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Ginsenoside Rg1 alleviated experimental colitis in obesity mice by regulating memory follicular T cells via Bcl-6/Blimp-1 pathway
Ulcerative colitis (UC) is a subtype of inflammatory bowel disease (IBD) characterized by recurrent nonspecific inflammato...
Diosgenin alleviates lipid accumulation in NAFLD through the pathways of ferroptosis defensive and executive system
Non-alcoholic fatty liver disease (NAFLD), which is marked by the atypical buildup of lipids in the liver, ranks among the...
Aspartame consumption linked to delayed puberty and mitochondrial Dysfunction: Evidence from human and animal studies
Aspartame, a widely used artificial sweetener, is consumed daily by approximately 25.1% of children globally, with reports...
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner
NAFLD is defined as fat accumulation in the liver without excessive alcohol consumption [1], Over the past four decades, N...
Resveratrol improves gasdermin D-mediated pyroptosis of vascular endothelial cells induced by a high-fat diet and palmitic acid possibly via the SIRT1-p66Shc-NLRP3 pathway
With the continuous improvement of global living standards, a high-fat diet (HFD) has become one of the most common and un...
Increased circulating apolipoprotein Cs are implicated in the association between elevated serum retinol and retinol-binding protein 4 and adverse progression of metabolic syndrome in adults: A prospective study
The global burden of metabolic syndrome (MetS) is substantial, with prevalence rates nearing 20% among adults and exhibiti...
Exposure to bisphenol A and sodium nitrate found in processed meat induces endocrine disruption and dyslipidemia through PI3K/AKT/SREBP pathway in zebrafish larvae
Meat consumption continues to rise yearly as the world's population and wealth grow [1]. Processed meat, including red mea...
Maternal omega-3 polyunsaturated fatty acids improved levels of DHA-enriched phosphatidylethanolamines and enriched lipid clustering in the neuronal membranes of C57BL/6 mice fetal brains during gestation
Volume 140, June 2025, 109891Author links open overlay panel, , , , , , Highlights•Brain lipidome changes as gestation pro...
Naringenin alleviates heat stress-induced liver injury in Ningdu yellow chickens by decreasing RIPK3 and PDC binding
With the rise in living standards, the demand for poultry products has increased [1]. Nevertheless, the transition to mode...
Time-restricted feeding mitigates HFD-induced sarcopenic obesity in aging mice through improving the sensitivity of FGF21
Sarcopenic obesity (SO) refers to the condition in which an individual simultaneously has excess body fat and reduced musc...
The roles and functions of ergothioneine in metabolic diseases
The increasing global prevalence of metabolic diseases, such as type 2 diabetes mellitus (T2DM), metabolic dysfunction-ass...
Folic acid intervention ameliorates hepatic steatosis after long-term alcohol exposure by alleviating endoplasmic reticulum stress
Alcoholic liver disease (ALD) poses a significant health concern stemming from prolonged and heavy alcohol consumption. Th...
Design and evaluation of curcumin-derived aldopentose compounds: Unlocking their antidiabetic potential through integrative in vitro, in vivo, and in silico studies on carbohydrate-degrading enzymes
Diabetes is on the rise, largely attributed to factors like the increasing rates of obesity, sedentary lifestyles, and the...
Establishing reliable blood biomarkers for trimethylamine N-oxide status in rodents: Effects of oral choline challenge, dietary choline and fasting conditions
Cardiovascular disease (CVD) is the leading cause of death worldwide and in the US [1,2]. According to a recent estimate, ...
A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease
Volume 141, July 2025, 109904Author links open overlay panel, , , , , , , , , , , , Highlights•The (prebiotic and probioti...
Benefits of inulin and fructo-oligosaccharides on high fat diet-induced type 2 diabetes mellitus by regulating the gut microbiota in mice
Type 2 diabetes mellitus (T2DM), the most prevalent form of diabetes, affects approximately 90% of individuals diagnosed w...
Berry supplementation in healthy volunteers modulates gut microbiota, increases fecal polyphenol metabolites and reduces viability of colon cancer cells exposed to fecal water- a randomized controlled trial
Volume 141, July 2025, 109906Author links open overlay panel, , , , , , , , Highlights•Berry consumption led to higher int...
Selenium alleviates high-fat diet induced hepatocyte lipid accumulation via exosome miR-22/FGFR1 pathway in grass carp
Grass carp (Ctenopharyngodon idella) is one of the most important cultured fish in China, and it is popular with consumers...
Sulforaphanin ameliorates the damage of the Cyprinus carpio liver induced by Aeromonas hydrophila via activating AMPK pathway
In recent decades, the demand for aquatic products has been continuously increasing, the global fisheries and aquaculture ...
Zinc amino acid chelate and the Aryl Hydrocarbon Receptor (AHR) cooperate in improving the barrier function of a Caco-2 cell intestinal epithelium
Zinc and several physiologically relevant ligands of the aryl hydrocarbon receptor (AHR) are nutrients that promote intest...
Influence of maternal α-lipoic acid supplementation in Sprague Dawley rats on maternal and fetal metabolic health in pregnancies complicated by obesity
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Neonatal overfeeding promotes anxiety, impairs episodic-like memory, and disrupts transcriptional regulation of hippocampal steroidogenic enzymes
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UV light exposure versus vitamin D supplementation: A comparison of health benefits and vitamin D metabolism in a pig model
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Paternal exercise induces antioxidant defenses by α-Klotho/Keap1 pathways in the skeletal muscle of offspring exposed to a high fat-diet without changing telomere length
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Coconut oil affects aging-related changes in Mongolian gerbil liver morphophysiology
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Leptin limits hepatic lipid accumulation and inflammation via vagal activation of the JAK2-STAT3/AMPK pathway
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Time-restricted feeding does not prevent adverse effects of palatable cafeteria diet on adiposity, cognition and gut microbiota in rats
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Calorie restriction exacerbates folic acid-induced kidney fibrosis by altering mitochondria metabolism
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Resistant starch confers protection of dietary against diabetic cardiomyopathy
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Chenodeoxycholic acid fortified diet drives ovarian steroidogenesis to improve embryo implantation through enhancing uterine receptivity via progesterone receptor signaling pathway in rats
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