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My approach to assessing for colorectal polyp cancer
My approach to assessing for colorectal polyp cancer
Assessing a locally excised colorectal adenoma for malignancy is a common but often challenging scenario. This article out...
Systematic literature review of published cases of reactive plasmacytosis in peripheral blood and bone marrow
Systematic literature review of published cases of reactive plasmacytosis in peripheral blood and bone marrow
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Intraductal carcinoma of the prostate: conflicting recommendations confuse clinicians
Intraductal carcinoma of the prostate: conflicting recommendations confuse clinicians
Intraductal carcinoma of the prostate (IDCP) generally represents a growth pattern of invasive aggressive acinar prostate ...
The highs and lows of grading intraductal carcinoma of the prostate
The highs and lows of grading intraductal carcinoma of the prostate
Accurate histological diagnosis and grading are essential for appropriate management of prostate cancer (PCa), yet there r...
Low interobserver agreement among subspecialised breast pathologists in evaluating HER2-low breast cancer
Low interobserver agreement among subspecialised breast pathologists in evaluating HER2-low breast cancer
IntroductionInvasive breast carcinomas with amplification of human epidermal growth factor receptor 2 (ERBB2) gene or over...
SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
WHAT IS ALREADY KNOWN ON THIS TOPICRecent studies have highlighted the effectiveness of epidermal growth factor receptor (...
Tumour-infiltrating lymphocyte subsets and their individual prognostic impact in oral squamous cell carcinoma
Tumour-infiltrating lymphocyte subsets and their individual prognostic impact in oral squamous cell carcinoma
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Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists
Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists
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Idiopathic granulomatous mastitis: a 5-year retrospective review of cases in a tertiary centre in Dublin, Ireland
Idiopathic granulomatous mastitis: a 5-year retrospective review of cases in a tertiary centre in Dublin, Ireland
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Performance evaluation of a CRISPR Cas9-based selective exponential amplification assay for the detection of KRAS mutations in plasma of patients with advanced pancreatic cancer
Performance evaluation of a CRISPR Cas9-based selective exponential amplification assay for the detection of KRAS mutations in plasma of patients with advanced pancreatic cancer
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Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays
Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays
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Rosai-Dorfman Disease of pancreas: rare aetiology mimicking malignancy
Rosai-Dorfman Disease of pancreas: rare aetiology mimicking malignancy
Rosai-Dorfman disease (RDD) is a non-Langerhans cell histiocytosis which usually presents as painless lymphadenopathy. Ext...
What motivates SARS-CoV-2 vaccine trial participants? A pre- and post-participation survey study
What motivates SARS-CoV-2 vaccine trial participants? A pre- and post-participation survey study
Scientific advancement, including the testing and licensing of new drugs, relies heavily on clinical trials with healthy i...
Implementing palliative care in hepatocellular carcinoma ambulatory clinics—study protocol for Accelerated translational research in PRImary liver CAncer (APRICA) randomised controlled palliative care trial
Implementing palliative care in hepatocellular carcinoma ambulatory clinics—study protocol for Accelerated translational research in PRImary liver CAncer (APRICA) randomised controlled palliative care trial
Integration of symptom and palliative care for people with advanced cancer is established in many tumour types, but its ro...
The intelligent diabetes telemonitoring using decision support to treat patients on insulin therapy (DiaTRUST) trial: study protocol for a randomized controlled trial
The intelligent diabetes telemonitoring using decision support to treat patients on insulin therapy (DiaTRUST) trial: study protocol for a randomized controlled trial
Diabetes affects 10.5% of adults globally, with type 2 diabetes accounting for 90–95% of cases. Achieving optimal gl...
The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo
Research ArticleInfectious disease Open Access | 10.1172/jci.insight.181309 Arne Echterhof,1,...
The STAT3/SETDB2 axis dictates NF-κB–mediated inflammation in macrophages during wound repair
Research ArticleInflammation Open Access | 10.1172/jci.insight.179017 Kevin D. Mangum,1,2 ...
CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer
IACS-70654 inhibited the growth of neutrophil-enriched syngeneic mammary tumor models. To examine the effects of CBP/P300...
Epstein-Barr virus infection induces tissue-resident memory T cells in mucosal lymphoid tissues
Sex as a biological variable. For all experiments, animals (described below) were distributed into different experimental...
Development of a humanized mouse model with functional human materno-fetal interface immunity
Establishment of a pregnant HIS mouse model. We first examined whether Thy/HSC HIS mice generated using the conventional ...
Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.179525 Ruth D. Azaria,1 Ad...
CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to skin in lichen planus
Immune cell landscape in LP skin consists predominantly of CD8+ T cells. We collected 4-millimeter skin biopsies from les...
Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species
Research ArticleCardiologyMetabolism Open Access | 10.1172/jci.insight.184940 Le Phuong Nguye...
Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation
General composition of the breastmilk T cell compartment throughout lactation. Live T cells were present in human breastm...
Targeted long-read sequencing enriches disease-relevant genomic regions of interest to provide complete Mendelian disease diagnostics
Research ArticleGeneticsOphthalmology Open Access | 10.1172/jci.insight.183902 Kenji Nakamich...
Quantitative proteomics of patient fibroblasts reveal biomarkers and diagnostic signatures of mitochondrial disease
Clinical MedicineMetabolism Open Access | 10.1172/jci.insight.178645 Sandrina P. Correia,1,2 ...
Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy
Spontaneous seizures and seizure-induced death in mice with selective expression of mutant Nav1.6 in PV interneurons. We ...
Characterization of SMA type II skeletal muscle from treated patients shows OXPHOS deficiency and denervation
Type II SMA muscle has similar levels of SMN RNA and protein to those of scoliotic controls. To characterize the muscle o...
Antibody levels versus vaccination status in the outcome of older adults with COVID-19
Participants. During the period spanning from August 1, 2021, and April 10, 2022, a total of 1,254 hospitalized patients ...
GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension
Sex as a biological variable. Our study examined male and female animals, as well as lung tissue samples from both male a...
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