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Patch-seq: Advances and Biological Applications
Patch-seq: Advances and Biological Applications
Multimodal analysis of gene-expression patterns, electrophysiological properties, and morphological phenotypes at the sing...
Liposome-Mediated Anti-Viral Drug Delivery Across Blood–Brain Barrier: Can Lipid Droplet Target Be Game Changers?
Liposome-Mediated Anti-Viral Drug Delivery Across Blood–Brain Barrier: Can Lipid Droplet Target Be Game Changers?
Lipid droplets (LDs) are subcellular organelles secreted from the endoplasmic reticulum (ER) that play a major role in lip...
Zika Virus Infection Alters the Circadian Clock Expression in Human Neuronal Monolayer and Neurosphere Cultures
Zika Virus Infection Alters the Circadian Clock Expression in Human Neuronal Monolayer and Neurosphere Cultures
Rhythmic regulations are virtually described in all physiological processes, including central nervous system development ...
Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology
Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology
Intracranial vascular malformations manifest on a continuum ranging from predominantly arterial to predominantly venous in...
Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury
Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury
The adult peripheral nervous system has a significant ability for regeneration compared to the central nervous system. Thi...
Genetic Discrimination of Grade 3 and Grade 4 Gliomas by Artificial Neural Network
Genetic Discrimination of Grade 3 and Grade 4 Gliomas by Artificial Neural Network
Gliomas, including anaplastic gliomas (AG; grade 3) and glioblastomas (GBM; grade 4), are malignant brain tumors associate...
Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases
Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases
The existence of lymphatic vessels or similar clearance systems in the central nervous system (CNS) that transport nutrien...
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
It was found that ischemic stroke (IS) was associated with abnormal platelet activity and thrombosis. However, the potenti...
CircSKA3 is Associated With the Risk of Extracranial Artery Stenosis and Plaque Instability Among Ischemic Stroke Patients
CircSKA3 is Associated With the Risk of Extracranial Artery Stenosis and Plaque Instability Among Ischemic Stroke Patients
Circular RNA circSKA3 (spindle and kinetochore-related complex subunit 3) has been identified as a prognostic factor in is...
Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling
Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling
Exercise can promote adult neurogenesis and improve symptoms associated with schizophrenia and other mental disorders via ...
Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF
Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF
Multiple studies have shown that clinical events resulting into neonatal IL-4 over-exposure, such as asthma in early life ...
Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period
Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period
Retinal vasoactive intestinal peptide amacrine cells (VIP-ACs) play an important role in various retinal light-mediated pa...
Disease-Associated Neurotoxic Astrocyte Markers in Alzheimer Disease Based on Integrative Single-Nucleus RNA Sequencing
Disease-Associated Neurotoxic Astrocyte Markers in Alzheimer Disease Based on Integrative Single-Nucleus RNA Sequencing
Alzheimer disease (AD) is an irreversible neurodegenerative disease, and astrocytes play a key role in its onset and progr...
Frequency and Focus of in Vitro Studies of Microglia-Expressed Cytokines in Response to Viral Infection: A Systematic Review
Frequency and Focus of in Vitro Studies of Microglia-Expressed Cytokines in Response to Viral Infection: A Systematic Review
It is well known that as part of their response to infectious agents such as viruses, microglia transition from a quiescen...
Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders
Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders
HOX transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA (lncRNA) which is increasingly being perceived a...
Expression of CGRP in the Trigeminal Ganglion and Its Effect on the Polarization of Macrophages in Rats with Temporomandibular Arthritis
Expression of CGRP in the Trigeminal Ganglion and Its Effect on the Polarization of Macrophages in Rats with Temporomandibular Arthritis
Calcitonin gene-related peptide (CGRP) is synthesized and secreted by trigeminal ganglion neurons, and is a key neuropepti...
A New Strategy for the Regulation of Neuroinflammation: Exosomes Derived from Mesenchymal Stem Cells
A New Strategy for the Regulation of Neuroinflammation: Exosomes Derived from Mesenchymal Stem Cells
Neuroinflammation is an important pathogenesis of neurological diseases and causes a series of physiopathological changes,...
Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Ferroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be clo...
Iron Deposition in Parkinson’s Disease: A Mini-Review
Iron Deposition in Parkinson’s Disease: A Mini-Review
Iron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientis...
Ultrastructural Changes in Hippocampal Region CA1 Neurons After Exposure to Permissive Hypercapnia and/or Normobaric Hypoxia
Ultrastructural Changes in Hippocampal Region CA1 Neurons After Exposure to Permissive Hypercapnia and/or Normobaric Hypoxia
Isolated exposure to intermittent hypoxia and permissive hypercapnia activates signaling mechanisms that induce ultrastruc...
Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/β-Catenin and PI3K/AKT Signaling Pathways
Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/β-Catenin and PI3K/AKT Signaling Pathways
Gliomas are a deadly primary malignant tumor of the central nervous system, with glioblastoma (GBM) representing the most ...
Association of mTOR Pathway and Conformational Alterations in C-Reactive Protein in Neurodegenerative Diseases and Infections
Association of mTOR Pathway and Conformational Alterations in C-Reactive Protein in Neurodegenerative Diseases and Infections
Inflammatory biomarkers have been very useful in detecting and monitoring inflammatory processes along with providing help...
Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis
This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mese...
Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons
Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons
To study key proteins associated with changes in synaptic transmission in the spiral ganglion in tinnitus, we build three ...
A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies
A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies
Delivering biologics to elicit a therapeutic response in the central nervous system (CNS) remains challenging due to the p...
The Neuroprotective Effects and Probable Mechanisms of Everolimus in a Rat Model of Intracerebral Hemorrhage
The Neuroprotective Effects and Probable Mechanisms of Everolimus in a Rat Model of Intracerebral Hemorrhage
Mammalian target of rapamycin (mTOR) is a central regulator of cellular growth and homeostasis. Changes in mTOR activity a...
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Ischemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferropt...
Genetic Features of Young and Aged Animals After Peripheral Nerve Injury: Implications for Diminished Regeneration Capacity
Genetic Features of Young and Aged Animals After Peripheral Nerve Injury: Implications for Diminished Regeneration Capacity
The spontaneous regeneration capacity of peripheral nerves is fundamentally reduced with advancing age, leading to severe ...
Neuromodulation Through Magnetic Fields Irradiation with AT-04 Improves Hyperalgesia in a Rat Model of Neuropathic Pain via Descending Pain Modulatory Systems and Opioid Analgesia
Neuromodulation Through Magnetic Fields Irradiation with AT-04 Improves Hyperalgesia in a Rat Model of Neuropathic Pain via Descending Pain Modulatory Systems and Opioid Analgesia
Neuromodulation through magnetic fields irradiation with ait® (AT-04), a device that irradiates a mixed alternating m...
Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders
MECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis o...
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