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f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo
f25, a novel synthetic quinoline derivative, inhibits tongue cancer cell invasion and survival by the PPAR pathway in vitro and vivo
Squamous cells are the flat, skin-like cells that cover the lining of the mouth, nose, larynx, thyroid gland, and throat i...
Pharmacokinetic interactions of niclosamide in rats: Involvement of organic anion transporters 1 and 3 and organic cation transporter 2
Pharmacokinetic interactions of niclosamide in rats: Involvement of organic anion transporters 1 and 3 and organic cation transporter 2
Niclosamide, a derivative of salicylamide, was approved by the United States Food and Drug Administration (FDA) in 1982 fo...
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement
PPAR γ activation in chondrocytes alleviates glucocorticoid-induced oxidative stress, mitochondrial impairment, and pyroptosis via autophagic flow enhancement
Osteoarthritis (OA) is an age-related, chronic, progressive disease characterised by pathological changes in the synovium,...
The comprehensive prediction of carcinogenic potency and tumorigenic dose (TD50) for two problematic N-nitrosamines in food: NMAMPA and NMAMBA using toxicology in silico methods
The comprehensive prediction of carcinogenic potency and tumorigenic dose (TD50) for two problematic N-nitrosamines in food: NMAMPA and NMAMBA using toxicology in silico methods
N-nitrosamines (N–NAs) are a group of organic compounds that are known to be potentially carcinogenic [1]. They are formed...
Cannabinoids improve mitochondrial function in skeletal muscle of exhaustive exercise training rats by inhibiting mitophagy through the PINK1/PARKIN and BNIP3 pathways
Cannabinoids improve mitochondrial function in skeletal muscle of exhaustive exercise training rats by inhibiting mitophagy through the PINK1/PARKIN and BNIP3 pathways
As one of the largest organ systems, skeletal muscle accounts for approximately 40 % of the mammalian body mass [1], and i...
GW4064 inhibits migration and invasion through cathepsin B and MMP2 downregulation in human bladder cancer
GW4064 inhibits migration and invasion through cathepsin B and MMP2 downregulation in human bladder cancer
Urothelial carcinoma is an important health issue worldwide. Previous studies have clearly shown that cigarette smoking is...
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway
As an important source of new drug discovery, natural products play a vital role in drug development [1,2]. According to s...
Vitamin D inhibits tamoxifen-induced non-alcoholic fatty liver disease through a nonclassical estrogen receptor/liver X receptor pathway
Vitamin D inhibits tamoxifen-induced non-alcoholic fatty liver disease through a nonclassical estrogen receptor/liver X receptor pathway
Non-Alcoholic Fatty Liver Disease (NAFLD) is a multifactorial disease, mainly characterized by diffuse bubble-like fatty d...
Aldose reductase is a potential therapeutic target for neurodegeneration
Aldose reductase is a potential therapeutic target for neurodegeneration
Aldose reductase (AR) is the rate-limiting step in the polyol pathway, where it converts glucose into sorbitol [1]. The ac...
HNF4A as a potential target of PFOA and PFOS leading to hepatic steatosis: Integrated molecular docking, molecular dynamic and transcriptomic analyses
HNF4A as a potential target of PFOA and PFOS leading to hepatic steatosis: Integrated molecular docking, molecular dynamic and transcriptomic analyses
PFASs refer to a group of emerging pollutants that have garnered remarkable attention. Since PFASs were synthesized in the...
Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis
Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis
Acute lung injury (ALI) is a frequent complication of sepsis, with pyroptosis playing a pivotal role. Analysis of Gene Exp...
Ferritinophagy-mediated ferroptosis of spermatogonia is involved in busulfan-induced oligospermia in the mice
Ferritinophagy-mediated ferroptosis of spermatogonia is involved in busulfan-induced oligospermia in the mice
Infertility, is a serious human reproductive health problem, affecting about 15 % of the couples of childbearing age world...
Mitochondrial reactive oxygen species initiate gasdermin D-mediated pyroptosis and contribute to paraquat-induced nephrotoxicity
Mitochondrial reactive oxygen species initiate gasdermin D-mediated pyroptosis and contribute to paraquat-induced nephrotoxicity
Paraquat (PQ) is a non-selective herbicide that is widely used owing to its low cost and high efficiency [1]. However, PQ ...
The marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol prevents TNF-α-mediated impairment of mineralization in mouse osteoblastic MC3T3-E1 cells: Impact of macrophage activation
The marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol prevents TNF-α-mediated impairment of mineralization in mouse osteoblastic MC3T3-E1 cells: Impact of macrophage activation
Bone homeostasis is regulated by the functions of osteoblasts, osteocytes, and osteoclasts in bone tissue, and it plays a ...
