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Circulating biomarkers in familial cerebral cavernous malformation
Circulating biomarkers in familial cerebral cavernous malformation
BackgroundCerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multip...
Prioritizing de novo potential non-canonical splicing variants in neurodevelopmental disorders
Prioritizing de novo potential non-canonical splicing variants in neurodevelopmental disorders
BackgroundGenomic variants outside of the canonical splicing site (±2) may generate abnormal mRNA splicing, which are defi...
Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 study
Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 study
BackgroundVaccines that minimize the risk of vaccine-induced antibody-dependent enhancement and severe dengue are needed t...
Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease
Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease
BackgroundMitochondrial dysfunction has been linked to the development of inflammatory bowel disease (IBD), but the geneti...
Relationship between bone marrow iron load and liver iron concentration in dialysis-associated haemosiderosis
Relationship between bone marrow iron load and liver iron concentration in dialysis-associated haemosiderosis
BackgroundIron overload due to the excessive use of parenteral iron in haemodialysis is now an increasingly recognised cli...
A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic mice
A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic mice
eBioMedicineVolume 99, January 2024, 104932Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryBa...
Dynamic prediction of malignant ventricular arrhythmias using neural networks in patients with an implantable cardioverter-defibrillator
Dynamic prediction of malignant ventricular arrhythmias using neural networks in patients with an implantable cardioverter-defibrillator
eBioMedicineVolume 99, January 2024, 104937Author links open overlay panel, , , , , , , , , , , , SummaryBackgroundRisk st...
11-deoxycortisol positively correlates with T cell immune traits in physiological conditions
11-deoxycortisol positively correlates with T cell immune traits in physiological conditions
eBioMedicineVolume 99, January 2024, 104935Author links open overlay panel, , , , , , , , , , , , , , , , , SummaryBackgro...
Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum
Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum
eBioMedicineVolume 99, January 2024, 104936Author links open overlay panel, , , , , , , , , , SummaryBackgroundEosinophili...
Neural connectivity moderators and mechanisms of ketamine treatment among treatment-resistant depressed patients: a randomized controlled trial
Neural connectivity moderators and mechanisms of ketamine treatment among treatment-resistant depressed patients: a randomized controlled trial
eBioMedicineVolume 99, January 2024, 104902Author links open overlay panel, , , , , SummaryBackgroundIntravenous (IV) keta...
Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness
Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness
BackgroundMultiple organ dysfunction syndrome (MODS) disproportionately drives morbidity and mortality among critically il...
Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities
Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities
BackgroundPathogenic variants in the centrosome protein (CEP) family have been implicated in primary microcephaly, Seckel ...
Clinical and genetic keys to cerebellar ataxia due to FGF14 GAA expansions
Clinical and genetic keys to cerebellar ataxia due to FGF14 GAA expansions
BackgroundSCA27B caused by FGF14 intronic heterozygous GAA expansions with at least 250 repeats accounts for 10–60% of cas...
Systems biology analysis reveals distinct molecular signatures associated with immune responsiveness to the BNT162b COVID-19 vaccine
Systems biology analysis reveals distinct molecular signatures associated with immune responsiveness to the BNT162b COVID-19 vaccine
eBioMedicineVolume 99, January 2024, 104947Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryBa...
Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in a COVID-19 hamster model
Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in a COVID-19 hamster model
eBioMedicineVolume 99, January 2024, 104950Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryBa...
Resistant and refractory migraine: clinical presentation, pathophysiology, and management
Resistant and refractory migraine: clinical presentation, pathophysiology, and management
Migraine is a leading cause of disability worldwide. A minority of individuals with migraine develop resistant or refracto...
Intact proviruses are enriched in the colon and associated with PD-1+TIGIT− mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapy
Intact proviruses are enriched in the colon and associated with PD-1+TIGIT− mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapy
BackgroundThe persistence of intact replication-competent HIV-1 proviruses is responsible for the virological rebound off ...
Multi-omics analyses reveal bacteria and catalase associated with keloid disease
Multi-omics analyses reveal bacteria and catalase associated with keloid disease
eBioMedicineVolume 99, January 2024, 104904Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryBa...
CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation
CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation
eBioMedicineVolume 99, January 2024, 104906Author links open overlay panel, , , , , , , , , , , SummaryBackgroundIn spite ...
Dynamic immune landscape in vaccinated-BA.5-XBB.1.9.1 reinfections revealed a 5-month protection-duration against XBB infection and a shift in immune imprinting
Dynamic immune landscape in vaccinated-BA.5-XBB.1.9.1 reinfections revealed a 5-month protection-duration against XBB infection and a shift in immune imprinting
BackgroundThe impact of previous vaccination on protective immunity, duration, and immune imprinting in the context of BA....
The potential impacts of micro-and-nano plastics on various organ systems in humans
The potential impacts of micro-and-nano plastics on various organ systems in humans
eBioMedicineVolume 99, January 2024, 104901Author links open overlay panel, , , , , SummaryHumans are exposed to micro-and...
ENLIGHT: A consensus checklist for reporting laboratory-based studies on the non-visual effects of light in humans
ENLIGHT: A consensus checklist for reporting laboratory-based studies on the non-visual effects of light in humans
BackgroundThere is no consensus on reporting light characteristics in studies investigating non-visual responses to light....
Rapid intraoperative multi-molecular diagnosis of glioma with ultrasound radio frequency signals and deep learning
Rapid intraoperative multi-molecular diagnosis of glioma with ultrasound radio frequency signals and deep learning
BackgroundMolecular diagnosis is crucial for biomarker-assisted glioma resection and management. However, some limitations...
Implications of cellular senescence in paediatric pituitary tumours
Implications of cellular senescence in paediatric pituitary tumours
eBioMedicineVolume 99, January 2024, 104905Author links open overlay panel, SummaryThe long-standing view of senescent cel...
Reduced tactile sensitivity is associated with mild cognitive impairment
Reduced tactile sensitivity is associated with mild cognitive impairment
BackgroundSensory impairment has been related to age-associated cognitive decline. While these associations were investiga...
NIR-II fluorescence-guided liver cancer surgery by a small molecular HDAC6 targeting probe
NIR-II fluorescence-guided liver cancer surgery by a small molecular HDAC6 targeting probe
BackgroundHepatocellular carcinoma (HCC) is the sixth most common malignancy globally and ranks third in terms of both mor...
A versatile microfluidic platform for malaria infection screening and Plasmodium species genotyping
A versatile microfluidic platform for malaria infection screening and Plasmodium species genotyping
eBioMedicineVolume 98, December 2023, 104898Author links open overlay panel, , , , , , , , SummaryBackgroundMalaria, a wid...
Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose booster
Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose booster
eBioMedicineVolume 98, December 2023, 104878Author links open overlay panel, , , , , , , , , , , , , , , , , , , …SummaryB...
High serum C-X-C motif chemokine ligand 10 (CXCL10) levels may be associated with new onset interstitial lung disease in patients with systemic sclerosis: evidence from observational, clinical, transcriptomic and in vitro studies
High serum C-X-C motif chemokine ligand 10 (CXCL10) levels may be associated with new onset interstitial lung disease in patients with systemic sclerosis: evidence from observational, clinical, transcriptomic and in vitro studies
eBioMedicineVolume 98, December 2023, 104883Author links open overlay panel, , , , , , , , , , , SummaryBackgroundSystemic...
Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort study
Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort study
BackgroundSocioeconomic inequalities in cardiovascular disease risk begin early in life and are more pronounced in females...
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