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ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis
ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer accounts for about 20% of all breast cancer cases a...
Development of a machine learning-based radiomics signature for estimating breast cancer TME phenotypes and predicting anti-PD-1/PD-L1 immunotherapy response
Development of a machine learning-based radiomics signature for estimating breast cancer TME phenotypes and predicting anti-PD-1/PD-L1 immunotherapy response
Since breast cancer patients respond diversely to immunotherapy, there is an urgent need to explore novel biomarkers to pr...
TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer
TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer
Patients with inflammatory breast cancer (IBC) have overall poor clinical outcomes, with triple-negative IBC (TN-IBC) bein...
Improving lesion detection in mammograms by leveraging a Cycle-GAN-based lesion remover
Improving lesion detection in mammograms by leveraging a Cycle-GAN-based lesion remover
The wide heterogeneity in the appearance of breast lesions and normal breast structures can confuse computerized detection...
Molecular subtypes of breast cancer predicting clinical benefits of radiotherapy after breast-conserving surgery: a propensity-score-matched cohort study
Molecular subtypes of breast cancer predicting clinical benefits of radiotherapy after breast-conserving surgery: a propensity-score-matched cohort study
Based on the molecular expression of cancer cells, molecular subtypes of breast cancer have been applied to classify patie...
Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer
Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and leads to the poorest patient outcome...
Histologic tumor type as a determinant of survival in hormone receptor-positive, HER2-negative, pT1-3 invasive ductal and lobular breast cancer
Histologic tumor type as a determinant of survival in hormone receptor-positive, HER2-negative, pT1-3 invasive ductal and lobular breast cancer
The aim of the study was to compare the difference in survival between invasive ductal (IDC) and lobular carcinoma (ILC). ...
Development and evaluation of a method to assess breast cancer risk using a longitudinal history of mammographic density: a cohort study
Development and evaluation of a method to assess breast cancer risk using a longitudinal history of mammographic density: a cohort study
Women with dense breasts have an increased risk of breast cancer. However, breast density is measured with variability, wh...
Integrative whole-genome and transcriptome analysis of HER2-amplified metastatic breast cancer
Integrative whole-genome and transcriptome analysis of HER2-amplified metastatic breast cancer
In breast cancer, the advent of anti-HER2 therapies has made HER2+ tumors a highly relevant subgroup. However, the exact c...
The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling
The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling
Breast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to re...
Multimodal prediction of neoadjuvant treatment outcome by serial FDG PET and MRI in women with locally advanced breast cancer
Multimodal prediction of neoadjuvant treatment outcome by serial FDG PET and MRI in women with locally advanced breast cancer
To investigate combined MRI and 18F-FDG PET for assessing breast tumor metabolism/perfusion mismatch and predicting pathol...
AMEERA-4: a randomized, preoperative window-of-opportunity study of amcenestrant versus letrozole in early breast cancer
AMEERA-4: a randomized, preoperative window-of-opportunity study of amcenestrant versus letrozole in early breast cancer
Window-of-opportunity (WOO) studies provide insights into the clinical activity of new drugs in breast cancer. AMEERA-4 (N...
Blocking channels to metastasis: targeting sodium transport in breast cancer
Blocking channels to metastasis: targeting sodium transport in breast cancer
The development of therapies that can suppress invasion and prevent metastasis, ‘anti-metastatic drugs’, is an...
PROACTING: predicting pathological complete response to neoadjuvant chemotherapy in breast cancer from routine diagnostic histopathology biopsies with deep learning
PROACTING: predicting pathological complete response to neoadjuvant chemotherapy in breast cancer from routine diagnostic histopathology biopsies with deep learning
Invasive breast cancer patients are increasingly being treated with neoadjuvant chemotherapy; however, only a fraction of ...
Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin
Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin
As in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue home...
The inhibitory effect of Gremlin-2 on adipogenesis suppresses breast cancer cell growth and metastasis
The inhibitory effect of Gremlin-2 on adipogenesis suppresses breast cancer cell growth and metastasis
Gremlin-1 (GREM1) and Gremlin-2 (GREM2) are bone morphogenetic protein antagonists that play important roles in organogene...
The chromatin architectural regulator SND1 mediates metastasis in triple-negative breast cancer by promoting CDH1 gene methylation
The chromatin architectural regulator SND1 mediates metastasis in triple-negative breast cancer by promoting CDH1 gene methylation
SND1 participates in tumorigenesis, tumour invasion and metastasis in different cancers. Previous studies have shown that ...
Single-cell transcriptomics provide insight into metastasis-related subsets of breast cancer
Single-cell transcriptomics provide insight into metastasis-related subsets of breast cancer
Breast cancer metastasis is a complex, multi-step process, with high cellular heterogeneity between primary and metastatic...
Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes
Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes
An elevated number of circulating neutrophils is a poor prognostic factor for breast cancer, where evidence of bone marrow...
Causal relationships between breast cancer risk factors based on mammographic features
Causal relationships between breast cancer risk factors based on mammographic features
Mammogram risk scores based on texture and density defined by different brightness thresholds are associated with breast c...
Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR
Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR
Breast cancer (BC) is the most common malignant disease in female patients worldwide. In HER-2+ BC patients, trastuzumab t...
Comparison of SP142 and 22C3 PD-L1 assays in a population-based cohort of triple-negative breast cancer patients in the context of their clinically established scoring algorithms
Comparison of SP142 and 22C3 PD-L1 assays in a population-based cohort of triple-negative breast cancer patients in the context of their clinically established scoring algorithms
Immunohistochemical (IHC) PD-L1 expression is commonly employed as predictive biomarker for checkpoint inhibitors in tripl...
MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib
MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib
Triple negative breast cancer (TNBC) is a particularly aggressive and difficult-to-treat subtype of breast cancer that req...
Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity
Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity
Breast cancer is a complex and heterogeneous disease with distinct subtypes and molecular profiles corresponding to differ...
Lipidome of mammographic breast density in premenopausal women
Lipidome of mammographic breast density in premenopausal women
High mammographic breast density (MBD) is a strong risk factor for breast cancer development, but the biological mechanism...
Symposium Mammographicum 2023
Symposium Mammographicum 2023
Background: This feasibility study was designed to evaluate if contrast-enhanced ultrasound (CEUS) can identify node-posit...
Pubertal exposure to dietary advanced glycation end products disrupts ductal morphogenesis and induces atypical hyperplasia in the mammary gland
Pubertal exposure to dietary advanced glycation end products disrupts ductal morphogenesis and induces atypical hyperplasia in the mammary gland
Advanced glycation end products (AGEs) are reactive metabolites intrinsically linked with modern dietary patterns. Process...
Interplay between ESR1/PIK3CA codon variants, oncogenic pathway alterations and clinical phenotype in patients with metastatic breast cancer (MBC): comprehensive circulating tumor DNA (ctDNA) analysis
Interplay between ESR1/PIK3CA codon variants, oncogenic pathway alterations and clinical phenotype in patients with metastatic breast cancer (MBC): comprehensive circulating tumor DNA (ctDNA) analysis
although being central for the biology and druggability of hormone-receptor positive, HER2 negative metastatic breast canc...
Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers
Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers
Latin American and Hispanic women are less likely to develop breast cancer (BC) than women of European descent. Observatio...
Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs
Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs
About 20% of breast cancers in humans are basal-like, a subtype that is often triple-negative and difficult to treat. An e...
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