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Targeting the insulin-like growth factor-1 receptor to overcome imatinib resistance in chronic myeloid leukemia
Targeting the insulin-like growth factor-1 receptor to overcome imatinib resistance in chronic myeloid leukemia
Patients with chronic myeloid leukemia (CML) frequently develop resistance to tyrosine kinase inhibitors such as imatinib....
Nuclear receptor profiling for subtype classification and as prognostic markers in 33 cancer types
Nuclear receptor profiling for subtype classification and as prognostic markers in 33 cancer types
Nuclear receptors, a group of 48 transcription factors that regulate a multitude of processes within our body, have long b...
JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α
JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α
Endometrial cancer (EC) is the ninth most common malignancy among women. While mutations in JAK2 are frequently observed i...
ADAMTS12 serves as a novel prognostic biomarker and promotes proliferation and invasion in gastric cancer
ADAMTS12 serves as a novel prognostic biomarker and promotes proliferation and invasion in gastric cancer
Gastric cancer (GC) remains a prevalent and aggressive malignancy with a poor prognosis. This study aimed to identify diag...
The PARPscore system using poly (ADP-ribose) polymerase (PARP) family features and tumor immune microenvironment in glioma
The PARPscore system using poly (ADP-ribose) polymerase (PARP) family features and tumor immune microenvironment in glioma
The immune response plays a pivotal role in tumor progression and therapy. However, the influence of protein PAR polymeras...
Global research on nanomaterials for liver cancer from 2004 to 2023: a bibliometric and visual analysis
Global research on nanomaterials for liver cancer from 2004 to 2023: a bibliometric and visual analysis
Primary liver cancer, particularly hepatocellular carcinoma, is one of the most common gastrointestinal cancers. An increa...
The role of KRT18 in lung adenocarcinoma development: integrative bioinformatics and experimental validation
The role of KRT18 in lung adenocarcinoma development: integrative bioinformatics and experimental validation
Lung adenocarcinoma (LUAD) represents one of the most common subtypes of lung cancer with high rates of incidence and mort...
The role of autophagy related 12 (ATG12) in the progression of hepatocellular carcinoma and its prognostic value
The role of autophagy related 12 (ATG12) in the progression of hepatocellular carcinoma and its prognostic value
The aim of our research was to explore the character of autophagy related 12 (ATG12) in the development of hepatocellular ...
Radiomic nomograms in CT diagnosis of gall bladder carcinoma: a narrative review
Radiomic nomograms in CT diagnosis of gall bladder carcinoma: a narrative review
Radiomics is a method that extracts many features from medical images using various algorithms. Medical nomograms are grap...
Advancements in research and clinical management of interstitial lung injury associated with ADC drugs administration in breast cancer
Advancements in research and clinical management of interstitial lung injury associated with ADC drugs administration in breast cancer
Antibody–drug conjugates (ADCs) represent a novel class of targeted anti-tumor medications that utilize the covalent...
A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database
A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database
The liver stands out as one of the most frequent sites for distant metastasis in breast cancer cases. However, effective r...
A novel histone acetylation-associated gene signature with prognostic value in Ewing sarcoma
A novel histone acetylation-associated gene signature with prognostic value in Ewing sarcoma
Histone acetylation is an important epigenetic modification, modulating the development of many tumors. However, the funct...
Integrated bioinformatics analysis identifies ALDH18A1 as a prognostic hub gene in glutamine metabolism in lung adenocarcinoma
Integrated bioinformatics analysis identifies ALDH18A1 as a prognostic hub gene in glutamine metabolism in lung adenocarcinoma
Glutamine metabolism is pivotal in cancer biology, profoundly influencing tumor growth, proliferation, and resistance to t...
Identification of biomarkers for chronic lymphocytic leukemia risk: a proteome-wide Mendelian randomization study
Identification of biomarkers for chronic lymphocytic leukemia risk: a proteome-wide Mendelian randomization study
Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy. Although previous research has explored association...
The molecular mechanism of gemcitabine in inhibiting the HIF-1α/VEGFB/FGF2/FGFR1 signaling pathway for ovarian cancer treatment
The molecular mechanism of gemcitabine in inhibiting the HIF-1α/VEGFB/FGF2/FGFR1 signaling pathway for ovarian cancer treatment
Ovarian cancer is a common malignant tumor in women, exhibiting a certain sensitivity to chemotherapy drugs like gemcitabi...
LncRNA MALAT-1 modulates EGFR-TKI resistance in lung adenocarcinoma cells by downregulating miR-125
LncRNA MALAT-1 modulates EGFR-TKI resistance in lung adenocarcinoma cells by downregulating miR-125
Molecular targeted therapy resistance remains a major challenge in treating lung adenocarcinoma (LUAD). The resistance of ...
