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Grand roles for microproteins
Grand roles for microproteins
Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading fr...
RNA communication between organisms inspires innovative eco-friendly strategies for disease control
Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secrete...
Connecting cells through TNT
Connecting cells through TNT
Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in...
Paleoproteomics sheds light on million-year-old fossils
It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequen...
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific rec...
Three decades of protein-fragment complementation
This year marks the 30th anniversary of the publication of a novel approach to measuring protein–protein in...
How proteins sense their cellular environment
The cellular environment is critical to protein function. How is information from many cellular components decoded in orde...
Telomere function and regulation from mouse models to human ageing and disease
Telomere function and regulation from mouse models to human ageing and disease
Telomeres protect the ends of chromosomes but shorten following cell division in the absence of telomerase activity. When ...
Heterochromatin as a balancing act between transcription and gene silencing
Heterochromatin as a balancing act between transcription and gene silencing
An elegant study revealed the distinct roles of different H3K9 methylation states in heterochromatin formation and function.
Long-lived proteomes in healthy ovaries
Long-lived proteomes in healthy ovaries
Many proteins in the mouse ovary are extremely stable; they enhance proteostasis and limit protein aggregation, thereby su...
Virus–host warfare by PROTACs
Virus–host warfare by PROTACs
The studies that paved the way for the development of PROTACs (proteolysis-targeting chimeras) as therapeutic strategies, ...
The discovery of cyclin-dependent kinases
The discovery of cyclin-dependent kinases
Paul Nurse discusses how a 1971 paper by Culotti and Hartwell inspired him to investigate the cell cycle in fission yeast,...
Cellular and pathological functions of tau
Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of m...
Regulation of and challenges in targeting NAD+ metabolism
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a reduction–oxidation (redox)...
What does it take to build a nucleus?
What does it take to build a nucleus?
Abigail Buchwalter recounts what happened to the nuclei of cells lacking all lamin genes.
MYB-related proteins make chloroplasts
MYB-related proteins make chloroplasts
MYB-related transcription factors are found to function in chloroplast biogenesis alongside GLK in the distantly related s...
Localized translation in the embryo
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the im...
A code within the genetic code
A code within the genetic code
The story of a paper that established the concept of codon optimality and its connection with translation efficiency and m...
Protein N-terminal acetylation is entering the degradation end game
Despite being one of the most common protein modifications in eukaryotes, the cellular effect of N-terminal acetylation re...
Single-cell live volume measurements using the fluorescence exclusion method
In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion met...
Cellular and molecular mechanisms of skin wound healing
Cellular and molecular mechanisms of skin wound healing
Wound healing is a complex process that involves the coordinated actions of many different tissues and cell lineages. It r...
How ancient RNA survives and what we can learn from it
Although normally transient, RNA can persist postmortem when preserved by cold, desiccation or chemical treatment. In this...
Opportunities and challenges in design and optimization of protein function
Opportunities and challenges in design and optimization of protein function
The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely...
Seeing transcription in real time
Seeing transcription in real time
Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenou...
The molecular basis of translation initiation and its regulation in eukaryotes
The molecular basis of translation initiation and its regulation in eukaryotes
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional regulation of gene expressi...
Does species-specific alternative splicing make us human?
Florian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdow...
Local and systemic mechanisms that control the hair follicle stem cell niche
Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregul...
Extended heterochronic parabiosis as an approach to study rejuvenation
In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis...
Senescent cells support limb regeneration
Yu et al. identify senescent cells as important players in the regeneration of complex structures.
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