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Effects of Dual Inhibition at Dopamine Transporter and {sigma} Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats [Behavioral Pharmacology]
Effects of Dual Inhibition at Dopamine Transporter and {sigma} Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats [Behavioral Pharmacology]
AbstractPrevious studies demonstrated that sigma receptor (σR) antagonists alone fail to alter cocaine self-administration...
The Potential of Cannabichromene (CBC) as a Therapeutic Agent [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
The Potential of Cannabichromene (CBC) as a Therapeutic Agent [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
Cannabichromene Synthesis.Cannabinoids are a class of terpenophenolic compounds obtained by the alkylation of olivetolic a...
Proteomic Analysis of Signaling Pathways Modulated by Fatty Acid Binding Protein 5 (FABP5) in Macrophages [Special Section: Cannabinoid Signaling in Human Health and Disease]
Proteomic Analysis of Signaling Pathways Modulated by Fatty Acid Binding Protein 5 (FABP5) in Macrophages [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractAlthough acute inflammation serves essential functions in maintaining tissue homeostasis, chronic inflammation is ...
The Intoxication Equivalency of 11-Hydroxy-{Delta}9-Tetrahydrocannabinol Relative to {Delta}9-Tetrahydrocannabinol [Special Section: Cannabinoid Signaling in Human Health and Disease]
The Intoxication Equivalency of 11-Hydroxy-{Delta}9-Tetrahydrocannabinol Relative to {Delta}9-Tetrahydrocannabinol [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractΔ9-Tetrahydrocannabinol (THC) is a psychoactive phytocannabinoid found in the Cannabis sativa plant. THC is primar...
Evaluating the Abuse Potential of Lenabasum, a Selective Cannabinoid Receptor 2 Agonist [Special Section: Cannabinoid Signaling in Human Health and Disease]
Evaluating the Abuse Potential of Lenabasum, a Selective Cannabinoid Receptor 2 Agonist [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractEndocannabinoids, which are present throughout the central nervous system (CNS), can activate cannabinoid receptor...
Sex Differences in the Neural and Behavioral Effects of Acute High-Dose Edible Cannabis Consumption in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease]
Sex Differences in the Neural and Behavioral Effects of Acute High-Dose Edible Cannabis Consumption in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractThe consumption of Δ9-tetrahydrocannabinol (THC)- or cannabis-containing edibles has increased in recent years; ho...
Chronic Administration of Cannabinoid Agonists ACEA, AM1241, and CP55,940 Induce Sex-Specific Differences in Tolerance and Sex Hormone Changes in a Chemotherapy-Induced Peripheral Neuropathy [Special Section: Cannabinoid Signaling in Human Health and Disease]
Chronic Administration of Cannabinoid Agonists ACEA, AM1241, and CP55,940 Induce Sex-Specific Differences in Tolerance and Sex Hormone Changes in a Chemotherapy-Induced Peripheral Neuropathy [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractChemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy treatment, routinely man...
Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice [Behavioral Pharmacology]
Low-Efficacy Mu Opioid Agonists as Candidate Analgesics: Effects of Novel C-9 Substituted Phenylmorphans on Pain-Depressed Behavior in Mice [Behavioral Pharmacology]
AbstractLow-efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relati...
Special Section on Cannabinoid Signaling in Human Health and Disease--Editorial [Special Section on Cannabinoid Signaling in Human Health and Disease-Editorial]
Special Section on Cannabinoid Signaling in Human Health and Disease--Editorial [Special Section on Cannabinoid Signaling in Human Health and Disease-Editorial]
EditorialSpecial Section on Cannabinoid Signaling in Human Health and Disease—Editorial ...
Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
AbstractCannabis and its products have been used for centuries for both medicinal and recreational purposes. The recent wi...
Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics [Special Section: Cannabinoid Signaling in Human Health and Disease-Minireview]
AbstractTargeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only...
The National Center for Complementary and Integrative Health: Priorities for Cannabis and Cannabinoid Research [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
The National Center for Complementary and Integrative Health: Priorities for Cannabis and Cannabinoid Research [Special Section: Cannabinoid Signaling in Human Health and Disease-Commentary]
AbstractThe National Center for Complementary and Integrative Health (NCCIH), which is part of the US National Institutes ...
