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LncRNA MALAT-1 modulates EGFR-TKI resistance in lung adenocarcinoma cells by downregulating miR-125
LncRNA MALAT-1 modulates EGFR-TKI resistance in lung adenocarcinoma cells by downregulating miR-125
Molecular targeted therapy resistance remains a major challenge in treating lung adenocarcinoma (LUAD). The resistance of ...
Decreased PANK1 expression in kidney renal clear cell carcinoma: impact on cell apoptosis, invasion, migration, and epithelial-mesenchymal transition
Decreased PANK1 expression in kidney renal clear cell carcinoma: impact on cell apoptosis, invasion, migration, and epithelial-mesenchymal transition
To investigate pantothenate kinases 1 (PANK1) expression in kidney renal clear cell carcinoma (KIRC) tissues, analyze its ...
BCAM (basal cell adhesion molecule) protein expression in different tumor populations
BCAM (basal cell adhesion molecule) protein expression in different tumor populations
Basal Cell Adhesion Molecule (BCAM), a receptor for laminin subunit α5, plays a crucial role in the pathogenesis of v...
An observational study on the efficacy of targeted therapy for pulmonary sarcomatoid carcinoma
An observational study on the efficacy of targeted therapy for pulmonary sarcomatoid carcinoma
Pulmonary sarcomatoid carcinoma is a rare tumor that is resistant to cytotoxic agents. This observational study aimed to e...
Integrated multi-omics characterization of SMAD4 mutant colorectal cancer
Integrated multi-omics characterization of SMAD4 mutant colorectal cancer
Colorectal cancer is one of the most common cancers around the world, which is a severe threat to people’s health. S...
MicroRNA-98 as a novel diagnostic marker and therapeutic target in cancer patients
MicroRNA-98 as a novel diagnostic marker and therapeutic target in cancer patients
The progress of cancer treatment methods in the last decade has significantly reduced mortality rate among these patients....
Assessment of the efficacy and safety of anlotinib for the treatment of recurrent epithelial ovarian cancer
Assessment of the efficacy and safety of anlotinib for the treatment of recurrent epithelial ovarian cancer
The current research aims to evaluate the efficacy and safety of anlotinib, an orally administered small-molecular tyrosin...
Glutamine and leukemia research: progress and clinical prospects
Glutamine and leukemia research: progress and clinical prospects
Leukemia is an abnormal proliferation of white blood cells that occurs in bone marrow and expands through the blood. It ar...
Exploring the prognosis value, immune correlation, and drug responsiveness prediction of homeobox C6 (HOXC6) in lung adenocarcinoma
Exploring the prognosis value, immune correlation, and drug responsiveness prediction of homeobox C6 (HOXC6) in lung adenocarcinoma
Homeobox C6 (HOXC6) is a gene that encodes for a transcription factor involved in various cellular processes, including de...
Tislelizumab synergizes with surgery to augment the survival benefit in stage II-III non-small cell lung cancer
Tislelizumab synergizes with surgery to augment the survival benefit in stage II-III non-small cell lung cancer
This retrospective study evaluated the individual benefits of tislelizumab and surgery, as well as their synergistic effec...
Impact the impact of gut microbiota on gastric cancer via immune cells: a comprehensive Mendelian randomization study and mediation analysis
Impact the impact of gut microbiota on gastric cancer via immune cells: a comprehensive Mendelian randomization study and mediation analysis
Recent observational studies have highlighted the role of altered gut microbiota (GM) in the activation of the host immune...
Identification of E3 ubiquitin ligase-associated prognostic genes and construction of a prediction model for uterine cervical cancer based on bioinformatics analysis
Identification of E3 ubiquitin ligase-associated prognostic genes and construction of a prediction model for uterine cervical cancer based on bioinformatics analysis
E3 ligases are engaged in a variety of physiological processes within cells and use ubiquitin-labeled substrates to contro...
Exosomal misfolded proteins released by cancer stem cells: dual functions in balancing protein homeostasis and orchestrating tumor progression
Exosomal misfolded proteins released by cancer stem cells: dual functions in balancing protein homeostasis and orchestrating tumor progression
Cancer stem cells (CSCs), the master regulators of tumor heterogeneity and progression, exert profound influence on cancer...
Differentiation between multifocal CNS lymphoma and glioblastoma based on MRI criteria
Differentiation between multifocal CNS lymphoma and glioblastoma based on MRI criteria
Differentiating between glioblastoma (GB) with multiple foci (mGB) and multifocal central nervous system lymphoma (mCNSL) ...
Causality between autoimmune diseases and breast cancer: a two-sample Mendelian randomization study in a European population
Causality between autoimmune diseases and breast cancer: a two-sample Mendelian randomization study in a European population
The incidence of autoimmune diseases and breast cancer is significantly higher in women compared to men. Previous observat...
