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Genetically Predicted Leucine Level Mediates Association Between CD4/CD8br T Lymphocytes and Insomnia
Genetically Predicted Leucine Level Mediates Association Between CD4/CD8br T Lymphocytes and Insomnia
Immune and metabolic factors play an important role in the onset and development of insomnia. This study aimed to investig...
Correction: Docosahexaenoic Acid Alleviates Oxidative Stress-Based Apoptosis Via Improving Mitochondrial Dynamics in Early Brain Injury After Subarachnoid Hemorrhage
Correction: Docosahexaenoic Acid Alleviates Oxidative Stress-Based Apoptosis Via Improving Mitochondrial Dynamics in Early Brain Injury After Subarachnoid Hemorrhage
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Organochlorine Pesticides and Epigenetic Alterations in Brain Cancer
Organochlorine Pesticides and Epigenetic Alterations in Brain Cancer
Epigenetic alterations have emerged as critical factors in the pathogenesis of brain cancer, particularly gliomas. This ar...
Single-Cell Analysis of Sex and Gender Differences in the Human Brain During Development and Disease
Single-Cell Analysis of Sex and Gender Differences in the Human Brain During Development and Disease
Sex and gender (SG) differences in the human brain are of interest to society and science as numerous processes are impact...
LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review
LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review
CNS diseases account for a major part of the comorbidity and mortality of the human population; moreover, neuroinflammatio...
Beyond Diabetes: Semaglutide's Role in Modulating Mood Disorders through Neuroinflammation Pathways
Beyond Diabetes: Semaglutide's Role in Modulating Mood Disorders through Neuroinflammation Pathways
Diabetes and mood disorders are intricately interconnected, with each condition elevating the risk of the other. This bidi...
Targeting Neuroinflammation in Preterm White Matter Injury: Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes
Targeting Neuroinflammation in Preterm White Matter Injury: Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes
Neuroinflammation is a key factor in the development of preterm white matter injury (PWMI), leading to glial cell dysfunct...
Comparing In vitro Protein Aggregation Modelling Using Strategies Relevant to Neuropathologies
Comparing In vitro Protein Aggregation Modelling Using Strategies Relevant to Neuropathologies
Protein aggregation is remarkably associated with several neuropathologies, including Alzheimer´s (AD) and Parkinson&...
The Effects and Mechanisms of n-3 and n-6 Polyunsaturated Fatty Acids in the Central Nervous System
The Effects and Mechanisms of n-3 and n-6 Polyunsaturated Fatty Acids in the Central Nervous System
The brain is rich in fatty acids (FAs), with polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (C22:6n-3, ...
A Closer Look at Dystonia with the Glycosylation
A Closer Look at Dystonia with the Glycosylation
Dystonia is characterized by abnormally repetitive and involuntary movements or postu...
Investigating Molecular Mechanisms in Ischemic Preconditioning-Induced Resiliency to Severe Acute Global Cerebral Ischemia Using a Mouse Model of Chronic Cerebral Hypoperfusion
Investigating Molecular Mechanisms in Ischemic Preconditioning-Induced Resiliency to Severe Acute Global Cerebral Ischemia Using a Mouse Model of Chronic Cerebral Hypoperfusion
Cerebral ischemic preconditioning offers a promising strategy to enhance resilience to severe ischemic insults. Unilateral...
Electroacupuncture Improves the Motor Function in Rats with Spinal Cord Injury by Regulating UCN2-Mediated cAMP-PKA Signaling in the Spinal Cord Microenvironment
Electroacupuncture Improves the Motor Function in Rats with Spinal Cord Injury by Regulating UCN2-Mediated cAMP-PKA Signaling in the Spinal Cord Microenvironment
Spinal cord injury (SCI) has a high mortality and disability rate and can result in severe neurological deficits and compl...
Genetic, Epigenetic, and Hormonal Regulation of Stress Phenotypes in Major Depressive Disorder: From Maladaptation to Resilience
Genetic, Epigenetic, and Hormonal Regulation of Stress Phenotypes in Major Depressive Disorder: From Maladaptation to Resilience
Major Depressive Disorder (MDD) is a complex psychiatric disorder with varied molecular mechanisms underlying its aetiolog...