Cannabinoid 2 Receptor Activation Protects against Diabetic Cardiomyopathy through Inhibition of AGE/RAGE-Induced Oxidative Stress, Fibrosis, and Inflammasome Activation [Special Section: Cannabinoid Signaling in Human Health and Disease]
Cannabinoid 2 Receptor Activation Protects against Diabetic Cardiomyopathy through Inhibition of AGE/RAGE-Induced Oxidative Stress, Fibrosis, and Inflammasome Activation [Special Section: Cannabinoid Signaling in Human Health and Disease]
AbstractOxidative stress, fibrosis, and inflammasome activation from advanced glycation end product (AGE)–receptor of adva...
Blood Pressure Lowering in Patients with Left Ventricular Hypertrophy - Navigating between Scylla and Charybdis [Viewpoint]
Blood Pressure Lowering in Patients with Left Ventricular Hypertrophy - Navigating between Scylla and Charybdis [Viewpoint]
Ever since the randomized controlled Systolic Blood Pressure Intervention Trial (SPRINT), we have known that targeting a s...
Achieving a Systolic Blood Pressure Below 130 mmHg Reduces the Incidence of Cardiovascular Events in Hypertensive Patients with Echocardiographic Left Ventricular Hypertrophy [Cardiovascular]
Achieving a Systolic Blood Pressure Below 130 mmHg Reduces the Incidence of Cardiovascular Events in Hypertensive Patients with Echocardiographic Left Ventricular Hypertrophy [Cardiovascular]
AbstractBackground: Recent reports have evidenced an increased mortality rate in hypertensive patients with electrocardiog...
The Evolving Challenge of New Psychoactive Substances: Understanding the Risks and Behavioral Effects of Novel Analogs of Dissociative Anesthetics [Viewpoint]
The Evolving Challenge of New Psychoactive Substances: Understanding the Risks and Behavioral Effects of Novel Analogs of Dissociative Anesthetics [Viewpoint]
New psychoactive substances (NPSs), also known as “designer drugs,” present a rapidly evolving challenge in the global dru...
Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents [Behavioral Pharmacology]
Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents [Behavioral Pharmacology]
AbstractAbuse of novel arylcyclohexylamines (ACX) poses risks for toxicities, including adverse neurocognitive effects. In...
Special Section on Nanotherapeutics in Cancer Research--Editorial [Editorial]
Special Section on Nanotherapeutics in Cancer Research--Editorial [Editorial]
Nanobiomaterials such as peptide-based nanoparticles (NPs), poly(lactic-co-glycolic acid) (PLGA)-based NPs, aluminum salt–...
Small Peptide-Based Nanodelivery Systems for Cancer Therapy and Diagnosis [Minireview]
Small Peptide-Based Nanodelivery Systems for Cancer Therapy and Diagnosis [Minireview]
AbstractDeveloping nano-biomaterials with tunable topology, size, and surface characteristics has shown tremendously favor...
Immunogenic Treatment of Metastatic Breast Cancer Using Targeted Carbon Nanotube Mediated Photothermal Therapy in Combination with Anti-Programmed Cell Death Protein-1 [Special Section on Nanotherapeutics in Cancer Research]
Immunogenic Treatment of Metastatic Breast Cancer Using Targeted Carbon Nanotube Mediated Photothermal Therapy in Combination with Anti-Programmed Cell Death Protein-1 [Special Section on Nanotherapeutics in Cancer Research]
AbstractThe high prevalence of breast cancer is a global health concern, compounded by the lack of safe or effective treat...
Clinical Advances in Triple Negative Breast Cancer Treatment: Focus on Poly (L-lactide-coglycolide) Nanoparticles [Minireview]
Clinical Advances in Triple Negative Breast Cancer Treatment: Focus on Poly (L-lactide-coglycolide) Nanoparticles [Minireview]
AbstractTriple negative breast cancer (TNBC) is the most aggressive type of breast cancer and is associated with high prob...
