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The role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media
The role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media
The use of in vivo and ex vivo diagnostic tools for delayed hypersensitivity reactions (DHRs) associated with iodinated co...
Characterizing the symptomatology and pathophysiology of allergic rhinitis using a nasal allergen challenge model – a subset of the allergic rhinitis microbiome study
Characterizing the symptomatology and pathophysiology of allergic rhinitis using a nasal allergen challenge model – a subset of the allergic rhinitis microbiome study
Since 2015, our nasal allergen challenge (NAC) protocol has been used to investigate the pathophysiology of allergic rhini...
NOURISH-US: a mixed-methods, randomized crossover study of a program designed to reduce the financial burden of food allergy
NOURISH-US: a mixed-methods, randomized crossover study of a program designed to reduce the financial burden of food allergy
Food allergy imposes considerable financial costs on families, but few programs are available in Canada to offset these co...
Immunoglobulin replacement therapy in patients with primary and secondary immunodeficiencies: impact of infusion method on immunoglobulin-specific perceptions of quality of life and treatment satisfaction
Immunoglobulin replacement therapy in patients with primary and secondary immunodeficiencies: impact of infusion method on immunoglobulin-specific perceptions of quality of life and treatment satisfaction
Immunoglobulin replacement therapy (IgRT) is the current standard of care for primary antibody deficiency patients (majori...
Inborn errors of immunity (primary immunodeficiencies)
Inborn errors of immunity (primary immunodeficiencies)
Primary immunodeficiencies (PID), now often referred to as inborn errors of immunity (IEI), are a large heterogeneous grou...
Nasal food challenge with hen's egg white allergen
Nasal food challenge with hen's egg white allergen
Nasal allergen provocation tests are an important part of the diagnostics of allergic diseases triggered by environmental ...
Hereditary or acquired? Comprehensive genetic testing assists in stratifying angioedema patients
Hereditary or acquired? Comprehensive genetic testing assists in stratifying angioedema patients
Hereditary angioedema (HAE) poses diagnostic challenges due to its episodic, non-specific symptoms and overlapping conditi...
Effectiveness of immunoglobulin replacement therapy in preventing infections in patients with chronic obstructive pulmonary disease: a systematic review
Effectiveness of immunoglobulin replacement therapy in preventing infections in patients with chronic obstructive pulmonary disease: a systematic review
Immunoglobulin replacement therapy is a standard treatment for patients with antibody production deficiencies, which is of...
A survey of severe asthma in Canada: results from the CASCADE practice reflective program
A survey of severe asthma in Canada: results from the CASCADE practice reflective program
Since the last guidance was published by the Canadian Thoracic Society, there have been several advances in the clinical m...
Genetic links between atopy, allergy, and alopecia areata: insights from a Mendelian randomization study
Genetic links between atopy, allergy, and alopecia areata: insights from a Mendelian randomization study
Alopecia areata (AA), a prevalent form of autoimmune hair loss, has a not well-defined relationship with atopic and allerg...
Patient outcomes associated with subcutaneous C1INH prophylaxis for hereditary angioedema: a retrospective analysis
Patient outcomes associated with subcutaneous C1INH prophylaxis for hereditary angioedema: a retrospective analysis
Real-world data on subcutaneous C1INH (C1INH[SC]) usage and patient-level impacts on hereditary angioedema (HAE)-related o...
Biologic use and treatment patterns in patients with chronic rhinosinusitis with nasal polyps: a US real-world study
Biologic use and treatment patterns in patients with chronic rhinosinusitis with nasal polyps: a US real-world study
Several biologics are now approved in the US as add-on treatments for chronic rhinosinusitus with nasal polyps (CRSwNP). T...
Successful use of dupilumab for egg-induced eosinophilic gastroenteritis with duodenal ulcer: a pediatric case report and review of literature
Successful use of dupilumab for egg-induced eosinophilic gastroenteritis with duodenal ulcer: a pediatric case report and review of literature
Non-esophageal eosinophilic gastrointestinal disorder (non-EoE-EGID) is a rare disease in which eosinophils infiltrate par...
Diagnostic validity of specific immunoglobulin E levels to alpha-gal in alpha-gal syndrome: a cross-sectional analysis
Diagnostic validity of specific immunoglobulin E levels to alpha-gal in alpha-gal syndrome: a cross-sectional analysis
The diagnosis of Alpha-gal Syndrome (AGS) is based on the presence of symptoms after being exposed to potential sources of...
