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Tim-3 promotes viral infection by suppressing the USP25-TRAF3-IRF7 signaling pathway
T-cell immunoglobulin and mucin domain 3 (Tim-3) is widely expressed on many immune cells including T cells and macrophage...
Breast cancer stem cells convert anti-tumor CD4+ T cells to pro-tumor T regulatory cells: Potential role of exosomal FOXP3
Emerging evidence indicates an inverse relationship between the percentage of regulatory T cells (Tregs) and poor prognosi...
In vitro ovarian tumor-conditioned CD163+ human macrophages retain phagocytic response to CD47 blockade
IntroductionCD163-expressing macrophages are abundant in ovarian cancer where they accelerate tumor growth and metastasis....
Nebulized mesenchymal stem cell-derived exosomes attenuate airway inflammation in a rat model of chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by persistent airflow limitation and t...
Immunity in children: How does it begin?
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Transfer of bone marrow niche-residential regulatory T cells ameliorates experimental colitis
Treg infusion has been drawing attention as a promising approach to control inflammatory diseases or autoimmune disorders ...
Characterization of Lysate from NK-92 cells and its potential use as immunotherapeutic modality
Using lysate from prokaryotic or eukaryotic cells for medical and laboratory purposes is not a new concept. Lysate from hu...
Lupeol mitigates spinal cord injury by modulating microglial M1/M2 polarization via Na+/K+-ATPase-mediated mitophagy
Spinal cord injury (SCI), a severe central nervous system disorder, often results in motor and sensory dysfunction, causin...
Apelin-13 enhances neurofunctional recovery and suppresses neuroinflammation via the SIRT1/NF-κB axis in ischemic stroke
Stroke is a leading cause of disability worldwide, with its epidemiology marked by a high incidence and prevalence, partic...
Divergent impact of endotoxin priming and endotoxin tolerance on macrophage responses to cancer cells
It is known that when primed with endotoxin, macrophages are more reactive and produce higher levels of inflammatory media...
Dexmedetomidine modulates peritoneal macrophage to attenuate lipopolysaccharide-induced inflammation
Dexmedetomidine's Potential: Dexmedetomidine (Dex), an α2-adrenergic receptor agonist, shows promise in modulating macroph...
USP14 inhibits sensitization-mediated degradation of KDM4D to epigenetically regulate dendritic cell tolerogenic capacity and mitigates airway allergy
Dendritic cells (DCs) are the fraction of immune cells that initiate immune responses in the body. Antigens are captured b...
METTL3 promotes infantile pneumonia-induced lung injury by the m6A-TBL1XR1-ACSL1 axis
Infantile pneumonia (IP) is an inflammation of the lungs caused by pathogens (such as bacteria and viruses) and other fact...
Immunology of familial chorea-acanthocytosis with presenting generalized tonic-clonic seizure: Blood cell study for early diagnosis and management
Chorea-acanthocytosis (ChAc) and McLeod syndrome (MLS) are the progressive neurodegenerative diseases with the rare incide...
A new chimeric protein composed by T-cell epitopes from peroxidoxin and pyridoxal kinase proteins is protective against visceral leishmaniasis
Leishmaniasis is a neglected tropical disease complex caused by intracellular protozoan parasites that present an estimate...
MAPK14 drives Ferroptosis and immune dysfunction in pediatric Sepsis-induced acute lung injury
Sepsis is a life-threatening condition characterized by an excessive immune response to infection that leads to multiple o...
Novel and effective tandem CD38 and CD19 targeting CAR-T cells inhibit hematological tumor immune escape
The 2024 Breakthrough Prize in Life Sciences was awarded to Carl June and Michel Sadelain for genetically engineering T ce...
Role of CD44+CCR2+CD64−monocyte-derived macrophage in chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis (CRS) is a chronic inflammatory disorder of nasal cavity and sinus, affecting about 10 % of the adu...
Hyperoside suppresses NSCLC progression by inducing ATG13-mediated autophagy and apoptosis
Indispensable advancements regarding non-small cell lung cancer (NSCLC) treatment have been made in the last two decades [...
Aged mice-derived bronchial epithelial cells regulate Th17 cell differentiation in asthma via the MBD2-sICOSL axis
Asthma is often induced by T helper type 2 (Th2) cells, which promote infiltration of eosinophils. However, due to the het...
ZFP36 family expression is suppressed by Th2 cells in asthma, leading to enhanced synthesis of inflammatory cytokines and cell surface molecules
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R406 reduces lipopolysaccharide-induced neutrophil activation
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HIF-1α is required to differentiate the neonatal Macrophage protein secretome from adults
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RORα negatively regulates BCG-induced trained immunity
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Cbl-b inhibition promotes less differentiated phenotypes of T cells with enhanced cytokine production
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Yersinia pestis and pneumonic plague: Insight into how a lethal pathogen interfaces with innate immune populations in the lung to cause severe disease
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BCG immunization induced KLRG1+ NK cells show memory-like responses to mycobacterial and HIV antigens
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IL-10: A Key Regulator and potential therapeutic target in uveitis
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B cell-intrinsic IFN-γ promotes excessive CD11c+ age-associated B cell differentiation and compromised germinal center selection in lupus mice
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Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages
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