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6
Osteoarthritis (OA) is a chronic and progressive degenerative debilitating joint disorder that is characterized by varying...
microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury
microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury
Spinal cord injury (SCI) is a state of severe neurological injury manifested as dysfunctions on the motion and nervous sys...
Piperlongumine inhibits esophageal squamous cell carcinoma in vitro and in vivo by triggering NRF2/ROS/TXNIP/NLRP3-dependent pyroptosis
Piperlongumine inhibits esophageal squamous cell carcinoma in vitro and in vivo by triggering NRF2/ROS/TXNIP/NLRP3-dependent pyroptosis
Esophageal cancer is a common malignant tumor of the digestive tract. Globally, there are about 572,000 new cases of esoph...
Computational analysis of human medium-chain dehydrogenases/reductases revealing substrate- and coenzyme-binding characteristics
Computational analysis of human medium-chain dehydrogenases/reductases revealing substrate- and coenzyme-binding characteristics
The medium-chain dehydrogenase/reductase (MDR) superfamily has more than 600,000 members in UniProt as of March 2023. As t...
Bisdemethoxycurcumin, a curcumin derivative, ameliorates adjuvant-induced arthritis by suppressing inflammatory reactions and macrophage migration
Bisdemethoxycurcumin, a curcumin derivative, ameliorates adjuvant-induced arthritis by suppressing inflammatory reactions and macrophage migration
Rheumatoid arthritis (RA) is a disorder linked with chronic synovial inflammation; it is untreatable and is characterized ...
Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH-SY5Y cells and Caenorhabditis elegans
Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH-SY5Y cells and Caenorhabditis elegans
Parkinson's disease (PD) is a common neurodegenerative disorder that causes motor dysfunction (slow limb movements, postur...
PODO/TERT256 – A promising human immortalized podocyte cell line and its potential use for in vitro research at different oxygen levels
PODO/TERT256 – A promising human immortalized podocyte cell line and its potential use for in vitro research at different oxygen levels
Podocytes are of key interest for the prediction of nephrotoxicity as they are especially sensitive to toxic insults due t...
Selenium bioavailability modulates the sensitivity of thyroid cells to iodide excess
Selenium bioavailability modulates the sensitivity of thyroid cells to iodide excess
Iodide (I-) is an essential micronutrient for the synthesis of thyroid hormones (TH). The NA+/I− symporter (NIS) actively ...
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease
Parkinson's disease (PD) is the most common neurodegenerative movement disorder and mainly exhibits motor symptoms includi...
Phytic acid improves osteogenesis and inhibits the senescence of human bone marrow mesenchymal stem cells under high-glucose conditions via the ERK pathway
Phytic acid improves osteogenesis and inhibits the senescence of human bone marrow mesenchymal stem cells under high-glucose conditions via the ERK pathway
Diabetes mellitus (DM) is a heterogeneous metabolic disease characterised by elevated blood glucose [1]. The number of pat...
Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: An in vitro and in vivo study
Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: An in vitro and in vivo study
Osteoarthritis (OA) and low back pain (LBP) are common musculoskeletal disorders in middle-aged and older adults, and acco...
Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1/ERK signaling pathway leading to fetal growth restriction
Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1/ERK signaling pathway leading to fetal growth restriction
Fetal growth restriction (FGR) is a prevalent complication in obstetrics, yet its exact aetiology remains unknown. Numerou...
A “toxic window” study on the hippocampal development of mice offspring exposed to azithromycin at different doses, courses, and time during pregnancy
A “toxic window” study on the hippocampal development of mice offspring exposed to azithromycin at different doses, courses, and time during pregnancy
Infection during pregnancy increases the risk of negative outcomes during childbirth, and prenatal mycoplasma infection is...
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells
Chronic myeloid leukemia (CML) accounts for approximately 14% of newly diagnosed cases of leukemia in adults [1]. The adve...
Interfering TRIB3 protects the blood brain barrier through PI3K/Akt pathway to alleviate cerebral ischemia-reperfusion injury in diabetes mellitus mice
Interfering TRIB3 protects the blood brain barrier through PI3K/Akt pathway to alleviate cerebral ischemia-reperfusion injury in diabetes mellitus mice
Stroke has imposed a heavy burden on human society due to its high incidence, disability and mortality rates [1]. Diabetes...
Targeting PKM2 improves the gemcitabine sensitivity of intrahepatic cholangiocarcinoma cells via inhibiting β-catenin signaling pathway
Targeting PKM2 improves the gemcitabine sensitivity of intrahepatic cholangiocarcinoma cells via inhibiting β-catenin signaling pathway
Intrahepatic cholangiocarcinoma (ICC) ranks as the second most prevalent form of primary liver cancer, constituting 10–15 ...
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