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Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD
Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD
Cross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver di...
Eldecalcitol prevents muscle loss and osteoporosis in disuse muscle atrophy via NF-κB signaling in mice
Eldecalcitol prevents muscle loss and osteoporosis in disuse muscle atrophy via NF-κB signaling in mice
We investigated the effect of eldecalcitol on disuse muscle atrophy. C57BL/6J male mice aged 6 weeks were randomly assigne...
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogen...
N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy
Multiple clinical trials to assess the efficacy of AAV-directed gene transfer in participants with Duchenne muscular dystr...
A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle
A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle
Human iPSC-derived 3D-tissue-engineered-skeletal muscles (3D-TESMs) offer advanced technology for disease modelling. Howev...
Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy
Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in DMD gene and loss of the protein dystrophi...
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice
The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle inflammation...
DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults
DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults
While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the...
Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy
Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy
The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 19...
Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle
Biomarkers for Duchenne muscular dystrophy progression: impact of age in the mdx tongue spared muscle
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy without an effective treatment, caused by mutatio...
Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle
Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of the skeletal muscle
Transcription factors (TFs) play key roles in regulating differentiation and function of stem cells, including muscle sate...
MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides
MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides
Histological analysis of skeletal muscle is of major interest for understanding its behavior in different pathophysiologic...
Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration
Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration
The occurrence of hyperplasia, through myofibre splitting, remains a widely debated phenomenon. Structural alterations and...
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Critical illness is hallmarked by severe stress and organ damage. Fibroblast growth factor 21 (FGF21) has been shown to ri...
Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes
Age-related gene expression signatures from limb skeletal muscles and the diaphragm in mice and rats reveal common and species-specific changes
As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakn...
TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype–phenotype correlation
TRIM32 biallelic defects cause limb-girdle muscular dystrophy R8: identification of two novel mutations and investigation of genotype–phenotype correlation
Limb-girdle muscular dystrophy R8 (LGMD R8) is a rare autosomal recessive muscle disease caused by TRIM32 gene biallelic d...
Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservati...
Expression of Myomaker and Myomerger in myofibers causes muscle pathology
Expression of Myomaker and Myomerger in myofibers causes muscle pathology
Skeletal muscle development and regeneration depend on cellular fusion of myogenic progenitors to generate multinucleated ...
New tools for the investigation of muscle fiber-type spatial distributions across histological sections
New tools for the investigation of muscle fiber-type spatial distributions across histological sections
The functional and metabolic properties of skeletal muscles are partly a function of the spatial arrangement of fibers acr...
Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy
Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy
Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, ...
An updated C. elegans nuclear body muscle transcriptome for studies in muscle formation and function
An updated C. elegans nuclear body muscle transcriptome for studies in muscle formation and function
The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is gene...
The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins
The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins
 We have previously demonstrated that double homeobox 4 centromeric (DUX4C) encoded for a functional DUX4c protei...
Angiogenesis precedes myogenesis during regeneration following biopsy injury of skeletal muscle
Angiogenesis precedes myogenesis during regeneration following biopsy injury of skeletal muscle
Acute injury to skeletal muscle damages myofibers and fragment capillaries, impairing contractile function and local perfu...
Sarcopenia: investigation of metabolic changes and its associated mechanisms
Sarcopenia: investigation of metabolic changes and its associated mechanisms
Sarcopenia is one of the most predominant musculoskeletal diseases of the elderly, defined as age-related progressive and ...
Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways
Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways
The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of the muscle cell membrane, providing a mechanic...
The prevalence of low muscle mass associated with obesity in the USA
The prevalence of low muscle mass associated with obesity in the USA
Sarcopenia is defined as age-related low muscle mass and function, and can also describe the loss of muscle mass in certai...
Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice
Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice
Limb-girdle muscular dystrophy (MD) type 2B (LGMD2B) and Duchenne MD (DMD) are caused by mutations to the Dysferlin and Dy...
Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat
Macroglossia and less advanced dystrophic change in the tongue muscle of the Duchenne muscular dystrophy rat
Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes ...
Megaconial congenital muscular dystrophy due to novel CHKB variants: a case report and literature review
Megaconial congenital muscular dystrophy due to novel CHKB variants: a case report and literature review
Choline kinase beta (CHKB) catalyzes the first step in the de novo biosynthesis of phosphatidyl choline and phosphatidylet...
Identification of the co-differentially expressed hub genes involved in the endogenous protective mechanism against ventilator-induced diaphragm dysfunction
Identification of the co-differentially expressed hub genes involved in the endogenous protective mechanism against ventilator-induced diaphragm dysfunction
In intensive care units (ICU), mechanical ventilation (MV) is commonly applied to save patients’ lives. However, ven...
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