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Development of a highly cytotoxic, clinical-grade virus-specific T cell product for adoptive T cell therapy
Development of a highly cytotoxic, clinical-grade virus-specific T cell product for adoptive T cell therapy
Opportunistic viral infections persist as the main cause of post-transplantation morbidity and mortality in allogeneic hem...
Concomitant assessment of PD-1 and CD56 expression identifies subsets of resting cord blood Vδ2 T cells with disparate cytotoxic potential
Concomitant assessment of PD-1 and CD56 expression identifies subsets of resting cord blood Vδ2 T cells with disparate cytotoxic potential
Vγ9Vδ2 T (Vδ2) cells survey cholesterol biosynthesis by sensing metabolic intermediates in an innate-like, MHC-unrestricte...
Helicobacter pylori secretary Proteins-Induced oxidative stress and its role in NLRP3 inflammasome activation
Helicobacter pylori secretary Proteins-Induced oxidative stress and its role in NLRP3 inflammasome activation
Helicobacter pylori inhabits more than 50 % ofworld population and is a major cause of gastric cancer. Gastric ulcers, ade...
Life-threatening infections in human newborns: Reconciling age-specific vulnerability and interindividual variability
Life-threatening infections in human newborns: Reconciling age-specific vulnerability and interindividual variability
Susceptibility to infection is highest during the neonatal period, extending from birth to the age of 28 days [1]. Infecti...
PIM kinase inhibitor AZD1208 in conjunction with Th1 cytokines potentiate death of breast cancer cells in vitro while also maximizing suppression of tumor growth in vivo when combined with immunotherapy
PIM kinase inhibitor AZD1208 in conjunction with Th1 cytokines potentiate death of breast cancer cells in vitro while also maximizing suppression of tumor growth in vivo when combined with immunotherapy
In the 20th century, three major modalities dominated the treatment of cancer: surgery, radiation therapy and cytotoxic ch...
Upregulation of CD8+ regulatory T cells following liver-directed AAV gene therapy
Upregulation of CD8+ regulatory T cells following liver-directed AAV gene therapy
Liver-directed AAV gene therapy represents a unique treatment modality for a host of diseases. This is due, in part, to th...
The mechanism by which cannabidiol (CBD) suppresses TNF-α secretion involves inappropriate localization of TNF-α converting enzyme (TACE)
The mechanism by which cannabidiol (CBD) suppresses TNF-α secretion involves inappropriate localization of TNF-α converting enzyme (TACE)
Cannabidiol (CBD) exerts its anti-inflammatory mechanisms under various inflammatory conditions, including neuroinflammati...
The research progression of direct NLRP3 inhibitors to treat inflammatory disorders
The research progression of direct NLRP3 inhibitors to treat inflammatory disorders
The NLRP3 inflammasome represents a cytoplasmic multiprotein complex with the capability to recognize a wide range of path...
Therapeutic potential of mesenchymal stem cell-derived exosomes for allergic airway inflammation
Therapeutic potential of mesenchymal stem cell-derived exosomes for allergic airway inflammation
Due to their immunomodulatory capacities, mesenchymal stem cells (MSCs) have been extensively used as therapeutic approach...
MALT1 inhibition suppresses antigen-specific T cell responses
MALT1 inhibition suppresses antigen-specific T cell responses
AbbreviationsMALT1mucosa-associated lymphoid tissue lymphoma translocation1PBMCperipheral blood mononuclear cellCTLA4cytot...
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
Asthma is a heterogenous immunological condition usually characterized by a chronic airway inflammation, with different un...
HLA-class-I expression loss, tumor microenvironment and breast cancer prognosis
HLA-class-I expression loss, tumor microenvironment and breast cancer prognosis
The human major histocompatibility complex (MHC) HLA codes polymorphic cell surface proteins that are grouped into two mai...
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Newborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-ut...
Loss of B1 and marginal zone B cells during ovarian cancer
Loss of B1 and marginal zone B cells during ovarian cancer
Immunity evolved not only to resist external challenges but also to serve in an internal, “housekeeping” function that ope...
Differential roles of regulatory T cells in Alzheimer's disease
Differential roles of regulatory T cells in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the major cause of dementia. Progressive memory l...
Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation
Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation
Asthma is a chronic respiratory disease that is characterized by airway inflammation and non-specific bronchial hyperrespo...
Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice
Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice
Inflammatory bowel disease (IBD) is clinically classified as ulcerative colitis (UC) and Crohn’s disease (CD). Although th...
Antitumor activity of pegylated human interferon β as monotherapy or in combination with immune checkpoint inhibitors via tumor growth inhibition and dendritic cell activation
Antitumor activity of pegylated human interferon β as monotherapy or in combination with immune checkpoint inhibitors via tumor growth inhibition and dendritic cell activation
Immune checkpoint inhibitors (ICIs), such as anti-programmed cell death protein 1/anti-programmed cell death 1 ligand 1 (P...
A single-cell atlas of immunocytes in the spleen of a mouse model of Wiskott-Aldrich syndrome
A single-cell atlas of immunocytes in the spleen of a mouse model of Wiskott-Aldrich syndrome
Wiskott-Aldrich syndrome (WAS) is a rare disorder caused by an X-linked genetic mutation that causes immune deficiency and...
Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-β/Smad3 signaling to promote Th17/Treg cell rebalance
Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-β/Smad3 signaling to promote Th17/Treg cell rebalance
Sarcoidosis is a systemic inflammatory disease with significant morbidity and increased mortality and affects patients of ...
One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8+ T cell activation and proliferation
One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8+ T cell activation and proliferation
Due to the central role in immune surveillance, the antigen peptide hold tremendous promise for treatment modalities in ca...
Response to “Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses”
Response to “Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses”
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Immunomodulatory action of synbiotic comprising of newly isolated lactic acid producing bacterial strains against allergic asthma in mice
Immunomodulatory action of synbiotic comprising of newly isolated lactic acid producing bacterial strains against allergic asthma in mice
Asthma is a heterogeneous respiratory syndrome of the lung airways characterized by intermittent episodes of wheezing and ...
Anti-CD19/CD8 bispecific T cell engager for the potential treatment of B cell malignancies
Anti-CD19/CD8 bispecific T cell engager for the potential treatment of B cell malignancies
As an important cause of mortality, cancer is listed as the first or second leading cause of death in 112 countries, accor...
Ro52/TRIM21 – From host defense to autoimmunity
Ro52/TRIM21 – From host defense to autoimmunity
Autoimmune diseases are a family represented by more than 100 cases of disorders. These illnesses affect about 3–5 % of th...
Variability of vaccine responsiveness in early life
Variability of vaccine responsiveness in early life
Vaccination is one of the most important interventions for public health, saving over 2.5 million lives each year worldwid...
Ferroptosis in the Post-Transplantation Inflammatory Response
Ferroptosis in the Post-Transplantation Inflammatory Response
Inflammation after solid organ transplantation is a key contributor to post-transplant complications. Post-transplant infl...
Early-immune development in asthma: a review of the literature
Early-immune development in asthma: a review of the literature
Asthma is the most common chronic disease in childhood, and according to the Global Asthma report, 14% of children worldwi...
ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer
ATM-AMPKα mediated LAG-3 expression suppresses T cell function in prostate cancer
LAG3Lymphocyte-activation gene 3CTLA4Cytotoxic T-lymphocyte-associated protein 4TIGITT cell Ig and ITIM domainTIM-3T cell ...
Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses
Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses
Available online 30 September 2023, 104772Author links open overlay panel, , Section snippetsTo the Editor2We read with gr...
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