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New latency-promoting agents for a block-and-lock functional cure strategy
New latency-promoting agents for a block-and-lock functional cure strategy
Purpose of review Currently, HIV-infected patients are treated with antiretroviral therapy. Howev
“Block and lock” viral integration sites in persons with drug-free control of HIV-1 infection
“Block and lock” viral integration sites in persons with drug-free control of HIV-1 infection
Purpose of review Elite controllers (ECs) and Posttreatment controllers (PTCs) represent a small
Harnessing natural killer cells to target HIV-1 persistence
Harnessing natural killer cells to target HIV-1 persistence
Purpose of review The purpose of this article is to review recent advances in the role of natural
Strategies to target the central nervous system HIV reservoir
Strategies to target the central nervous system HIV reservoir
Purpose of the review The central nervous system (CNS) is an hotspot for HIV persistence and may
What's in a cure: designing a broad-spectrum HIV gene therapy
What's in a cure: designing a broad-spectrum HIV gene therapy
Purpose of review The leading gene editing strategy for a human immunodeficiency virus type 1 (HI
The multifaceted nature of HIV tissue reservoirs
The multifaceted nature of HIV tissue reservoirs
Purpose of review To underline the complexity and the heterogeneity of the HIV reservoir. Recen
The sounds of silencing: dynamic epigenetic control of HIV latency
The sounds of silencing: dynamic epigenetic control of HIV latency
Purpose of review This review highlights advances in understanding the epigenetic control mechani
Persistent HIV-1 transcription during ART: time to reassess its significance?
Persistent HIV-1 transcription during ART: time to reassess its significance?
Purpose of review Despite suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and
Humanized mice for studying HIV latency and potentially its eradication
Humanized mice for studying HIV latency and potentially its eradication
Purpose of the review The quest for an HIV cure faces a formidable challenge: the persistent pres
EDITORIAL: Putting HIV in the big sleep with the block-and-lock strategy
EDITORIAL: Putting HIV in the big sleep with the block-and-lock strategy
Molecular Virology and Gene Therapy, KU Leuven, Leuven, Flanders, Belgium Correspondence to Zeger Debyser, KU...
Obesity among women with HIV
Obesity among women with HIV
Purpose of review With the introduction of novel and more potent antiretroviral therapies (ART),
Epidemiology of obesity among people with HIV
Epidemiology of obesity among people with HIV
Purpose of review People with HIV (PWH) on antiretroviral therapy (ART) globally are disproportio
Intersections between HIV and obesity in emerging economies
Intersections between HIV and obesity in emerging economies
Purpose of review HIV epidemics are increasing in many emerging economy countries, whilst the ver
The pathogenesis of obesity in people living with HIV
The pathogenesis of obesity in people living with HIV
Purpose of review The public health challenge of overweight and obesity increasingly affects peop
Recent data on the role of antiretroviral therapy in weight gain and obesity in persons living with HIV
Recent data on the role of antiretroviral therapy in weight gain and obesity in persons living with HIV
Purpose of review Antiretroviral therapy (ART) has long been implicated in fat alterations and we
Clinical consequences of weight gain during treatment for HIV infection
Clinical consequences of weight gain during treatment for HIV infection
Purpose of review The introduction of dolutegravir, an oral integrase inhibitor, within public he
Anticipating HIV viral escape – resistance to active and passive immunization
Anticipating HIV viral escape – resistance to active and passive immunization
Purpose Active and passive immunization strategies are challenged by the extraordinary diversity
‘Immunization during ART and ATI for HIV-1 vaccine discovery/development’
‘Immunization during ART and ATI for HIV-1 vaccine discovery/development’
Purpose of review Explore whether immunization with germline-targeting Env immunogens during ART,
Accelerating HIV vaccine development through meaningful engagement of local scientists and communities
Accelerating HIV vaccine development through meaningful engagement of local scientists and communities
Purpose of review There is a need to conduct multiple experimental medicine trials in regions wit
Guiding HIV-1 vaccine development with preclinical nonhuman primate research
Guiding HIV-1 vaccine development with preclinical nonhuman primate research
Purpose of the review Nonhuman primates (NHPs) are seen as the closest animal model to humans in
Control groups for HIV prevention efficacy trials: what does the future hold?
Control groups for HIV prevention efficacy trials: what does the future hold?
Purpose of review Ending the HIV epidemic will require the development of additional effective im
Discovery medicine – the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine
Discovery medicine – the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine
Purpose of review In the past two decades, there has been an explosion in the discovery of HIV-1
Targeting enhanced neutralizing antibody responses via increased germinal center activity: early-phase vaccine trials with novel clinical designs
Targeting enhanced neutralizing antibody responses via increased germinal center activity: early-phase vaccine trials with novel clinical designs
Purpose of review Recent advances in the understanding of the difficult immunologic requirements
Generating and measuring effective vaccine-elicited HIV-specific CD8+ T cell responses
Generating and measuring effective vaccine-elicited HIV-specific CD8+ T cell responses
Purpose of review There is growing consensus that eliciting CD8+ T cells in addition to antibodie
Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development
Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development
Purpose of review Design of an HIV vaccine that can induce broadly neutralizing antibodies (bnAbs
Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV disease and posttreatment control in children
Impact of early antiretroviral therapy, early life immunity and immune sex differences on HIV disease and posttreatment control in children
Purpose of review To review recent insights into the factors affecting HIV disease progression in
Decrypting biological hallmarks of aging in people with HIV
Decrypting biological hallmarks of aging in people with HIV
Purpose of review HIV infection adds further complexity to the heterogenous process of aging. In
Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and protein levels
Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and protein levels
Purpose of review The success of HIV-1 eradication strategies relies on in-depth understanding of
HIV-1 transcriptional modulation: novel host factors and prospective therapeutic strategies
HIV-1 transcriptional modulation: novel host factors and prospective therapeutic strategies
Purpose of review This review highlights advances in HIV transcription and epigenetic latency mec
Features of functional and dysfunctional CD8+ T cells to guide HIV vaccine development
Features of functional and dysfunctional CD8+ T cells to guide HIV vaccine development
Purpose of review CD8+ T cell responses are a key component of the host immune response to human
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