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Intestinal alterations and mild glucose homeostasis impairments in the offspring born to overweight rats
Intestinal alterations and mild glucose homeostasis impairments in the offspring born to overweight rats
Obesity has become a threat to global metabolic health. Obesity rates have risen to 511 million people with a body mass in...
16α-OHE1 alleviates hypoxia-induced inflammation and myocardial damage via the activation of β2-Adrenergic receptor
16α-OHE1 alleviates hypoxia-induced inflammation and myocardial damage via the activation of β2-Adrenergic receptor
Hypoxia is a form of physiological stress characterized by insufficient oxygen supply to bodily tissues, which has emerged...
Diverse genetic causes of amenorrhea in an ethnically homogeneous cohort and an evolving approach to diagnosis
Diverse genetic causes of amenorrhea in an ethnically homogeneous cohort and an evolving approach to diagnosis
Available online 22 March 2024, 112212Author links open overlay panel, , , , , , , , , , , , , , , , Highlights•Discovery ...
Deficiency of nucleosome-destabilizing factor GLYR1 dampens spermatogenesis in mice
Deficiency of nucleosome-destabilizing factor GLYR1 dampens spermatogenesis in mice
Spermatogenesis, the intricate process governing the production of male gametes, specifically spermatozoa, is a highly reg...
Npy transcription is regulated by noncanonical STAT3 signaling in hypothalamic neurons: Implication with lipotoxicity and obesity
Npy transcription is regulated by noncanonical STAT3 signaling in hypothalamic neurons: Implication with lipotoxicity and obesity
Neuropeptide Y (Npy) is an abundant neuropeptide expressed in the central and peripheral nervous systems. NPY-secreting ne...
The Caenorhabditis elegans neuroendocrine system and their modulators: An overview
The Caenorhabditis elegans neuroendocrine system and their modulators: An overview
Caenorhabditis elegans (C. elegans) is a soil-dwelling free-living nematode that has been established as a model system si...
Revisiting the evolution of Family B1 GPCRs and ligands: Insights from mollusca
Revisiting the evolution of Family B1 GPCRs and ligands: Insights from mollusca
Family B1 G protein-coupled receptors (GPCRs) are one of the most well studied neuropeptide receptor families since they p...
Glycoprotein hormone subunit alpha 2 (GPHA2): A pituitary stem cell-expressed gene associated with NOTCH2 signaling
Glycoprotein hormone subunit alpha 2 (GPHA2): A pituitary stem cell-expressed gene associated with NOTCH2 signaling
Hypopituitarism is a condition defined as a shortage of one or more kinds of pituitary hormones, which can then lead to va...
Dichloroacetate ameliorates apoptosis, EMT and oxidative stress in diabetic cataract via inhibiting the IDO1-dependent p38 MAPK pathway
Dichloroacetate ameliorates apoptosis, EMT and oxidative stress in diabetic cataract via inhibiting the IDO1-dependent p38 MAPK pathway
As a group of endocrine and metabolic diseases characterized by hyperglycemia (Gothai et al., 2016), diabetes mellitus (DM...
Excess homocysteine inhibits pancreatic β-cell secretory function by repressing Zbtb20 expression
Excess homocysteine inhibits pancreatic β-cell secretory function by repressing Zbtb20 expression
Homocysteine (Hcy) is a sulfur-containing nonprotein amino acid derived from the metabolism of methionine. Elevated levels...
Association between nitric oxide synthase (NOS3) gene polymorphisms and diabetic nephropathy: An updated meta-analysis
Association between nitric oxide synthase (NOS3) gene polymorphisms and diabetic nephropathy: An updated meta-analysis
Alarming statistics shows a constant increase in the number of people with type 2 diabetes mellitus (T2DM) – by 49% over a...
Autophagy inhibition suppresses hormone production and cell growth in pituitary tumor cells: A potential approach to pituitary tumors
Autophagy inhibition suppresses hormone production and cell growth in pituitary tumor cells: A potential approach to pituitary tumors
Pituitary tumors (PTs): PTs are common, occurring in almost 17% of the population over the lifetime (Daly et al., 2006; Fe...
Single microcystin exposure impairs the hypothalamic-pituitary-gonadal axis at different levels in female rats
Single microcystin exposure impairs the hypothalamic-pituitary-gonadal axis at different levels in female rats
Industrial progress has resulted in the improper disposal of wastewater containing pollutants into rivers and lakes ( S. L...
Intestinal remodeling during Xenopus metamorphosis as a model for studying thyroid hormone signaling and adult organogenesis
Intestinal remodeling during Xenopus metamorphosis as a model for studying thyroid hormone signaling and adult organogenesis
The epithelium of vertebrate intestine undergoes continuous self-renewal throughout adulthood. This has made the intestine...
Endocrine factors modulating vitellogenesis and oogenesis in insects: An update
Endocrine factors modulating vitellogenesis and oogenesis in insects: An update
The large populations and great variety of insects, with over a million species known, are related to their high rates of ...
USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy
USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy
A prospective human pregnancy requires successful implantation and decidualization, which are two critically orchestrated ...