Decreased PANK1 expression in kidney renal clear cell carcinoma: impact on cell apoptosis, invasion, migration, and epithelial-mesenchymal transition
Decreased PANK1 expression in kidney renal clear cell carcinoma: impact on cell apoptosis, invasion, migration, and epithelial-mesenchymal transition
To investigate pantothenate kinases 1 (PANK1) expression in kidney renal clear cell carcinoma (KIRC) tissues, analyze its ...
BCAM (basal cell adhesion molecule) protein expression in different tumor populations
BCAM (basal cell adhesion molecule) protein expression in different tumor populations
Basal Cell Adhesion Molecule (BCAM), a receptor for laminin subunit α5, plays a crucial role in the pathogenesis of v...
An observational study on the efficacy of targeted therapy for pulmonary sarcomatoid carcinoma
An observational study on the efficacy of targeted therapy for pulmonary sarcomatoid carcinoma
Pulmonary sarcomatoid carcinoma is a rare tumor that is resistant to cytotoxic agents. This observational study aimed to e...
Integrated multi-omics characterization of SMAD4 mutant colorectal cancer
Integrated multi-omics characterization of SMAD4 mutant colorectal cancer
Colorectal cancer is one of the most common cancers around the world, which is a severe threat to people’s health. S...
MicroRNA-98 as a novel diagnostic marker and therapeutic target in cancer patients
MicroRNA-98 as a novel diagnostic marker and therapeutic target in cancer patients
The progress of cancer treatment methods in the last decade has significantly reduced mortality rate among these patients....
Assessment of the efficacy and safety of anlotinib for the treatment of recurrent epithelial ovarian cancer
Assessment of the efficacy and safety of anlotinib for the treatment of recurrent epithelial ovarian cancer
The current research aims to evaluate the efficacy and safety of anlotinib, an orally administered small-molecular tyrosin...
Glutamine and leukemia research: progress and clinical prospects
Glutamine and leukemia research: progress and clinical prospects
Leukemia is an abnormal proliferation of white blood cells that occurs in bone marrow and expands through the blood. It ar...
Exploring the prognosis value, immune correlation, and drug responsiveness prediction of homeobox C6 (HOXC6) in lung adenocarcinoma
Exploring the prognosis value, immune correlation, and drug responsiveness prediction of homeobox C6 (HOXC6) in lung adenocarcinoma
Homeobox C6 (HOXC6) is a gene that encodes for a transcription factor involved in various cellular processes, including de...
Tislelizumab synergizes with surgery to augment the survival benefit in stage II-III non-small cell lung cancer
Tislelizumab synergizes with surgery to augment the survival benefit in stage II-III non-small cell lung cancer
This retrospective study evaluated the individual benefits of tislelizumab and surgery, as well as their synergistic effec...
Impact the impact of gut microbiota on gastric cancer via immune cells: a comprehensive Mendelian randomization study and mediation analysis
Impact the impact of gut microbiota on gastric cancer via immune cells: a comprehensive Mendelian randomization study and mediation analysis
Recent observational studies have highlighted the role of altered gut microbiota (GM) in the activation of the host immune...
Identification of E3 ubiquitin ligase-associated prognostic genes and construction of a prediction model for uterine cervical cancer based on bioinformatics analysis
Identification of E3 ubiquitin ligase-associated prognostic genes and construction of a prediction model for uterine cervical cancer based on bioinformatics analysis
E3 ligases are engaged in a variety of physiological processes within cells and use ubiquitin-labeled substrates to contro...
Exosomal misfolded proteins released by cancer stem cells: dual functions in balancing protein homeostasis and orchestrating tumor progression
Exosomal misfolded proteins released by cancer stem cells: dual functions in balancing protein homeostasis and orchestrating tumor progression
Cancer stem cells (CSCs), the master regulators of tumor heterogeneity and progression, exert profound influence on cancer...
Differentiation between multifocal CNS lymphoma and glioblastoma based on MRI criteria
Differentiation between multifocal CNS lymphoma and glioblastoma based on MRI criteria
Differentiating between glioblastoma (GB) with multiple foci (mGB) and multifocal central nervous system lymphoma (mCNSL) ...
Causality between autoimmune diseases and breast cancer: a two-sample Mendelian randomization study in a European population
Causality between autoimmune diseases and breast cancer: a two-sample Mendelian randomization study in a European population
The incidence of autoimmune diseases and breast cancer is significantly higher in women compared to men. Previous observat...
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