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Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients
Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients
Calprotectin (S100A8/A9) is a pro-inflammatory mediator primarily released from neutrophils. Previous studies have reveale...
Normal saline versus Ringer’s solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study
Normal saline versus Ringer’s solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study
Fluid resuscitation is fundamental in acute pancreatitis (AP) treatment. However, the optimal choice between normal saline...
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial
Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial
Inspiratory muscle training (IMT) is well-established as a safe option for combating inspiratory muscles weakness in the i...
Nutritional therapy for the prevention of post-intensive care syndrome
Nutritional therapy for the prevention of post-intensive care syndrome
Post-intensive care syndrome (PICS) is a triad of physical, cognitive, and mental impairments that occur during or followi...
Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial
Risk factors for arterial catheter failure and complications during critical care hospitalisation: a secondary analysis of a multisite, randomised trial
Arterial catheters (ACs) are critical for haemodynamic monitoring and blood sampling but are prone to complications. We in...
Predictors and outcomes of withholding and withdrawal of life-sustaining treatments in intensive care units in Singapore: a multicentre observational study
Predictors and outcomes of withholding and withdrawal of life-sustaining treatments in intensive care units in Singapore: a multicentre observational study
Clinical practice guidelines on limitation of life-sustaining treatments (LST) in the intensive care unit (ICU), in the fo...
Respiratory drive: a journey from health to disease
Respiratory drive: a journey from health to disease
Respiratory drive is defined as the intensity of respiratory centers output during the breath and is primarily affected by...
Prognostic nutritional index as a predictive marker for acute kidney injury in adult critical illness population: a systematic review and diagnostic test accuracy meta-analysis
Prognostic nutritional index as a predictive marker for acute kidney injury in adult critical illness population: a systematic review and diagnostic test accuracy meta-analysis
The prognostic nutritional index (PNI), integrating nutrition and inflammation markers, has been increasingly recognized a...
Light and dark sides of evidence-based and supportive ICU care for patients undergoing extracorporeal membrane oxygenation
Light and dark sides of evidence-based and supportive ICU care for patients undergoing extracorporeal membrane oxygenation
Authors and AffiliationsNon-Profit Organization ICU Collaboration Network (ICON), 2-15-13 Hongo, Bunkyo-Ku, Tokyo, 113-003...
Intensive care unit mortality and cost-effectiveness associated with intensivist staffing: a Japanese nationwide observational study
Intensive care unit mortality and cost-effectiveness associated with intensivist staffing: a Japanese nationwide observational study
Japan has four types of intensive care units (ICUs) that are divided into two categories according to the management fee c...
Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study
Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study
Heterogeneity among critically ill patients undergoing invasive mechanical ventilation (IMV) treatment could result in hig...
Visualizing the dynamic mechanical power and time burden of mechanical ventilation patients: an analysis of the MIMIC-IV database
Visualizing the dynamic mechanical power and time burden of mechanical ventilation patients: an analysis of the MIMIC-IV database
Limiting driving pressure and mechanical power is associated with reduced mortality risk in both patients with and without...
Optimized ventilation power to avoid VILI
Optimized ventilation power to avoid VILI
The effort to minimize VILI risk must be multi-pronged. The need to adequately ventilate, a key determinant of hazardous p...
The optimal dose of mobilisation therapy in the ICU: a prospective cohort study
The optimal dose of mobilisation therapy in the ICU: a prospective cohort study
This study aimed to assess the impact of duration of early mobilisation on survivors of critical illness. The hypothesis w...
Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study
Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study
Unfractionated heparin (UFH) is primarily monitored using activated partial thromboplastin time (APTT). However, the recen...
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study
Neuromuscular blockade agents (NMBAs) can be used to facilitate mechanical ventilation in critically ill patients. Accumul...
Translation of patients’ advance directives in intensive care units: are we there yet?
Translation of patients’ advance directives in intensive care units: are we there yet?
This review examined studies regarding the implementation and translation of patients’ advance directives (AD) in in...
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials
The efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing optimization strategies on pharmacokinetics/p...
Lacosamide dosing in patients receiving continuous renal replacement therapy
Lacosamide dosing in patients receiving continuous renal replacement therapy
Lacosamide is one of the anticonvulsants used in critically ill patients. This study aimed to suggest appropriate lacosami...
A deep learning model for predicting multidrug-resistant organism infection in critically ill patients
A deep learning model for predicting multidrug-resistant organism infection in critically ill patients
This study aimed to apply the backpropagation neural network (BPNN) to develop a model for predicting multidrug-resistant ...
Concerns with the revised Japanese recommendation for administering vitamin C to septic patients
Concerns with the revised Japanese recommendation for administering vitamin C to septic patients
Guideline committee of The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020; Japanese ...
Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study
Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study
The aims of this study were to evaluate the efficacy, safety, and pharmacokinetics (PK) of continuous intravenous administ...
Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study
Trends in massive transfusion practice for trauma in Japan from 2011 to 2020: a nationwide inpatient database study
Previous studies have reported conflicting results regarding fresh frozen plasma (FFP)-to-red blood cell (RBC) ratio and p...
Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?
Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?
While not traditionally included in the conceptual understanding of circulation, the interstitium plays a critical role in...
Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study
Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study
The prognosis for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is poor, and there is no established treatm...
Long-term prognostic significance of gasping in out-of-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation: a post hoc analysis of a multi-center prospective cohort study
Long-term prognostic significance of gasping in out-of-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation: a post hoc analysis of a multi-center prospective cohort study
Gasping during resuscitation has been reported as a favorable factor for out-of-hospital cardiac arrest. We examined wheth...
High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury
High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury
Mechanical ventilation may cause pulmonary hypertension in patients with acute lung injury (ALI), but the underlying mecha...
A novel method for diaphragm-based electrode belt position of electrical impedance tomography by ultrasound
A novel method for diaphragm-based electrode belt position of electrical impedance tomography by ultrasound
This aim of study was to introduce a diaphragm-based EIT-belt placement method based on diaphragm position by ultrasound, ...
Ultrasonographic evaluation of the diaphragm in critically ill patients to predict invasive mechanical ventilation
Ultrasonographic evaluation of the diaphragm in critically ill patients to predict invasive mechanical ventilation
Diaphragm dysfunction is common in critically ill patients and associated with poorer outcomes. The function of the diaphr...
Association between diaphragmatic dysfunction after adult cardiovascular surgery and prognosis of mechanical ventilation: a retrospective cohort study
Association between diaphragmatic dysfunction after adult cardiovascular surgery and prognosis of mechanical ventilation: a retrospective cohort study
Diaphragmatic dysfunction often occurs after adult cardiovascular surgery. The prognostic effect of diaphragmatic dysfunct...
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