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Metabolic dysfunction-associated steatohepatitis treated by poly(ethylene glycol)-block-poly(cysteine) block copolymer-based self-assembling antioxidant nanoparticles
Metabolic dysfunction-associated steatohepatitis treated by poly(ethylene glycol)-block-poly(cysteine) block copolymer-based self-assembling antioxidant nanoparticles
Metabolic dysfunction-associated steatohepatitis (MASH), also known as non-alcoholic steatohepatitis (NASH), is associated...
Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria
Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria
Although various types of mRNA-based vaccines have been explored, the optimal conditions for induction of both humoral and...
UiO-66(Zr) as drug delivery system for non-steroidal anti-inflammatory drugs
UiO-66(Zr) as drug delivery system for non-steroidal anti-inflammatory drugs
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most prescribed drugs for pain and inflammatory treatment ar...
Small extracellular vesicles of organoid-derived human retinal stem cells remodel Müller cell fate via miRNA: A novel remedy for retinal degeneration
Small extracellular vesicles of organoid-derived human retinal stem cells remodel Müller cell fate via miRNA: A novel remedy for retinal degeneration
Remodeling retinal Müller glial fate, including gliosis inhibition and pro-reprogramming, represents a crucial avenue for ...
Cell selective BCL-2 inhibition enabled by lipid nanoparticles alleviates lung fibrosis
Cell selective BCL-2 inhibition enabled by lipid nanoparticles alleviates lung fibrosis
American Lung Association has revealed the incidence and prevalence of almost 50,000 new cases of Idiopathic pulmonary fib...
Biodegradable pyroptosis inducer with multienzyme-mimic activity kicks up reactive oxygen species storm for sensitizing immunotherapy
Biodegradable pyroptosis inducer with multienzyme-mimic activity kicks up reactive oxygen species storm for sensitizing immunotherapy
Cancer immunotherapy is an efficient strategy to achieve an anti-tumor immune response by activating or reconstructing the...
Long-term combined blockade of CXCR4 and PD-L1 with in vivo reassembly for intensive tumor interference
Long-term combined blockade of CXCR4 and PD-L1 with in vivo reassembly for intensive tumor interference
Cancer immunotherapy harnessed an individual's immune system to detect and destroy tumor cells. [[1], [2], [3]] The bloomi...
Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.
A critical parameter during the development of protein therapeutics is to endow them with suitable pharmacokinetic and pha...
Multidimensional opioid abuse deterrence using a nanoparticle-polymer hybrid formulation
Multidimensional opioid abuse deterrence using a nanoparticle-polymer hybrid formulation
Driven by increasing opioid addiction, drug overdose has become a leading cause of death in the United States [1]. The dis...
An ultrasound-activated nanoplatform remodels tumor microenvironment through diverse cell death induction for improved immunotherapy
An ultrasound-activated nanoplatform remodels tumor microenvironment through diverse cell death induction for improved immunotherapy
Globally, cancer remains a significant public health threat [1]. Despite great progression for cancer therapies in past de...
A hyaluronic acid hydrogel as a mild photothermal antibacterial, antioxidant, and nitric oxide release platform for diabetic wound healing
A hyaluronic acid hydrogel as a mild photothermal antibacterial, antioxidant, and nitric oxide release platform for diabetic wound healing
Diabetes mellitus is a chronic disease with rising global prevalence and younger age of onset, which has a significant imp...
A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection
A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection
Current antigen delivery platforms, such as alum and nanoparticles, are not readily tunable, thus may not generate optimal...
Superior COL7A1 and TGM1 gene expression in difficult-to-transfect skin cell mediated by highly branched poly(β-amino esters) through stepwise fractionation
Superior COL7A1 and TGM1 gene expression in difficult-to-transfect skin cell mediated by highly branched poly(β-amino esters) through stepwise fractionation
Hereditary cutaneous disorders contain a diverse array of diseases stemming from genetic aberrations. Two principal catego...
Lipo-Xenopeptide Polyplexes for CRISPR/Cas9 based Gene editing at ultra-low dose
Lipo-Xenopeptide Polyplexes for CRISPR/Cas9 based Gene editing at ultra-low dose
Double pH-responsive xenopeptide carriers containing succinoyl tetraethylene pentamine (Stp) and lipo amino fatty acids (L...
Emerging advances in delivery systems for mRNA cancer vaccines
Emerging advances in delivery systems for mRNA cancer vaccines
With the FDA's emergency use/authorization of two lipid nanoparticles (LNPs) based mRNA vaccines for COVID-19 pandemic pre...
Site-selective antibody-lipid conjugates for surface functionalization of red blood cells and targeted drug delivery
Site-selective antibody-lipid conjugates for surface functionalization of red blood cells and targeted drug delivery
Antibodies serve as a primary defense mechanism in mammalian immune systems. Due to their precise and robust binding to sp...
