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Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation
Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation
Our Kaplan–Meier analysis reveals that gastric cancer patients with high androgen receptor (AR) expression demonstra...
Positive association between anti- IgG antibody titers and atrophic gastritis in a Latvian cohort
Positive association between anti- IgG antibody titers and atrophic gastritis in a Latvian cohort
Although H. pylori is the most important risk factor for gastric cancer, the role of anti-H. pylori antibody titers in gas...
Predicting response to patients with gastric cancer via a dynamic-aware model with longitudinal liquid biopsy data
Predicting response to patients with gastric cancer via a dynamic-aware model with longitudinal liquid biopsy data
Gastric cancer (GC) presents challenges in predicting treatment responses due to its patient-specific heterogeneity. Recen...
YAP as a therapeutic target to reverse trastuzumab resistance
YAP as a therapeutic target to reverse trastuzumab resistance
Trastuzumab resistance in HER2-positive cancers remains a significant clinical challenge with limited therapeutic options....
The oncogenic role of hypomethylated in gastric carcinoma: a focus on cell survival and stemness
The oncogenic role of hypomethylated in gastric carcinoma: a focus on cell survival and stemness
Although genome-wide promoter CpG island hypermethylation of Epstein–Barr virus-associated gastric carcinoma (EBV GC...
Evaluating boron neutron capture therapy as a potential treatment for unresectable gastrointestinal stromal tumors
Evaluating boron neutron capture therapy as a potential treatment for unresectable gastrointestinal stromal tumors
Boron neutron capture therapy selectively delivers the boron isotope 10B to tumors, where neutron irradiation induces a nu...
Efficacy of nodal dissection for locoregional gastric neuroendocrine carcinoma: a multicenter retrospective observational study
Efficacy of nodal dissection for locoregional gastric neuroendocrine carcinoma: a multicenter retrospective observational study
Gastric neuroendocrine carcinoma (NEC) is a rare and aggressive malignancy for which no standard treatment has been establ...
Effect of anamorelin on body weight in patients with gastric cancer-associated cachexia: an observational study
Effect of anamorelin on body weight in patients with gastric cancer-associated cachexia: an observational study
In 2021, anamorelin, a ghrelin receptor agonist, was approved in Japan for cancer cachexia in select cancers, including ga...
Q-TWiST analysis of first-line nivolumab plus chemotherapy versus chemotherapy in patients with advanced gastric cancer, gastroesophageal junction cancer, or esophageal adenocarcinoma from CheckMate 649: 4-year follow-up results
Q-TWiST analysis of first-line nivolumab plus chemotherapy versus chemotherapy in patients with advanced gastric cancer, gastroesophageal junction cancer, or esophageal adenocarcinoma from CheckMate 649: 4-year follow-up results
Nivolumab plus chemotherapy demonstrated clinically significant improvement in quality-adjusted survival versus chemothera...
An observational study of the effectiveness and safety of nivolumab plus chemotherapy for untreated advanced or recurrent gastric cancer in Japanese real-world settings: the G-KNIGHT study
An observational study of the effectiveness and safety of nivolumab plus chemotherapy for untreated advanced or recurrent gastric cancer in Japanese real-world settings: the G-KNIGHT study
Nivolumab plus chemotherapy has shown efficacy in clinical trials for advanced or recurrent gastric cancer (GC). However, ...
Intraoperative corticosteroid administration for resectable gastric cancer: a multicenter, randomized, open-label, phase II/III study
Intraoperative corticosteroid administration for resectable gastric cancer: a multicenter, randomized, open-label, phase II/III study
Excessive surgical stress induces inflammatory cytokine release, negatively impacting prognosis in patients with malignanc...
Resveratrol targets mitochondrial USP36–SOD2 to induce autophagy-ferroptosis and inhibit gastric cancer progression
Resveratrol targets mitochondrial USP36–SOD2 to induce autophagy-ferroptosis and inhibit gastric cancer progression
Gastric cancer is an aggressive malignancy with high metastatic potential, limiting effective treatments. Resveratrol, a n...
