SCI Abstract

search
+
Aggressive pituitary tumours and pituitary carcinomas: molecular insights guiding management and the role of precision oncology.
Available online 5 June 2025, 112598Author links open overlay panel, , , Highlights•Genome instability and mutations deter...
Structural comparison of androstenediol recognition by the human estrogen receptor ligand binding domains
Estrogen receptor α (ERα) and estrogen receptor β (ERβ) are ligand-regulated nuclear receptor transcription factors. Both ...
From Gut to Brain: The Roles of Intestinal Microbiota, Immune System, and Hormones in Intestinal Physiology and Gut–Brain–Axis
The intestine plays numerous roles in the normal physiology of our body. Gut-brain axis (GBA) is a complex communication n...
The environmental contaminants, tributyltin and bisphenol S, alone or in combination, harm the hypothalamus-pituitary-gonadal axis and uterus
Endocrine disrupting-chemicals (EDCs) are xenobiotic substances (or mixtures of substances) that interfere with any aspect...
Estrogen increases Setdb1 cytoplasmic localization to stabilize Serpinh1 and improve protein homeostasis in osteoblasts
Osteoporosis, marked by reductions in bone mass and the deterioration of bone microstructure, increases vulnerability to b...
The role of aldosterone on the endothelial dysfunction induced by female hormone deficiency
Estrogen and progesterone have beneficial effects on the cardiovascular system, by modulating vascular and endothelial fun...
Interactive effects of light at night and high fructose intake on the central circadian clock and endocrine outputs in rats
The global increase in metabolic, cardiovascular, and neurological diseases is a major public health concern (Chew et al.,...
Selective steroid receptor modulators, degraders and PROTACs: Therapeutic strategies in management of endocrine-related cancers
Nuclear receptors (NRs) are a superfamily of intracellular ligand-modulated transcription factors. These factors regulate ...
c-Jun regulates postpartum β-cell apoptosis and survival downstream of prolactin signaling
Expansion and reduction of maternal β-cells during pregnancy and postpartum is a physiologic example of rapid and dynamic ...
Hepatic estrogen-related receptor gamma is a key regulator of GDF15 production in acute and chronic liver injury
The NR3B subfamily of orphan nuclear receptors contains three members: estrogen-related receptor α, β, and γ (ERRα, ERRβ, ...
The interplay between FOXO1 and glucocorticoid signaling in promoting the terminal differentiation of somatotropes
Pituitary gland development is dependent on the pituitary-specific transcription factors, POU1F1 and PROP1. PROP1 is requi...
Transcriptomic characterization of the synergy between human induced pluripotent stem cells-derived liver- and pancreas-on-chip coculture
Metabolic syndrome refers to a complex disorder involving several tissues and organs and their interactions possibly resul...
Dehydroepiandrosterone (DHEA)-induced autophagy protects against lipotoxicity in hepatic cells
Hormones play a central role in regulating cellular metabolism in many tissues, including the liver (Brubaker and Martchen...
Açaí seed extract mitigates intestinal and hypothalamic alterations in obese mice
Obesity is a complex disease of great public health significance worldwide. It involves complications including cardiovasc...
Embryo-derived human chorionic gonadotropin promotes human decidualization through activating epithelial prostaglandin F2α secretion
Decidualization is a process in which endometrial stromal cells undergo morphological and functional changes from fibrobla...
Androgen receptor plays critical role in regulating cervical cancer cell migration
Cervical cancer (CC) is a significant health issue globally, ranking fourth in terms of both incidence and mortality world...
Disease-associated SNP variants of THRβ: Insights into the molecular determinants of aberrant receptor function
The thyroid hormone receptor β (THRβ), a member of the nuclear receptor (NR) superfamily, governs thyroid hormone (TH or T...
White beans (Phaseolus vulgaris L.) in diet reduces hypothalamic pro-inflammatory cytokines improving insulin resistance in small litter grown rats
Obesity and insulin resistance (IR) in later life have been associated to nutritional insults in early life (Chooi et al.,...
The lysosome-associated SLAMF7 inhibits the development of ovarian cancer by promoting lysosomal damage
Ovarian cancer (OC) is currently the 5th cancer-related death in the United States (Torre et al., 2018; Armstrong et al., ...
TIGAR relieves PCOS by inhibiting granulosa cell apoptosis and oxidative stress through activating Nrf2
Update your browser to view ScienceDirect. ...
Beta cell specific ZnT8 gene deficiency and resulting loss in zinc content significantly improve insulin secretion
Update your browser to view ScienceDirect. ...
Bone action of the phytoestrogen genistein under hypoestrogenism and obesity
Update your browser to view ScienceDirect. ...
Identifying prognostic hub genes and key pathways in pediatric adrenocortical tumors through RNA sequencing and Co-expression analysis
Update your browser to view ScienceDirect. ...
Vasopressinergic sexual dimorphism: Sex chromosome complement and organizational hormonal effects
Update your browser to view ScienceDirect. ...
High glucose elevates intracellular calcium level and induces ferroptosis in glomerular endothelial cells through the miR-223-3p/ITPR3 pathway
Update your browser to view ScienceDirect. ...
The impact of acyl-CoA:cholesterol transferase (ACAT) inhibitors on biophysical membrane properties depends on membrane lipid composition
Update your browser to view ScienceDirect. ...
Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells
Update your browser to view ScienceDirect. ...
The impact of mineralocorticoid and glucocorticoid receptor interaction on corticosteroid transcriptional outcomes
Update your browser to view ScienceDirect. ...
The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity
Update your browser to view ScienceDirect. ...
Relation of mitochondrial DNA copy number and variants with the clinical characteristics of polycystic ovary syndrome
Update your browser to view ScienceDirect. ...
Load More
format_indent_increase