Knocking down of Xkr8 enhances chemotherapy efficacy through modulating tumor immune microenvironment
Knocking down of Xkr8 enhances chemotherapy efficacy through modulating tumor immune microenvironment
Phosphatidylserine (PS) primarily locates in the inner leaflet of cell membrane and this asymmetry is actively maintained ...
The impact of, and expectations for, lipid nanoparticle technology: From cellular targeting to organelle targeting
The impact of, and expectations for, lipid nanoparticle technology: From cellular targeting to organelle targeting
RNAs are promising therapeutics for the treatment of a variety of genetic and intractable diseases. Short interfering RNAs...
Orally available dextran-aspirin nanomedicine modulates gut inflammation and microbiota homeostasis for primary colorectal cancer therapy
Orally available dextran-aspirin nanomedicine modulates gut inflammation and microbiota homeostasis for primary colorectal cancer therapy
Colorectal cancer (CRC), characterized with a high incidence rate (∼ 10% of all cancer) and a high mortality rate (47.8% w...
Biomimetic “nano-spears” for CAFs-targeting: splintered three “shields” with enhanced cisplatin anti-TNBC efficiency
Biomimetic “nano-spears” for CAFs-targeting: splintered three “shields” with enhanced cisplatin anti-TNBC efficiency
Breast cancer has surpassed lung cancer to become the most common type of tumor [1]. Triple-negative breast cancer (TNBC),...
pH-dependent pressure-sensitive colonic capsules for the delivery of aqueous bacterial suspensions
pH-dependent pressure-sensitive colonic capsules for the delivery of aqueous bacterial suspensions
Microbiome-based therapies hold great promise for treating various diseases, but the efficient delivery of live bacteria t...
A radioactive CRISPR interference system using 89Zr-labeled LbCas12a
A radioactive CRISPR interference system using 89Zr-labeled LbCas12a
Recently, CRISPR proteins have been recognized as promising candidates for drug development. However, there is still a lac...
Antigen-specific T cell activation through targeted delivery of in-situ generated antigen and calcium ionophore to enhance antitumor immunotherapy
Antigen-specific T cell activation through targeted delivery of in-situ generated antigen and calcium ionophore to enhance antitumor immunotherapy
Current cancer immunotherapy primarily focuses on the activation of T cells to initiate an immune response. The sustained ...
MicroRNA-195 liposomes for therapy of Alzheimer's disease
MicroRNA-195 liposomes for therapy of Alzheimer's disease
Alzheimer's disease (AD) is a progressive disorder that starts with mild memory impairment and eventually results in a sev...
Effective delivery of miR-511-3p with mannose-decorated exosomes with RNA nanoparticles confers protection against asthma
Effective delivery of miR-511-3p with mannose-decorated exosomes with RNA nanoparticles confers protection against asthma
Our previous studies have shown that miR-511-3p treatment has a beneficial effect in alleviating allergic airway inflammat...
Co-delivery of oxaliplatin prodrug liposomes with Bacillus Calmette-Guérin for chemo-immunotherapy of orthotopic bladder cancer
Co-delivery of oxaliplatin prodrug liposomes with Bacillus Calmette-Guérin for chemo-immunotherapy of orthotopic bladder cancer
Bladder cancer (BC) is a prevalent and costly malignancy among urinary carcinomas globally, primarily due to the need for ...
Fish oil-based microemulsion can efficiently deliver oral peptide blocking PD-1/PD-L1 and simultaneously induce ferroptosis for cancer immunotherapy
Fish oil-based microemulsion can efficiently deliver oral peptide blocking PD-1/PD-L1 and simultaneously induce ferroptosis for cancer immunotherapy
In the past decade, significant advances have been made in cancer immunotherapy, demonstrating that the immune system, and...
Micronanoparticled risedronate exhibits potent vaccine adjuvant effects
Micronanoparticled risedronate exhibits potent vaccine adjuvant effects
Bisphosphonates (BPs) are derivatives of inorganic pyrophosphate, characterized by a highly stable phosphorus‑carbon‑phosp...
Albumin hydrogels for repeated capture of drugs from the bloodstream and release into the tumor
Albumin hydrogels for repeated capture of drugs from the bloodstream and release into the tumor
Malignant tumors are one of the leading causes of death worldwide [1,2]. Surgery is often the primary treatment option, pa...
Harnessing astaxanthin-loaded diselenium cross-linked apotransferrin nanoparticles for the treatment of secretory otitis media
Harnessing astaxanthin-loaded diselenium cross-linked apotransferrin nanoparticles for the treatment of secretory otitis media
Secretory otitis media (SOM) is a type of non-suppurative inflammation of the middle ear characterized by tympanic effusio...
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