Alpha-Synuclein Pathophysiology in Neurodegenerative Disorders: A Review Focusing on Molecular Mechanisms and Treatment Advances in Parkinson’s Disease
Alpha-Synuclein Pathophysiology in Neurodegenerative Disorders: A Review Focusing on Molecular Mechanisms and Treatment Advances in Parkinson’s Disease
Worldwide aging has contributed to the growth of prevalence of neurodegenerative diseases (NDDs), including Parkinson̵...
Extracellular Vesicle-Derived miRNAs in Ischemic Stroke: Roles in Neuroprotection, Tissue Regeneration, and Biomarker Potential
Extracellular Vesicle-Derived miRNAs in Ischemic Stroke: Roles in Neuroprotection, Tissue Regeneration, and Biomarker Potential
Ischemic stroke (IS) is one of the most common causes of death and disability worldwide. Despite its prevalence, knowledge...
Downregulation of Hmox1 and Rpgrip1l Expression Linked to Risk-Taking Behavior, Reduced Depressive Symptoms, and Diminished Novelty Socialization in SUMO1 Knockout Mice
Downregulation of Hmox1 and Rpgrip1l Expression Linked to Risk-Taking Behavior, Reduced Depressive Symptoms, and Diminished Novelty Socialization in SUMO1 Knockout Mice
SUMO1 is involved in the normal physiological functions of the nervous system and is also associated with the development ...
The STING Signaling: A Novel Target for Central Nervous System Diseases
The STING Signaling: A Novel Target for Central Nervous System Diseases
The canonical cyclic GMP-AMP (cGAMP) synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway has been widely recogn...
Evaluation of 5 Intermediate Structural Variations of Microglia Within an Organotypic Hippocampal Slice Model After Regionalized Toxic Injury
Evaluation of 5 Intermediate Structural Variations of Microglia Within an Organotypic Hippocampal Slice Model After Regionalized Toxic Injury
The dendritic cell of the CNS, the microglia (MG), is an initiation point of the immunological response within the post-bl...
TIMP-3 Alleviates White Matter Injury After Subarachnoid Hemorrhage in Mice by Promoting Oligodendrocyte Precursor Cell Maturation
TIMP-3 Alleviates White Matter Injury After Subarachnoid Hemorrhage in Mice by Promoting Oligodendrocyte Precursor Cell Maturation
Subarachnoid hemorrhage (SAH) is associated with high mortality and disability rates, and secondary white matter injury is...
FoxG1 as a Potential Therapeutic Target for Alzheimer’s Disease: Modulating NLRP3 Inflammasome via AMPK/mTOR Autophagy Pathway
FoxG1 as a Potential Therapeutic Target for Alzheimer’s Disease: Modulating NLRP3 Inflammasome via AMPK/mTOR Autophagy Pathway
An increasing body of research suggests that promoting microglial autophagy hinders the neuroinflammation initiated though...
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
Surgical brain injury (SBI), induced by neurosurgical procedures or instruments, has not attracted adequate attention. The...
Correction: Inhibition of mTOR Alleviates Early Brain Injury After Subarachnoid Hemorrhage Via Relieving Excessive Mitochondrial Fission
Correction: Inhibition of mTOR Alleviates Early Brain Injury After Subarachnoid Hemorrhage Via Relieving Excessive Mitochondrial Fission
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of Glioblastoma: Role of the Neutrophil
Correction: Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of Glioblastoma: Role of the Neutrophil
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Inhibition of UHRF1 Improves Motor Function in Mice with Spinal Cord Injury
Inhibition of UHRF1 Improves Motor Function in Mice with Spinal Cord Injury
Spinal-cord injury (SCI) is a severe condition that can lead to limb paralysis and motor dysfunction, and its pathogenesis...
Correction: GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms
Correction: GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Association of Cadherin-Related Family Member 1 with Traumatic Brain Injury
Association of Cadherin-Related Family Member 1 with Traumatic Brain Injury
The cadherin family plays a pivotal role in orchestrating synapse formation in the central nervous system. Cadherin-relate...
Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
Lewy Body Dementias (LBD), including Parkinson’s disease dementia and Dementia with Lewy Bodies, are characterized b...
The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis
The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis
Cell transplantation is a promising treatment option for spinal cord injury (SCI). However, there is no consensus on the c...
Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment
Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by inflammation and dem...
Correction: CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4
Correction: CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
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