Potential Influence of Tryptophan Metabolites on Translocation of Bacterial DNA into the Blood in Normal Conditions and in Various Obesity Phenotypes

Kell, D.B. and Pretorius, E., No effects without causes: The Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases, Biol. Rev., 2018, vol. 93, pp. 11–22. https://doi.org/10.1111/brv.12407

Article  Google Scholar 

Visser, M.J.E., Kell, D.B., and Pretorius, E., Bacterial dysbiosis and translocation in psoriasis vulgaris, Front. Cell. Infect. Microbiol., 2019, vol. 9, p. 7. https://doi.org/10.3389/fcimb.2019.00007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Potgieter, M., Bester, J., Kell, D.B., and Pretorius, E., The dormant blood microbiome in chronic, inflammatory diseases, FEMS Microbiol. Rev., 2015, vol. 39, pp. 567–591. https://doi.org/10.1093/femsre/fuv013

Article  PubMed  PubMed Central  Google Scholar 

Reyes-Farias, M., Fos-Domenech, J., Serra, D., Herrero, L., and Sánchez-Infantes, D., White adipose tissue dysfunction in obesity and aging, Biochem. Pharmacol., 2021, vol. 192, p. 114723. https://doi.org/10.1016/j.bcp.2021.114723

Article  CAS  PubMed  Google Scholar 

Han, V.X., Jones, H.F., Patel, S., Mohammad, S.S., Hofer, M.J., Alshammery, S., Maple-Brown, E., Gold, W., Brilot, F., and Dale, R.C., Emerging evidence of Toll-like receptors as a putative pathway linking maternal inflammation and neurodevelopmental disorders in human offspring: A systematic review, Brain, Behav., Immun., 2022, vol. 99, pp. 91–105. https://doi.org/10.1016/j.bbi.2021.09.009

Article  CAS  PubMed  Google Scholar 

Kim, S.J., Choi, Y., Choi, Y.H., and Park, T., Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice, J. Nutr. Biochem., 2012, vol. 23, pp. 113–122. https://doi.org/10.1016/j.jnutbio.2010.10.012

Article  CAS  PubMed  Google Scholar 

Kolesnikova, I.M., Karbyshev, M.S., Gaponov, A.M., Khusnutdinova, D.R., Grigorieva, T.V., Borisenko, O.V., Makarov, V.V., Yudin, S.M., Roumiantsev, S.A., and Shestopalov, A.V., Features of bacterial DNA taxonomy in blood of patients with various metabolic phenotypes of obesity, Bull. Sib. Med., 2023, vol. 22, pp. 61–67. https://doi.org/10.20538/1682-0363-2023-2-61-67

Article  Google Scholar 

Shestopalov, A.V., Shatova, O.P., Karbyshev, M.S., Gaponov, A.M., Moskaleva, N.E., Appolonova, S.A., Tutelyan, A.V., Makarov, V.V., Yudin, S.M., and Roumiantsev, S.A., “Kynurenine switch” and obesity, Bull. Sib. Med., 2021, vol. 20, pp. 103–111. https://doi.org/10.20538/1682-0363-2021-4-103-111

Article  Google Scholar 

Shestopalov, A.V., Shatova, O.P., Zabolotneva, A.A., Gaponov, A.M., Moskaleva, N.E., Appolonova, S.A., Makarov, V.V., Yudin, S.M., Rumyantsev, A.G., and Roumiantsev, S.A., Coupling features of intestinal and serum indole pools in obesity, Probl. Biol. Med. Pharm. Chem., 2021, vol. 24, pp. 3–12. https://doi.org/10.29296/25877313-2021-10-01

Article  CAS  Google Scholar 

Shatova, O.P. and Shestopalov, A.V., Tryptophan metabolism: A new look at the role of tryptophan derivatives in the human body, Biol. Bull. Rev., 2023, vol. 13, pp. 81–91. https://doi.org/10.1134/s2079086423020068

Article  Google Scholar 

Paeslack, N., Mimmler, M., Becker, S., Gao, Z., Khuu, M.P., Mann, A., Malinarich, F., Regen, T., and Reinhardt, C., Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease, Amino Acids, 2022m vol. 54, pp. 1339–1356. https://doi.org/10.1007/s00726-022-03161-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhuang, H., Li, B., Xie, T., Xu, C., Ren, X., Jiang, F., Lei, T., and Zhou, P., Indole-3-aldehyde alleviates chondrocytes inflammation through the AhR-NF-κB signalling pathway, Int. Immunopharmacol., 2022, vol. 113, p. 109314. https://doi.org/10.1016/j.intimp.2022.109314

Article  CAS  PubMed  Google Scholar 

Shatova, O.P., Yagodkina, E.M., Kaydoshko, S.S., Zabolotneva, A.A., and Shestopalov, A.V., Role of tryptophan metabolites and short-chain fatty acids in pathogenesis of autoimmune diseases, J. Evol. Biochem. Physiol., 2023, vol. 59, pp. 1360–1373. https://doi.org/10.1134/s0022093023040270

Article  CAS  Google Scholar 

Cani, P.D. and Van Hul, M., Gut microbiota in overweight and obesity: Crosstalk with adipose tissue, Nat. Rev. Gastroenterol. Hepatol., 2024, vol. 21, pp. 164–183. https://doi.org/10.1038/s41575-023-00867-z

Article  CAS  PubMed  Google Scholar 

Fila, M., Chojnacki, C., Chojnacki, J., and Blasiak, J., The kynurenine pathway of tryptophan metabolism in abdominal migraine in children – a therapeutic potential?, Eur. J. Paediatr. Neurol., 2024, vol. 48, pp. 1–12. https://doi.org/10.1016/j.ejpn.2023.11.001

Article  CAS  PubMed  Google Scholar 

NCEP, Third Report of the National Cholesterol Education Program (NCEP) Expert Panel no. 01-3670, 2001.