Nrf2 inhibition regulates intracellular lipid accumulation in mouse insulinoma cells and improves insulin secretory function
Nrf2 inhibition regulates intracellular lipid accumulation in mouse insulinoma cells and improves insulin secretory function
Obesity and overweight can raise the risk of type 2 diabetes (T2D). A high amount of fat in the pancreas, known as intrapa...
Temperature- and genotype-dependent stress response and activation of the hypothalamus-pituitary-interrenal axis during temperature-induced sex reversal in pejerrey Odontesthes bonariensis, a species with genotypic and environmental sex determination
Temperature- and genotype-dependent stress response and activation of the hypothalamus-pituitary-interrenal axis during temperature-induced sex reversal in pejerrey Odontesthes bonariensis, a species with genotypic and environmental sex determination
In fish, genetic and environmental factors may interact to determine gonadal fate (Hattori et al., 2020). Genetic factors ...
Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology
Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology
Available online 20 November 2023, 112107Author links open overlay panel, , AbstractCompartmentalization of GPCR signaling...
A MUFA/carotenoid-rich oil ameliorated insulin resistance by improving inflammation and oxidative stress in obese rats
A MUFA/carotenoid-rich oil ameliorated insulin resistance by improving inflammation and oxidative stress in obese rats
Obesity is characterized by excessive fat accumulation in adipose tissue, and its origin is multifactorial. The excessive ...
The BRAFV600E mutation maintains the aggressiveness of papillary thyroid cancers requiring downregulation of primary cilia
The BRAFV600E mutation maintains the aggressiveness of papillary thyroid cancers requiring downregulation of primary cilia
Papillary thyroid cancers (PTCs) account for more than 80% of all thyroid cancers (TCs). PTC generally has an indolent nat...
17β-Estradiol inhibits hydrogen peroxide-induced senescence and apoptosis in human umbilical vein endothelial cells by regulating the THBS1/TGF-β/Smad axis
17β-Estradiol inhibits hydrogen peroxide-induced senescence and apoptosis in human umbilical vein endothelial cells by regulating the THBS1/TGF-β/Smad axis
Cardiovascular diseases (CVDs), including a series of high age-associated disorders, such as atherosclerosis, hypertension...
Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells
Novel regulatory roles of small G protein GDP dissociation stimulator (smgGDS) in insulin secretion from pancreatic β-cells
It is well established that GSIS from pancreatic β-cells requires the generation of soluble second messengers including cy...
Downregulation of homeobox A1 in human granulosa cells is involved in diminished ovarian reserve through promoting cell apoptosis and mitochondrial dysfunction
Downregulation of homeobox A1 in human granulosa cells is involved in diminished ovarian reserve through promoting cell apoptosis and mitochondrial dysfunction
Diminished ovarian reserve (DOR) is a reproductive endocrine disease that causes impaired female fertility due to a reduct...
Male-specific vasotocin expression in the medaka tuberal hypothalamus: Androgen dependence and probable role in aggression
Male-specific vasotocin expression in the medaka tuberal hypothalamus: Androgen dependence and probable role in aggression
Aggression is an adaptive behavioral trait that is crucial for competition for territories, food, and mating partners and ...
Comparison of INSM1 immunostaining with established neuroendocrine markers synaptophysin and chromogranin A in over 14,000 neuroendocrine and non-neuroendocrine tumors
Comparison of INSM1 immunostaining with established neuroendocrine markers synaptophysin and chromogranin A in over 14,000 neuroendocrine and non-neuroendocrine tumors
Author links open overlay panelKatharina Möller a, Ria Uhlig a, Natalia Gorbokon a, David Dum a, Anne Menz a, Franziska Bü...
Activation of mitophagy improves cognitive dysfunction in diabetic mice with recurrent non-severe hypoglycemia
Activation of mitophagy improves cognitive dysfunction in diabetic mice with recurrent non-severe hypoglycemia
Maintaining blood sugar level is critical for the management of patients with diabetes. However, accidental recurrent exce...
Deregulation of ABCG1 early in life contributes to prostate carcinogenesis in maternally malnourished offspring rats
Deregulation of ABCG1 early in life contributes to prostate carcinogenesis in maternally malnourished offspring rats
Over the past decades, the incidence of non-communicable chronic diseases (NCDs), such as cardiovascular diseases, respira...
SPI1 exacerbates iron accumulation and promotes osteoclast formation through inhibiting the expression of Hepcidin
SPI1 exacerbates iron accumulation and promotes osteoclast formation through inhibiting the expression of Hepcidin
Degenerative orthopedic diseases such as osteoporosis (OP) are common and frequent in the elderly, especially the postmeno...
Endocrine regulation of reproductive biology in echinoderms: An evolutionary perspective from closest marine invertebrate relatives to chordates
Endocrine regulation of reproductive biology in echinoderms: An evolutionary perspective from closest marine invertebrate relatives to chordates
Echinoderms are a phylum of invertebrate deuterostomes, which contain echinoids, asteroids, holothuroids, crinoids, and op...
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