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LDL Cholesterol and Cardiovascular Events in a Population Network: One More Twist of an Endless Story [Viewpoint]
LDL Cholesterol and Cardiovascular Events in a Population Network: One More Twist of an Endless Story [Viewpoint]
High plasma levels of low-density lipoprotein cholesterol (LDL-C) have long been known to associate with a measurable incr...
Long-Lasting Control of LDL Cholesterol Induces a 40% Reduction in the Incidence of Cardiovascular Events: New Insights from a 7-Year Study [Cardiovascular]
Long-Lasting Control of LDL Cholesterol Induces a 40% Reduction in the Incidence of Cardiovascular Events: New Insights from a 7-Year Study [Cardiovascular]
AbstractRecent studies have yielded controversial results on the long-term effects of statins on the risk of cardiovascula...
How to Make Glucocorticoids Safer [Viewpoint]
How to Make Glucocorticoids Safer [Viewpoint]
Glucocorticoids (GCs) are among the most prescribed medications and are used to treat myriad autoimmune and inflammation d...
Preclinical Evidence for the Glucocorticoid-Sparing Potential of a Dual Toll-Like Receptor 7/8 Inhibitor in Autoimmune Diseases [Drug Discovery and Translational Medicine]
Preclinical Evidence for the Glucocorticoid-Sparing Potential of a Dual Toll-Like Receptor 7/8 Inhibitor in Autoimmune Diseases [Drug Discovery and Translational Medicine]
AbstractToll-like receptor 7 (TLR7) and TLR8 are single-stranded RNA-sensing endosomal pattern recognition receptors that ...
12-(S)-Hydroxyeicosatetraenoic Acid and GPR31 Signaling in Spinal Cord in Neuropathic Pain [Drug Discovery and Translational Medicine]
12-(S)-Hydroxyeicosatetraenoic Acid and GPR31 Signaling in Spinal Cord in Neuropathic Pain [Drug Discovery and Translational Medicine]
AbstractNeuropathic pain is a pressing unmet medical need requiring novel nonopioid-based therapeutic approaches. Using un...
Anti-Inflammatory Effects of a Novel Nuclear Factor-{kappa}B Inhibitory Derivative Derived from Pyrazolo[3,4-d]Pyrimidine in Three Inflammation Models [Drug Discovery and Translational Medicine]
Anti-Inflammatory Effects of a Novel Nuclear Factor-{kappa}B Inhibitory Derivative Derived from Pyrazolo[3,4-d]Pyrimidine in Three Inflammation Models [Drug Discovery and Translational Medicine]
AbstractNuclear factor–κB (NF-κB) plays a central role in inflammatory responses, and its physiologic functions are essent...
Parthenolide As a Therapeutic for Disseminated Canine Neoplasms [Drug Discovery and Translational Medicine]
Parthenolide As a Therapeutic for Disseminated Canine Neoplasms [Drug Discovery and Translational Medicine]
AbstractThis study provides a unique translational research opportunity to help both humans and dogs diagnosed with diseas...
Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796 [Drug Discovery and Translational Medicine]
Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796 [Drug Discovery and Translational Medicine]
AbstractSystemic and cerebral inflammatory responses are implicated in the pathogenesis of obesity and associated metaboli...
Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency [Drug Discovery and Translational Medicine]
Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency [Drug Discovery and Translational Medicine]
Reagents.CP-456,773, NT-0796, and NDT-19795 were synthesized by NodThera; synthetic details relating to NT-0796 and NDT-19...
Involvement of Extracellular Vesicles in the Proinflammatory Response to Clozapine: Implications for Clozapine-Induced Agranulocytosis [Toxicology]
Involvement of Extracellular Vesicles in the Proinflammatory Response to Clozapine: Implications for Clozapine-Induced Agranulocytosis [Toxicology]
AbstractMost idiosyncratic drug reactions (IDRs) appear to be immune-mediated, but mechanistic events preceding severe rea...
Is Overexpression of the Plasma Membrane Transporter (SLC29A4) a New Option to Stratify Patients with High-Risk Neuroblastoma for Treatment with 131I-mIBG? [Viewpoint]
Is Overexpression of the Plasma Membrane Transporter (SLC29A4) a New Option to Stratify Patients with High-Risk Neuroblastoma for Treatment with 131I-mIBG? [Viewpoint]
Neuroblastoma (NB) is a heterogenous disease with solid tumors in infants and young children originating from neural crest...
