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Cervical cancer is primarily driven by persistent infection with high-risk human papillomavirus (HPV) strains and remains ...

Tumour Virus Research

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Too many cooks in the kitchen: HPV driven carcinogenesis – The result of collaboration or competition?

Infection by Human Papillomaviruses accounts for the most widespread sexually transmitted infection worldwide. Clinical pr...

Tumour Virus Research

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Regulation of epithelial growth factor receptors by the oncoprotein E5 during the HPV16 differentiation-dependent life cycle

Human papillomavirus (HPV) 16 infection initiates upon viral entry into the basal cells of the epithelium. The virus manip...

Tumour Virus Research

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Daxx and HIRA go viral – How chromatin remodeling complexes affect DNA virus infection

Daxx and HIRA are key proteins in the host response to DNA virus infections. Daxx is involved in apoptosis, transcription ...

Tumour Virus Research

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The oncogenic role of the NSD histone methyltransferases in head and neck and cervical cancers

Understanding the role of NSD proteins in virus-induced cancers could reveal new therapeutic strategies. Targeting NSD pro...

Tumour Virus Research

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Fibroblasts regulate the transcriptional signature of human papillomavirus-positive keratinocytes

Tumour Virus Research

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The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7

Human papillomaviruses (HPVs) are a diverse family of viruses with over 450 members that have been identified and fully se...

Tumour Virus Research

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Polyomavirus large T antigens: Unraveling a complex interactome

All members of the polyomavirus family encode a large T antigen (LT) protein that plays essential roles in viral DNA repli...

Tumour Virus Research

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Analysis of the progression of cervical cancer in a low-and-middle-income country: From pre-malignancy to invasive disease

To better understand cervical cancer progression, we analyzed RNA from 262 biopsies from women referred for colposcopy. We...

Tumour Virus Research

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Intraperitoneal delivery of cannabidiol (CBD) and Δ9-tetrahydocannabinol (THC) promotes papillomavirus infections in athymic nude mice

We used our mouse papillomavirus (MmuPV1) model to test the hypothesis that two primary psychoactive ingredients of mariju...

Tumour Virus Research

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Rapid-onset cancer

4-NQO4-Nitroquinoline 1-oxideWNTWingless-related integration siteAPCAdenomatous Polyposis ColiPI3KPhosphatidylinositol 3 K...

Tumour Virus Research

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How can HPV E6 manipulate host cell differentiation process to maintain the reservoir of infection

Tumour Virus Research

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De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment

Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs are the cause of almost a...

Tumour Virus Research

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The adenoviral E4orf4 protein: A multifunctional protein serving as a guide for treating cancer, a multifactorial disease

Viruses exploit several cellular pathways to support their replication, and many of these virus-targeted pathways are also...

Tumour Virus Research

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Drosophila model of HPV18-Induced pathogenesis reveals a role for E6 oncogene in regulation of NF-κB and Wnt to inhibit apoptosis

Cancers caused by high-risk human papillomavirus (HPV) remain a significant health threat resulting in more than 300,000 d...

Tumour Virus Research

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Evaluating the performance of the Xpert HPV assay in detecting HPV positive cases in Morocco

Recently, the World Health Organization recommended integrating HPV testing into cervical cancer screening programs global...

Tumour Virus Research

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Clinical performance of the SureX PCR HPV test versus hybrid capture assays (DH2/careHPV) in primary cervical cancer screening

BackgroundEvaluating novel human papillomavirus (HPV) tests in well-designed, population-based screening studies is essent...

Tumour Virus Research

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Modulation of epithelial homeostasis by HPV using Notch and Wnt