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Genetics, cell biology and a novel mechanism for ALS
Genetics, cell biology and a novel mechanism for ALS
Syeda and colleagues used an elegant combination of genetics, meticulous clinical evaluation and cell biology to demonstra...
Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis
Recurrent de-novo gain-of-function mutation in SPTLC2 confirms dysregulated sphingolipid production to cause juvenile amyotrophic lateral sclerosis
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Unilateral focused ultrasound subthalamotomy in early Parkinsons disease: a pilot study
Unilateral focused ultrasound subthalamotomy in early Parkinsons disease: a pilot study
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Cognitive and psychiatric outcomes in the GALAXY trial: effect of anaesthesia in deep brain stimulation
Cognitive and psychiatric outcomes in the GALAXY trial: effect of anaesthesia in deep brain stimulation
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Effect of long-term Tai Chi training on Parkinsons disease: a 3.5-year follow-up cohort study
Effect of long-term Tai Chi training on Parkinsons disease: a 3.5-year follow-up cohort study
IntroductionParkinson’s disease (PD) is a common debilitating and progressive neurodegenerative movement disorder characte...
Early treatment of type II SMA slows rate of progression of scoliosis
Early treatment of type II SMA slows rate of progression of scoliosis
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Incidence and prevalence of paediatric-onset multiple sclerosis in two Canadian provinces: a population-based study representing over half of Canadas population
Incidence and prevalence of paediatric-onset multiple sclerosis in two Canadian provinces: a population-based study representing over half of Canadas population
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSBetween 2003 and 2019, this population-based study found that the P...
Reduced long-term mortality after successful resective epilepsy surgery: a population-based study
Reduced long-term mortality after successful resective epilepsy surgery: a population-based study
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSTo the best of our knowledge, this is the largest population-based ...
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
MethodsParticipantsThis study included participants with ALS and neurologically healthy controls, using previously reporte...
Beyond antithrombotics: recent advances in pharmacological risk factor management for secondary stroke prevention
Beyond antithrombotics: recent advances in pharmacological risk factor management for secondary stroke prevention
Patients with ischaemic stroke represent a diverse group with several cardiovascular risk factors and comorbidities, which...
Direct Versus Indirect Revascularization for Moyamoya: a Large Multicenter Study
Direct Versus Indirect Revascularization for Moyamoya: a Large Multicenter Study
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Cognitive and executive impairments in Parkinsons disease psychosis: a Bayesian meta-analysis
Cognitive and executive impairments in Parkinsons disease psychosis: a Bayesian meta-analysis
IntroductionPsychotic symptoms in Parkinson’s disease (PD) are one of the most common non-motor symptoms, manifesting typi...
Improved naming in patients with Brocas aphasia with tDCS
Improved naming in patients with Brocas aphasia with tDCS
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Leukoencephalopathy caused by a 17p13.3 microdeletion
Leukoencephalopathy caused by a 17p13.3 microdeletion
IntroductionInherited white matter disorders (IWMDs) comprise a group of genetic disorders with onset from childhood to la...
Heterozygous SPTLC1 p.Leu39del is a major cause of slow-progressing juvenile ALS
Heterozygous SPTLC1 p.Leu39del is a major cause of slow-progressing juvenile ALS
IntroductionJuvenile amyotrophic lateral sclerosis (JALS) is a rare and severe motor neuron disease defined by an onset be...
Autism and FND
Autism and FND
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17 The national hospital for neurology and neurosurgeryand functional seizures: a historical perspective using a collective case analysis of archived records from 1863 to 1945
17 The national hospital for neurology and neurosurgeryand functional seizures: a historical perspective using a collective case analysis of archived records from 1863 to 1945
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Autism and neurodiversity: a new paradigm
Autism and neurodiversity: a new paradigm
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14 Neural circuit mapping of waiting impulsivity and proactive inhibition with convergent evidence from fMRI and TMS
14 Neural circuit mapping of waiting impulsivity and proactive inhibition with convergent evidence from fMRI and TMS
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24 Intelligent sensing in ADHD trial (ISAT) - pilot study
24 Intelligent sensing in ADHD trial (ISAT) - pilot study
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12 A pilot investigation of interoceptive accuracy, awareness, and sensibility in functional neurological disorder
12 A pilot investigation of interoceptive accuracy, awareness, and sensibility in functional neurological disorder
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19 Direct neural recordings from human bed nucleus of stria terminalis link alpha activity in empathy and affect evaluation tasks with depression severity
19 Direct neural recordings from human bed nucleus of stria terminalis link alpha activity in empathy and affect evaluation tasks with depression severity
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19 Dimensions of interoception in people with epilepsy and people with functional non-epileptic seizures
19 Dimensions of interoception in people with epilepsy and people with functional non-epileptic seizures
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20 Reflexive downregulation of memory systems in dissociative amnesia: a case series
20 Reflexive downregulation of memory systems in dissociative amnesia: a case series
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22 How does the free cog compare to the Addenbrookes cognitive examination (ACE III) in traumatic brain injury (TBI)?
22 How does the free cog compare to the Addenbrookes cognitive examination (ACE III) in traumatic brain injury (TBI)?
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21 How can we collaborate with experts-by-example to improve the ecological validity of computational psychiatry? A pilot study where the experts-by-experience are people with functional neurological disorder (FND) and the overall aim is to understand what leads patients unilaterally to disengage from psychotherapy
21 How can we collaborate with experts-by-example to improve the ecological validity of computational psychiatry? A pilot study where the experts-by-experience are people with functional neurological disorder (FND) and the overall aim is to understand what leads patients unilaterally to disengage from psychotherapy
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2 Understanding quality of life in mild-to-moderate dementia and what we can do to maintain or enhance it
2 Understanding quality of life in mild-to-moderate dementia and what we can do to maintain or enhance it
Linda Clare is Professor of Clinical Psychology of Ageing and Dementia at the University of Exeter Medical School and lead...
23 How the emotions of others capture our attention: a human amygdala disruption study
23 How the emotions of others capture our attention: a human amygdala disruption study
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Interstitial laser ablation for epilepsy: beauty lies in the eye of the beholder
Interstitial laser ablation for epilepsy: beauty lies in the eye of the beholder
MRI-guided laser interstitial thermal therapy (MRgLITT) is among the most promising approaches for the surgical treatment ...
15 The clinical relevance of serum versus CSF NMDAR autoantibodies associated exclusively with psychiatric features: a systematic review and meta-analysis of individual patient data
15 The clinical relevance of serum versus CSF NMDAR autoantibodies associated exclusively with psychiatric features: a systematic review and meta-analysis of individual patient data
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