The Plasma Membrane Monoamine Transporter is Highly Expressed in Neuroblastoma and Functions as an mIBG Transporter [Metabolism, Transport, and Pharmacogenetics]
The Plasma Membrane Monoamine Transporter is Highly Expressed in Neuroblastoma and Functions as an mIBG Transporter [Metabolism, Transport, and Pharmacogenetics]
AbstractNeuroblastoma (NB) is a pediatric cancer with low survival rates in high-risk patients. 131I-mIBG has emerged as a...
Unlocking the Goldenseal Reveals the Complexities of Natural Product-Drug Interactions [Viewpoint]
Unlocking the Goldenseal Reveals the Complexities of Natural Product-Drug Interactions [Viewpoint]
Botanical natural products are a rich source of diverse phytochemicals that allow for the continued development of novel t...
An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations [Metabolism, Transport, and Pharmacogenetics]
An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations [Metabolism, Transport, and Pharmacogenetics]
AbstractThe natural product goldenseal is a clinical inhibitor of CYP3A activity, as evidenced by a 40%–60% increase in mi...
Role of Cannabinoid Signaling in Cardiovascular Function and Ischemic Injury [Minireview]
Role of Cannabinoid Signaling in Cardiovascular Function and Ischemic Injury [Minireview]
AbstractCardiovascular disease represents a leading cause of death, morbidity, and societal economic burden. The prevalenc...
Chidamide Induces Epstein-Barr Virus (EBV) Lytic Infection and Acts Synergistically with Tenofovir to Eliminate EBV-Positive Burkitt Lymphoma [Drug Discovery and Translational Medicine]
Chidamide Induces Epstein-Barr Virus (EBV) Lytic Infection and Acts Synergistically with Tenofovir to Eliminate EBV-Positive Burkitt Lymphoma [Drug Discovery and Translational Medicine]
1Blood Diseases Institute (L.X., M.Z., D.T., Z.L., T.L., Y.Z., S.Z., Y.M., D.Y., X.W., W.S.) and Key Laboratory of Bone Ma...
Serum Glucocorticoid-Regulated Kinase-1 in Ischemia-Reperfusion Injury: Blessing or Curse [Minireview]
Serum Glucocorticoid-Regulated Kinase-1 in Ischemia-Reperfusion Injury: Blessing or Curse [Minireview]
AbstractThe family of serum-glucocorticoid-regulated kinase (SGK) consists of three paralogs, SGK-1, SGK-2, and SGK-3, wit...
First-in-Human Phase 1 Randomized Trial with the Anti-CD40 Monoclonal Antibody KPL-404: Safety, Tolerability, Receptor Occupancy, and Suppression of T-Cell-Dependent Antibody Response [Inflammation, Immunopharmacology, and Asthma]
First-in-Human Phase 1 Randomized Trial with the Anti-CD40 Monoclonal Antibody KPL-404: Safety, Tolerability, Receptor Occupancy, and Suppression of T-Cell-Dependent Antibody Response [Inflammation, Immunopharmacology, and Asthma]
AbstractBlockade of the cluster of differentiation 40 (CD40)–CD40L interaction has potential for treating autoimmune disea...
Dimethyl Fumarate Ameliorated Cardiorenal Anemia Syndrome and Improved Overall Survival in Dahl/Salt-Sensitive Rats [Drug Discovery and Translational Medicine]
Dimethyl Fumarate Ameliorated Cardiorenal Anemia Syndrome and Improved Overall Survival in Dahl/Salt-Sensitive Rats [Drug Discovery and Translational Medicine]
IntroductionPatients with chronic kidney disease often develop cardiovascular disease and die before reaching end-stage re...
Biodistribution of Agmatine to Brain and Spinal Cord after Systemic Delivery [Neuropharmacology]
Biodistribution of Agmatine to Brain and Spinal Cord after Systemic Delivery [Neuropharmacology]
AbstractAgmatine, an endogenous polyamine, has been shown to reduce chronic pain behaviors in animal models and in patient...
