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When pyro(ptosis) meets palm(itoylation)
When pyro(ptosis) meets palm(itoylation)
Pyroptosis is a type of programmed cell death that is involved in host defense against microbial infections and the regula...
Interleukins and interferons in mesenchymal stromal stem cell-based gene therapy of cancer
Interleukins and interferons in mesenchymal stromal stem cell-based gene therapy of cancer
Mesenchymal stromal stem cells (MSCs) are the most widely clinically studied cell type within the scope of both regenerati...
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders
MIF, a 12.5 kDa cytokine discovered in 1993, is produced by T cells and modulates the inflammatory responses [1]. It plays...
From orphan to oncogene: The role of GPR35 in cancer and immune modulation
From orphan to oncogene: The role of GPR35 in cancer and immune modulation
GPCRs, a family of transmembrane proteins representing 3% of the human genome, play a pivotal role in cellular signaling a...
Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death
Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death
As host’s first line of defense, innate immune cells not only recognize various pathogen-associated molecular patterns (PA...
Targeting NKG2D/NKG2DL axis in multiple myeloma therapy
Targeting NKG2D/NKG2DL axis in multiple myeloma therapy
Rong Fu received her M.D. degree from the Chinese Union Medical College in 2002. She is the vice president of Tianjin Medi...
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy
Traditionally, cancer has been viewed primarily as a disease of unchecked cellular proliferation, with treatments predomin...
Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system
Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system
Beneath the hard surfaces of the bone lies the source of all blood cells: the bone marrow (BM) [1]. When compared with oth...
Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression
Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression
Mona Alibolandi received her Ph.D. degree in Medical Biotechnology in 2015 from Mashhad University of Medical Sciences, Ir...
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs
Dr.S.Jubie, Associate Professor, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ooty, She pursued a B.Ph...
Myeloid-derived growth factor and its effects on cardiovascular and metabolic diseases
Myeloid-derived growth factor and its effects on cardiovascular and metabolic diseases
Professor Guangda Xiang, M.D. & Ph.D. He is a chief physician at department of endocrinology, general hospital of cent...
Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy
Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy
Professor Carlos Salomon (PhD, DMedSc, MSc, BSc (Hons)) Professor Salomon is the head of the Translational Extracellular V...
Regulation of regulated cell death by extracellular vesicles in acute kidney injury and chronic kidney disease
Regulation of regulated cell death by extracellular vesicles in acute kidney injury and chronic kidney disease
Kidney disease is one of the growing causes of disability and death worldwide, and CKD is projected to rise to fifth place...
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases
Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases
Yong-ming Yao, MD., Ph.D., Professor of Surgery, Director of Translational Medicine Research Center, Medical Innovation Re...
Corrigendum to “Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron” [Cytokine Growth Factor Rev. 70 (2023) 13–25]
Corrigendum to “Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron” [Cytokine Growth Factor Rev. 70 (2023) 13–25]
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs
Łukasz Opaliński is associate professor and a project leader at The Protein Engineering Department, Faculty of Biotechnolo...
Unveiling IL-17's role: Therapeutic insights and cardiovascular implications
Unveiling IL-17's role: Therapeutic insights and cardiovascular implications
A new cytokine IL-17 was discovered in 1995 generated by CD4+ helper T cell (now recognized as type 17 T helper cell). IL-...
COVID-19: from emerging variants to vaccination
COVID-19: from emerging variants to vaccination
The vigorous spread of SARS-CoV-2 resulted in the rapid infection of millions of people worldwide and devastation of not o...
Harnessing the Potential of CD40 Agonism in Cancer Therapy
Harnessing the Potential of CD40 Agonism in Cancer Therapy
Dr. Chi Yan is an Assistant Professor in the Department of Pharmacology at Vanderbilt University School of Medicine, Nashv...
Radiation-targeted immunotherapy: a new perspective in cancer radiotherapy
Radiation-targeted immunotherapy: a new perspective in cancer radiotherapy
Radiation therapy is widely used in cancer treatment[1], [2]. Its mechanism is to destroy the DNA of cancer cells through ...
The impact of COVID-19 on cancer patients
The impact of COVID-19 on cancer patients
In December 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus causing Coronavirus di...
An emerging paradigm of CXCL12 involvement in the metastatic cascade
An emerging paradigm of CXCL12 involvement in the metastatic cascade
George S. Karagiannis, D.V.M, Ph.D. is an assistant professor in the Department of Microbiology and Immunology at the Albe...
Progranulinopathy: A Diverse Realm of Disorders Linked to Progranulin Imbalances
Progranulinopathy: A Diverse Realm of Disorders Linked to Progranulin Imbalances
Progranulin (PGRN), also known as granulin–epithelin precursor (GEP), proepithelin, acrogranin, and GP88/PC-cell derived g...
Immunosuppressive Tumor Microenvironment and Uterine Fibroids:Role in Collagen Synthesis
Immunosuppressive Tumor Microenvironment and Uterine Fibroids:Role in Collagen Synthesis
Uterine fibroids (UF), also known as leiomyoma, is a benign uterine tumor with an unclear etiology that predominately affe...
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: biological and clinical aspects
CDK4/6 inhibition in hormone receptor-positive/HER2-negative breast cancer: biological and clinical aspects
Andrea Pretta is a MD specialized in Medical Oncology and a Researcher He works in the Medical Oncology Department at the ...
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors
Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors
Dr. Bin Di, Ph.D. is a professor of pharmaceutical analysis and vice-dean of School of Pharmacy in the China Pharmaceutica...
The Odyssey of cGAS: from Cytosol to Nucleus
The Odyssey of cGAS: from Cytosol to Nucleus
Dr. Li is an Associate Professor at Tulane University, New Orleans, LA, USA. He received a Ph.D. from Wuhan University in ...
Extracellular Vesicles in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Therapy
Extracellular Vesicles in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Therapy
Extracellular vesicles (EVs) are heterogeneous cell-derived lipid-bilayer membranous nanoparticles serving as intercellula...
Bioengineering strategies to enhance the interleukin-18 bioactivity in the modern toolbox of cancer immunotherapy
Bioengineering strategies to enhance the interleukin-18 bioactivity in the modern toolbox of cancer immunotherapy
The collaboration of immunology and oncology for cancer treatment has experienced revolutionary development during the rec...
Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway
Protein-protein interactions and related inhibitors involved in the NLRP3 inflammasome pathway
The human innate immune system plays a crucial role as the first line of defense against the invasion of harmful substance...
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