamycin reduces lymphocytes in LNs and spleen. To investigate the immunological effects of rapamycin within secondary l...
Reshaping the chromatin landscape in HUVECs from small-for-gestational-age newborns
Research ArticleAngiogenesisCardiology Open Access | 10.1172/jci.insight.186812 Lingling Yan,...
Chronic pancreatitis in T7C140S mice with misfolding cationic trypsinogen mutant
Hereditary chronic pancreatitis (CP) is caused by risk alleles that increase the intrapancreatic activation of the digest...
Glycine receptor activation promotes pancreatic islet cell proliferation via the PI3K/mTORC1/p70S6K pathway
Research ArticleEndocrinology Open Access | 10.1172/jci.insight.178754 Ziyi Zhang,1,2 Wen...
A small molecule PKCε inhibitor reduces hyperalgesia induced by paclitaxel or opioid withdrawal
Characterization of the PKCε inhibitor CP612. We developed an efficient enantioselective synthesis and carried out struct...
The ACTH test fails to diagnose adrenal insufficiency and augments cytokine production in sepsis
The ACTH test fails to correctly identify adrenal insufficiency in early/acute and middle/subacute stages of sepsis. Firs...
CD8+ TEMRAs in severe asthma associate with asthma symptom duration and escape proliferation arrest
Research ArticleImmunologyPulmonology Open Access | 10.1172/jci.insight.185061 Richard P. Ram...
Vitamin A treatment restores vision failures arising from Leber’s hereditary optic neuropathy–linked mtDNA mutation
scRNA-Seq reveals changes in retinal composition and transcriptional profiles. To investigate the impact of the ND6 mutat...
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation
Research ArticleAgingImmunology Open Access | 10.1172/jci.insight.187271 Cody S. Nelson,1,2 ...
Primary intraosseous Rosai-Dorfman disease: Clinicopathological features and an assessment of a possible relationship with IgG4-related disease
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A new histomorphological finding in the follow-up of celiac disease: Intraepithelial lymphocyte localization is a reliable indicator of dietary compliance
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Gamna-Gandy bodies in renal neoplasms: A multi-institutional clinicopathologic study of 350 consecutive nephrectomies
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Morphologic and immunohistochemical characterization of small and large duct cholangiocarcinomas in a Western cohort: A panel of pCEA, CRP, N-cadherin, and albumin in situ hybridization aids in subclassification
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Assessing the predictive value of Ki-67 and progesterone receptor algorithms for recurrence and disease-free survival in meningiomas
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GPNMB expression differentiates subependymal giant cell astrocytoma from other mimickers
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Clinicopathological and prognostic significance of stromal p16 and p53 expression in oral squamous cell carcinoma
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Digital image analysis of tumour pattern and histological models for prognostic evaluation of invasive non-mucinous adenocarcinoma of the lung
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Utility of the manual hematology cell counter for Ki-67 assessment in gastrointestinal and pancreatobiliary well-differentiated neuroendocrine tumors
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Salivary gland-like low-grade clear cell carcinomas of the thoracic cavity: A clinical, immunohistochemical, and molecular analysis of three cases
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