Cleeman, J.I., Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III), J. Am. Med. Assoc., 2001, vol. 285, pp. 2486–2497. https://doi.org/10.1001/jama.285.19.2486

Article  Google Scholar 

Bioanalytical Method Validation, Guidance for Industry. Revision 1. U.S. Department of Health and Human Services, Food and Drug Administration, 2013.

Google Scholar 

Shestopalov, A.V., Kolesnikova, I.M., Gaponov, A.M., Grigoryeva, T.V., Khusnutdinova, D.R., Kamal-dinova, D.R., Volkova, N.I., Makarov, V.V., Yudin, S.M., Rumyantsev, A.G., and Rumyantsev, S.A., Effect of metabolic type of obesity on blood microbiome, Probl. Biol. Med. Pharm. Chem., 2022, vol. 25, pp. 35–41. https://doi.org/10.29296/25877313-2022-02-06

Article  CAS  Google Scholar 

Wu, S., Zhong, L., Liao, S., Li, T., Zhou, Z., and Wang, G., Sediminibacterium soli sp. nov., isolated from soil, Arch. Microbiol., 2021, vol. 203, pp. 967–973. https://doi.org/10.1007/s00203-020-02089-2

Article  CAS  PubMed  Google Scholar 

Morinaga, K., Yoshida, K., Takahashi, K., and Toyofuku, M., Peculiarities of biofilm formation by Paracoccus denitrificans, Appl. Microbiol. Biotechnol., 2020, vol. 104, pp. 2427–2433. https://doi.org/10.1007/s00253-020-10400-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, Y., Xu, C., Han, L., Li, C., Xiao, W., and Cui, X., Diversity and distribution of culturable thermus species in terrestrial hot springs of southwestern Yunnan Province in China, Diversity (Basel), 2021, vol. 13, p. 455. https://doi.org/10.3390/d13090455

Article  CAS  Google Scholar 

Niou, Y.K., Wu, W.L., Lin, L.C., Yu, M.S., Shu, H.Y., Yang, H.H., and Lin, G.H., Role of galE on biofilm formation by Thermus spp., Biochem. Biophys. Res. Commun., 2009, vol. 390, pp. 313–318. https://doi.org/10.1016/j.bbrc.2009.09.120

Article  CAS  PubMed  Google Scholar 

He, Z., Guo, J., Zhang, H., Yu, J., Zhou, Y., Wang, Y., Li, T., Yan, M., Li, B., Chen, Y., Chen, S., Lv, G., and Su, J., Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites, Int. J. Biol. Macromol., 2023, vol. 253, p. 126987. https://doi.org/10.1016/j.ijbiomac.2023.126987

Article  CAS  PubMed  Google Scholar 

Hendrikx, T. and Schnabl, B., Indoles: Metabolites produced by intestinal bacteria capable of controlling liver disease manifestation, J. Intern. Med., 2019, vol. 286, pp. 32–40. https://doi.org/10.1111/joim.12892

Article  CAS  PubMed  Google Scholar 

Sharara, S.H., Cleaver, L.M., Saloom, H., Carpenter, G.H., and Cobourne, M.T., Salivary bacterial community profile in normal-weight and obese adolescent patients prior to orthodontic treatment with fixed appliances, Orthod. Craniofac. Res., 2022, vol. 25, pp. 569–575. https://doi.org/10.1111/ocr.12571

Article  PubMed  PubMed Central  Google Scholar 

Andoh, A., Nishida, A., Takahashi, K., Inatomi, O., Imaeda, H., Bamba, S., Kito, K., Sugimoto, M., and Kobayashi, T., Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population, J. Clin. Biochem. Nutr., 2016, vol. 59, pp. 65–70. https://doi.org/10.3164/jcbn.15-152

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie, R., Gu, Y., Li, M., Li, L., Yang, Y., Sun, Y., Zhou, B., Liu, T., Wang, S., Liu, W., Yang, R., Su, X., Zhong, W., Wang, B., and Cao, H., Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis, Microbiome, 2024, vol. 12, p. 4. https://doi.org/10.1186/s40168-023-01722-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin, Y.C., Lin, H.F., Wu, C.C., Chen, C.L., and Ni, Y.H., Pathogenic effects of Desulfovibrio in the gut on fatty liver in diet-induced obese mice and children with obesity, J. Gastroenterol., 2022, vol. 57, pp. 913–925. https://doi.org/10.1007/s00535-022-01909-0

Article  CAS  PubMed 

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