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The role of transforming growth factor β in cervical carcinogenesis
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Impact of chronic stress on intestinal mucosal immunity in colorectal cancer progression
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Cholecystokinin and gastrin as immune modulating hormones: Implications and applications
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Central role of Galectin-3 at the cross-roads of cardiac inflammation and fibrosis: Implications for heart failure and transplantation
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Molecular mechanisms of regulation of IL-1 and its receptors
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Ubiquitination in pyroptosis pathway: A potential therapeutic target for sepsis
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JAK inhibitors in immune regulation and treatment of vitiligo
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Glioblastoma-associated macrophages: A key target in overcoming glioblastoma therapeutic resistance
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Adeno-associated virus therapies: Pioneering solutions for human genetic diseases
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Distinct roles of MIF in the pathogenesis of ischemic heart disease
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NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies
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Unraveling the intricacies of neutrophil extracellular traps in inflammatory bowel disease: Pathways, biomarkers, and promising therapies
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Mechanisms of Rho GTPases in regulating tumor proliferation, migration and invasion
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Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases
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LC3B: A microtubule-associated protein influences disease progression and prognosis
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Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy
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The Immunopathogenesis of a Cytokine Storm: The Key Mechanisms Underlying Severe COVID-19
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Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights
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Mechanisms coupling the mTOR pathway to chronic obstructive pulmonary disease (COPD) pathogenesis
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Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy
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When pyro(ptosis) meets palm(itoylation)
When pyro(ptosis) meets palm(itoylation)
Pyroptosis is a type of programmed cell death that is involved in host defense against microbial infections and the regula...
Interleukins and interferons in mesenchymal stromal stem cell-based gene therapy of cancer
Interleukins and interferons in mesenchymal stromal stem cell-based gene therapy of cancer
Mesenchymal stromal stem cells (MSCs) are the most widely clinically studied cell type within the scope of both regenerati...
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders
Macrophage migration inhibitor factor (MIF): Potential role in cognitive impairment disorders
MIF, a 12.5 kDa cytokine discovered in 1993, is produced by T cells and modulates the inflammatory responses [1]. It plays...
From orphan to oncogene: The role of GPR35 in cancer and immune modulation
From orphan to oncogene: The role of GPR35 in cancer and immune modulation
GPCRs, a family of transmembrane proteins representing 3% of the human genome, play a pivotal role in cellular signaling a...
Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death
Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death
As host’s first line of defense, innate immune cells not only recognize various pathogen-associated molecular patterns (PA...
Targeting NKG2D/NKG2DL axis in multiple myeloma therapy
Targeting NKG2D/NKG2DL axis in multiple myeloma therapy
Rong Fu received her M.D. degree from the Chinese Union Medical College in 2002. She is the vice president of Tianjin Medi...
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy
Cytokines and soluble mediators as architects of tumor microenvironment reprogramming in cancer therapy
Traditionally, cancer has been viewed primarily as a disease of unchecked cellular proliferation, with treatments predomin...
Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system
Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system
Beneath the hard surfaces of the bone lies the source of all blood cells: the bone marrow (BM) [1]. When compared with oth...
Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression
Signaling crosstalk between mesenchymal stem cells and tumor cells: Implications for tumor suppression or progression
Mona Alibolandi received her Ph.D. degree in Medical Biotechnology in 2015 from Mashhad University of Medical Sciences, Ir...
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs
Dr.S.Jubie, Associate Professor, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ooty, She pursued a B.Ph...
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