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Retroviral PBS-segment sequence and structure: Orchestrating early and late replication events
Retroviral PBS-segment sequence and structure: Orchestrating early and late replication events
An essential regulatory hub for retroviral replication events, the 5’ untranslated region (UTR) encodes an ensemble ...
High level of genomic divergence in orf-I p12 and hbz genes of HTLV-1 subtype-C in Central Australia
High level of genomic divergence in orf-I p12 and hbz genes of HTLV-1 subtype-C in Central Australia
Human T cell lymphotropic virus type 1 (HTLV-1) infection remains a largely neglected public health problem, particularly ...
The cell biology of HIV-1 latency and rebound
The cell biology of HIV-1 latency and rebound
Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4+ T c...
HERV-W upregulation expression in bipolar disorder and schizophrenia: unraveling potential links to systemic immune/inflammation status
HERV-W upregulation expression in bipolar disorder and schizophrenia: unraveling potential links to systemic immune/inflammation status
Bipolar disorder (BD) and schizophrenia (SZ) are the two main mental disorders with unknown etiology that significantly im...
Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue
Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue
The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immu...
HIV-1 with gag processing defects activates cGAS sensing
HIV-1 with gag processing defects activates cGAS sensing
Detection of viruses by host pattern recognition receptors induces the expression of type I interferon (IFN) and IFN-stimu...
The KT Jeang retrovirology prize 2023: Thumbi Ndung’u
The KT Jeang retrovirology prize 2023: Thumbi Ndung’u
Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta re...
Murine leukemia virus (MLV) P50 protein induces cell transformation via transcriptional regulatory function
Murine leukemia virus (MLV) P50 protein induces cell transformation via transcriptional regulatory function
The murine leukemia virus (MLV) has been a powerful model of pathogenesis for the discovery of genes involved in cancer. I...
Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
Human immunodeficiency virus (HIV) and other lentiviruses adapt to new hosts by evolving to evade host-specific innate imm...
Analysis of PERV-C superinfection resistance using HA-tagged viruses
Analysis of PERV-C superinfection resistance using HA-tagged viruses
Using pigs as organ donors has advanced xenotransplantation to the point that it is almost ready for clinical use. However...
Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques
Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques
A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary....
Correction to: DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence
Correction to: DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence
Institut Cochin, INSERM, Université Paris Cité, CNRS, Paris, F-75014, FranceMaría José Lista, AnneCaroline Jousset, Elenia...
A complex network of transcription factors and epigenetic regulators involved in bovine leukemia virus transcriptional regulation
A complex network of transcription factors and epigenetic regulators involved in bovine leukemia virus transcriptional regulation
Bovine Leukemia Virus (BLV) is the etiological agent of enzootic bovine leukosis, a disease characterized by the neoplasti...
DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence
DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence
Once integrated in the genome of infected cells, HIV-1 provirus is transcribed by the cellular transcription machinery. Th...
Reduced CCR5 expression among Uganda HIV controllers
Reduced CCR5 expression among Uganda HIV controllers
Several mechanisms including reduced CCR5 expression, protective HLA, viral restriction factors, broadly neutralizing anti...
Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Neutralizing antibodies (NAbs) protect against HIV-1 acquisition in animal models and show promise in treatment of infecti...
Intestinal endothelial cells increase HIV infection and latency in resting and activated CD4 + T cells, particularly affecting CCR6 + CD4 + T cells
Intestinal endothelial cells increase HIV infection and latency in resting and activated CD4 + T cells, particularly affecting CCR6 + CD4 + T cells
With suppressive antiretroviral therapy, HIV infection is well-managed in most patients. However, eradication and cure are...
Origin and functional role of antisense transcription in endogenous and exogenous retroviruses
Origin and functional role of antisense transcription in endogenous and exogenous retroviruses
Most proteins expressed by endogenous and exogenous retroviruses are encoded in the sense (positive) strand of the genome ...
Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is...
Biomolecular condensates: insights into early and late steps of the HIV-1 replication cycle
Biomolecular condensates: insights into early and late steps of the HIV-1 replication cycle
A rapidly evolving understanding of phase separation in the biological and physical sciences has led to the redefining of ...
HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity
Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the...
HIV-1 infection of renal epithelial cells: 30 years of evidence from transgenic animal models, human studies and in vitro experiments
HIV-1 infection of renal epithelial cells: 30 years of evidence from transgenic animal models, human studies and in vitro experiments
Although antiretroviral therapy (ART) has increased life expectancy in people with HIV-1 (PWH), acute and chronic kidney d...
HIV infection of non-classical cells in the brain
HIV infection of non-classical cells in the brain
HIV-associated neurological disorders (HAND) affect up to 50% of people living with HIV (PLWH), even in the era of combina...
An endogenous lentivirus in the germline of a rodent
An endogenous lentivirus in the germline of a rodent
Lentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike ma...
A detailed analysis of F-MuLV- and SFFV-infected cells in Friend virus-infected mice reveals the contribution of both F-MuLV- and SFFV-infected cells to the interleukin-10 host response
A detailed analysis of F-MuLV- and SFFV-infected cells in Friend virus-infected mice reveals the contribution of both F-MuLV- and SFFV-infected cells to the interleukin-10 host response
Friend virus (FV) is a complex of the Friend murine leukemia virus (F-MuLV) and the replication-defective, pathogenic sple...
A large population sample of African HIV genomes from the 1980s reveals a reduction in subtype D over time associated with propensity for CXCR4 tropism
A large population sample of African HIV genomes from the 1980s reveals a reduction in subtype D over time associated with propensity for CXCR4 tropism
We present 109 near full-length HIV genomes amplified from blood serum samples obtained during early 1986 from across Ugan...
Pericyte infection by HIV-1: a fatal attraction
Pericyte infection by HIV-1: a fatal attraction
While HIV-1 is primarily an infection of CD4 + T cells, there is an emerging interest towards understanding ho...
Modulation of human endogenous retroviruses and cytokines expression in peripheral blood mononuclear cells from autistic children and their parents
Modulation of human endogenous retroviruses and cytokines expression in peripheral blood mononuclear cells from autistic children and their parents
Putative pathogenic effects mediated by human endogenous retroviruses (HERVs) in neurological and psychiatric disorders in...
The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1)
The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1)
Viroporins are virally encoded ion channels involved in virus assembly and release. Human immunodeficiency virus type 1 (H...
A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human immunodeficiency virus (HIV). There are...
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