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Graves disease: latest understanding of pathogenesis and treatment options
Graves disease: latest understanding of pathogenesis and treatment options
Graves disease is the most common cause of hyperthyroidism in iodine-sufficient areas. The main responsible mechanism is r...
The interactions between energy homeostasis and neurovascular plasticity
The interactions between energy homeostasis and neurovascular plasticity
Food intake and energy expenditure are sensed and processed by multiple brain centres to uphold energy homeostasis. Eviden...
Endocrine effects of heat exposure and relevance to climate change
Endocrine effects of heat exposure and relevance to climate change
Climate change is increasing both seasonal temperatures and the frequency and severity of heat extremes. As the endocrine ...
Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern
We applaud the Pituitary Society on the latest prolactinoma Consensus Statement (Petersenn, S. et al....
Sex differences in diabetic kidney disease explained
Sex differences in diabetic kidney disease explained
Diabetic kidney disease (DKD) is a common complication of diabetes mellitus and can lead to chronic kidney failure. Howeve...
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
Alzheimer disease has a sex bias: women are twice as likely as men to be affected. Studies have linked elevated follicle-s...
Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’
We are grateful to Tetsuro Kobayashi and Takashi Kadowaki for their correspondence on our Review (Red...
Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2
We have read with great interest the Review by Maria J. Redondo and Noel G. Morgan (Redondo, M.J., Mo...
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein (IGFBP) complex, encoded in humans b...
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signal...
Metformin acts through appetite-suppressing metabolite: Lac-Phe
Metformin acts through appetite-suppressing metabolite: Lac-Phe
Metformin is a first-line medication for type 2 diabetes mellitus (T2DM) that acts to reduce blood levels of glucose, food...
Type 1 diabetes mellitus: a brave new world
Type 1 diabetes mellitus: a brave new world
One hundred years after the Nobel prize was bestowed on Banting and McLeod for the ‘discovery’ of insulin, we ...
Highlights from SfE BES 2023
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Advances in incretin-based therapeutics for obesity
The year 2023 brought reports of highly effective glucagon-like peptide 1 (GLP1) mono-agonists or combinations with amylin...
Harnessing the inflammatory processes in endometriosis
The pathophysiology of endometriosis is underpinned by a complex interplay of inflammatory processes that are responsible ...
Endocrinology in the multi-omics era
Endocrinology in the multi-omics era
Over the past decade, technological advances have enabled cost-efficient, high-throughput analysis of different types of o...
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
An individual’s nutritional status has a powerful effect on sexual maturation. Puberty onset is delayed in response ...
Genomic alterations in thyroid cancer: biological and clinical insights
Genomic alterations in thyroid cancer: biological and clinical insights
Tumours can arise from thyroid follicular cells if they acquire driver mutations that constitutively activate the MAPK sig...
GIP regulates body weight via GABAergic neurons
GIP regulates body weight via GABAergic neurons
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β-cells protected from T1DM by early senescence programme
β-cells protected from T1DM by early senescence programme
Pancreatic β-cells undergo high levels of cellular stress in the early stages of type 1 diabetes mellitus (T1DM), includin...
SGLT inhibitors: a serendipitous glycaemic tale
Competing interests S.A. declares no competing interests. I.L. has received gran...
The metabolic mythos of ketones
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How a common NAFLD genetic risk variant affects human metabolism
How a common NAFLD genetic risk variant affects human metabolism
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A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
Over the past decade, the focus on modelling the human endometrium and its cyclical transformations has intensified, drive...
Macrophage and T cell networks in adipose tissue
Macrophage and T cell networks in adipose tissue
The signals and structure of the tissues in which leukocytes reside critically mould leukocyte function and development an...
Antivirals in the treatment of new-onset T1DM
Antivirals in the treatment of new-onset T1DM
The pathogenesis of type 1 diabetes mellitus (T1DM) involves genetic and environmental factors. However, the process is co...
Health equity in endocrinology
Health equity is when every person can achieve their full potential for health and wellbeing. In this Viewpoint, global ex...
The ageing thyroid: implications for longevity and patient care
The ageing thyroid: implications for longevity and patient care
Thyroid hormones have vital roles in development, growth and energy metabolism. Within the past two decades, disturbances ...
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and pancreatic β-cell dysfunct...
Author Correction: Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement
ENDOC Center for Endocrine Tumors, Hamburg, GermanyStephan PetersennUniversity of Duisburg-Essen, Essen, GermanyStephan Pe...
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