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Cyclic-di-AMP modulates cellular turgor in response to defects in bacterial cell wall synthesis
Cyclic-di-AMP modulates cellular turgor in response to defects in bacterial cell wall synthesis
Cyclic-di-AMP (c-di-AMP) is an essential second messenger in Bacillus subtilis and many other Gram-positive bacteria. Work...
A xanthone-derived antibiotic with a multifaceted mode of action
Bacterial resistance to available antibiotics continues to pose a great challenge to the successful treatment of infection...
Retracing a tangled tree of archaeal evolution
Retracing a tangled tree of archaeal evolution
Updated phylogenetic analyses yield a more nuanced view of the evolution of the DPANN archaea, a diverse superphylum of en...
Defining ultra-slow-growing extremophilic microorganisms as aeonophiles
Defining ultra-slow-growing extremophilic microorganisms as aeonophiles
In environments like the deep subsurface, microorganisms with long doubling times can remain metabolically active for mill...
Guidelines for preventing and reporting contamination in low-biomass microbiome studies
Guidelines for preventing and reporting contamination in low-biomass microbiome studies
Numerous important environments harbour low levels of microbial biomass, including certain human tissues, the atmosphere, ...
Author Correction: ARF4-mediated intracellular transport as a broad-spectrum antiviral target
These authors contributed equally: Ming-Yuan Li, Kao Deng, Xiao-He Cheng.State Key Laboratory of Pathogen and Biosecurity,...
Environmental stress drives clearance of a persistent enteric virus in mice
Environmental stress drives clearance of a persistent enteric virus in mice
Persistent viral infections are associated with long-term health issues and prolonged transmission. How external perturbat...
Searching for high pathogenicity avian influenza virus in Antarctica
Searching for high pathogenicity avian influenza virus in Antarctica
We gratefully acknowledge funding of the Australis Expedition by the International Association of Antarctica Tour Operator...
Engineering history with Asgard archaea of the kingdom Promethearchaeati
Engineering history with Asgard archaea of the kingdom Promethearchaeati
Multiple histories converge in Masaru Nobu’s story of culturing an archaeon closely related to us eukaryotes.
Coffee habits help shape gut communities
Coffee habits help shape gut communities
Routine coffee consumption is associated with a gut microbiome signature characterized by elevated levels of Lawsonibacter...
The Parkinson’s disease drug entacapone disrupts gut microbiome homoeostasis via iron sequestration
The Parkinson’s disease drug entacapone disrupts gut microbiome homoeostasis via iron sequestration
Many human-targeted drugs alter the gut microbiome, leading to implications for host health. However, the mechanisms under...
Parkinson’s drug starves gut microbes of iron
Parkinson’s drug starves gut microbes of iron
Entacapone, a drug used in the treatment of Parkinson’s disease, disrupts gut microbial communities by sequestering ...
Retraction Note: Culture of previously uncultured members of the human gut microbiota by culturomics
Aix Marseille Université URMITE, UM63, CNRS 7278, IRD 198, INSERM 1095, 27 Boulevard Jean Moulin, Marseille, Cedex 5, Fran...
Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes
Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes
Microbial pathogenesis is mediated by the expression of virulence genes. However, as microbes with identical virulence gen...
The neonatal Fc receptor is a cellular receptor for human astrovirus
The neonatal Fc receptor is a cellular receptor for human astrovirus
Human astroviruses (HAstV) are major causes of gastroenteritis, especially in children, and there are no vaccines or antiv...
Primal FEAR protects against infection
Primal FEAR protects against infection
FEAR is an ancestral histone chaperone complex that can control virus infections in an interferon-independent manner.
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon
Secretion systems are protein export machines that enable bacteria to exploit their environment through the release of pro...
FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins
FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins
The human facilitates chromatin transcription (FACT) complex is a chromatin remodeller composed of human suppressor of Ty ...
Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis
Brain exposure to SARS-CoV-2 virions perturbs synaptic homeostasis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with short- and long-term neurologica...
Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Cri...
Phase transition of GvpU regulates gas vesicle clustering in bacteria
Phase transition of GvpU regulates gas vesicle clustering in bacteria
Gas vesicles (GVs) are microbial protein organelles that support cellular buoyancy. GV engineering has multiple applicatio...
Low-dose dengue virus 3 human challenge model: a phase 1 open-label study
Low-dose dengue virus 3 human challenge model: a phase 1 open-label study
Dengue human infection models present an opportunity to explore the potential of a vaccine, anti-viral or immuno-compound ...
Close the gender gap in Africa’s HIV epidemic
Close the gender gap in Africa’s HIV epidemic
Improving HIV interventions for men could reduce HIV acquisition in women, close the growing gender gap in HIV infections ...
Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome
Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome
Interbacterial antagonism and associated defensive strategies are both essential during bacterial competition. The human g...
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility
Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and...
Placental group B Streptococcus is associated with increased risk of adverse foetal outcome
Placental group B Streptococcus is associated with increased risk of adverse foetal outcome
The placenta nourishes the foetus and supports its development and growth. Our study now identifies the placenta as a pote...
Longitudinal population-level HIV epidemiologic and genomic surveillance highlights growing gender disparity of HIV transmission in Uganda
Longitudinal population-level HIV epidemiologic and genomic surveillance highlights growing gender disparity of HIV transmission in Uganda
HIV incidence in eastern and southern Africa has historically been concentrated among girls and women aged 15–24 yea...
Tackling climate change and deforestation to protect against vector-borne diseases
Tackling climate change and deforestation to protect against vector-borne diseases
The spread of vector-borne infectious diseases is driven by a complex array of environmental and social drivers, including...
Small organisms with big climate impact
Small organisms with big climate impact
To coincide with the 28th United Nations Climate Change Conference (COP28), taking place in Dubai, United Arab Emirates, w...
Global warming could drive the emergence of new fungal pathogens
Global warming could drive the emergence of new fungal pathogens
Increased heat tolerance in fungi with pathogenic potential due to global warming could bring new fungal diseases.
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