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Answer to the comments by Ouchi et al.
Answer to the comments by Ouchi et al.
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A novel combination approach to effectively reduce inflammation and neurodegeneration in multiple sclerosis models
A novel combination approach to effectively reduce inflammation and neurodegeneration in multiple sclerosis models
Multiple sclerosis (MS) is a multifaceted demyelinating disease, involving deleterious interactions between the immune sys...
Anticonvulsant effect of (±) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: In vivo and in silico studies
Anticonvulsant effect of (±) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: In vivo and in silico studies
Epilepsy is a chronic neurological condition characterized by recurrent or unexpected seizures, which may be categorized i...
Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption
Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption
Vascular dementia (VD) is now recognized as the second most common form of dementia after Alzheimer's disease (AD) (Cipoll...
Factors promoting the release of picrotoxin from the trap in the GABA(A) receptor pore
Factors promoting the release of picrotoxin from the trap in the GABA(A) receptor pore
γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system which plays a fundamental...
Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation
Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation
Alzheimer's disease (AD) is a clinically common degenerative disease of the central nervous system, characterized by progr...
Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models
Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models
Parkinson's disease (PD) primarily affects the substantia nigra (SN) and striatum strata, causing progressive deterioratio...
STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway
STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway
As a age-related neurodegenerative disorder, Parkinson's disease (PD) is clinically manifested by tremor, bradykinesia, ga...
Potential of the Blue Calm® food supplement in the treatment of alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio)
Potential of the Blue Calm® food supplement in the treatment of alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio)
Ethanol, also known as ethyl alcohol (EtOH), is a psychoactive ingredient present in various alcoholic beverages (Ngui et ...
The avBNSTGABA–VTA and avBNSTGABA–DRN pathways are respectively involved in the regulation of anxiety-like behaviors in parkinsonian rats
The avBNSTGABA–VTA and avBNSTGABA–DRN pathways are respectively involved in the regulation of anxiety-like behaviors in parkinsonian rats
Parkinson's disease (PD) is a neurodegenerative disease that causes a movement disorder. It is classically characterized b...
Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy
Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy
Frontotemporal lobar degeneration (FTLD) comprises a spectrum of dementia disorders with diverse pathologic underpinnings....
Echinatin protects from ischemic brain injury by attenuating NLRP3-related neuroinflammation
Echinatin protects from ischemic brain injury by attenuating NLRP3-related neuroinflammation
Ischemic stroke is a common, severe, disabling health-care problem (Wafa et al., 2020), and contributes to a high mortalit...
Binding of the monoacylglycerol lipase (MAGL) radiotracer [3H]T-401 in the rat brain after status epilepticus
Binding of the monoacylglycerol lipase (MAGL) radiotracer [3H]T-401 in the rat brain after status epilepticus
ObjectivesMonoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase considered a potential novel drug target for the ...
Role of GABAB receptors in cognition and EEG activity in aged APP and PS1 transgenic mice
Role of GABAB receptors in cognition and EEG activity in aged APP and PS1 transgenic mice
Alzheimer's disease (AD) is a primary neurodegenerative disease that is highly prevalent in the elderly. With the advent o...
Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction
Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction
Olfactory, cognitive, and psychiatric disorders are known sequelae of the COVID-19 infection (Chippa et al., 2023; Delgado...
Glycerophospholipid dysregulation after traumatic brain injury
Glycerophospholipid dysregulation after traumatic brain injury
Glycerophospholipids are amphipathic lipids that contain polar phosphate groups and hydrophobic fatty acyl chains attached...
Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy
Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy
Epilepsy is a common neurological disease affecting approximately 65 million people worldwide that manifests as spontaneou...
Radiation-induced bystander effect on the brain after fractionated spinal cord irradiation of aging rats
Radiation-induced bystander effect on the brain after fractionated spinal cord irradiation of aging rats
Radiation-induced injury of CNS is a dynamic and complex process. Based on a time sequence and clinical symptoms, it can b...
The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation
The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation
Depression is a serious mental disorder with a high incidence rate (McCarron et al., 2021; Monroe and Harkness, 2022). Dep...
Deferasirox exerts anti-epileptic effects by improving brain iron homeostasis via regulation of ITPRIP
Deferasirox exerts anti-epileptic effects by improving brain iron homeostasis via regulation of ITPRIP
Epilepsy, a prevalent brain disorder in the field of neurology (Fisher et al., 2005), remains undertreated, with approxima...
An overview of mild traumatic brain injuries and emerging therapeutic targets
An overview of mild traumatic brain injuries and emerging therapeutic targets
The majority of traumatic brain injuries (TBIs), approximately 90%, are classified as mild (mTBIs). Globally, an estimated...
Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia
Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia
Ischemic stroke (IS), is caused by a transient or permanent reduction in local cerebral blood flow, leading to downstream ...
Trends and hotspots in research of traumatic brain injury from 2000 to 2022: A bibliometric study
Trends and hotspots in research of traumatic brain injury from 2000 to 2022: A bibliometric study
Traumatic brain injury (TBI) has become a major public health burden worldwide (Rubiano et al., 2015; Flanagan, 2015) and ...
PKR inhibitor protects spinal cord injury through mitigating endoplasmic reticulum stress and pyroptosis
PKR inhibitor protects spinal cord injury through mitigating endoplasmic reticulum stress and pyroptosis
Spinal cord injury (SCI) is a common neurological disorder characterized by severe inflammation as well as eternal deficit...
Inhibition of PTEN-induced kinase 1 autophosphorylation may assist in preventing epileptogenesis induced by pentylenetetrazol
Inhibition of PTEN-induced kinase 1 autophosphorylation may assist in preventing epileptogenesis induced by pentylenetetrazol
Epilepsy is a common neurological disease, characterized by repeated seizures (Lopes et al., 2015). At present, the effect...
Matrix Metalloproteinase-9 inhibitors as therapeutic drugs for traumatic brain injury
Matrix Metalloproteinase-9 inhibitors as therapeutic drugs for traumatic brain injury
Despite the advances in our knowledge of the complex pathophysiology of TBI, it remains one of the leading causes of morbi...
Interleukin-33 has the protective effect on oligodendrocytes against impairment induced by cuprizone intoxication
Interleukin-33 has the protective effect on oligodendrocytes against impairment induced by cuprizone intoxication
Oligodendrocytes (OLs) are a cell population in the central nervous system (CNS) responsible for producing myelin that wra...
Role of regulatory non-coding RNAs in traumatic brain injury
Role of regulatory non-coding RNAs in traumatic brain injury
Traumatic brain injury (TBI) is widely acknowledged as a predominant public health issue, as it has the highest incidence ...
Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia
Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia
Neuroinflammation is described as an inflammatory cascade in the nervous tissue that plays a pivotal role in various neuro...
P2Y12 receptor mediates apoptosis and demyelination to affect functional recovery in mice with spinal cord injury
P2Y12 receptor mediates apoptosis and demyelination to affect functional recovery in mice with spinal cord injury
Spinal cord injury (SCI) has long been regarded as a devastating condition that frequently results in motor, sensory, and ...
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