Central Nervous System Distribution of Panobinostat in Preclinical Models to Guide Dosing for Pediatric Brain Tumors [Metabolism, Transport, and Pharmacogenetics]
Central Nervous System Distribution of Panobinostat in Preclinical Models to Guide Dosing for Pediatric Brain Tumors [Metabolism, Transport, and Pharmacogenetics]
AbstractAchieving adequate exposure of the free therapeutic agent at the target is a critical determinant of efficacious c...
Correction to "Could a Nebulized or Dry Powder Inhalation of a Dopamine D1R Agonist Be a Treatment of Idiopathic Pulmonary Fibrosis?" [Erratum]
Correction to "Could a Nebulized or Dry Powder Inhalation of a Dopamine D1R Agonist Be a Treatment of Idiopathic Pulmonary Fibrosis?" [Erratum]
In the above article, [Andresen B (2023) Could a Nebulized or Dry Powder Inhalation of a Dopamine D1R Agonist Be a Treatme...
A Novel Approach to Predicting Organic Anion Transporting Polypeptide Function in Human Hepatic Drug Disposition and Biliary Clearance [Viewpoint]
A Novel Approach to Predicting Organic Anion Transporting Polypeptide Function in Human Hepatic Drug Disposition and Biliary Clearance [Viewpoint]
The transport of drugs into and out of the liver plays a critical role in determining drug disposition and therapeutic eff...
Quantitative Prediction of OATP-Mediated Disposition and Biliary Clearance Using Human Liver Chimeric Mice [Drug Discovery and Translational Medicine]
Quantitative Prediction of OATP-Mediated Disposition and Biliary Clearance Using Human Liver Chimeric Mice [Drug Discovery and Translational Medicine]
AbstractDrug biliary clearance (CLbile) in vivo is among the most difficult pharmacokinetic parameters to predict accurate...
Hydrocodone, Oxycodone, and Morphine Metabolism and Drug-Drug Interactions [Minireview]
Hydrocodone, Oxycodone, and Morphine Metabolism and Drug-Drug Interactions [Minireview]
AbstractAwareness of drug interactions involving opioids is critical for patient treatment as they are common therapeutics...
The Anti-Inflammatory Action of Cannabigerol Accompanied by the Antioxidant Effect of 3-O-ethyl Ascorbic Acid in UVA-Irradiated Human Keratinocytes [Cellular and Molecular]
The Anti-Inflammatory Action of Cannabigerol Accompanied by the Antioxidant Effect of 3-O-ethyl Ascorbic Acid in UVA-Irradiated Human Keratinocytes [Cellular and Molecular]
AbstractExcessive daily exposure of human skin to natural UVA radiation leads to impaired redox homeostasis in epidermal k...
Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23 [Drug Discovery and Translational Medicine]
Generation and Characterization of Mirikizumab, a Humanized Monoclonal Antibody Targeting the p19 Subunit of IL-23 [Drug Discovery and Translational Medicine]
AbstractInterleukin (IL)-23 exists as a heterodimer consisting of p19 and p40 and is a key cytokine for promoting inflamma...
The Novel GlycoPEGylated FGF21 Analog Pegozafermin Activates Human FGF Receptors and Improves Metabolic and Liver Outcomes in Diabetic Monkeys and Healthy Human Volunteers [Drug Discovery and Translational Medicine]
The Novel GlycoPEGylated FGF21 Analog Pegozafermin Activates Human FGF Receptors and Improves Metabolic and Liver Outcomes in Diabetic Monkeys and Healthy Human Volunteers [Drug Discovery and Translational Medicine]
AbstractPegozafermin (also known as BIO89-100) is a glycoPEGylated analog of fibroblast growth factor 21 (FGF21) under dev...
Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice [Drug Discovery and Translational Medicine]
Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice [Drug Discovery and Translational Medicine]
AbstractPompe disease is a rare glycogen storage disorder caused by a deficiency in the lysosomal enzyme acid α-glucosidas...
Characterization of Selective M5 Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum [Neuropharmacology]
Characterization of Selective M5 Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum [Neuropharmacology]
AbstractThe type-5 muscarinic acetylcholine receptor (mAChR, M5) is almost exclusively expressed in dopamine (DA) neurons ...
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