Constitutive Androstane Receptor and Peroxisome Proliferator-Activated Receptor {alpha} Do Not Perform Liquid-Liquid Phase Separation in Cells [Cellular and Molecular]
Constitutive Androstane Receptor and Peroxisome Proliferator-Activated Receptor {alpha} Do Not Perform Liquid-Liquid Phase Separation in Cells [Cellular and Molecular]
AbstractConstitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor α (PPARα) are members of the...
Chemotherapeutics-Loaded Poly(Dopamine) Core-Shell Nanoparticles for Breast Cancer Treatment [Chemotherapy, Antibiotics, and Gene Therapy]
Chemotherapeutics-Loaded Poly(Dopamine) Core-Shell Nanoparticles for Breast Cancer Treatment [Chemotherapy, Antibiotics, and Gene Therapy]
AbstractChemophotothermal therapy is an emerging treatment of metastatic and drug-resistant cancer anomalies. Among variou...
Rapamycin and Starvation Mitigate Indomethacin-Induced Intestinal Damage through Preservation of Lysosomal Vacuolar ATPase Integrity [Gastrointestinal, Hepatic, Pulmonary, and Renal]
Rapamycin and Starvation Mitigate Indomethacin-Induced Intestinal Damage through Preservation of Lysosomal Vacuolar ATPase Integrity [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractNonsteroidal anti-inflammatory drugs (NSAIDs) possess anti-inflammatory, antipyretic, and analgesic properties and...
Unique Binding Sites of Uricosuric Agent Dotinurad for Selective Inhibition of Renal Uric Acid Reabsorptive Transporter URAT1 [Drug Discovery and Translational Medicine]
Unique Binding Sites of Uricosuric Agent Dotinurad for Selective Inhibition of Renal Uric Acid Reabsorptive Transporter URAT1 [Drug Discovery and Translational Medicine]
AbstractDotinurad was developed as a uricosuric agent, inhibiting urate (UA) reabsorption through the UA transporter URAT1...
High-dose Agomelatine Combined with Haloperidol Decanoate Improves Cognition, Downregulates MT2, Upregulates D5, and Maintains Krüppel-like Factor 9 But Alters Cardiac Electrophysiology [Neuropharmacology]
High-dose Agomelatine Combined with Haloperidol Decanoate Improves Cognition, Downregulates MT2, Upregulates D5, and Maintains Krüppel-like Factor 9 But Alters Cardiac Electrophysiology [Neuropharmacology]
IntroductionOver time, the cholinergic deficiency hypothesis culminating in cognitive and memory disruptions has proven re...
Tauroursodeoxycholic Acid Reverses Dextran Sulfate Sodium-Induced Colitis in Mice via Modulation of Intestinal Barrier Dysfunction and Microbiome Dysregulation [Gastrointestinal, Hepatic, Pulmonary, and Renal]
Tauroursodeoxycholic Acid Reverses Dextran Sulfate Sodium-Induced Colitis in Mice via Modulation of Intestinal Barrier Dysfunction and Microbiome Dysregulation [Gastrointestinal, Hepatic, Pulmonary, and Renal]
AbstractUlcerative colitis (UC) is an immune-mediated inflammatory disease that can lead to persistent damage and even can...
Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine [Toxicology]
Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine [Toxicology]
IntroductionHalogens such as chlorine (Cl2) and bromine (Br2) are commonly produced highly reactive and very toxic gases t...
LDL Cholesterol and Cardiovascular Events in a Population Network: One More Twist of an Endless Story [Viewpoint]
LDL Cholesterol and Cardiovascular Events in a Population Network: One More Twist of an Endless Story [Viewpoint]
High plasma levels of low-density lipoprotein cholesterol (LDL-C) have long been known to associate with a measurable incr...
Long-Lasting Control of LDL Cholesterol Induces a 40% Reduction in the Incidence of Cardiovascular Events: New Insights from a 7-Year Study [Cardiovascular]
Long-Lasting Control of LDL Cholesterol Induces a 40% Reduction in the Incidence of Cardiovascular Events: New Insights from a 7-Year Study [Cardiovascular]
AbstractRecent studies have yielded controversial results on the long-term effects of statins on the risk of cardiovascula...
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