Asian consensus on normothermic intraperitoneal and systemic treatment for gastric cancer with peritoneal metastasis
Asian consensus on normothermic intraperitoneal and systemic treatment for gastric cancer with peritoneal metastasis
Peritoneal metastasis (PM) is a major challenge in advanced gastric cancer (GC) with poor prognosis. Normothermic intraper...
Impact of perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel delivery on postoperative survival in locally advanced oesophagogastric adenocarcinoma
Impact of perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel delivery on postoperative survival in locally advanced oesophagogastric adenocarcinoma
Perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) is the standard of care for locally advanced oes...
Concurrent hypermethylation of CpG islands and hypomethylation of CpG-poor regions are associated with gastric cancer risk after Helicobacter pylori eradication
Concurrent hypermethylation of CpG islands and hypomethylation of CpG-poor regions are associated with gastric cancer risk after Helicobacter pylori eradication
Aberrant DNA methylation persists in the gastric mucosa after Helicobacter pylori (H. pylori) eradication and may contribu...
Serum TFF2 as a more reliable biomarker for gastric cancer and early gastric cancer: a cross-sectional population-based study
Serum TFF2 as a more reliable biomarker for gastric cancer and early gastric cancer: a cross-sectional population-based study
TFF2 is a promising yet underexplored biomarker for gastric cancer. We aimed to investigate the relationship between serum...
Assessing efficacy of anti-glypican-1 antibody–drug conjugate as potential therapeutic approach for gastric cancer
Assessing efficacy of anti-glypican-1 antibody–drug conjugate as potential therapeutic approach for gastric cancer
Despite significant advancements in cancer treatment, gastric cancer (GC) continues to have a high incidence and mortality...
Clinical impact of primary and secondary mutations on the efficacy of molecular-targeted therapies in gastrointestinal stromal tumors
Clinical impact of primary and secondary mutations on the efficacy of molecular-targeted therapies in gastrointestinal stromal tumors
Gastrointestinal stromal tumors (GISTs) are commonly driven by primary mutations in KIT or PDGFRA. Imatinib is the first-l...
Post-antibiotics microbiome restoration driven by diet
Gut microbiome dysbiosis is associated with a wide range of diseases, but factors influencing restoration of the microbiom...
The IDEAL framework for machine perfusion in liver transplantation
The IDEAL framework for machine perfusion in liver transplantation
Liver transplantation is challenged by organ scarcity and ageing donors. Machine perfusion is a promising technique to enh...
The oesophagus as an immune organ
The oesophagus as an immune organ
The oesophagus has traditionally been viewed as a simple conduit for food transport. In performing this delivery function,...
Promise and pitfalls of liver xenotransplantation
Promise and pitfalls of liver xenotransplantation
Liver xenotransplantation and genetically engineered pig livers have potential to save human lives. Liver xenotransplants ...
Reply to ‘Pregnancy and liver health: delivering new collaborations to advance the MASLD and MASH field’
Competing interests A.M.A. has received grants from the National Institutes of H...
Lessons from incretin-based therapy in MASH and obesity
Lessons from incretin-based therapy in MASH and obesity
Glucagon-like peptide 1 receptor agonists are effective pharmacotherapies for the treatment of obesity and related disorde...
Pregnancy and liver health: delivering new collaborations to advance the MASLD and MASH field
We read with great interest the article by Allen et al. (Envisioning how to advance the MASH field. Nat. Rev. Gastroentero...
Intestinal pH: a major driver of human gut microbiota composition and metabolism
Intestinal pH: a major driver of human gut microbiota composition and metabolism
In the human gastrointestinal tract, pH is a key factor in shaping gut microbial composition and activity, while also bein...
A rare case of colonic spirochetosis
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Gallstone ileus due to cholecystocolonic fistula with transverse colon
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From food to alcohol: Why some patients develop new addictions after bariatric surgery
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Spanish Working Group in Crohn’s Disease and Ulcerative Colitis (GETECCU) position paper on cardiovascular disease in patients with inflammatory bowel disease
Volume 48, Issue 5, May 2025, 502314Author links open overlay panel, , , , , , , , , AbstractCardiovascular diseases (CVD)...
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