Presence of variable extrathoracic airflow limitation in patients with a negative methacholine challenge test
Presence of variable extrathoracic airflow limitation in patients with a negative methacholine challenge test
Determine whether variable extrathoracic airflow limitation (VEAL) is observed in patients with negative methacholine chal...
Infantile atopic dermatitis and maternal-infant bonding: a mixed methods study
Infantile atopic dermatitis and maternal-infant bonding: a mixed methods study
Childhood atopic dermatitis can have a negative effect on caregivers’ quality of life and stress levels due to the b...
Quality of life is lower in food allergic adolescents compared to young children at a community educational symposium
Quality of life is lower in food allergic adolescents compared to young children at a community educational symposium
Food allergies (FA) can detrimentally impact physical, emotional, and psychological quality of life (QoL) among pediatric ...
Human placental extract suppresses mast cell activation and induces mast cell apoptosis
Human placental extract suppresses mast cell activation and induces mast cell apoptosis
Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. Howeve...
Helicobacter pylori infection attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in C57/BL6 mice
Helicobacter pylori infection attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in C57/BL6 mice
Although numerous studies have suggested a negative correlation between Helicobacter pylori (H. pylori) infection and alle...
Sensitization to avian and fungal proteins in different work environments
Sensitization to avian and fungal proteins in different work environments
Hypersensitivity pneumonitis (HP) is usually caused by the inhalation of avian and fungal proteins. The present study asse...
Osimertinib tolerance in a patient with Stevens Johnson syndrome during osimertinib therapy after treatment with pembrolizumab
Osimertinib tolerance in a patient with Stevens Johnson syndrome during osimertinib therapy after treatment with pembrolizumab
Osimertinib has emerged as an important tool in the treatment of non-small cell lung cancers (NSCLC) with certain activati...
Safety and effectiveness of the Canadian food ladders for children with IgE-mediated food allergies to cow’s milk and/or egg
Safety and effectiveness of the Canadian food ladders for children with IgE-mediated food allergies to cow’s milk and/or egg
Food ladders are tools designed to facilitate home-based dietary advancement in children with food allergies through stepw...
Validation of adult asthma case definitions for primary care sentinel surveillance
Validation of adult asthma case definitions for primary care sentinel surveillance
Most asthma diagnoses and patient care take place in primary care settings. Electronic medical records (EMRs) offer an opp...
Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome
Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare but severe and sometimes fatal adverse dr...
Immunological responses in SARS-CoV-2 and HIV co-infection versus SARS-CoV-2 mono-infection: case report of the interplay between SARS-CoV-2 and HIV
Immunological responses in SARS-CoV-2 and HIV co-infection versus SARS-CoV-2 mono-infection: case report of the interplay between SARS-CoV-2 and HIV
There is an urgent need to understand the interplay between SARS-CoV-2 and HIV to inform risk-mitigation approaches for HI...
Patient education in atopic dermatitis: a scoping review
Patient education in atopic dermatitis: a scoping review
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects children and adults. Poor treatment adherence i...
Cost-effectiveness analysis of biologics for the treatment of chronic rhinosinusitis with nasal polyps in Canada
Cost-effectiveness analysis of biologics for the treatment of chronic rhinosinusitis with nasal polyps in Canada
Dupilumab, omalizumab, and mepolizumab are the three biologics currently approved for use in CRSwNP in Canada. Despite evi...
Barriers to penicillin allergy de-labeling in the inpatient and outpatient settings: a qualitative study
Barriers to penicillin allergy de-labeling in the inpatient and outpatient settings: a qualitative study
Penicillin allergy is the most commonly reported drug allergy in the US. Despite evidence demonstrating that up to 90% of ...
Using the canadian egg ladder in children with food protein-induced enterocolitis syndrome: a case series
Using the canadian egg ladder in children with food protein-induced enterocolitis syndrome: a case series
Current management of food protein-induced enterocolitis syndrome (FPIES) involves strict avoidance of the offending food ...
Two cases of successful sirolimus treatment for patients with activated phosphoinositide 3-kinase δ syndrome 1
Two cases of successful sirolimus treatment for patients with activated phosphoinositide 3-kinase δ syndrome 1
Activated phosphoinositide3-kinase (PI3K) δ syndrome 1 (APDS1) is a novel inborn errors of immunity (IEIs) caused by ...
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