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Highlighting the past and future of inherited peripheral neuropathies
Highlighting the past and future of inherited peripheral neuropathies
Inherited peripheral neuropathies (IPN) are among the most common inherited conditions in Neurology and are still largely ...
Genetics of inherited peripheral neuropathies and the next frontier: looking backwards to progress forwards
Genetics of inherited peripheral neuropathies and the next frontier: looking backwards to progress forwards
IntroductionInherited peripheral neuropathies (IPNs) are a group of inherited diseases affecting the peripheral nervous sy...
Pathogenesis of multiple sclerosis: genetic, environmental and random mechanisms
Pathogenesis of multiple sclerosis: genetic, environmental and random mechanisms
IntroductionThe pathogenesis of multiple sclerosis (MS) requires both environmental events and genetic factors.1–4 Conside...
Trajectories of self-reported fatigue following initiation of multiple sclerosis disease-modifying therapy
Trajectories of self-reported fatigue following initiation of multiple sclerosis disease-modifying therapy
IntroductionSelf-reported fatigue, a prevalent and debilitating symptom affecting up to two-thirds of people with multiple...
Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study
Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study
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A phase I trial of accelerated intermittent theta burst rTMS for amnestic MCI
A phase I trial of accelerated intermittent theta burst rTMS for amnestic MCI
WHAT IS ALREADY KNOWN ON THIS TOPICThere is emerging evidence that suggests accelerated intermittent theta burst stimulati...
Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales
Algorithmic approach to finding people with multiple sclerosis using routine healthcare data in Wales
IntroductionThe challenge of monitoring changing patterns of disease at population levels1 arises from variations in healt...
Oral corticosteroid dosage and taper duration at onset in myelin oligodendrocyte glycoprotein antibody-associated disease influences time to first relapse
Oral corticosteroid dosage and taper duration at onset in myelin oligodendrocyte glycoprotein antibody-associated disease influences time to first relapse
WHAT IS ALREADY KNOWN ON THIS TOPICMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) patients may ex...
Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment
Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment
WHAT IS ALREADY KNOWN ON THIS TOPICPlasma pTau217 is the most promising biomarker for cerebral amyloidosis and Alzheimer’s...
Exercise as medicine in Parkinsons disease
Exercise as medicine in Parkinsons disease
IntroductionParkinson’s disease (PD) is a chronic debilitating disorder of the central nervous system. It is the fastest g...
Identification of DAGLA as an autoantibody target in cerebellar ataxia
Identification of DAGLA as an autoantibody target in cerebellar ataxia
IntroductionCerebellar ataxia can be caused by different aetiologies including genetic, infectious or neurodegenerative di...
Nigrostriatal blood-brain barrier opening in Parkinsons disease
Nigrostriatal blood-brain barrier opening in Parkinsons disease
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Searches for biomarkers using highly sensitive techniques might reveal more about pathogenesis of a disease than provide clinically useful molecular tests
Searches for biomarkers using highly sensitive techniques might reveal more about pathogenesis of a disease than provide clinically useful molecular tests
The era of modern medicine is often linked to the first clinical application of penicillin in 1943.1 How far we have come ...
Therapeutic interventions increasing seizure risk in multiple sclerosis: resolving discordant meta-analyses
Therapeutic interventions increasing seizure risk in multiple sclerosis: resolving discordant meta-analyses
In their JNNP meta-analysis Pozzilli et al concludes that sphingosine-1-phosphate receptor (S1PR) modulators substantially...
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy
Proximity extension assay-based discovery of biomarkers for disease activity in chronic inflammatory demyelinating polyneuropathy
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Effect of sodium phenylbutyrate and taurursodiol on plasma concentrations of neuroinflammatory biomarkers in amyotrophic lateral sclerosis: results from the CENTAUR trial
Effect of sodium phenylbutyrate and taurursodiol on plasma concentrations of neuroinflammatory biomarkers in amyotrophic lateral sclerosis: results from the CENTAUR trial
IntroductionSafety and efficacy of an oral, fixed-dose sodium phenylbutyrate and taurursodiol combination (PB and TURSO) i...
Excellent response to anti-CD38 therapy with daratumumab in a patient with severe refractory CANOMAD
Excellent response to anti-CD38 therapy with daratumumab in a patient with severe refractory CANOMAD
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Emulating randomised clinical trials in relapsing-remitting multiple sclerosis with non-randomised real-world evidence: an application using data from the MSBase Registry
Emulating randomised clinical trials in relapsing-remitting multiple sclerosis with non-randomised real-world evidence: an application using data from the MSBase Registry
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Incidence and determinants of seizures in multiple sclerosis: a meta-analysis of randomised clinical trials
Incidence and determinants of seizures in multiple sclerosis: a meta-analysis of randomised clinical trials
IntroductionSeizures are more prevalent in individuals with multiple sclerosis (MS) compared with the general population.1...
Stratifying quality of life outcome in subthalamic stimulation for Parkinsons disease
Stratifying quality of life outcome in subthalamic stimulation for Parkinsons disease
IntroductionSubthalamic nucleus deep brain stimulation (STN-DBS) is a safe and effective treatment of advanced Parkinson’s...
Long-term disability progression in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: a retrospective analysis of 101 patients
Long-term disability progression in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: a retrospective analysis of 101 patients
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Prevalence and burden of pain across the entire spectrum of Huntingtons disease
Prevalence and burden of pain across the entire spectrum of Huntingtons disease
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Flavonoid intake and risk of Parkinsons disease
Flavonoid intake and risk of Parkinsons disease
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Impact of white matter networks on risk for memory decline following resection versus ablation in temporal lobe epilepsy
Impact of white matter networks on risk for memory decline following resection versus ablation in temporal lobe epilepsy
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ON/OFF non-motor evaluation: a new way to evaluate non-motor fluctuations in Parkinsons disease
ON/OFF non-motor evaluation: a new way to evaluate non-motor fluctuations in Parkinsons disease
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The influence of epigenetic biological age on key complications and outcomes in aneurysmal subarachnoid haemorrhage
The influence of epigenetic biological age on key complications and outcomes in aneurysmal subarachnoid haemorrhage
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NICE guideline on ME/CFS: robust advice based on a thorough review of the evidence
NICE guideline on ME/CFS: robust advice based on a thorough review of the evidence
Guidelines produced by the National Institute for Health and Care Excellence (NICE) are developed by independent advisory ...
Genotype-specific spinal cord damage in spinocerebellar ataxias: an ENIGMA-Ataxia study
Genotype-specific spinal cord damage in spinocerebellar ataxias: an ENIGMA-Ataxia study
WHAT IS ALREADY KNOWN ON THIS TOPICSpinal cord degeneration is thought to be a key aspect of many spinocerebellar disorder...
Genetics, cell biology and a novel mechanism for ALS
Genetics, cell biology and a novel mechanism for ALS
Syeda and colleagues used an elegant combination of genetics, meticulous clinical evaluation and cell biology to demonstra...
Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis
Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis
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