SCI Abstract

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Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses
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Discovery of novel third generation P-glycoprotein inhibitors bearing an azo moiety with MDR-reversing effect
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Synthesis, evaluation and mechanistic insights of novel IMPDH inhibitors targeting ESKAPEE bacteria
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Identification of novel and potent triazoles targeting CYP51 for antifungal: Design, synthesis, and biological study
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First fragment-based screening identifies new chemotypes inhibiting ERAP1-metalloprotease
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Discovery of sp3-rich diazatricycloundecanes as lysosomotropic autophagy inhibitors
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Design, synthesis and enzymatic inhibition evaluation of novel 4-hydroxy Pd–C-Ⅲ derivatives as α-glucosidase and PTP1B dual-target inhibitors
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Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics
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Adenanthin exhibits anti-inflammatory effects by covalently targeting the p65 subunit in the NF-κB signaling pathway
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Hit-to-lead optimization of 4,5-dihydrofuran-3-sulfonyl scaffold against Leishmania amazonensis. Effect of an aliphatic moiety
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Development of selective heterocyclic PDE4 inhibitors for treatment of psoriasis
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Identification of novel indolinone derivatives as CTSC inhibitors to treat inflammatory bowel disease by modulating inflammatory factors
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Design, synthesis, and bioactivity investigation of novel cyclic lipopeptide antibiotics targeting top-priority multidrug-resistant gram-negative bacteria
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Synthesis and anti-influenza virus activity of substituted dibenzoxepine-based baloxavir derivatives
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Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders
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Oleanolic acid derivatives against drug-resistant bacteria and fungi by multi-targets to avoid drug resistance
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Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b
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Discovery of pyrazolo[1,5-a]pyrimidine derivatives targeting TLR4−TLR4∗ homodimerization via AI-powered next-generation screening
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Discovery of CLKs inhibitors for the treatment of non-small cell lung cancer
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New rhodol-sulforaphane conjugates as innovative isothiocyanate-based cytotoxic agents for cancer cells
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Exploration of 1-(indolin-1-yl)-2-(thiazol-2-yl)ethan-1-one derivatives as novel anti-HBV agent with potential TLR7-agonistic effect
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Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors
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Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects
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Discovery of autophagy-tethering compounds as potent NLRP3 degraders for IBD Immunotherapy
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Discovery of orally bioavailable phenyltetrazolium derivatives for the acute treatment and the secondary prevention of ischemic stroke
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Evaluation of potency and metabolic stability of diphyllin-derived Vacuolar-ATPase inhibitors
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Discovery and biological evaluation of biaryl acetamide derivatives as selective and in vivo active sphingosine kinase-2 inhibitors
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Novel thiosemicarbazide-based β-carboline derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation
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Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile
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Discovery of a potent CDKs/FLT3 PROTAC with enhanced differentiation and proliferation inhibition for AML
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