Longitudinal tracking of circulating rare events in the liquid biopsy of stage III–IV non-small cell lung cancer patients
Longitudinal tracking of circulating rare events in the liquid biopsy of stage III–IV non-small cell lung cancer patients
In the United States, lung cancer is the second most common type of cancer with non-small cell lung cancer (NSCLC) encompa...
circ_WASF2 regulates ferroptosis by miR-634/ GPX4 signaling in pancreatic cancer
circ_WASF2 regulates ferroptosis by miR-634/ GPX4 signaling in pancreatic cancer
Pancreatic cancer (PC) is one of the most lethal malignant gastrointestinal tumors (GI) characterized by a poor prognosis....
Crosstalk between cancer cells and macrophages promotes OSCC cell migration and invasion through a CXCL1/EGF positive feedback loop
Crosstalk between cancer cells and macrophages promotes OSCC cell migration and invasion through a CXCL1/EGF positive feedback loop
C-X-C motif chemokine ligand 1 (CXCL1) and epithelial growth factor (EGF) are highly secreted by oral squamous cell carcin...
The regulation of hypoxia-related lncRNAs in hepatocellular carcinoma
The regulation of hypoxia-related lncRNAs in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is still a public health disease with its high prevalence and morbidity. Short of early dia...
Pan-cancer analysis for the prognostic and immunological role of CD47: interact with TNFRSF9 inducing CD8 + T cell exhaustion
Pan-cancer analysis for the prognostic and immunological role of CD47: interact with TNFRSF9 inducing CD8 + T cell exhaustion
The research endeavors to explore the implications of CD47 in cancer immunotherapy effectiveness. Specifically, there is a...
miRNA-200c-3p deficiency promotes epithelial-mesenchymal transition in triple-negative breast cancer by activating CRKL expression
miRNA-200c-3p deficiency promotes epithelial-mesenchymal transition in triple-negative breast cancer by activating CRKL expression
Epithelial-mesenchymal transition (EMT) plays an important role in malignant progression of Triple-negative breast cancer ...
CXCL10 could be a prognostic and immunological biomarker in bladder cancer
CXCL10 could be a prognostic and immunological biomarker in bladder cancer
As proteins that promote immune cell differentiation, chemokines have attracted great interest regarding their role in ant...
Nomogram for predicting survival in T1–T2 stage patients with supraglottic squamous cell carcinoma
Nomogram for predicting survival in T1–T2 stage patients with supraglottic squamous cell carcinoma
Supraglottic squamous cell carcinoma (SGSCC) is characterized by low differentiation, rapid growth, and inconspicuous init...
Mechanism study of lncRNA RMRP regulating esophageal squamous cell carcinoma through miR-580-3p/ATP13A3 axis
Mechanism study of lncRNA RMRP regulating esophageal squamous cell carcinoma through miR-580-3p/ATP13A3 axis
It is well-known that lncRNAs regulate energy metabolism in tumors. This study focused on the action of RMRP on esophageal...
Hsp90α and cell death in cancers: a review
Hsp90α and cell death in cancers: a review
Heat shock protein 90α (Hsp90α), an important molecular chaperone, plays a crucial role in regulating the activi...
Elucidating the impact of parthanatos-related microRNAs on the tumoral immune microenvironment and clinical outcome in low-grade gliomas
Elucidating the impact of parthanatos-related microRNAs on the tumoral immune microenvironment and clinical outcome in low-grade gliomas
Parthanatos, a cell death mechanism triggered by PARP-1 activation, is implicated in oncogenic processes, yet their role i...
Exploration of the influence of GOLGA8B on prostate cancer progression and the resistance of castration-resistant prostate cancer to cabazitaxel
Exploration of the influence of GOLGA8B on prostate cancer progression and the resistance of castration-resistant prostate cancer to cabazitaxel
Castration-resistant prostate cancer (CRPC) represents the final stage of prostate cancer (PCa). Cabazitaxel, a taxane che...
Preclinical efficacy of CBR-5884 against epithelial ovarian cancer cells by targeting the serine synthesis pathway
Preclinical efficacy of CBR-5884 against epithelial ovarian cancer cells by targeting the serine synthesis pathway
Reprogramming of the serine synthesis pathway (SSP) is intricately linked to the progression of epithelial ovarian cancer ...
Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis
Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis
Clear cell renal cell carcinoma (ccRCC), the most common pathological subtype of kidney cancer, accounts for approximately...
Identification of NINJ1 as a novel prognostic predictor for retroperitoneal liposarcoma
Identification of NINJ1 as a novel prognostic predictor for retroperitoneal liposarcoma
Retroperitoneal liposarcoma (RPLS) is known for its propensity for local recurrence and short survival time. We aimed to i...
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